Karen Ashe

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Brain amyloid-β oligomers in ageing and Alzheimer's disease
    Sylvain E Lesne
    University of Minnesota, Department of Neurology 2101 Sixth Street, SE Minneapolis, MN 55455, USA
    Brain 136:1383-98. 2013
  2. pmc Prions, prionoids and pathogenic proteins in Alzheimer disease
    Karen H Ashe
    Department of Neurology, N Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA
    Prion 7:55-9. 2013
  3. pmc Probing the biology of Alzheimer's disease in mice
    Karen H Ashe
    N Bud Grossman Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuron 66:631-45. 2010
  4. ncbi request reprint In search of the molecular basis of memory loss in Alzheimer disease
    Karen Hsiao Ashe
    Department of Neurology, Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455 0323, USA
    Alzheimer Dis Assoc Disord 20:200-1. 2006
  5. ncbi request reprint Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease
    Karen H Ashe
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    J Alzheimers Dis 9:123-6. 2006
  6. ncbi request reprint Mechanisms of memory loss in Abeta and tau mouse models
    K H Ashe
    Department of Neurology and Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Soc Trans 33:591-4. 2005
  7. ncbi request reprint Learning and memory in transgenic mice modeling Alzheimer's disease
    K H Ashe
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Learn Mem 8:301-8. 2001
  8. ncbi request reprint Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice
    Jill V Steidl
    Department of Neuroscience, The University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Neuroreport 14:219-23. 2003
  9. doi request reprint Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease
    Allison Ning
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Invest Ophthalmol Vis Sci 49:5136-43. 2008
  10. ncbi request reprint Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression
    Joseph Krezowski
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Hum Mol Genet 13:1989-97. 2004

Collaborators

Detail Information

Publications13

  1. pmc Brain amyloid-β oligomers in ageing and Alzheimer's disease
    Sylvain E Lesne
    University of Minnesota, Department of Neurology 2101 Sixth Street, SE Minneapolis, MN 55455, USA
    Brain 136:1383-98. 2013
    ..We propose that Aβ*56 may play a pathogenic role very early in the pathogenesis of Alzheimer's disease...
  2. pmc Prions, prionoids and pathogenic proteins in Alzheimer disease
    Karen H Ashe
    Department of Neurology, N Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA
    Prion 7:55-9. 2013
    ..Far from being a mere academic nuance, this distinction between Aβ and PrP begs the crucial questions of what, exactly, controls prion toxicity and how prion toxicity relates to prion infectivity...
  3. pmc Probing the biology of Alzheimer's disease in mice
    Karen H Ashe
    N Bud Grossman Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuron 66:631-45. 2010
    ....
  4. ncbi request reprint In search of the molecular basis of memory loss in Alzheimer disease
    Karen Hsiao Ashe
    Department of Neurology, Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455 0323, USA
    Alzheimer Dis Assoc Disord 20:200-1. 2006
  5. ncbi request reprint Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease
    Karen H Ashe
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    J Alzheimers Dis 9:123-6. 2006
    ..Herein, I describe my perspective on what we have learned about how Abeta impairs memory from research on Alzheimer's disease in mice and rats...
  6. ncbi request reprint Mechanisms of memory loss in Abeta and tau mouse models
    K H Ashe
    Department of Neurology and Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Soc Trans 33:591-4. 2005
    ..This paper presents my perspective on what we have learnt about mechanisms of memory loss from Abeta and tau mouse models of Alzheimer's disease...
  7. ncbi request reprint Learning and memory in transgenic mice modeling Alzheimer's disease
    K H Ashe
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Learn Mem 8:301-8. 2001
    ..Future studies in composite transgenic mice developing amyloid plaques, neurofibrillary tangles, and other AD pathology may allow for the determination of the relative contribution of A Beta and non-A Beta components to dementia...
  8. ncbi request reprint Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice
    Jill V Steidl
    Department of Neuroscience, The University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Neuroreport 14:219-23. 2003
    ..These results suggest that mutant alpha-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity...
  9. doi request reprint Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease
    Allison Ning
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Invest Ophthalmol Vis Sci 49:5136-43. 2008
    ..To compare the temporal and spatial expression patterns of amyloid precursor protein (APP), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of Alzheimer disease (AD)...
  10. ncbi request reprint Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression
    Joseph Krezowski
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Hum Mol Genet 13:1989-97. 2004
    ....
  11. ncbi request reprint Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
    Takeshi Kawarabayashi
    Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700 8558, Japan
    J Neurosci 24:3801-9. 2004
    ..A similar increase in ApoE and a large increase in phosphorylated tau was observed in lipid rafts from AD brain. These findings suggest that lipid rafts may be an important site for interaction between dimeric Abeta, ApoE, and tau...
  12. pmc Genes contributing to prion pathogenesis
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA
    J Gen Virol 89:1777-88. 2008
    ....

Research Grants27

  1. The beta-amyloid molecule in learning and memory
    Karen Ashe; Fiscal Year: 2007
    ..We have evidence that abnormal forms of AB are associated with memory loss, and propose to further delineate the corresponding AI3 species, called AB*. ..
  2. Modulating cognitive function in Tg2576 mice modeling AD
    Karen Ashe; Fiscal Year: 2006
    ..beta* causes cognitive impairment in Tg2576 and other mouse models of Alzheimer's disease. These results may provide important new information on the pathogenesis of dementia in Alzheimer's disease. ..
  3. The Biology of Alzheimer's Disease in Transgenic Mice
    Karen Ashe; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  4. In Search of the Molecular Basis of Memory Loss in Tauopathy
    Karen H Ashe; Fiscal Year: 2010
    ....
  5. Mechanisms of memory loss caused by the beta-amyloid molecule
    Karen Ashe; Fiscal Year: 2009
    ..Determining how multiple A oligomers trigger mechanisms at different stages of the disease may not only provide therapeutic targets for AD but also address why AD affects specific neural circuits in the brain. ..
  6. DISSECTING PATHOGENIC DOMAINS OF APP IN TRANSGENIC MICE
    Karen Ashe; Fiscal Year: 2003
    ....
  7. Mechanisms of memory loss caused by the beta-amyloid molecule
    Karen H Ashe; Fiscal Year: 2010
    ..Determining how multiple A oligomers trigger mechanisms at different stages of the disease may not only provide therapeutic targets for AD but also address why AD affects specific neural circuits in the brain. ..