Elena L Aronovich

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, University of Minnesota, Minneapolis, 55455, USA
    Mol Ther 17:1136-44. 2009
  2. ncbi The Sleeping Beauty transposon system: a non-viral vector for gene therapy
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, The Center for Genome Engineering, Institute of Human Genetics, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Hum Mol Genet 20:R14-20. 2011
  3. ncbi Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development and The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    J Gene Med 9:403-15. 2007
  4. ncbi Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection
    Jason B Bell
    Department of Genetics, Cell Biology and Development, Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Nat Protoc 2:3153-65. 2007
  5. ncbi Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies
    Perry B Hackett
    Dept of Genetics, Cell Biology and Development, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Gene Ther 11:341-9. 2011
  6. ncbi Excision of Sleeping Beauty transposons: parameters and applications to gene therapy
    Geyi Liu
    Department of Genetics, Cell Biology and Development and The Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    J Gene Med 6:574-83. 2004
  7. ncbi Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery
    Jason B Bell
    Department of Genetics, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Ther 18:1796-802. 2010
  8. ncbi Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration
    Daniel A Wolf
    Gene Therapy Program, Institute of Human Genetics, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis MN 55455, USA
    Mol Genet Metab 106:131-4. 2012
  9. ncbi Sleeping Beauty-mediated correction of Fanconi anemia type C
    Kendra A Hyland
    Discovery Genomics, Inc, Minneapolis, MN, USA
    J Gene Med 13:462-9. 2011

Collaborators

Detail Information

Publications9

  1. ncbi Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, University of Minnesota, Minneapolis, 55455, USA
    Mol Ther 17:1136-44. 2009
    ....
  2. ncbi The Sleeping Beauty transposon system: a non-viral vector for gene therapy
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, The Center for Genome Engineering, Institute of Human Genetics, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Hum Mol Genet 20:R14-20. 2011
    ..Progress in delivery of SB transposons to liver for treatment of various systemic diseases, such as hemophilia and mucopolysaccharidoses types I and VII, has encountered some problems, but even here progress is being made...
  3. ncbi Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development and The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    J Gene Med 9:403-15. 2007
    ..The Sleeping Beauty (SB) transposon system is a non-viral vector system that can integrate precise sequences into chromosomes. We evaluated the SB transposon system as a tool for gene therapy of mucopolysaccharidosis (MPS) types I and VII...
  4. ncbi Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection
    Jason B Bell
    Department of Genetics, Cell Biology and Development, Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Nat Protoc 2:3153-65. 2007
    ..Several weeks after injection, transgene expression stabilizes at approximately 1% of the level at 24 h, presumably owing to integration of the transposons into chromosomes...
  5. ncbi Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies
    Perry B Hackett
    Dept of Genetics, Cell Biology and Development, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Gene Ther 11:341-9. 2011
    ..The ability to correct genetic diseases through the infusion of DNA plasmids remains an appealing goal...
  6. ncbi Excision of Sleeping Beauty transposons: parameters and applications to gene therapy
    Geyi Liu
    Department of Genetics, Cell Biology and Development and The Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    J Gene Med 6:574-83. 2004
    ..The excision assay appears to be a relatively quick and easy method to optimize protocols for delivery of genes in SB transposons to mammalian chromosomes in living animals...
  7. ncbi Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery
    Jason B Bell
    Department of Genetics, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Ther 18:1796-802. 2010
    ..Thus, within the limits of current technology, we show that SB transposons appear to be as stably integrated as their viral counterparts...
  8. ncbi Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration
    Daniel A Wolf
    Gene Therapy Program, Institute of Human Genetics, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis MN 55455, USA
    Mol Genet Metab 106:131-4. 2012
    ..These results suggest that intranasal routes of delivery may be efficacious in the treatment of lysosomal storage disorders...
  9. ncbi Sleeping Beauty-mediated correction of Fanconi anemia type C
    Kendra A Hyland
    Discovery Genomics, Inc, Minneapolis, MN, USA
    J Gene Med 13:462-9. 2011
    ..Our goal is to develop the SB system for nonviral complementation of Fanconi anemia (FA), a rare autosomal recessive disorder accompanied by progressive bone marrow failure...