Research Topics
Genomes and Genes
| Steven E ArnoldSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
|
Detail Information
Publications
Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementiaSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Alzheimers Dis 33:1089-95. 2013..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study...- Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's diseaseSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Aging 34:157-68. 2013..These data characterize cellular and synaptic features and identify novel biochemical targets that may be associated with resilient cognitive brain aging in the setting of pathological AD... - Plasma biomarkers of depressive symptoms in older adultsS E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Transl Psychiatry 2:e65. 2012.... - Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
BMC Med 9:42. 2011..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people... - Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
BMC Geriatr 10:77. 2010..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons... - Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer diseaseSteven E Arnold
Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 67:462-9. 2010..However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established... - Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease centerMelissa Gartenberg Livney
From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 19:430-9. 2011.... - Plasma multianalyte profiling in mild cognitive impairment and Alzheimer diseaseWilliam T Hu
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
Neurology 79:897-905. 2012..Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI)... - Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementiasMark Yarchoan
3615 Chestnut Street, Philadelphia, PA 19104, USA
Brain 135:3749-56. 2012.... 
Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measuresPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Exp Neuropsychol 28:1444-61. 2006....- Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic locationKonrad Talbot
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e16886. 2011..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific... - Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairmentWilliam T Hu
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 119:669-78. 2010..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone... - Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platformsDavid J Irwin
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Arch Neurol 69:1018-25. 2012..To use values of cerebrospinal fluid tau and β-amyloid obtained from 2 different analytical immunoassays to differentiate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD)... - Dysbindin-1 is a synaptic and microtubular protein that binds brain snapinKonrad Talbot
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Mol Genet 15:3041-54. 2006..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin... - Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's diseaseWilliam T Hu
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Acta Neuropathol 120:385-99. 2010.... - CSF biomarkers cutoffs: the importance of coincident neuropathological diseasesJon B Toledo
Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
Acta Neuropathol 124:23-35. 2012.... - Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imagingRaquel E Gur
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Psychiatry 164:442-9. 2007..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging... - Plasma epidermal growth factor levels predict cognitive decline in Parkinson diseaseAlice S Chen-Plotkin
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Ann Neurol 69:655-63. 2011..Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD... - Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expressionJunxia Tang
Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
Hum Mol Genet 18:3851-63. 2009.... - Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's diseaseNatalia Louneva
Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Pathol 173:1488-95. 2008..These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression... - Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophreniaBruce I Turetsky
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
Arch Gen Psychiatry 60:1193-200. 2003..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established... - Apolipoprotein E genotype and odor identification in schizophreniaPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Neuropsychiatry Clin Neurosci 18:231-3. 2006..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele... - Building an integrated neurodegenerative disease database at an academic health centerSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Alzheimers Dement 7:e84-93. 2011..These comparative studies rely on powerful database tools to quickly generate data sets that match diverse and complementary criteria set by them... - Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathologyRoy Hamilton
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Ann Neurol 68:535-40. 2010.... - Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosisDavid J Irwin
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
J Neurol Neurosurg Psychiatry 84:163-9. 2013..To clarify this issue, we compared a large C9P cohort with carefully matched non-expansion (C9N) cases with a known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy... - Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineKonrad Talbot
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
J Clin Invest 122:1316-38. 2012.... - Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humansAinie Soetanto
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Arch Gen Psychiatry 67:448-57. 2010..In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines... - Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-oldJohn L Robinson
Center for Neurodegenerative Disease Research, Institute on Ageing, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Brain 134:3708-15. 2011.... - Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophreniaGregory C Carlson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Proc Natl Acad Sci U S A 108:E962-70. 2011..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes... - Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathiesDavid J Irwin
Centre for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Centre, Institute on Ageing, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Brain 135:807-18. 2012..Thus, inhibiting tau acetylation could be a disease-modifying target for drug discovery target in tauopathies... - In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expressionGlenn A Doyle
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e23373. 2011..We conclude that CHRNA5 promoter variants may affect relative risk for NA in some heterozygous individuals... - In vivo and in vitro neurogenesis in human olfactory epitheliumChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Comp Neurol 483:154-63. 2005..These data highlight species-related differences in OE development and demonstrate the utility of explant culture for experimental studies of human neuronal development... - Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle densityEric Falke
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Pathol 163:1615-21. 2003..The pattern of dendritic loss in the subiculum and the correlations with NFT densities respectively suggest that deafferentation and intrinsic neurofibrillary degeneration both may contribute to dendritic loss in AD... - Co-morbidity of TDP-43 proteinopathy in Lewy body related diseasesHanae Nakashima Yasuda
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 114:221-9. 2007..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders... - Impairment of odor hedonics in men with schizophreniaPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, the Smell and Taste Center, PA 1914, USA
Am J Psychiatry 160:1784-9. 2003..This study examined intensity and hedonic judgments in patients with schizophrenia to determine whether these functions were differentially impaired... - Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophreniaNatasha Lowery
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Geriatr Psychiatry 11:621-8. 2003..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia... - Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalusSunil Patel
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fluids Barriers CNS 9:7. 2012..abstract:.. 
Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathologySelam Negash
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 9:e89-95. 2013..The aim of the present study was to examine cognitive and cerebral reserve factors associated with resilient functioning in the setting of AD pathology...- Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomographyDavid A Wolk
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
J Neurol Neurosurg Psychiatry 83:923-6. 2012..Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11... - Quality, and not just quantity, of education accounts for differences in psychometric performance between african americans and white non-hispanics with Alzheimer's diseaseAlexander L Chin
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Int Neuropsychol Soc 18:277-85. 2012..These findings suggest that quality, and not just quantity, of education needs to be taken into account when assessing cognitive performance in African Americans with AD... - Olfactory receptor neuron dysfunction in schizophreniaBruce I Turetsky
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 34:767-74. 2009..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons... - Rate of decline in Alzheimer disease measured by a Dementia Severity Rating ScaleSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Alzheimer Dis Assoc Disord 23:268-74. 2009..To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire... - Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI studyRuben C Gur
Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Brain Mapp 28:263-74. 2007..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences... - Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophreniaKonrad Talbot
Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
J Clin Invest 113:1353-63. 2004..Such changes may contribute to the cognitive deficits common in schizophrenia... - Frontotemporal dementia: clinicopathological correlationsMark S Forman
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 59:952-62. 2006.... - Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's diseaseThomas W Mitchell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ann Neurol 51:182-9. 2002.... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNIJon B Toledo
Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 8:e55531. 2013.... - Distribution of microtubule-associated protein MAP2-immunoreactive interstitial neurons in the parahippocampal white matter in subjects with schizophreniaLise Rioux
Department of Psychiatry, University of Pennsylvania, 547 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
Am J Psychiatry 160:149-55. 2003.... - Initial clinical comparison of 18F-florbetapir and 18F-FDG PET in patients with Alzheimer disease and controlsAndrew B Newberg
Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania 19107, USA
J Nucl Med 53:902-7. 2012..The purpose of this study was to determine how clinical interpretations of the (18)F-amyloid tracer florbetapir compares diagnostically with (18)F-FDG PET when evaluating patients with Alzheimer disease (AD) and controls... - Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brainJulia W Cohen
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Synapse 65:763-70. 2011.... - The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnessesChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
PLoS ONE 4:e5251. 2009..This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined... - Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorderFalk W Lohoff
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:2739-47. 2006..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology... - Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illnessFelix Geser
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Arch Neurol 67:1238-50. 2010.... - Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathologyDavid A Wolk
Penn Memory Center, 3615 Chestnut St, Philadelphia, PA 19104, USA
Arch Neurol 68:1398-403. 2011..To determine the correspondence of in vivo quantitative estimates of brain uptake of fluorine 18-labeled flutemetamol with immunohistochemical estimates of amyloid levels in patients who underwent previous biopsy... - Low olfactory bulb volume in first-degree relatives of patients with schizophreniaBruce I Turetsky
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
Am J Psychiatry 160:703-8. 2003..This study examined olfactory bulbs in patients' relatives to determine whether low bulb volume represents an endophenotypic marker of genetic vulnerability... - Evidence for oxidative DNA damage in the hippocampus of elderly patients with chronic schizophreniaNaoya Nishioka
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 12:167-75. 2004..These findings could have important implications for cellular metabolism, gene expression, and membrane functioning in schizophrenia... - Neurodevelopment, neuroplasticity, and new genes for schizophreniaSteven E Arnold
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Prog Brain Res 147:319-45. 2005..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity... - Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaChang Gyu Hahn
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:824-8. 2006..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia... - Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's diseaseSara M Bodner
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Med Genet B Neuropsychiatr Genet 134:1-5. 2005..The three SNPs studied were closely linked (D' = 0.99 across the region). We discuss possible reasons for our failure to confirm the previously reported associations... - Vascular disease and dementias: paradigm shifts to drive research in new directionsMitchel A Kling
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 9:76-92. 2013..This strategy will require funding from multiple public and private sources to support collaborative and interdisciplinary research efforts to take full advantage of these opportunities and realize their societal benefits... - Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational SummitMary D Naylor
Institute on Aging, University of Pennsylvania, Philadelphia, USA
Alzheimers Dement 8:445-52. 2012..The workgroups shared, discussed, and compiled an integrated set of priorities, recommendations, and action plans, which are presented in this article... - A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary researchJohn Q Trojanowski
Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Electronic address
Alzheimers Dement 8:564-73. 2012..The "Ware-UPenn" program has been presented in this report as a useful prototype for partnerships between private philanthropy and academia in planning and developing programs to address a major national public health problem... - Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's diseaseThomas McBride
Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
Schizophr Res 55:217-27. 2002..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile... - Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's diseaseErik S Musiek
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Alzheimers Dement 8:51-9. 2012..Recently, measurement of cerebral blood flow using arterial spin labeling magnetic resonance imaging (ASL-MRI) has shown diagnostic potential in AD, although it has never been directly compared with FDG-PET... - Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strainAndrew H Fairless
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
Brain Res 1230:211-7. 2008..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system... - Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's diseaseQuan Zhang
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
J Alzheimers Dis 32:677-87. 2012..Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations... - alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseasesNigel J Cairns
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 108:213-23. 2004..The discovery of alpha-internexin in neuronal cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological filamentous neuronal inclusions... - Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouseDavid Kapfhamer
Center for Neurobiology of Behavior of the Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Genet 32:290-5. 2002..Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors...