Affiliation: University of Minnesota
- Brain amyloid-β oligomers in ageing and Alzheimer's diseaseSylvain E Lesne
University of Minnesota, Department of Neurology 2101 Sixth Street, SE Minneapolis, MN 55455, USA
Brain 136:1383-98. 2013..We propose that Aβ*56 may play a pathogenic role very early in the pathogenesis of Alzheimer's disease...
- Prions, prionoids and pathogenic proteins in Alzheimer diseaseKaren H Ashe
Department of Neurology, N Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA
Prion 7:55-9. 2013..Far from being a mere academic nuance, this distinction between Aβ and PrP begs the crucial questions of what, exactly, controls prion toxicity and how prion toxicity relates to prion infectivity...
- Probing the biology of Alzheimer's disease in miceKaren H Ashe
N Bud Grossman Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Neuron 66:631-45. 2010....
- In search of the molecular basis of memory loss in Alzheimer diseaseKaren Hsiao Ashe
Department of Neurology, Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN 55455 0323, USA
Alzheimer Dis Assoc Disord 20:200-1. 2006
- Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's diseaseKaren H Ashe
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
J Alzheimers Dis 9:123-6. 2006..Herein, I describe my perspective on what we have learned about how Abeta impairs memory from research on Alzheimer's disease in mice and rats...
- Mechanisms of memory loss in Abeta and tau mouse modelsK H Ashe
Department of Neurology and Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Biochem Soc Trans 33:591-4. 2005..This paper presents my perspective on what we have learnt about mechanisms of memory loss from Abeta and tau mouse models of Alzheimer's disease...
- Learning and memory in transgenic mice modeling Alzheimer's diseaseK H Ashe
Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Learn Mem 8:301-8. 2001..Future studies in composite transgenic mice developing amyloid plaques, neurofibrillary tangles, and other AD pathology may allow for the determination of the relative contribution of A Beta and non-A Beta components to dementia...
- Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic miceJill V Steidl
Department of Neuroscience, The University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Neuroreport 14:219-23. 2003..These results suggest that mutant alpha-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity...
- Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer diseaseAllison Ning
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
Invest Ophthalmol Vis Sci 49:5136-43. 2008..To compare the temporal and spatial expression patterns of amyloid precursor protein (APP), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of Alzheimer disease (AD)...
- Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpressionJoseph Krezowski
McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
Hum Mol Genet 13:1989-97. 2004....
- Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's diseaseTakeshi Kawarabayashi
Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700 8558, Japan
J Neurosci 24:3801-9. 2004..A similar increase in ApoE and a large increase in phosphorylated tau was observed in lipid rafts from AD brain. These findings suggest that lipid rafts may be an important site for interaction between dimeric Abeta, ApoE, and tau...
- Genes contributing to prion pathogenesisGULTEKIN TAMGUNEY
Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA
J Gen Virol 89:1777-88. 2008....
- The beta-amyloid molecule in learning and memoryKaren Ashe; Fiscal Year: 2007..We have evidence that abnormal forms of AB are associated with memory loss, and propose to further delineate the corresponding AI3 species, called AB*. ..
- Modulating cognitive function in Tg2576 mice modeling ADKaren Ashe; Fiscal Year: 2006..beta* causes cognitive impairment in Tg2576 and other mouse models of Alzheimer's disease. These results may provide important new information on the pathogenesis of dementia in Alzheimer's disease. ..
- The Biology of Alzheimer's Disease in Transgenic MiceKaren Ashe; Fiscal Year: 2007..Abstract Not Provided. ..
- In Search of the Molecular Basis of Memory Loss in TauopathyKaren H Ashe; Fiscal Year: 2010....
- Mechanisms of memory loss caused by the beta-amyloid moleculeKaren Ashe; Fiscal Year: 2009..Determining how multiple A oligomers trigger mechanisms at different stages of the disease may not only provide therapeutic targets for AD but also address why AD affects specific neural circuits in the brain. ..
- DISSECTING PATHOGENIC DOMAINS OF APP IN TRANSGENIC MICEKaren Ashe; Fiscal Year: 2003....
- Mechanisms of memory loss caused by the beta-amyloid moleculeKaren H Ashe; Fiscal Year: 2010..Determining how multiple A oligomers trigger mechanisms at different stages of the disease may not only provide therapeutic targets for AD but also address why AD affects specific neural circuits in the brain. ..