Steven E Arnold

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition
    Selam Negash
    Penn Memory Center, 3615 Chestnut Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Alzheimer Res 10:844-51. 2013
  2. pmc Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 33:1089-95. 2013
  3. pmc Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 34:157-68. 2013
  4. pmc Plasma biomarkers of depressive symptoms in older adults
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Transl Psychiatry 2:e65. 2012
  5. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
  6. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
  7. pmc Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease
    Steven E Arnold
    Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 67:462-9. 2010
  8. pmc Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center
    Melissa Gartenberg Livney
    From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 19:430-9. 2011
  9. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
  10. pmc Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology
    Selam Negash
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:e89-95. 2013

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition
    Selam Negash
    Penn Memory Center, 3615 Chestnut Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Alzheimer Res 10:844-51. 2013
    ....
  2. pmc Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 33:1089-95. 2013
    ..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study...
  3. pmc Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 34:157-68. 2013
    ..These data characterize cellular and synaptic features and identify novel biochemical targets that may be associated with resilient cognitive brain aging in the setting of pathological AD...
  4. pmc Plasma biomarkers of depressive symptoms in older adults
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Transl Psychiatry 2:e65. 2012
    ....
  5. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
    ..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...
  6. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
    ..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...
  7. pmc Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease
    Steven E Arnold
    Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 67:462-9. 2010
    ..However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established...
  8. pmc Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center
    Melissa Gartenberg Livney
    From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 19:430-9. 2011
    ....
  9. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
    ..Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  10. pmc Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology
    Selam Negash
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:e89-95. 2013
    ..The aim of the present study was to examine cognitive and cerebral reserve factors associated with resilient functioning in the setting of AD pathology...
  11. pmc Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
    Mark Yarchoan
    3615 Chestnut Street, Philadelphia, PA 19104, USA
    Brain 135:3749-56. 2012
    ....
  12. pmc Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location
    Konrad Talbot
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16886. 2011
    ..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific...
  13. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  14. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  15. pmc Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Arch Neurol 69:1018-25. 2012
    ..To use values of cerebrospinal fluid tau and β-amyloid obtained from 2 different analytical immunoassays to differentiate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD)...
  16. ncbi request reprint Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
    ..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin...
  17. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
    ....
  18. pmc CSF biomarkers cutoffs: the importance of coincident neuropathological diseases
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 124:23-35. 2012
    ....
  19. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
    ....
  20. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  21. pmc Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 69:655-63. 2011
    ..Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD...
  22. pmc Acetylated tau neuropathology in sporadic and hereditary tauopathies
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 183:344-51. 2013
    ..The close association of AC-K280 with amyloid and pre-amyloid conformations of tau suggests a potential role in tangle maturation and, thus, could serve as a useful biomarker or therapeutic target in a variety of tauopathies. ..
  23. pmc Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Ageing, Centre for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain 136:2697-706. 2013
    ....
  24. ncbi request reprint Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  25. ncbi request reprint Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  26. pmc Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
    ....
  27. pmc Building an integrated neurodegenerative disease database at an academic health center
    Sharon X Xie
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Alzheimers Dement 7:e84-93. 2011
    ..These comparative studies rely on powerful database tools to quickly generate data sets that match diverse and complementary criteria set by them...
  28. pmc Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
    Natalia Louneva
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 173:1488-95. 2008
    ..These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression...
  29. pmc Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e55531. 2013
    ....
  30. pmc Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 84:163-9. 2013
    ..To clarify this issue, we compared a large C9P cohort with carefully matched non-expansion (C9N) cases with a known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy...
  31. pmc Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
    Ainie Soetanto
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Arch Gen Psychiatry 67:448-57. 2010
    ..In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines...
  32. pmc Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    J Clin Invest 122:1316-38. 2012
    ....
  33. pmc In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression
    Glenn A Doyle
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23373. 2011
    ..We conclude that CHRNA5 promoter variants may affect relative risk for NA in some heterozygous individuals...
  34. pmc Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old
    John L Robinson
    Center for Neurodegenerative Disease Research, Institute on Ageing, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain 134:3708-15. 2011
    ....
  35. pmc Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
    David J Irwin
    Centre for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Centre, Institute on Ageing, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Brain 135:807-18. 2012
    ..Thus, inhibiting tau acetylation could be a disease-modifying target for drug discovery target in tauopathies...
  36. pmc Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
    ..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes...
  37. pmc Quality, and not just quantity, of education accounts for differences in psychometric performance between african americans and white non-hispanics with Alzheimer's disease
    Alexander L Chin
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Int Neuropsychol Soc 18:277-85. 2012
    ..These findings suggest that quality, and not just quantity, of education needs to be taken into account when assessing cognitive performance in African Americans with AD...
  38. ncbi request reprint Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
    Thomas W Mitchell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 51:182-9. 2002
    ....
  39. pmc Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density
    Eric Falke
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 163:1615-21. 2003
    ..The pattern of dendritic loss in the subiculum and the correlations with NFT densities respectively suggest that deafferentation and intrinsic neurofibrillary degeneration both may contribute to dendritic loss in AD...
  40. ncbi request reprint Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophrenia
    Natasha Lowery
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Geriatr Psychiatry 11:621-8. 2003
    ..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia...
  41. ncbi request reprint Impairment of odor hedonics in men with schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, the Smell and Taste Center, PA 1914, USA
    Am J Psychiatry 160:1784-9. 2003
    ..This study examined intensity and hedonic judgments in patients with schizophrenia to determine whether these functions were differentially impaired...
  42. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
    ..abstract:..
  43. doi request reprint Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging
    David R Roalf
    Department of Psychiatry, Neuropsychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:529-37. 2013
    ....
  44. pmc Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases
    Steven E Arnold
    Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104
    J Comp Neurol 521:4339-55. 2013
    ....
  45. pmc Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD
    David A Wolk
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychologia 51:1094-102. 2013
    ....
  46. pmc The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e5251. 2009
    ..This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined...
  47. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  48. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  49. doi request reprint Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography
    David A Wolk
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Neurol Neurosurg Psychiatry 83:923-6. 2012
    ..Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11...
  50. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
    ..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons...
  51. pmc Rate of decline in Alzheimer disease measured by a Dementia Severity Rating Scale
    Sharon X Xie
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Alzheimer Dis Assoc Disord 23:268-74. 2009
    ..To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire...
  52. pmc Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 67:1238-50. 2010
    ....
  53. pmc Olfaction and apathy in Alzheimer's disease, mild cognitive impairment, and healthy older adults
    Sarah C Seligman
    Department of Psychology, Temple University, Philadelphia, PA, USA
    Aging Ment Health 17:564-70. 2013
    ....
  54. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  55. pmc Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease
    Mark Yarchoan
    Department of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States
    J Neurol Sci 333:9-12. 2013
    ..Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD. ..
  56. ncbi request reprint In vivo and in vitro neurogenesis in human olfactory epithelium
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Comp Neurol 483:154-63. 2005
    ..These data highlight species-related differences in OE development and demonstrate the utility of explant culture for experimental studies of human neuronal development...
  57. ncbi request reprint Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  58. ncbi request reprint Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease
    Sara M Bodner
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 134:1-5. 2005
    ..The three SNPs studied were closely linked (D' = 0.99 across the region). We discuss possible reasons for our failure to confirm the previously reported associations...
  59. pmc Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's disease
    Quan Zhang
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
    J Alzheimers Dis 32:677-87. 2012
    ..Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations...
  60. pmc Design of comprehensive Alzheimer's disease centers to address unmet national needs
    John Q Trojanowski
    Institute on Aging, Philadelphia, PA, USA
    Alzheimers Dement 6:150-5. 2010
    ..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders...
  61. pmc A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research
    John Q Trojanowski
    Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 8:564-73. 2012
    ..The "Ware-UPenn" program has been presented in this report as a useful prototype for partnerships between private philanthropy and academia in planning and developing programs to address a major national public health problem...
  62. ncbi request reprint Distribution of microtubule-associated protein MAP2-immunoreactive interstitial neurons in the parahippocampal white matter in subjects with schizophrenia
    Lise Rioux
    Department of Psychiatry, University of Pennsylvania, 547 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Am J Psychiatry 160:149-55. 2003
    ....
  63. doi request reprint Initial clinical comparison of 18F-florbetapir and 18F-FDG PET in patients with Alzheimer disease and controls
    Andrew B Newberg
    Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 53:902-7. 2012
    ..The purpose of this study was to determine how clinical interpretations of the (18)F-amyloid tracer florbetapir compares diagnostically with (18)F-FDG PET when evaluating patients with Alzheimer disease (AD) and controls...
  64. pmc Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2739-47. 2006
    ..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology...
  65. pmc Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain
    Julia W Cohen
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Synapse 65:763-70. 2011
    ....
  66. pmc Vascular disease and dementias: paradigm shifts to drive research in new directions
    Mitchel A Kling
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:76-92. 2013
    ..This strategy will require funding from multiple public and private sources to support collaborative and interdisciplinary research efforts to take full advantage of these opportunities and realize their societal benefits...
  67. doi request reprint Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
    David A Wolk
    Penn Memory Center, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Arch Neurol 68:1398-403. 2011
    ..To determine the correspondence of in vivo quantitative estimates of brain uptake of fluorine 18-labeled flutemetamol with immunohistochemical estimates of amyloid levels in patients who underwent previous biopsy...
  68. ncbi request reprint Low olfactory bulb volume in first-degree relatives of patients with schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
    Am J Psychiatry 160:703-8. 2003
    ..This study examined olfactory bulbs in patients' relatives to determine whether low bulb volume represents an endophenotypic marker of genetic vulnerability...
  69. ncbi request reprint Evidence for oxidative DNA damage in the hippocampus of elderly patients with chronic schizophrenia
    Naoya Nishioka
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:167-75. 2004
    ..Oxidative damage is one form of cellular injury that may cause cellular dysfunction without necessarily leading to neuron death...
  70. ncbi request reprint Neurodevelopment, neuroplasticity, and new genes for schizophrenia
    Steven E Arnold
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Prog Brain Res 147:319-45. 2005
    ..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity...
  71. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  72. pmc Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit
    Mary D Naylor
    Institute on Aging, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:445-52. 2012
    ..The workgroups shared, discussed, and compiled an integrated set of priorities, recommendations, and action plans, which are presented in this article...
  73. ncbi request reprint Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
    Thomas McBride
    Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Schizophr Res 55:217-27. 2002
    ..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile...
  74. pmc Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease
    Erik S Musiek
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:51-9. 2012
    ..Recently, measurement of cerebral blood flow using arterial spin labeling magnetic resonance imaging (ASL-MRI) has shown diagnostic potential in AD, although it has never been directly compared with FDG-PET...
  75. pmc Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Brain Res 1230:211-7. 2008
    ..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system...
  76. pmc alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 108:213-23. 2004
    ..The discovery of alpha-internexin in neuronal cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological filamentous neuronal inclusions...
  77. ncbi request reprint Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse
    David Kapfhamer
    Center for Neurobiology of Behavior of the Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:290-5. 2002
    ..Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors...