N N Aronson

Summary

Affiliation: University of South Alabama
Country: USA

Publications

  1. pmc Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family
    Jane D Funkhouser
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    BMC Evol Biol 7:96. 2007
  2. ncbi request reprint Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biosci Biotechnol Biochem 70:1537-41. 2006
  3. ncbi request reprint Mutation of a conserved tryptophan in the chitin-binding cleft of Serratia marcescens chitinase A enhances transglycosylation
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, AL 36688, USA
    Biosci Biotechnol Biochem 70:243-51. 2006
  4. pmc Family 18 chitinase-oligosaccharide substrate interaction: subsite preference and anomer selectivity of Serratia marcescens chitinase A
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biochem J 376:87-95. 2003
  5. ncbi request reprint Aspartylglycosaminuria: biochemistry and molecular biology
    N N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile 36688 0002, USA
    Biochim Biophys Acta 1455:139-54. 1999
  6. ncbi request reprint Glycosylation and phosphorylation of lysosomal glycosylasparaginase
    H Park
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    Arch Biochem Biophys 328:73-7. 1996
  7. ncbi request reprint Structure of the human gene for lysosomal di-N-acetylchitobiase
    B Liu
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Glycobiology 9:589-93. 1999
  8. ncbi request reprint Site-directed mutagenesis of essential residues involved in the mechanism of bacterial glycosylasparaginase
    Y Liu
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 273:9688-94. 1998
  9. ncbi request reprint Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda
    Y Liu
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    Glycobiology 6:527-36. 1996
  10. ncbi request reprint Single base deletion in exon 7 of the glycosylasparaginase gene causes a mild form of aspartylglycosaminuria in a patient of Mauritian origin
    H Park
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    J Inherit Metab Dis 19:76-83. 1996

Collaborators

Detail Information

Publications13

  1. pmc Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family
    Jane D Funkhouser
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    BMC Evol Biol 7:96. 2007
    ....
  2. ncbi request reprint Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biosci Biotechnol Biochem 70:1537-41. 2006
    ..The biochemical behavior of di-N-acetylchitobiase indicates it has three subsites, -2, -1, +1, in which the reducing-end trimer of any sized chitooligosaccharide is bound. The +1 site is specific for an alpha-anomer...
  3. ncbi request reprint Mutation of a conserved tryptophan in the chitin-binding cleft of Serratia marcescens chitinase A enhances transglycosylation
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, AL 36688, USA
    Biosci Biotechnol Biochem 70:243-51. 2006
    ..Greater retention of the glycosyl fragment at the active site of the -3 mutant of Serratia marcescens chitinase A might favor transglycosylation due to a stabilized conformation of its D313...
  4. pmc Family 18 chitinase-oligosaccharide substrate interaction: subsite preference and anomer selectivity of Serratia marcescens chitinase A
    Nathan N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biochem J 376:87-95. 2003
    ....
  5. ncbi request reprint Aspartylglycosaminuria: biochemistry and molecular biology
    N N Aronson
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile 36688 0002, USA
    Biochim Biophys Acta 1455:139-54. 1999
    ..This interesting biochemical feature is also shared by most of the Ntn-hydrolase family of proteins. Many of the disease-causing mutations prevent proper folding and subsequent activation of the glycosylasparaginase...
  6. ncbi request reprint Glycosylation and phosphorylation of lysosomal glycosylasparaginase
    H Park
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    Arch Biochem Biophys 328:73-7. 1996
    ..Yield of enzyme for all mutants was increased in cells treated with brefeldin A. The N308 glycosylation site of the beta-subunit appears to be more important in maintaining normal transport and stability of human glycosylasparaginase...
  7. ncbi request reprint Structure of the human gene for lysosomal di-N-acetylchitobiase
    B Liu
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Glycobiology 9:589-93. 1999
    ..These evolutionary differences in the 5'-flanking region of the chitobiase genes from human and bovine could account for the widely varied expression levels of the hydrolase within these two species...
  8. ncbi request reprint Site-directed mutagenesis of essential residues involved in the mechanism of bacterial glycosylasparaginase
    Y Liu
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 273:9688-94. 1998
    ..The overall active site structure involving these catalytic residues resembles the glutaminase domain of glucosamine 6-phosphate synthase, another member of the Ntn-amidohydrolase family of enzymes...
  9. ncbi request reprint Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda
    Y Liu
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    Glycobiology 6:527-36. 1996
    ....
  10. ncbi request reprint Single base deletion in exon 7 of the glycosylasparaginase gene causes a mild form of aspartylglycosaminuria in a patient of Mauritian origin
    H Park
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    J Inherit Metab Dis 19:76-83. 1996
    ..The resulting truncated polypeptide was defective in its post-translational proteolytic processing and remained as a single chain (36 kDa) with no GA activity...
  11. ncbi request reprint Structure of human G protein G gamma 5 gene GNG5
    B Liu
    College of Medicine, University of South Alabama, Mobile, Alabama, 36688, USA
    Biochem Biophys Res Commun 251:88-94. 1998
    ..Alternative transcriptional start sites that result from two separate, closely linked promoters in the 5'-flanking region of the gene were confirmed by luciferase reporter-gene assay...
  12. ncbi request reprint Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22
    W Ahmad
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688 0002, USA
    Cytogenet Cell Genet 71:44-6. 1995
    ..Both genes have now been mapped to 1p by PCR analysis of somatic cell hybrids and further refined to 1p22 by fluorescence in situ hybridization (FISH) using a YAC clone that contains both the chitobiase and gamma 5 genes...
  13. pmc Family 18 chitolectins: comparison of MGP40 and HUMGP39
    - Zaheer-Ul-Haq
    Department of Chemistry and Biochemistry, Center for Computational Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Biochem Biophys Res Commun 359:221-6. 2007
    ..Furthermore, a mechanism for the interaction between the chitolectin and oligosaccharides was proposed...