Gary Aston-Jones

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal pool
    Gary Aston-Jones
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2313-21. 2004
  2. ncbi An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
    Gary Aston-Jones
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Annu Rev Neurosci 28:403-50. 2005
  3. ncbi Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance
    Gary Aston-Jones
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 493:99-110. 2005
  4. ncbi The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal
    G Aston-Jones
    University of Pennsylvania, Department of Psychiatry, VA Medical Center, Philadelphia 19104, USA
    Ann N Y Acad Sci 877:486-98. 1999
  5. ncbi Brain structures and receptors involved in alertness
    Gary Aston-Jones
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep Med 6:S3-7. 2005
  6. ncbi Brain substrates for increased drug seeking during protracted withdrawal
    Gary Aston-Jones
    Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Neuropharmacology 47:167-79. 2004
  7. ncbi Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations
    G Aston-Jones
    Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC, Building 15, Room 520, Woodland and University Avenues, Philadelphia, PA 19104, USA
    J Neurosci Methods 103:51-61. 2000
  8. ncbi A neural circuit for circadian regulation of arousal
    G Aston-Jones
    Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC 151, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 4:732-8. 2001
  9. ncbi A role for lateral hypothalamic orexin neurons in reward seeking
    Glenda C Harris
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100 422 Curie Blvd, Philadelphia, Pennsylvania 19104 6100, USA
    Nature 437:556-9. 2005
  10. pmc Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity
    Heinrich S Gompf
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1224:43-52. 2008

Collaborators

Detail Information

Publications25

  1. ncbi Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal pool
    Gary Aston-Jones
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2313-21. 2004
    ..These results indicate that a population of small GABAergic neurons in the peri-LC dendritic zone may provide interneuronal integration for LC noradrenergic neurons...
  2. ncbi An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
    Gary Aston-Jones
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Annu Rev Neurosci 28:403-50. 2005
    ..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales...
  3. ncbi Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance
    Gary Aston-Jones
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 493:99-110. 2005
    ..We propose that these prefrontal areas produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales...
  4. ncbi The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal
    G Aston-Jones
    University of Pennsylvania, Department of Psychiatry, VA Medical Center, Philadelphia 19104, USA
    Ann N Y Acad Sci 877:486-98. 1999
    ..Together, these results indicate that beta-receptor activation in the BNST is critical for aversive withdrawal symptoms, and that A1 and A2 neurons in the medulla are the source of this critical NE...
  5. ncbi Brain structures and receptors involved in alertness
    Gary Aston-Jones
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep Med 6:S3-7. 2005
    ....
  6. ncbi Brain substrates for increased drug seeking during protracted withdrawal
    Gary Aston-Jones
    Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Neuropharmacology 47:167-79. 2004
    ..The combination of anxiety, decreased valence of natural rewards, and sensitized incentive for drugs make a potent formula for relapse and drug seeking during protracted withdrawal...
  7. ncbi Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations
    G Aston-Jones
    Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC, Building 15, Room 520, Woodland and University Avenues, Philadelphia, PA 19104, USA
    J Neurosci Methods 103:51-61. 2000
    ..A set of recipes for various procedures are included at the end of this article...
  8. ncbi A neural circuit for circadian regulation of arousal
    G Aston-Jones
    Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC 151, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 4:732-8. 2001
    ..Lesions of the DMH eliminated these circadian changes in LC activity, confirming the functionality of the SCN-DMH-LC circuit. These results reveal mechanisms for regulation of circadian and sleep-waking functions...
  9. ncbi A role for lateral hypothalamic orexin neurons in reward seeking
    Glenda C Harris
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100 422 Curie Blvd, Philadelphia, Pennsylvania 19104 6100, USA
    Nature 437:556-9. 2005
    ..Moreover, administration of the orexin A peptide directly into the ventral tegmental area also reinstated drug-seeking. These data reveal a new role for lateral hypothalamus orexin neurons in reward-seeking, drug relapse and addiction...
  10. pmc Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity
    Heinrich S Gompf
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1224:43-52. 2008
    ..Therefore, we propose that DMH orexin neurons play a role in modulating the day-night differences of LC impulse activity...
  11. pmc Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathway
    Alice H Luo
    Psychiatry Department, University of Pennsylvania, Philadelphia, PA, USA
    Eur J Neurosci 29:748-60. 2009
    ..This pathway may function in the circadian regulation of numerous behavioral processes including arousal and motivation...
  12. pmc Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 S 31st Street, Philadelphia, PA 19104, United States
    Behav Brain Res 176:251-8. 2007
    ....
  13. pmc Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 S 31st Street, Philadelphia, PA 19104, United States
    Behav Brain Res 183:43-51. 2007
    ..These results demonstrate the importance of LH orexin neurons and their projections to the VTA in the formation of associations between environmental cues and drug reward...
  14. ncbi Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:73-6. 2003
    ..These data indicate that glutamatergic activity in the VTA may be crucial for learning to associate environmental stimuli with cocaine exposure...
  15. ncbi Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice task
    Edwin C Clayton
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:9914-20. 2004
    ..This role of the LC in regulating the behavioral outcome of decisional processes contrasts with more traditional views of LC responses as primarily related to sensory processes...
  16. ncbi Prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine: participation of imidazoline and norepinephrine receptors
    François Georges
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:1140-9. 2003
    ..These results indicate that the pharmacological effects of clonidine on VTA DA neurons during morphine withdrawal is related to actions on I1Rs as well as alpha2Rs...
  17. ncbi Arousal and reward: a dichotomy in orexin function
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 29:571-7. 2006
    ..Evidence also indicates roles for lateral hypothalamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory...
  18. ncbi Circadian regulation of arousal: role of the noradrenergic locus coeruleus system and light exposure
    Mónica M C González
    Department of Psychiatry, School of Medicine, University of Pennsylvania, PA, USA
    Sleep 29:1327-36. 2006
    ..This is mediated by an indirect circuit projection from the suprachiasmatic nucleus (SCN) to the LC. Here we sought to evaluate the hypothesis that the LC regulates the circadian properties of the sleep-wake cycle...
  19. ncbi Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdala
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:292-9. 2003
    ..These results indicate a relationship between place preference behavior and neural indices of activation in the forebrain in response to morphine-conditioned cues that may be chronically modulated by prior morphine exposure...
  20. ncbi Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons
    François Georges
    Laboratory for Neuromodulation and Behavior, Department of Psychiatry, Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:5173-87. 2002
    ..These results reveal that inputs from the vBNST exert a strong excitatory influence on VTA DA neurons mediated by both NMDA and non-NMDA receptors...
  21. ncbi Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task
    Janusz Rajkowski
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    J Neurophysiol 92:361-71. 2004
    ..These and other results lead us to hypothesize that LC responses are driven by decision processes and help facilitate subsequent behavioral responses...
  22. ncbi Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model
    Yan Zhu
    Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10060-71. 2007
    ..It is anticipated that severe obstructive sleep apnea in humans destroys catecholaminergic wake neurons...
  23. ncbi Altered motivation and learning following opiate withdrawal: evidence for prolonged dysregulation of reward processing
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:865-71. 2003
    ..These data suggest that prior morphine exposure may have prolonged effects on the motivation for natural rewards, which in turn may compromise the ability of former addicts to overcome their addictions...
  24. pmc Adrenergic and noradrenergic innervation of the midbrain ventral tegmental area and retrorubral field: prominent inputs from medullary homeostatic centers
    CARLOS A MEJIAS-APONTE
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 29:3613-26. 2009
    ..The identification of medullary noradrenergic and adrenergic afferents to DA neuron areas indicates new pathways for visceral-related inputs to reward-related areas in the midbrain...
  25. doi Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycle
    Alice H Luo
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Neurosci 27:408-22. 2008
    ..These findings reveal previously unknown populations of VTA neurons whose activities are sensitive to diurnal phase, and whose functions may be in the temporal regulation of arousal and motivational processes...