John D Ash
Affiliation: University of Florida
Xu L, Kong L, Wang J, Ash J. Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2018;115:10475-10480 pubmed publisher
..Our data demonstrate that increasing the activity of AMPK in retinal neurons or glia can delay or prevent degeneration of photoreceptors and the RPE from multiple types of cell-death triggers. ..
Santiago C, Keuthan C, Boye S, Boye S, Imam A, Ash J. A Drug-Tunable Gene Therapy for Broad-Spectrum Protection against Retinal Degeneration. Mol Ther. 2018;26:2407-2417 pubmed publisher
..We further show that stabilized RPF2 can protect photoreceptors and prevent blindness in treated mice. ..
Brown E, Lewin A, Ash J. Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration. Adv Exp Med Biol. 2018;1074:11-17 pubmed publisher
..Therefore, one protective strategy may involve the use of small molecule therapies that target the regulation of mitochondrial biogenesis and mitochondrial fission and mitophagy. ..
Hooper M, Ash J. Müller Cell Biological Processes Associated with Leukemia Inhibitory Factor Expression. Adv Exp Med Biol. 2018;1074:479-484 pubmed publisher
..Some enriched processes include divalent inorganic cation homeostasis, negative regulation of stem cell proliferation, and gamma-glutamyl transferase activity. ..
Hooper M, Wang J, Browning R, Ash J. Damage-associated molecular pattern recognition is required for induction of retinal neuroprotective pathways in a sex-dependent manner. Sci Rep. 2018;8:9115 pubmed publisher
..Lastly, using publicly available gene expression data, we show that TLR2 is expressed highly in resting microglia prior to injury, but is also induced in Müller cells in inherited retinal degeneration. ..
Reagan A, Gu X, Hauck S, Ash J, Cao G, Thompson T, et al
. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016;854:411-8 pubmed publisher
..Thus, Cav-1 modulates neuroprotective signaling by regulating the endogenous production of neuroprotective factors. ..
Xu L, Ash J. The Role of AMPK Pathway in Neuroprotection. Adv Exp Med Biol. 2016;854:425-30 pubmed publisher
..Because of this, it is likely that the AMPK signaling pathway plays an important role in maintaining energy balance, and therefore may be a therapeutic target to prevent or delay retinal degeneration. ..
Abrahan C, Ash J. The Potential Use of PGC-1Î± and PGC-1Î² to Protect the Retina by Stimulating Mitochondrial Repair. Adv Exp Med Biol. 2016;854:403-9 pubmed publisher
..We propose that PGC-1Î± and PGC-1Î² could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration. ..