STEVEN ARNOLD

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
  2. ncbi request reprint Dysregulation of olfactory receptor neuron lineage in schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, 142 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 58:829-35. 2001
  3. ncbi request reprint Challenges, status, and opportunities for studying developmental neuropathology in adult schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia 19104, USA
    Schizophr Bull 27:395-416. 2001
  4. ncbi request reprint Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
    Thomas W Mitchell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 51:182-9. 2002
  5. pmc Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
  6. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
  7. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
  8. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
  9. pmc Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2739-47. 2006
  10. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006

Research Grants

Detail Information

Publications57

  1. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
    ..abstract:..
  2. ncbi request reprint Dysregulation of olfactory receptor neuron lineage in schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, 142 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 58:829-35. 2001
    ..We hypothesized that OE neurons exhibit deviant progress through neurodevelopment in schizophrenia characterized by an increase in immature neurons...
  3. ncbi request reprint Challenges, status, and opportunities for studying developmental neuropathology in adult schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia 19104, USA
    Schizophr Bull 27:395-416. 2001
    ....
  4. ncbi request reprint Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
    Thomas W Mitchell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 51:182-9. 2002
    ....
  5. pmc Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
    ....
  6. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  7. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  8. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  9. pmc Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2739-47. 2006
    ..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology...
  10. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  11. ncbi request reprint Low olfactory bulb volume in first-degree relatives of patients with schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
    Am J Psychiatry 160:703-8. 2003
    ..This study examined olfactory bulbs in patients' relatives to determine whether low bulb volume represents an endophenotypic marker of genetic vulnerability...
  12. ncbi request reprint Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  13. ncbi request reprint Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  14. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  15. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
    ..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons...
  16. pmc The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e5251. 2009
    ..This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined...
  17. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
    ....
  18. pmc Rate of decline in Alzheimer disease measured by a Dementia Severity Rating Scale
    Sharon X Xie
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Alzheimer Dis Assoc Disord 23:268-74. 2009
    ..To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire...
  19. pmc Design of comprehensive Alzheimer's disease centers to address unmet national needs
    John Q Trojanowski
    Institute on Aging, Philadelphia, PA, USA
    Alzheimers Dement 6:150-5. 2010
    ..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders...
  20. pmc Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease
    Steven E Arnold
    Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 67:462-9. 2010
    ..However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established...
  21. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  22. ncbi request reprint Distribution of microtubule-associated protein MAP2-immunoreactive interstitial neurons in the parahippocampal white matter in subjects with schizophrenia
    Lise Rioux
    Department of Psychiatry, University of Pennsylvania, 547 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Am J Psychiatry 160:149-55. 2003
    ....
  23. ncbi request reprint Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  24. ncbi request reprint Impairment of odor hedonics in men with schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, the Smell and Taste Center, PA 1914, USA
    Am J Psychiatry 160:1784-9. 2003
    ..This study examined intensity and hedonic judgments in patients with schizophrenia to determine whether these functions were differentially impaired...
  25. ncbi request reprint Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
    Thomas McBride
    Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Schizophr Res 55:217-27. 2002
    ..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile...
  26. ncbi request reprint Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophrenia
    Natasha Lowery
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Geriatr Psychiatry 11:621-8. 2003
    ..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia...
  27. ncbi request reprint In vivo and in vitro neurogenesis in human olfactory epithelium
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Comp Neurol 483:154-63. 2005
    ..These data highlight species-related differences in OE development and demonstrate the utility of explant culture for experimental studies of human neuronal development...
  28. pmc alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 108:213-23. 2004
    ..The discovery of alpha-internexin in neuronal cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological filamentous neuronal inclusions...
  29. ncbi request reprint Neurodevelopment, neuroplasticity, and new genes for schizophrenia
    Steven E Arnold
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Prog Brain Res 147:319-45. 2005
    ..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity...
  30. ncbi request reprint Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease
    Sara M Bodner
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 134:1-5. 2005
    ..The three SNPs studied were closely linked (D' = 0.99 across the region). We discuss possible reasons for our failure to confirm the previously reported associations...
  31. pmc Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density
    Eric Falke
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 163:1615-21. 2003
    ..The pattern of dendritic loss in the subiculum and the correlations with NFT densities respectively suggest that deafferentation and intrinsic neurofibrillary degeneration both may contribute to dendritic loss in AD...
  32. ncbi request reprint Evidence for oxidative DNA damage in the hippocampus of elderly patients with chronic schizophrenia
    Naoya Nishioka
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:167-75. 2004
    ..Oxidative damage is one form of cellular injury that may cause cellular dysfunction without necessarily leading to neuron death...
  33. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  34. ncbi request reprint Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
    ..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin...
  35. pmc Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
    Ainie Soetanto
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Arch Gen Psychiatry 67:448-57. 2010
    ..In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines...
  36. pmc Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 67:1238-50. 2010
    ....
  37. pmc Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
    Natalia Louneva
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 173:1488-95. 2008
    ..These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression...
  38. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
    ....
  39. ncbi request reprint Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse
    David Kapfhamer
    Center for Neurobiology of Behavior of the Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:290-5. 2002
    ..Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors...
  40. ncbi request reprint Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older persons
    David A Bennett
    Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 12:211-9. 2004
    ....
  41. ncbi request reprint Odor identification and decline in different cognitive domains in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:61-7. 2006
    ..The results indicate that impaired odor identification in old age is associated with impaired global cognition and more rapid decline in perceptual processing speed and episodic memory...
  42. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  43. ncbi request reprint Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    David A Bennett
    Rush Alzheimer s Disease Center and the Department of Neurological Sciences Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 61:378-84. 2004
    ..To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles...
  44. ncbi request reprint Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:1204-12. 2007
    ..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...
  45. ncbi request reprint FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
    Norman L Foster
    Center for Alzheimer s Care, Imaging and Research and Department of Neurology, University of Utah, USA
    Brain 130:2616-35. 2007
    ..FDG-PET adds important information that appropriately increases diagnostic confidence, even among experienced dementia specialists...
  46. ncbi request reprint Olfactory identification and incidence of mild cognitive impairment in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:802-8. 2007
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  47. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    ..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...
  48. ncbi request reprint Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex
    Scott E Hemby
    Department of Pharmacology, Yerkes Regional Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 59:631-40. 2002
    ..We used single-cell gene expression technologies to assess coordinate changes in the expression of multiple genes, including neuronal signaling and synaptic-related markers in EC layer II stellate neurons...
  49. ncbi request reprint Harm avoidance and disability in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 32:243-61. 2006
    ..The results suggest that harm avoidance is associated with disability in old age...
  50. ncbi request reprint A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?
    Paul T Francis
    Wolfson Centre for Age Related Diseases, Guy s Campus, St Thomas Street, Kings College London, London SE1 1UL, UK
    Trends Pharmacol Sci 26:104-11. 2005
    ..The mechanisms by which these actions are mediated might or might not be directly related to their primary mode of action...
  51. ncbi request reprint A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging
    Roger Higdon
    University of Washington, Seattle, USA
    Stat Med 23:315-26. 2004
    ..Methods using PLS appear to be more successful. Averaging or using VOI data may also be helpful...
  52. ncbi request reprint Chronic distress, age-related neuropathology, and late-life dementia
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:47-53. 2007
    ..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...
  53. ncbi request reprint Chronic psychological distress and risk of Alzheimer's disease in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
    Neuroepidemiology 27:143-53. 2006
    ..The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association...
  54. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
    ..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...
  55. pmc Childhood adversity and psychosocial adjustment in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 14:307-15. 2006
    ..The objective of this study was to test the hypothesis that higher level of childhood adversity is associated with lower level of psychosocial adjustment in old age...
  56. ncbi request reprint The use of biomarkers in the elderly: current and future challenges
    Trey Sunderland
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 58:272-6. 2005
    ..While some progress has been made in the search for adequate biomarkers in the elderly, in particular with Alzheimer disease, much more work is needed before these potential biomarkers can be reliably used in clinical practice...
  57. doi request reprint Change in depressive symptoms during the prodromal phase of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 65:439-45. 2008
    ..Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain...

Research Grants11

  1. Neurobiology of Dysbindin in Schizophrenia and sdy Mouse
    STEVEN ARNOLD; Fiscal Year: 2007
    ....
  2. OLFACTORY NEURODEVELOPMENTAL PATHOLOGY IN SCHIZOPHRENIA
    STEVEN ARNOLD; Fiscal Year: 2002
    ..The relative densities of immunohistochemically distinct populations of neurons will be determined and the spatial arrangement of neurons will be assessed using spatial point pattern analyses. ..