Aroumougame Asaithamby

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
  2. pmc Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8293-8. 2011
  3. doi request reprint Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
  4. pmc Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, United States
    Mutat Res 711:87-99. 2011
  5. pmc Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity
    J Jefferson P Perry
    Division of Molecular Radiation Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:25699-707. 2010
  6. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
  7. pmc Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nucleic Acids Res 37:3912-23. 2009
  8. pmc Ku recruits XLF to DNA double-strand breaks
    Ken ichi Yano
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, TX 75390 9187, USA
    EMBO Rep 9:91-6. 2008
  9. pmc Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
    Shibani Mukherjee
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Biol Psychiatry 68:503-11. 2010

Collaborators

Detail Information

Publications9

  1. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
    ..Our data suggest that downregulation of multiple DNA repair pathway genes in differentiated cells renders them vulnerable to DSBs, promoting genome instability that may lead to carcinogenesis...
  2. pmc Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8293-8. 2011
    ..Difficulties associated with clustered DNA damage repair and checkpoint release before the completion of clustered DNA damage repair appear to promote genome instability that may lead to carcinogenesis...
  3. doi request reprint Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
    ..Collectively, these data demonstrate that the inability of cells to rejoin DSBs within clustered DNA lesions likely contributes to the greater biological effectiveness of HZE particles...
  4. pmc Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, United States
    Mutat Res 711:87-99. 2011
    ..Understanding the mechanism underlying the repair of DNA damage induced by HZE particles will have important implications for estimating the risks to human health associated with HZE particle exposure...
  5. pmc Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity
    J Jefferson P Perry
    Division of Molecular Radiation Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:25699-707. 2010
    ....
  6. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
    ..These results indicate that although IR-induced DNA-PKcs phosphorylation is attenuated in the S phase, DNA-PKcs is preferentially activated by the physiologically relevant DNA replication-associated DSBs at the sites of DNA synthesis...
  7. pmc Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nucleic Acids Res 37:3912-23. 2009
    ..These findings have important implications for estimating the risk associated with low-dose radiation exposure on human health...
  8. pmc Ku recruits XLF to DNA double-strand breaks
    Ken ichi Yano
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, TX 75390 9187, USA
    EMBO Rep 9:91-6. 2008
    ..Our observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition...
  9. pmc Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
    Shibani Mukherjee
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Biol Psychiatry 68:503-11. 2010
    ..Previously, we reported that mice with a mutation in the Clock gene (ClockDelta19) display a behavioral profile that is strikingly similar to bipolar patients in the manic state...