Research Topics
Species | Gary Aston-JonesSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal poolGary Aston-Jones
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:2313-21. 2004..These results indicate that a population of small GABAergic neurons in the peri-LC dendritic zone may provide interneuronal integration for LC noradrenergic neurons...- An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Annu Rev Neurosci 28:403-50. 2005..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales... - Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 493:99-110. 2005..We propose that these prefrontal areas produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales... - The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawalG Aston-Jones
University of Pennsylvania, Department of Psychiatry, VA Medical Center, Philadelphia 19104, USA
Ann N Y Acad Sci 877:486-98. 1999..Together, these results indicate that beta-receptor activation in the BNST is critical for aversive withdrawal symptoms, and that A1 and A2 neurons in the medulla are the source of this critical NE... - Brain structures and receptors involved in alertnessGary Aston-Jones
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Sleep Med 6:S3-7. 2005.... - Brain substrates for increased drug seeking during protracted withdrawalGary Aston-Jones
Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
Neuropharmacology 47:167-79. 2004..The combination of anxiety, decreased valence of natural rewards, and sensitized incentive for drugs make a potent formula for relapse and drug seeking during protracted withdrawal... - Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitationsG Aston-Jones
Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC, Building 15, Room 520, Woodland and University Avenues, Philadelphia, PA 19104, USA
J Neurosci Methods 103:51-61. 2000..A set of recipes for various procedures are included at the end of this article... - A neural circuit for circadian regulation of arousalG Aston-Jones
Department of Psychiatry, University of Pennsylvania School of Medicine, VAMC 151, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
Nat Neurosci 4:732-8. 2001..Lesions of the DMH eliminated these circadian changes in LC activity, confirming the functionality of the SCN-DMH-LC circuit. These results reveal mechanisms for regulation of circadian and sleep-waking functions... - A role for lateral hypothalamic orexin neurons in reward seekingGlenda C Harris
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance 6100 422 Curie Blvd, Philadelphia, Pennsylvania 19104 6100, USA
Nature 437:556-9. 2005..Moreover, administration of the orexin A peptide directly into the ventral tegmental area also reinstated drug-seeking. These data reveal a new role for lateral hypothalamus orexin neurons in reward-seeking, drug relapse and addiction... 
Role of orexin input in the diurnal rhythm of locus coeruleus impulse activityHeinrich S Gompf
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Brain Res 1224:43-52. 2008..Therefore, we propose that DMH orexin neurons play a role in modulating the day-night differences of LC impulse activity...
Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathwayAlice H Luo
Psychiatry Department, University of Pennsylvania, Philadelphia, PA, USA
Eur J Neurosci 29:748-60. 2009..This pathway may function in the circadian regulation of numerous behavioral processes including arousal and motivation...- Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawalGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 S 31st Street, Philadelphia, PA 19104, United States
Behav Brain Res 176:251-8. 2007.... - Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine rewardGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 S 31st Street, Philadelphia, PA 19104, United States
Behav Brain Res 183:43-51. 2007..These results demonstrate the importance of LH orexin neurons and their projections to the VTA in the formation of associations between environmental cues and drug reward... - Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environmentGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
Neuropsychopharmacology 28:73-6. 2003..These data indicate that glutamatergic activity in the VTA may be crucial for learning to associate environmental stimuli with cocaine exposure... - Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice taskEdwin C Clayton
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:9914-20. 2004..This role of the LC in regulating the behavioral outcome of decisional processes contrasts with more traditional views of LC responses as primarily related to sensory processes... - Prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine: participation of imidazoline and norepinephrine receptorsFrançois Georges
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
Neuropsychopharmacology 28:1140-9. 2003..These results indicate that the pharmacological effects of clonidine on VTA DA neurons during morphine withdrawal is related to actions on I1Rs as well as alpha2Rs... - Arousal and reward: a dichotomy in orexin functionGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Translational Research Labs/3403, 125 South 31st Street, Philadelphia, PA 19104, USA
Trends Neurosci 29:571-7. 2006..Evidence also indicates roles for lateral hypothalamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory... - Circadian regulation of arousal: role of the noradrenergic locus coeruleus system and light exposureMónica M C González
Department of Psychiatry, School of Medicine, University of Pennsylvania, PA, USA
Sleep 29:1327-36. 2006..This is mediated by an indirect circuit projection from the suprachiasmatic nucleus (SCN) to the LC. Here we sought to evaluate the hypothesis that the LC regulates the circadian properties of the sleep-wake cycle... - Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdalaGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:292-9. 2003..These results indicate a relationship between place preference behavior and neural indices of activation in the forebrain in response to morphine-conditioned cues that may be chronically modulated by prior morphine exposure... - Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neuronsFrançois Georges
Laboratory for Neuromodulation and Behavior, Department of Psychiatry, Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Neurosci 22:5173-87. 2002..These results reveal that inputs from the vBNST exert a strong excitatory influence on VTA DA neurons mediated by both NMDA and non-NMDA receptors... - Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection taskJanusz Rajkowski
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, 705 Stellar-Chance/6100, 422 Curie Blvd, Philadelphia, PA 19104-6100, USA
J Neurophysiol 92:361-71. 2004..These and other results lead us to hypothesize that LC responses are driven by decision processes and help facilitate subsequent behavioral responses... - Selective loss of catecholaminergic wake active neurons in a murine sleep apnea modelYan Zhu
Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:10060-71. 2007..It is anticipated that severe obstructive sleep apnea in humans destroys catecholaminergic wake neurons... - Altered motivation and learning following opiate withdrawal: evidence for prolonged dysregulation of reward processingGlenda C Harris
Department of Psychiatry, University of Pennsylvania, 705 Stellar Chance/6100, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:865-71. 2003..These data suggest that prior morphine exposure may have prolonged effects on the motivation for natural rewards, which in turn may compromise the ability of former addicts to overcome their addictions... - Adrenergic and noradrenergic innervation of the midbrain ventral tegmental area and retrorubral field: prominent inputs from medullary homeostatic centersCARLOS A MEJIAS-APONTE
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
J Neurosci 29:3613-26. 2009..The identification of medullary noradrenergic and adrenergic afferents to DA neuron areas indicates new pathways for visceral-related inputs to reward-related areas in the midbrain... - Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycleAlice H Luo
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Eur J Neurosci 27:408-22. 2008..These findings reveal previously unknown populations of VTA neurons whose activities are sensitive to diurnal phase, and whose functions may be in the temporal regulation of arousal and motivational processes...