Michael Atchison

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment
    Arindam Basu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA and College of Science Health and Liberal Arts, Philadelphia University, 4201 Henry Avenue, Philadelphia, PA 19144, USA
    Nucleic Acids Res 42:2208-23. 2014
  2. pmc Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells
    Xuan Pan
    Department of Animal Biology, School of Veterinary, University of Pennsylvania, Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e30656. 2012
  3. pmc YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels
    Kristina Zaprazna
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:1542-54. 2012
  4. pmc Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects
    Michael Atchison
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Crit Rev Oncog 16:143-61. 2011
  5. doi request reprint Factors that attract veterinarians to or discourage them from research careers: a program director's perspective
    Michael L Atchison
    Universit of Pennsylvania School of Veterinary, Philadelphia, PA19104, USA
    J Vet Med Educ 36:76-82. 2009
  6. ncbi request reprint VMSTP Combined Degree Training (VMD/PhD): key features of the program at the University of Pennsylvania
    Michael Atchison
    University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Vet Med Educ 32:337-41. 2005
  7. pmc Transcription factor YY1 functions as a PcG protein in vivo
    Lakshmi Atchison
    Department of Biology, Chestnut Hill College, 9601 Germantown Avenue, Philadelphia, PA 19118, USA
    EMBO J 22:1347-58. 2003
  8. pmc YY1 DNA binding and PcG recruitment requires CtBP
    Lakshmi Srinivasan
    University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:2596-601. 2004
  9. ncbi request reprint Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue
    Lakshmi Srinivasan
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    J Cell Biochem 96:689-99. 2005
  10. ncbi request reprint Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor
    Ettickan Boopathi
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:35242-54. 2004

Research Grants

  1. Roles of Oct4 dimers during mouse germline development
    Michael Atchison; Fiscal Year: 2006
  2. PcG Function of YY1 in Transcription and Development
    Michael Atchison; Fiscal Year: 2007
  3. SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESS. SCHOOLS
    Michael Atchison; Fiscal Year: 2007
  4. Veterinarians in Biomedical Research: Building Capacity
    Michael Atchison; Fiscal Year: 2007
  5. Developmental Control of Enhancer Function
    Michael L Atchison; Fiscal Year: 2010
  6. Control of B cell Development by YY1
    Michael L Atchison; Fiscal Year: 2010
  7. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2005
  8. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 1993
  9. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 1991
  10. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2001

Collaborators

  • Frank Wilkinson
  • Debabrata Chakravarti
  • Nancy Bonini
  • John Monroe
  • Wei Hong
  • Arindam Basu
  • Lakshmi Srinivasan
  • Kristina Zaprazna
  • Xuan Pan
  • Duonan Yu
  • Daniel C McDevit
  • Leslie Perkins
  • Yuchen Bai
  • Ettickan Boopathi
  • Lakshmi Atchison
  • Kristen Colavita
  • Sujatha Nagulapalli
  • Colin Fennelly
  • Warren Pear
  • Morgan Jones
  • Jie Jiang
  • Ivan Maillard
  • Barbara S Nikolajczyk
  • Agata Giallongo
  • Ji Kang Fang
  • Narayan G Avadhani
  • Nibedita Lenka
  • Subbuswamy K Prabu
  • Andrei Thomas-Tikhonenko
  • David Allman
  • Michael H Goldschmidt
  • Ayesha Ghias
  • Lawrence P McIntosh
  • Leslie Pitt
  • Aisha Goheer

Detail Information

Publications19

  1. doi request reprint YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment
    Arindam Basu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA and College of Science Health and Liberal Arts, Philadelphia University, 4201 Henry Avenue, Philadelphia, PA 19144, USA
    Nucleic Acids Res 42:2208-23. 2014
    ..We present a model of YAF2-dependent and independent PcG DNA recruitment by YY1. ..
  2. pmc Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells
    Xuan Pan
    Department of Animal Biology, School of Veterinary, University of Pennsylvania, Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e30656. 2012
    ..B cell apoptosis and LT-HSC enrichment induced by YY1 suggest that novel strategies to induce YY1 expression could have beneficial effects in the treatment of B lineage malignancies while preserving normal HSCs...
  3. pmc YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels
    Kristina Zaprazna
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:1542-54. 2012
    ..We show for the first time that YY1 plays a novel role in CSR and controls nuclear AID protein levels...
  4. pmc Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects
    Michael Atchison
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Crit Rev Oncog 16:143-61. 2011
    ..Disruption of these functions may causally initiate cancer or may contribute to disease progression. Targeting YY1 functions provides possible avenues for clinical intervention...
  5. doi request reprint Factors that attract veterinarians to or discourage them from research careers: a program director's perspective
    Michael L Atchison
    Universit of Pennsylvania School of Veterinary, Philadelphia, PA19104, USA
    J Vet Med Educ 36:76-82. 2009
    ..Finally, students must be made aware of career options after graduation...
  6. ncbi request reprint VMSTP Combined Degree Training (VMD/PhD): key features of the program at the University of Pennsylvania
    Michael Atchison
    University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Vet Med Educ 32:337-41. 2005
    ....
  7. pmc Transcription factor YY1 functions as a PcG protein in vivo
    Lakshmi Atchison
    Department of Biology, Chestnut Hill College, 9601 Germantown Avenue, Philadelphia, PA 19118, USA
    EMBO J 22:1347-58. 2003
    ..Finally, we found that YY1, as well as Polycomb, required the co-repressor protein CtBP for repression in vivo. These results provide a mechanism for recruitment of vertebrate PcG complexes to DNA and demonstrate new functions for YY1...
  8. pmc YY1 DNA binding and PcG recruitment requires CtBP
    Lakshmi Srinivasan
    University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:2596-601. 2004
    ..These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA...
  9. ncbi request reprint Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue
    Lakshmi Srinivasan
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    J Cell Biochem 96:689-99. 2005
    ..Therefore, YY1 was transiently required for correction of fly defects and was dispensable past the pharate adult stage. Possible mechanisms of repression by YY1 are discussed...
  10. ncbi request reprint Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor
    Ettickan Boopathi
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:35242-54. 2004
    ..Our results show a novel mechanism of protein factor switching in transcription regulation of the cytochrome c oxidase Vb gene during myogenesis...
  11. pmc CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA
    Arindam Basu
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    J Cell Biochem 110:62-9. 2010
    ..Our results support a model in which CtBP regulates expression of intergenic transcripts that controls DNA binding by PcG proteins and subsequent histone modifications and transcriptional activity...
  12. pmc Polycomb recruitment to DNA in vivo by the YY1 REPO domain
    Frank H Wilkinson
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:19296-301. 2006
    ..We propose that this motif be named the REPO domain for its function in recruitment of Polycomb. The REPO domain is well conserved in YY1 orthologs and in related proteins...
  13. pmc Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1
    Wei Hong
    Division of Hematology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 22:3729-43. 2002
    ..1 and possibly other members of the Ets family of oncoproteins subverts normal cellular differentiation in part by inhibiting the acetylation of critical nuclear factors involved in balancing cellular proliferation and maturation...
  14. pmc PcG recruitment by the YY1 REPO domain can be mediated by Yaf2
    Frank Wilkinson
    School of Science and Health, Philadelphia University, Schoolhouse Lane and Henry Avenue, Philadelphia, Pennsylvania 19144, USA
    J Cell Biochem 109:478-86. 2010
    ..When the Drosophila homolog of Yaf2 (dRYBP) is mutated, PcG recruitment to DNA is reduced. Taken together, our results suggest that Yaf2 serves as a molecular bridge between YY1 and other PcG complex proteins...
  15. ncbi request reprint Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway
    Duonan Yu
    Departments of Pathobiology, Pathology and Laboratory Medicine, and Animal Biology, University of Pennsylvania, Philadelphia, PA 19104 6051, USA
    Blood 101:1950-5. 2003
    ..Our data demonstrate that some Myc target cells are bipotent B-lymphoid/myeloid progenitors with the astonishing capacity to undergo successive rounds of lineage switching...
  16. pmc Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts
    Sujatha Nagulapalli
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 22:7337-50. 2002
    ..However, a Pip dominant negative mutant inhibited germ line I micro transcripts. The importance of these results for late B-cell functions is discussed...
  17. ncbi request reprint Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity
    Yuchen Bai
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:5160-9. 2005
    ..Using chromatin immunoprecipitation assays we found that TSA caused preferential acetylation of histone H3 at the 3' enhancer. The relevance of these studies for PU.1 function in transcription and hemopoietic development is discussed...
  18. ncbi request reprint The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association
    Daniel C McDevit
    Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, Boston Medical Center, Boston, MA 02118, USA
    J Immunol 174:2834-42. 2005
    ..This analysis demonstrates kappa activation is a multistep process initiated in early B cell precursors before Igmu recombination and finalized only after the pre-B cell stage...

Research Grants32

  1. Roles of Oct4 dimers during mouse germline development
    Michael Atchison; Fiscal Year: 2006
    ..The anticipated results will have relevant applicability to stem cell and germline biology and lead to a better understanding of human reproduction. ..
  2. PcG Function of YY1 in Transcription and Development
    Michael Atchison; Fiscal Year: 2007
    ..PcG proteins are also implicated in muscle differentiation. Therefore, we will test the roles of YY1, CtBP, SUMO-1, and PCNA in differentation of myblasts into myotubes. ..
  3. SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESS. SCHOOLS
    Michael Atchison; Fiscal Year: 2007
    ..Students also participate in a school-wide research day held each Spring. Future goals include further expansion of funded slots and development of additional strategies for recruitment of veterinary students into research careers. ..
  4. Veterinarians in Biomedical Research: Building Capacity
    Michael Atchison; Fiscal Year: 2007
    ..The unique perspectives offered by veterinarian-scientists are likely to promote innovation in diagnosis and treatment, and to stimulate the development of multidisciplinary research teams consistent with the goals of the NIH Roadmap. ..
  5. Developmental Control of Enhancer Function
    Michael L Atchison; Fiscal Year: 2010
    ..Understanding these processes therefore directly relates to public health. ..
  6. Control of B cell Development by YY1
    Michael L Atchison; Fiscal Year: 2010
    ..These studies may provide new mechanisms for enhancing the success of bone marrow transplantation treatments, and may provide new targets for diseases caused by PcG proteins or stem cell dysfunction. ..
  7. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2005
    ..These studies represent parallel in vitro and in vivo approaches to study gene regulation and cellular differentiation. ..
  8. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 1993
    ..Our long-term goals are to determine whether the factors that control kappaE3' enhancer activity also play a role in B cell differentiation...
  9. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 1991
    ..Finally, we will pursue studies relating to position- independent and copy number-dependent transcription of transfected Ig kappa genes...
  10. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2001
    ..Many of the proteins that bind to the 3 prime enhancer are encoded by proto-oncogenes. Therefore, these studies will also be useful for understanding the roles of these proteins in oncogenesis. ..
  11. PcG Function of YY1 in Transcription and Development
    Michael L Atchison; Fiscal Year: 2010
    ..PcG proteins are also implicated in muscle differentiation. Therefore, we will test the roles of YY1, CtBP, SUMO-1, and PCNA in differentation of myblasts into myotubes. ..