Research Topics
| James AsheSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Cortical control of motor sequencesJames Ashe
Brain Sciences Center, Veterans Administration Medical Center, Minneapolis, MN, USA
Curr Opin Neurobiol 16:213-21. 2006..The challenge for the future will be to develop a coherent and internally consistent theory of sequence control...
High accuracy decoding of movement target direction in non-human primates based on common spatial patterns of local field potentialsNuri F Ince
Brain Sciences Center, VA Health Care System, Minneapolis, Minnesota, United States of America
PLoS ONE 5:e14384. 2010..In addition, the understanding of the relation between potentially more stable neural signals, such as local field potentials, and motor behavior is still in its early stages...- Differential effect of reward and punishment on procedural learningTobias Wächter
Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Neurosci 29:436-43. 2009..Our results suggest that reward and punishment engage separate motivational systems with distinctive behavioral effects and neural substrates... 
The neural substrate of predictive motor timing in spinocerebellar ataxiaMartin Bares
Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN, USA
Cerebellum 10:233-44. 2011..The lack of any areas with greater activity in the spinocerebellar group than in controls suggests that limited functional reorganization occurs in this condition...- Strategic modulation of cognitive controlOvidiu V Lungu
Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
J Cogn Neurosci 19:1302-15. 2007..We suggest that having separate control mechanisms based on local or global task features allows humans to be persistent in pursuing their goals, yet flexible enough to adapt to changes in the environment... - Lack of adaptation to random conflicting force fields of variable magnitudeRahul Gupta
Brain Sciences Center, Veterans Affairs Medical Center, 11B VAMC, One Veterans Drive, Minneapolis, MN 55417, USA
J Neurophysiol 97:738-45. 2007..The data suggest that multiple conflicting internal models cannot be learned in all environments, and provide support for the unstable nature or limited capacity of motor memories... - Frames of reference during implicit and explicit learningTao Liu
Brain Sciences Center 11B, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
Exp Brain Res 180:273-80. 2007..Finally, explicit subjects were also able to benefit from the allocentric frame in transfer, which suggests that explicit procedural knowledge may have two tiers comprising egocentric and allocentric representations... - On the relations between single cell activity in the motor cortex and the direction and magnitude of three-dimensional dynamic isometric forceJyl Boline
Brain Sciences Center, 11B, VAMC, Minneapolis, MN 55417, USA
Exp Brain Res 167:148-59. 2005..Furthermore, the data suggest that the control of static and dynamic motor systems is based, to a great extent, on a common control process... - Negative covariation between task-related responses in alpha/beta-band activity and BOLD in human sensorimotor cortex: an EEG and fMRI study of motor imagery and movementsHan Yuan
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
Neuroimage 49:2596-606. 2010..These results suggest an inverse functional coupling relationship between task-induced changes of BOLD and low-frequency EEG signals... - Overcoming measurement time variability in brain machine interfaceB Vikrham Gowreesunker
University of Minnesota, Minneapolis, MN, USA
Conf Proc IEEE Eng Med Biol Soc 2009:3134-7. 2009..Furthermore, we saw an increase from 86% to 90% DP with another subject which exhibited significantly less variability... - Offline decoding of end-point forces using neural ensembles: application to a brain-machine interfaceRahul Gupta
Brain Sciences Center, VA Medical Center, Minneapolis, MN 55417, USA
IEEE Trans Neural Syst Rehabil Eng 17:254-62. 2009..Our results represent a useful extension of the current BMI technology, making dynamic control of a prosthetic device a distinct possibility in the near future... - Role of olivocerebellar system in timing without awarenessXiang Wu
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 108:13818-22. 2011.... - Impaired predictive motor timing in patients with cerebellar disordersMartin Bares
Brain Sciences Center, Veterans Affairs Medical Center, One Veterans Drive 11B, Minneapolis, MN 55417, USA
Exp Brain Res 180:355-65. 2007..The findings demonstrate that the cerebellum may have properties that would facilitate the processing or storage of internal models of motor behavior... - Anticipatory activity in primary motor cortex codes memorized movement sequencesXiaofeng Lu
Brain Sciences Center, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA
Neuron 45:967-73. 2005..Our results challenge the role of medial motor areas in the control of well-practiced movement sequences and suggest that motor cortex contains a complete apparatus for the planning and production of this complex behavior... - Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's diseaseNuri Firat Ince
Departments of Neurosurgery and Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
Neurosurgery 67:390-7. 2010..However, DBS device programming remains difficult and is a possible source of decreased efficacy... - The evaluation of preprocessing choices in single-subject BOLD fMRI using NPAIRS performance metricsStephen LaConte
Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
Neuroimage 18:10-27. 2003..Among the particular analysis chains considered, we found little impact in performance metrics with alignment, some benefit with temporal detrending, and greatest improvement with spatial smoothing... - Role of the olivo-cerebellar system in timingDuo Xu
Neurology Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Neurosci 26:5990-5. 2006..Our results suggest that the primary role of the inferior olive and the climbing fiber system in timing is the encoding of temporal information independent of motor behavior... - Adaptation of arm trajectory during continuous drawing movements in different dynamic environmentsTamami Fukushi
Departments of Neuroscience and Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Exp Brain Res 148:95-104. 2003..These results show that human subjects can adapt to a variety of different dynamic transformations and that the time-course of adaptation is dependent on both the state space and the direction of the load... - Intelligence in actionMatthew V Chafee
Nat Neurosci 10:142-3. 2007 - The representation of explicit motor sequence knowledgeRobert Knee
University of Virginia, Charlottesville, Virginia 22904 4400, USA
Mem Cognit 35:326-33. 2007..This conclusion held true for both self-report measures (subjects said that they learned stimuli) and performance measures, but when stimuli changed, performance degraded. We interpret these data in a multiple-memory-systems framework...
Research Grants
- LEARNING IN THE HUMAN MOTOR CORTEXJames Ashe; Fiscal Year: 2007..The work outlined here will provide a fundamental understanding of these disabilities and may lead to the development of strategies for rehabilitation and treatment of these patients. ..
- Cortical control of sequential motor behaviorJames Ashe; Fiscal Year: 2005..abstract_text> ..
- LEARNING IN THE HUMAN MOTOR CORTEXJames Ashe; Fiscal Year: 2003..As much of our motor behavior is based on implicit learning it is possible that implicit learning paradigms could be used beneficially for motor rehabilitation in stroke. ..