Brad C Astor

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 59:653-62. 2012
  2. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
  3. pmc Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans
    Adrienne Tin
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Nephrol Dial Transplant 28:1497-504. 2013
  4. pmc Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
    Audrey Y Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 10:108. 2009
  5. pmc Combined association of creatinine, albuminuria, and cystatin C with all-cause mortality and cardiovascular and kidney outcomes
    Salman Waheed
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin J Am Soc Nephrol 8:434-42. 2013
  6. ncbi request reprint Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patients
    Bernard G Jaar
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Chronic Kidney Dis 14:304-13. 2007
  7. pmc Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes
    Elizabeth Selvin
    Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Diabetes 60:298-305. 2011
  8. pmc Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Genet 58:461-6. 2013
  9. ncbi request reprint Type of vascular access and survival among incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study
    Brad C Astor
    Johns Hopkins Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Suite 2 600 Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 16:1449-55. 2005
  10. pmc Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury
    Morgan E Grams
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Soc Nephrol 21:1757-64. 2010

Collaborators

Detail Information

Publications65

  1. pmc Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 59:653-62. 2012
    ..It is unknown whether this advantage extends to other outcomes, such as kidney failure, or whether other novel renal filtration markers share this advantage in predicting outcomes...
  2. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
    ..Thus, these relationships are consistent with CKD stage classifications based on eGFR and suggest that albuminuria provides additional prognostic information among individuals with CKD...
  3. pmc Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans
    Adrienne Tin
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Nephrol Dial Transplant 28:1497-504. 2013
    ..Beta-trace protein (BTP), measured in serum or plasma, has potential as a novel biomarker for kidney function. Little is known about the genes influencing BTP levels...
  4. pmc Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
    Audrey Y Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 10:108. 2009
    ..However, few data are available in non-European ethnic groups or in a population-based cohort...
  5. pmc Combined association of creatinine, albuminuria, and cystatin C with all-cause mortality and cardiovascular and kidney outcomes
    Salman Waheed
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin J Am Soc Nephrol 8:434-42. 2013
    ..Combining multiple kidney markers to predict risk is an area of substantial interest...
  6. ncbi request reprint Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patients
    Bernard G Jaar
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Chronic Kidney Dis 14:304-13. 2007
    ..This study identifies several novel risk factors (eg, Lp(a) and total homocysteine) and underscores the need for further research to reduce the burden of PAD in this high-risk group of patients...
  7. pmc Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes
    Elizabeth Selvin
    Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Diabetes 60:298-305. 2011
    ....
  8. pmc Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Genet 58:461-6. 2013
    ..However, careful attention must be paid to the correlation of systematic errors and inconsistent associations when different biomarkers or methods are used to measure the quantitative trait. ..
  9. ncbi request reprint Type of vascular access and survival among incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study
    Brad C Astor
    Johns Hopkins Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Suite 2 600 Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 16:1449-55. 2005
    ....
  10. pmc Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury
    Morgan E Grams
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Soc Nephrol 21:1757-64. 2010
    ..Patterns persisted within subgroups of age, race, and gender. In summary, albuminuria and eGFR have strong, independent associations with incident AKI...
  11. pmc Prevalence of kidney disease in anaemia differs by GFR-estimating method: the Third National Health and Nutrition Examination Survey (1988-94)
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Nephrol Dial Transplant 25:2542-8. 2010
    ..Serum cystatin C is purportedly a more sensitive marker of kidney disease and a better predictor of mortality than serum creatinine. However, studies suggest that extrarenal factors also influence cystatin C levels...
  12. pmc Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population
    Stephen P Juraschek
    Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 8:584-92. 2013
    ..This study compares the distribution of all four markers in the general population and their associations with possible determinants of GFR...
  13. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    ..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
  14. pmc Diabetes medication use and blood lactate level among participants with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study
    Morgana L Mongraw-Chaffin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    PLoS ONE 7:e51237. 2012
    ..The objective of this study is to compare lactate levels between users and non-users of diabetes medications under the hypothesis that the level of lactate is a marker of oxidative capacity...
  15. pmc Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD 21287, USA
    Am J Kidney Dis 55:648-59. 2010
    ..Although the CKD-EPI equation estimates GFR more precisely compared with the MDRD Study equation, whether this equation improves risk prediction is unknown...
  16. pmc Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III)
    Tariq Shafi
    Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Nephrol 13:42. 2012
    ....
  17. doi request reprint Chronic kidney disease, plasma lipoproteins, and coronary artery calcium incidence: the Multi-Ethnic Study of Atherosclerosis
    Julio A Lamprea-Montealegre
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 33:652-8. 2013
    ..To determine the association of chronic kidney disease and coronary artery calcium (CAC) incidence, and the distribution of lipoproteins across categories of kidney function and their association with CAC risk...
  18. pmc Blood pressure, atherosclerosis, and albuminuria in 10,113 participants in the atherosclerosis risk in communities study
    Charles C Hsu
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Hypertens 27:397-409. 2009
    ..Albuminuria predicts cardiovascular risk, but its function as a marker of endothelial damage and atherosclerosis is uncertain, as is the complex relationship with hypertension and diabetes...
  19. pmc Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease
    Julia J Scialla
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Clin J Am Soc Nephrol 6:1526-32. 2011
    ..We tested the association between estimated NEAP and serum bicarbonate in patients with CKD...
  20. pmc Comparison of measured GFR, serum creatinine, cystatin C, and beta-trace protein to predict ESRD in African Americans with hypertensive CKD
    Nrupen A Bhavsar
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 58:886-93. 2011
    ....
  21. pmc APOL1 variants associate with increased risk of CKD among African Americans
    Meredith C Foster
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 24:1484-91. 2013
    ..22, 95% CI=1.01 to 4.84). In conclusion, APOL1 risk variants are risk factors for the development of CKD and progression from CKD to ESRD among African Americans in the general population...
  22. doi request reprint Risk of incident ESRD: a comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study
    Lori D Bash
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
    Am J Kidney Dis 55:31-41. 2010
    ..Previous studies suggest that other cardiovascular risk factors also may increase the risk of ESRD; however, risk associated with a comprehensive cardiovascular risk-factor assessment has not been quantified in a population-based sample...
  23. pmc Intensive blood-pressure control in hypertensive chronic kidney disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 363:918-29. 2010
    ..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...
  24. pmc Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21287, USA
    Am J Nephrol 34:291-7. 2011
    ..35; 95% CI: 1.11, 1.64). Conclusions: Higher urinary TFF3 levels may indicate ongoing repair of damage in the kidney. Additional studies are needed to confirm whether TFF3 can be useful as a marker of increased risk for CKD...
  25. pmc Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis
    Bakhtawar K Mahmoodi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 380:1649-61. 2012
    ..However, whether the association of the kidney disease measures, estimated glomerular filtration rate (eGFR) and albuminuria, with mortality or end-stage renal disease (ESRD) differs by hypertensive status is unknown...
  26. pmc Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study
    Lori D Bash
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21201, USA
    Am J Kidney Dis 53:596-605. 2009
    ..Inflammation and hemostasis may increase the risk of kidney function decline; however, data from prospective studies are sparse...
  27. pmc Chronic kidney disease and estimates of kidney function in HIV infection: a cross-sectional study in the multicenter AIDS cohort study
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 57:380-6. 2011
    ..Cystatin C has been proposed as an alternative marker of kidney function among HIV-infected persons in whom serum creatinine is affected by extrarenal factors...
  28. doi request reprint Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population
    Brad C Astor
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 167:1226-34. 2008
    ..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria...
  29. pmc Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study
    Ghanshyam Palamaner Subash Shantha
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Atherosclerosis 228:249-55. 2013
    ..In order to examine this hypothesis, we assessed the association between elevated blood lactate, a marker of mitochondrial dysfunction, and carotid atherosclerosis...
  30. pmc sRAGE and risk of diabetes, cardiovascular disease, and death
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Diabetes 62:2116-21. 2013
    ..34-1.79]). In conclusion, we found that low levels of sRAGE were a marker of future chronic disease risk and mortality in the community and may represent an inflammatory state. Racial differences in sRAGE deserve further examination...
  31. ncbi request reprint Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ....
  32. pmc Heart rate variability predicts ESRD and CKD-related hospitalization
    Daniel J Brotman
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Soc Nephrol 21:1560-70. 2010
    ..These results suggest that autonomic dysfunction may be an important risk factor for ESRD and CKD-related hospitalizations and call for further studies to define the mechanisms that underlie these associations...
  33. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    ..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease...
  34. ncbi request reprint Cohort profile: the Chronic Kidney Disease Prognosis Consortium
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, Department of Medicine and Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Departments of Medicine, University of Calgary, Calgary, AB, Canada, Division of Nephrology, Tufts Medical Center, Boston, MA, USA, Department of Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada, China Medical University Hospital, Taichung, Taiwan and Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan and George Institute, University of Sydney, Australia
    Int J Epidemiol 42:1660-8. 2013
    ..Each cohort can opt in/out for each topic. CKD-PC has established a productive and effective collaboration, allowing flexible participation and complex meta-analyses for studying CKD. ..
  35. pmc Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study
    Salman Waheed
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Kidney Dis 60:207-16. 2012
    ....
  36. pmc MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: methods, reliability and descriptive statistics
    Bruce A Wasserman
    The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Magn Reson Imaging 31:406-15. 2010
    ..To measure carotid plaque components using MRI and estimate reliability in the population-based Atherosclerosis Risk in Communities (ARIC) study...
  37. pmc Change in estimated GFR associates with coronary heart disease and mortality
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 E Monument Street, Baltimore, MD 21287, USA
    J Am Soc Nephrol 20:2617-24. 2009
    ..In conclusion, a steeper than average decline in eGFR associates with a higher risk for CHD and all-cause mortality. Increases in eGFR among participants with chronic kidney disease associate with similar increased risks...
  38. pmc Defining incident chronic kidney disease in the research setting: The ARIC Study
    Lori D Bash
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
    Am J Epidemiol 170:414-24. 2009
    ..3, confidence interval: 4.4, 8.9). Associations with gender differed in direction and magnitude across definitions. Case definition can impact relative risk estimates for CKD risk factors...
  39. pmc Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Hum Genet 132:619-27. 2013
    ..The identification of the two novel loci for B2M extends our understanding of its metabolism and informs its use as a kidney filtration biomarker...
  40. pmc Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study
    Nrupen A Bhavsar
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 60:233-40. 2012
    ....
  41. ncbi request reprint Predictors of amputation and survival following lower extremity revascularization in hemodialysis patients
    Bernard G Jaar
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 65:613-20. 2004
    ..We studied the prognosis of ESRD patients undergoing their first revascularization procedure...
  42. ncbi request reprint Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994)
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Arch Intern Med 162:1401-8. 2002
    ..Kidney failure is known to cause anemia, which is associated with a higher risk of cardiac failure and mortality. The impact of milder decreases in kidney function on hemoglobin levels and anemia in the US population, however, is unknown...
  43. pmc Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) Study
    Lori D Bash
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Arch Intern Med 168:2440-7. 2008
    ....
  44. pmc Method of glomerular filtration rate estimation affects prediction of mortality risk
    Brad C Astor
    Department of Epidemiology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Welch Center for Prevention, Baltimore, Maryland 21287, USA
    J Am Soc Nephrol 20:2214-22. 2009
    ..In conclusion, despite better performance in terms of estimating GFR, equations based on both cystatin C and creatinine do not predict mortality as well as equations based on cystatin C alone...
  45. pmc Remodeling of carotid arteries detected with MR imaging: atherosclerosis risk in communities carotid MRI study
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research and Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Radiology 256:879-86. 2010
    ..To determine the extent of thickening of the carotid arterial walls that may be accommodated by outward remodeling...
  46. ncbi request reprint Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal function
    Eliseo Guallar
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 163:700-8. 2006
    ..The association of lead and cadmium with PAD risk deserves further investigation...
  47. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  48. ncbi request reprint Screening for proteinuria in patients with lupus: a survey of practice preferences among American rheumatologists
    Mark J Siedner
    Divisions of Nephrology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 34:973-7. 2007
    ..Recent studies have called into question the validity of qualitative proteinuria measurements. We set out to assess if American rheumatologists have changed their practice preferences in response to these data...
  49. ncbi request reprint Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Kidney Dis 43:836-45. 2004
    ..It is unknown whether kidney function and lower hemoglobin levels are associated with LV morphological characteristics among African Americans with moderate kidney dysfunction, independent of blood pressure...
  50. ncbi request reprint Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000
    Josef Coresh
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Am Soc Nephrol 16:180-8. 2005
    ..Despite a high prevalence, CKD awareness in the U.S. population is low. In contrast to the dramatic increase in treated kidney failure, overall CKD prevalence in the U.S. population has been relatively stable...
  51. ncbi request reprint Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am Heart J 151:492-500. 2006
    ..Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both conditions are present...
  52. pmc The impact of kidney function at highly active antiretroviral therapy initiation on mortality in HIV-infected women
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 55:217-20. 2010
    ..We re-examined this association in the later HAART period to determine whether chronic kidney disease remains a predictor of death after HAART initiation...
  53. pmc CKD, plasma lipids, and common carotid intima-media thickness: results from the multi-ethnic study of atherosclerosis
    Julio A Lamprea-Montealegre
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin J Am Soc Nephrol 7:1777-85. 2012
    ....
  54. pmc Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study
    Stephen O Crawford
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Int J Epidemiol 39:1647-55. 2010
    ..Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies...
  55. ncbi request reprint Association of kidney disease measures with ischemic versus hemorrhagic strokes: pooled analyses of 4 prospective community-based cohorts
    Bakhtawar K Mahmoodi
    From the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD B K M, K M, Y S, M W, J C Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands B K M, R T G Department of Public Health, Fujita Health University, Toyoake, Japan H Y Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD R F G Department of Medicine and Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison B C A George Institute, University of Sydney, Sydney, New South Wales, Australia M W Departments of Neurology and Epidemiology, University of Washington, Seattle W T L Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology and Health Service, University of Washington and Group Health Research Institute, Group Health Cooperative, Seattle B M P Division of General Internal Medicine, San Francisco VA Medical Center, University of California San Francisco M G S and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis A R F
    Stroke 45:1925-31. 2014
    ..We contrasted the association of these kidney measures with ischemic versus hemorrhagic stroke...
  56. ncbi request reprint Increased risk of type 2 diabetes from a family history of coronary heart disease and type 2 diabetes
    Edwina H Yeung
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 30:154-6. 2007
  57. ncbi request reprint Influence of intravenous drug abuse on vascular access placement and survival in HIV-seropositive patients
    Joseph A Eustace
    Division of Nephrology, The Welch Center for Disease Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Nephron Clin Pract 100:c38-45. 2005
    ..The influence of intravenous drug abuse (IVDA) on hemodialysis access placement practices and access survival in HIV-infected patients is unknown...
  58. ncbi request reprint Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate
    Josef Coresh
    Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Am J Kidney Dis 39:920-9. 2002
    ..73 m2), but result in progressively larger differences at higher GFRs. Both clinical and research use of serum creatinine or equations to estimate GFR require knowledge of the calibration of the serum creatinine assay...
  59. doi request reprint Mortality risks for all causes and cardiovascular diseases and reduced GFR in a middle-aged working population in Taiwan
    Ting Yuan David Cheng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Kidney Dis 52:1051-60. 2008
    ..Effects of decreased estimated glomerular filtration rate (eGFR) on cardiovascular disease (CVD) mortality are uncertain in Chinese general populations...
  60. ncbi request reprint Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Surve
    Ruth M Belin
    Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 89:6077-86. 2004
    ..Understanding the underlying mechanism could help identify potential pathways for the prevention of autoimmune thyroid disease...
  61. ncbi request reprint Arterial reactivity in lower extremities is progressively reduced as cardiovascular risk factors increase: comparison with upper extremities using magnetic resonance imaging
    Harry A Silber
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 49:939-45. 2007
    ..Our goal was to investigate whether the association between established cardiovascular risk factors and arterial reactivity differs between the lower and upper extremities...
  62. doi request reprint Intracranial arterial wall imaging using three-dimensional high isotropic resolution black blood MRI at 3.0 Tesla
    Ye Qiao
    The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Magn Reson Imaging 34:22-30. 2011
    ..To develop a high isotropic-resolution sequence to evaluate intracranial vessels at 3.0 Tesla (T)...
  63. ncbi request reprint Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis
    Lisa Christopher-Stine
    Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    J Rheumatol 31:1557-9. 2004
    ..To evaluate the 24-hour urine protein-to-creatinine (U pr:cr) ratio compared to 24-h urine total protein excretion as a measure of proteinuria in patients with lupus nephritis...
  64. ncbi request reprint Race-specific association of lipoprotein(a) with vascular access interventions in hemodialysis patients: the CHOICE Study
    Brad C Astor
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21205, USA
    Kidney Int 61:1115-23. 2002
    ..Lp(a) may be more atherothrombotic in whites than in blacks. Data on the relation of Lp(a) and apo(a) isoform size to hemodialysis vascular access complications are limited...
  65. ncbi request reprint Wash-in kinetics for gadolinium-enhanced magnetic resonance imaging of carotid atheroma
    Bruce A Wasserman
    Russell H Morgan Department of Radiology and Radiological Sciences, Baltimore, Maryland, USA
    J Magn Reson Imaging 21:91-5. 2005
    ..To determine the wash-in kinetics of intravenous gadolinium into the fibrous cap and lipid core of carotid atheroma, and identify the time following gadolinium administration that maximizes contrast between the cap and core...