Adam R Aron

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus
    Adam R Aron
    Department of Psychology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:2424-33. 2006
  2. ncbi The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder
    Adam R Aron
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 57:1285-92. 2005
  3. pmc Stimulation of contacts in ventral but not dorsal subthalamic nucleus normalizes response switching in Parkinson's disease
    Ian Greenhouse
    Department of Psychology, University of California, 9500 Gilman Drive, La Jolla, CA, USA
    Neuropsychologia 51:1302-9. 2013
  4. pmc Deep brain stimulation of the subthalamic nucleus alters the cortical profile of response inhibition in the beta frequency band: a scalp EEG study in Parkinson's disease
    Nicole Swann
    Department of Psychology, Neuroscience Graduate Program, Institute for Neural Computation, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 31:5721-9. 2011
  5. doi Basal ganglia atrophy in prodromal Huntington's disease is detectable over one year using automated segmentation
    D S Adnan Majid
    Department of Psychology, University of California, San Diego, San Diego, California 92093 0841, USA
    Mov Disord 26:2544-51. 2011
  6. pmc Transcranial magnetic stimulation reveals dissociable mechanisms for global versus selective corticomotor suppression underlying the stopping of action
    D S Adnan Majid
    Department of Psychology, University of California San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 22:363-71. 2012
  7. pmc Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
    Neuroimage 59:2452-63. 2012
  8. pmc Different forms of self-control share a neurocognitive substrate
    Golnaz Tabibnia
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
    J Neurosci 31:4805-10. 2011
  9. pmc Proactive selective response suppression is implemented via the basal ganglia
    D S Adnan Majid
    Department of Psychology, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 33:13259-69. 2013
  10. pmc The role of the right presupplementary motor area in stopping action: two studies with event-related transcranial magnetic stimulation
    Weidong Cai
    Department of Psychology, University of California San Diego, La Jolla, California, USA
    J Neurophysiol 108:380-9. 2012

Collaborators

Detail Information

Publications43

  1. ncbi Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus
    Adam R Aron
    Department of Psychology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:2424-33. 2006
    ..Future research is required to establish whether Stop-signal inhibition could be implemented via a direct functional neuroanatomic projection between IFC and STN (a "hyperdirect" pathway)...
  2. ncbi The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder
    Adam R Aron
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 57:1285-92. 2005
    ..Moreover, a dissection of response inhibition into more basic components such as rule maintenance, vigilance, and target detection may provide yet better targets for association with genes for neuromodulation and brain development...
  3. pmc Stimulation of contacts in ventral but not dorsal subthalamic nucleus normalizes response switching in Parkinson's disease
    Ian Greenhouse
    Department of Psychology, University of California, 9500 Gilman Drive, La Jolla, CA, USA
    Neuropsychologia 51:1302-9. 2013
    ..As response switching is an executive function known to rely on prefrontal cortex, these results suggest that ventral contact stimulation affected an executive/associative cortico-basal ganglia circuit...
  4. pmc Deep brain stimulation of the subthalamic nucleus alters the cortical profile of response inhibition in the beta frequency band: a scalp EEG study in Parkinson's disease
    Nicole Swann
    Department of Psychology, Neuroscience Graduate Program, Institute for Neural Computation, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 31:5721-9. 2011
    ..The results also suggest that deep brain stimulation of the STN may improve task performance by increasing the fidelity of information transfer within a fronto-basal-ganglia circuit...
  5. doi Basal ganglia atrophy in prodromal Huntington's disease is detectable over one year using automated segmentation
    D S Adnan Majid
    Department of Psychology, University of California, San Diego, San Diego, California 92093 0841, USA
    Mov Disord 26:2544-51. 2011
    ..This underscores the utility of this automatic image segmentation and longitudinal nonlinear registration method for upcoming studies of preHD and other neurodegenerative disorders...
  6. pmc Transcranial magnetic stimulation reveals dissociable mechanisms for global versus selective corticomotor suppression underlying the stopping of action
    D S Adnan Majid
    Department of Psychology, University of California San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 22:363-71. 2012
    ..We predict that different fronto-basal-ganglia pathways underpin these different suppression mechanisms...
  7. pmc Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease
    Tyler M Seibert
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
    Neuroimage 59:2452-63. 2012
    ..Within the premanifest Huntington's group, though, there was evidence that decreased striatal functional correlations might be associated with disease severity, as gauged by estimated years to symptom onset or by striatal volume...
  8. pmc Different forms of self-control share a neurocognitive substrate
    Golnaz Tabibnia
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
    J Neurosci 31:4805-10. 2011
    ..These findings suggest that self-control in different psychological domains involves a common substrate in the right pars opercularis, and that successful self-control depends on integrity of this substrate...
  9. pmc Proactive selective response suppression is implemented via the basal ganglia
    D S Adnan Majid
    Department of Psychology, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 33:13259-69. 2013
    ..By linking this suppression to the striatum and pallidum, these results provide compelling functional evidence in humans of the basal ganglia's inhibitory indirect pathway. ..
  10. pmc The role of the right presupplementary motor area in stopping action: two studies with event-related transcranial magnetic stimulation
    Weidong Cai
    Department of Psychology, University of California San Diego, La Jolla, California, USA
    J Neurophysiol 108:380-9. 2012
    ..Future studies are required to establish whether this was due to stimulation of the right preSMA itself or because of remote effects on the wider stopping network...
  11. pmc Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans
    Dara G Ghahremani
    Departments of Psychiatry and Biobehavioral Sciences and Molecular and Medical Pharmacology, and Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 32:7316-24. 2012
    ....
  12. pmc Stopping speech suppresses the task-irrelevant hand
    Weidong Cai
    Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA
    Brain Lang 120:412-5. 2012
    ..This shows that when speech is quickly stopped, there is a broad suppression across the motor system. This has implications for the neural basis of speech control and stuttering...
  13. pmc Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year
    D S Adnan Majid
    Department of Psychology, University of California, San Diego UCSD, San Diego, California, USA
    Mov Disord 26:1481-8. 2011
    ..This MRI biomarker approach could be used to evaluate neuroprotection in preHD...
  14. pmc Engagement of large-scale networks is related to individual differences in inhibitory control
    Eliza Congdon
    Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
    Neuroimage 53:653-63. 2010
    ..The results also highlight the usefulness of using dimensionality reduction to increase the power to detect brain/behavior correlations in individual differences research...
  15. doi Stimulation at dorsal and ventral electrode contacts targeted at the subthalamic nucleus has different effects on motor and emotion functions in Parkinson's disease
    Ian Greenhouse
    Department of Psychology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0109, USA
    Neuropsychologia 49:528-34. 2011
    ..These results support the hypothesis that different territories within the STN region implement motor and emotion functions...
  16. ncbi Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
    Adam R Aron
    Department of Psychology, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 27:3743-52. 2007
    ..The results also demonstrate a three-way functional-anatomical network in the right hemisphere that could either brake or completely stop responses...
  17. pmc Responding with restraint: what are the neurocognitive mechanisms?
    Sara Jahfari
    Department of Psychology, University of California, San Diego, La Jolla, CA92023, USA
    J Cogn Neurosci 22:1479-92. 2010
    ..These results further our understanding of how people respond with restraint by pointing to proactive recruitment of a neurocognitive mechanism heretofore associated with outright stopping...
  18. pmc Stimulating deep cortical structures with the batwing coil: how to determine the intensity for transcranial magnetic stimulation using coil-cortex distance
    Weidong Cai
    Department of Psychology, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0109, USA
    J Neurosci Methods 204:238-41. 2012
    ..This is the first study to demonstrate the effects of coil-cortical distance on stimulation efficiency via a monophasic system using a batwing coil...
  19. pmc Having a goal to stop action is associated with advance control of specific motor representations
    Michael P Claffey
    Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropsychologia 48:541-8. 2010
    ..This shows that having a goal of what response may need to be stopped in the future consists in applying advance control onto a specific motor representation...
  20. pmc A proactive mechanism for selective suppression of response tendencies
    Weidong Cai
    Department of Psychology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:5965-9. 2011
    ..This provides novel evidence for an active mechanism of suppression in the brain that is setup according to the subject's goals and even before action ensues...
  21. pmc Intracranial EEG reveals a time- and frequency-specific role for the right inferior frontal gyrus and primary motor cortex in stopping initiated responses
    Nicole Swann
    University of California, San Diego, La Jolla, CA 92093 0662, USA
    J Neurosci 29:12675-85. 2009
    ..Together with other findings, the results suggest that behavioral stopping is implemented via synchronized activity in the beta frequency band in a right IFG/basal ganglia network, with downstream effects on M1...
  22. pmc Intracranial electroencephalography reveals different temporal profiles for dorsal- and ventro-lateral prefrontal cortex in preparing to stop action
    Nicole C Swann
    Neuroscience Graduate Program, University of California, San Diego, CA, USA
    Cereb Cortex 23:2479-88. 2013
    ..These different temporal profiles suggest that DLPFC and VLPFC could have dissociable roles, with DLPFC representing task goals and VLPFC implementing action control. ..
  23. pmc Frontal theta is a signature of successful working memory manipulation
    Sirawaj Itthipuripat
    Neurosciences Graduate Program, University of California, San Diego, La Jolla, San Diego, CA 92093, USA
    Exp Brain Res 224:255-62. 2013
    ..This establishes a clear-cut EEG signature of WM manipulation. Future studies could employ this to test the fronto-basal-ganglia hypothesis of WM updating/manipulation...
  24. doi Common neural substrates for inhibition of spoken and manual responses
    Gui Xue
    FPR UCLA Center for Culture, Brain and Development, University of California, Los Angeles, CA 90095 1563, USA
    Cereb Cortex 18:1923-32. 2008
    ..These findings suggest a functional dissociation of left and right IFC in initiating versus inhibiting vocal responses, and that manual responses and speech acts share a common inhibitory mechanism localized in the right IFC and pre-SMA...
  25. doi Urges for food and money spill over into motor system excitability before action is taken
    Nitin Gupta
    Department of Psychology, University of California, San Diego, La Jolla, CA, USA
    Eur J Neurosci 33:183-8. 2011
    ..Implications are discussed for theories of embodied cognition and for methodological progress in studying urge control...
  26. ncbi Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition
    Adam R Aron
    Department of Psychology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:11860-4. 2007
  27. ncbi Inhibition and the right inferior frontal cortex
    Adam R Aron
    Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 8:170-7. 2004
    ..Future research should investigate the generality of this proposed inhibitory function to other task domains, and its interaction within a wider network...
  28. ncbi The neural basis of inhibition in cognitive control
    Adam R Aron
    Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroscientist 13:214-28. 2007
    ..This article examines the role that neuroscience can play when examining whether the psychological concept of active inhibition can be meaningfully applied in cognitive control research...
  29. pmc Long-term test-retest reliability of functional MRI in a classification learning task
    Adam R Aron
    Department of Psychology, Franz Hall Box 951563, University of California, Los Angeles, CA 90095, USA
    Neuroimage 29:1000-6. 2006
    ..We conclude that fMRI can have high long-term test-retest reliability, making it suitable as a biomarker for brain development and neurodegeneration...
  30. pmc From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses
    Adam R Aron
    Department of Psychology, University of California San Diego, LaJolla, CA 92093, USA
    Biol Psychiatry 69:e55-68. 2011
    ..This may have wider validity than reactive control as an experimental model for stopping inappropriate responses...
  31. doi Evaluating imaging biomarkers for neurodegeneration in pre-symptomatic Huntington's disease using machine learning techniques
    Angela Rizk-Jackson
    Department of Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
    Neuroimage 56:788-96. 2011
    ..We have shown that several neuroimaging measures contain multivariate patterns of information that are useful for the development of disease-state biomarkers for HD...
  32. ncbi Stop the presses: dissociating a selective from a global mechanism for stopping
    Adam R Aron
    Department of Psychology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92103 0109, USA
    Psychol Sci 19:1146-53. 2008
    ..We suggest that the selective mechanism is used when people maintain the goal of controlling particular responses, whereas the global mechanism is used when it is essential to stop quickly...
  33. ncbi Inhibition and the right inferior frontal cortex: one decade on
    Adam R Aron
    Department of Psychology, University of California, San Diego, CA, USA Electronic address
    Trends Cogn Sci 18:177-85. 2014
    ..We affirm inhibition as a central component of executive control that relies upon the rIFC and associated networks, and explain why rIFC disruption could generally underpin response control disorders. ..
  34. ncbi Deficits in response inhibition associated with chronic methamphetamine abuse
    John R Monterosso
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Drug Alcohol Depend 79:273-7. 2005
    ..If such differences are established then response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials...
  35. ncbi Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function
    Adam R Aron
    University of Cambridge, UK
    J Cogn Neurosci 15:629-42. 2003
    ....
  36. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  37. ncbi Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder
    Adam R Aron
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 54:1465-8. 2003
    ..Many studies of childhood ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate (MPH). The current study tested response inhibition and the effect of MPH in adult ADHD...
  38. ncbi Association between response inhibition and working memory in adult ADHD: a link to right frontal cortex pathology?
    Luke Clark
    Department of Experimental Psychology, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 61:1395-401. 2007
    ..We sought to assess the relationship between response inhibition and working memory in adult patients with attention-deficit/hyperactivity disorder (ADHD) and neurosurgical patients with frontal lobe damage...
  39. pmc Automatic independent component labeling for artifact removal in fMRI
    Jussi Tohka
    Institute of Signal Processing, Tampere University of Technology, Tampere, Finland
    Neuroimage 39:1227-45. 2008
    ..We conclude that automatic ICA-based denoising offers a potentially useful approach to improve the quality of fMRI data and consequently increase the accuracy of the statistical analysis of these data...
  40. ncbi Cognitive enhancing effects of modafinil in healthy volunteers
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 165:260-9. 2003
    ....
  41. ncbi Relative lack of cognitive effects of methylphenidate in elderly male volunteers
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 168:455-64. 2003
    ....
  42. ncbi Distractibility during selection-for-action: differential deficits in Huntington's disease and following frontal lobe damage
    Adam R Aron
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Box 189, CB2 2QQ, Cambridge, UK
    Neuropsychologia 41:1137-47. 2003
    ....
  43. ncbi A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex
    Adam R Aron
    Department of Psychiatry, University of Cambridge, UK
    Brain 127:1561-73. 2004
    ..This study localizes two components of the complex task-switching process (inhibition of task-sets and/or responses and top-down control of task-set) to the right IFG/POp and the left MFG respectively...