W J Aronson
Affiliation: University of California
- Nutrition, dietary interventions and prostate cancer: the latest evidencePao Hwa Lin
Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham 27710, NC, USA
BMC Med 13:3. 2015..This pattern includes rich fruits and vegetables, reduced refined carbohydrates, total and saturated fats, and reduced cooked meats. Further carefully designed prospective trials are warranted. ..
- Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomyColette Galet
Department of Urology, University of California Los Angeles, Box 951738, Los Angeles, CA 90095 1738
Cancer Prev Res (Phila) 7:97-104. 2014..Further studies are warranted to determine whether the LFFO diet antiproliferative effects are mediated through the LTB4/BLT1 and 15(S)-HETE pathways...
- Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenograftsRamdev Konijeti
Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
Mol Cancer Ther 11:1539-46. 2012..Whereas the combination of low-fat diet and IGF-1R blockade did not have additive inhibitory effects on tumor weight, it led to reduced tumor cell proliferation and a reduction in serum insulin and TNF-α levels...
- Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomyWilliam J Aronson
Department of Urology, School of Medicine, University of California Los Angeles, Box 951738, Los Angeles, CA 90095, USA
Cancer Prev Res (Phila) 4:2062-71. 2011..These results support further studies evaluating reduction of dietary fat with fish oil supplementation on modulating prostate cancer biology...
- Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancerWilliam J Aronson
Urology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095 1738, USA
J Urol 183:345-50. 2010..We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer...
- Decreased growth of human prostate LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavonesW J Aronson
Department of Urology, University of California, Los Angeles 90095, USA
Nutr Cancer 35:130-6. 1999..05). In this xenograft model for prostate cancer, there were statistically significant effects on tumor growth rate and final tumor weight attributable to a low-fat + soy protein + isoflavone extract diet...
- Impact of nerve sparing on surgical margins and biochemical recurrence: results from the SEARCH databaseJ L Nelles
Department of Urology, San Francisco School of Medicine, University of California, San Francisco, CA, USA
Prostate Cancer Prostatic Dis 12:172-6. 2009..The risk for biochemical recurrence was not affected by bilateral or unilateral nerve sparing. When used on appropriately selected patients, nerve sparing does not increase the probability of PSM or biochemical recurrence after RP...
- Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital databaseB M Whitley
Duke Prostate Center, Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
Prostate Cancer Prostatic Dis 14:361-6. 2011..We examined the relationship between weight change in the year before radical prostatectomy (RP) and biochemical recurrence (BCR) and adverse pathology...
- The effect of race on the discriminatory accuracy of models to predict biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databasesD M Moreira
Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
Prostate Cancer Prostatic Dis 13:87-93. 2010..This indicates that currently used predictive models have similar performances among CM and AAM. Therefore, nomograms represent a valid and accurate method to predict BCR regardless of race...
- The influence of hepatic function on prostate cancer outcomes after radical prostatectomyL L Bañez
Department of Surgery, Duke University Medical Center, Durham, NC, USA
Prostate Cancer Prostatic Dis 13:173-7. 2010..The effect of moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated...
- Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomyZ Li
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Eur J Clin Nutr 62:526-36. 2008..To evaluate the feasibility and long-term compliance with a low-fat diet supplemented with soy protein in men at increased risk for recurrence after radical prostatectomy...
- Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancerW J Aronson
Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
Urology 58:283-8. 2001..The potential for this diet to prevent the development and progression of prostate cancer by way of altered COX-2 expression and prostaglandin production in prostatic tissue requires further study...
- Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH databaseE H Allott
1 Division of Urology, Department of Surgery, Duke University School of Medicine, Durham, NC, USA 2 Cancer Prevention, Detection and Control Program, Duke Cancer Institute, Durham, NC, USA 3 Section of Urology, Veterans Affairs Medical Center, Durham, NC, USA
Prostate Cancer Prostatic Dis 16:391-7. 2013..We investigated the association between pre-operative metformin use, dose and duration of use and biochemical recurrence (BCR) in PC patients with diabetes who underwent radical prostatectomy (RP)...
- Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expressionJ C Lloyd
1 Department of Surgery, Durham VA Medical Center, Durham, NC, USA 2 Division of Urology, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
Prostate Cancer Prostatic Dis 16:285-91. 2013..To our knowledge, no study has yet compared the effect of multiple different fats on PCa progression. We sought to systematically compare the effect of fish oil, olive oil, corn oil and animal fat on PCa progression...
- Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growthC N Tymchuk
Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA, USA
J Urol 166:1185-9. 2001..CONCLUSIONS: A low fat, high fiber diet and exercise intervention resulted in serum changes that significantly reduced the growth of androgen responsive LNCaP prostate cancer cells in vitro...
- Preoperative PSA velocity and doubling time do not predict adverse pathologic features or biochemical recurrence after radical prostatectomyS J Freedland
Department of Urology, UCLA School of Medicine, Los Angeles, California 90095-1738, USA
Urology 57:476-80. 2001..In addition, there was no difference in PSA velocity or doubling time between the races studied...
- Effect of diet and exercise intervention on the growth of prostate epithelial cellsR J Barnard
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Prostate Cancer Prostatic Dis 11:362-6. 2008..Future prospective trials should address the effects of this lifestyle modification on BPH symptomatology and progression...
- Prostate cancer: another aspect of the insulin-resistance syndrome?R J Barnard
Obes Rev 3:303-8. 2002..This needs to be tested with prospective studies...
- Is there a difference in outcome after radical prostatectomy between patients with biopsy Gleason sums 4, 5, and 6? Results from the SEARCH databaseS J Freedland
Department of Urology, UCLA School of Medicine, Los Angeles, California 90095 1738, USA
Prostate Cancer Prostatic Dis 6:261-5. 2003..We sought to examine the significance of biopsy Gleason sum for predicting biochemical failure following radical prostatectomy (RP) for men with biopsy Gleason sums of 4, 5, and 6...