S E Arnold

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Cellular and molecular neuropathology of the parahippocampal region in schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 911:275-92. 2000
  2. ncbi request reprint Quantitative neurohistological features of frontotemporal degeneration
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Neurobiol Aging 21:913-9. 2000
  3. ncbi request reprint Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania
    Dev Psychopathol 11:439-56. 1999
  4. ncbi request reprint Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 855:762-75. 1998
  5. pmc Protease resistant prion proteins are not present in sporadic "poor outcome" schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Neurol Neurosurg Psychiatry 66:90-2. 1999
  6. ncbi request reprint Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Gen Psychiatry 55:225-32. 1998
  7. ncbi request reprint The medial temporal lobe in schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    J Neuropsychiatry Clin Neurosci 9:460-70. 1997
  8. ncbi request reprint Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia
    R E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Gen Psychiatry 57:761-8. 2000
  9. ncbi request reprint Dysregulation of olfactory receptor neuron lineage in schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, 142 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 58:829-35. 2001
  10. ncbi request reprint Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Acta Neuropathol 91:269-77. 1996

Detail Information

Publications30

  1. ncbi request reprint Cellular and molecular neuropathology of the parahippocampal region in schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 911:275-92. 2000
    ....
  2. ncbi request reprint Quantitative neurohistological features of frontotemporal degeneration
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Neurobiol Aging 21:913-9. 2000
    ..The molecular neurodegenerative mechanisms that lead to FTD remain to be elucidated...
  3. ncbi request reprint Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania
    Dev Psychopathol 11:439-56. 1999
    ....
  4. ncbi request reprint Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 855:762-75. 1998
    ..Finally, both the olfactory epithelium and central olfactory pathways represent model systems in which to study the neurobiology of these disorders, which ultimately may yield clues with diagnostic and therapeutic utility...
  5. pmc Protease resistant prion proteins are not present in sporadic "poor outcome" schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Neurol Neurosurg Psychiatry 66:90-2. 1999
    ..No PrPres was found in the brains of any of the cases, providing evidence against a role for abnormal prion proteins in the pathogenesis of schizophrenia...
  6. ncbi request reprint Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Gen Psychiatry 55:225-32. 1998
    ..However, we hypothesized that relatively small accumulations of age- or disease-related neurodegenerative lesions occurring in an otherwise abnormal brain could result in deterioration in schizophrenia...
  7. ncbi request reprint The medial temporal lobe in schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    J Neuropsychiatry Clin Neurosci 9:460-70. 1997
    ..These findings appear most consistent with models of aberrant development of medial temporal lobe structures in schizophrenia...
  8. ncbi request reprint Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia
    R E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Gen Psychiatry 57:761-8. 2000
    ..Inconsistent reports may relate to variable methods and small samples. We attempted to resolve volume differences within sectors of the prefrontal lobe in a large sample, relating volumes to clinical and neurocognitive features...
  9. ncbi request reprint Dysregulation of olfactory receptor neuron lineage in schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, 142 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 58:829-35. 2001
    ..We hypothesized that OE neurons exhibit deviant progress through neurodevelopment in schizophrenia characterized by an increase in immature neurons...
  10. ncbi request reprint Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Acta Neuropathol 91:269-77. 1996
    ..In the absence of any diagnostic neuropathological findings in this subgroup, the implications of these observations for the pathogenesis of schizophrenia remain to be determined...
  11. ncbi request reprint Human fetal hippocampal development: II. The neuronal cytoskeleton
    S E Arnold
    Department of Psychiatry and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Comp Neurol 367:293-307. 1996
    ..These observations have implications for understanding the role of the neuronal cytoskeleton in the developing, mature, and diseased CNS...
  12. ncbi request reprint Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    H I Hurtig
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 54:1916-21. 2000
    ..Although Alzheimer's pathology has been a frequent finding, recent advances in immunostaining of alpha-synuclein have suggested the possible importance of cortical Lewy bodies (CLBs) in the brains of demented patients with PD...
  13. ncbi request reprint Inositol 1,4,5-trisphosphate receptor expression in odontoblast cells
    G Smutzer
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Biochim Biophys Acta 1358:221-8. 1997
    ..These findings also suggest that inositol 1,4,5-trisphosphate receptor/channels regulate calcium flux in odontoblasts during mineralization of dentin, or in growth and differentiation of incisor tissue...
  14. pmc Cognition and neuropathology in aging: multidimensional perspectives from the Rush Religious Orders Study and Rush Memory And Aging Project
    S Negash
    Penn Memory Center, University of Pennsylvania, PA 19104, USA
    Curr Alzheimer Res 8:336-40. 2011
    ..It is hypothesized that the concept of resilient aging can serve as a useful entity in understanding mechanisms that underlie healthy aging amidst disease-related pathology...
  15. pmc Novel CSF biomarkers for frontotemporal lobar degenerations
    W T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neurology 75:2079-86. 2010
    ..To identify antemortem CSF diagnostic biomarkers that can potentially distinguish between the 2 main causes of frontotemporal lobar degeneration (FTLD), i.e., FTLD with TDP-43 pathology (FTLD-TDP) and FTLD with tau pathology (FTLD-tau)...
  16. ncbi request reprint Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment
    T W Mitchell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Histochem Cytochem 48:1627-38. 2000
    ..On the basis of data presented here using this novel strategy, we conclude that this quantitative imaging technique will facilitate efforts to determine the behavioral correlations of neuritic lesions in AD and other brain disorders...
  17. pmc Plasma biomarkers of depressive symptoms in older adults
    S E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Transl Psychiatry 2:e65. 2012
    ....
  18. ncbi request reprint The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases
    J E Duda
    Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA
    Exp Neurol 160:515-22. 1999
    ..Thus, our data on synuclein expression within the OE may signify that synuclein plays a role in the regeneration and plasticity of ORNs in the adult human OE...
  19. ncbi request reprint Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia
    V Zhukareva
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Neurol 49:165-75. 2001
    ..The presence of tau mRNA in these brains suggests that the level of tau protein may be controlled posttranscriptionally, at the level of either translation or mRNA stability...
  20. ncbi request reprint Contributions of neuropathology to understanding schizophrenia in late life
    S E Arnold
    Laboratory of Cellular and Molecular Neuropathology, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Harv Rev Psychiatry 9:69-76. 2001
    ....
  21. ncbi request reprint Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features
    S E Arnold
    Department of Psychiatry and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Comp Neurol 367:274-92. 1996
    ..These studies delineate normal neuroanatomic development and can be used to understand better the mechanisms underlying human neurodevelopmental and neurodegenerative disorders of the hippocampal formation...
  22. ncbi request reprint Cognitive impairment and functional status in elderly institutionalized patients with schizophrenia
    M M Kurtz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Int J Geriatr Psychiatry 16:631-8. 2001
    ..The relationship of cognitive impairment to functional status in older adults with schizophrenia was investigated...
  23. ncbi request reprint Reduced olfactory bulb volume in patients with schizophrenia
    B I Turetsky
    Department of Psychiatry, Radiology, and Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 157:828-30. 2000
    ..The authors' goal in this study was to compare the size of olfactory bulbs of patients with schizophrenia and those of healthy subjects...
  24. pmc Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease
    N J Cairns
    Center for Neurodegenerative Disease Research, Department University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurology 63:1376-84. 2004
    ..Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity...
  25. ncbi request reprint Challenges, status, and opportunities for studying developmental neuropathology in adult schizophrenia
    S E Arnold
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia 19104, USA
    Schizophr Bull 27:395-416. 2001
    ....
  26. pmc Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease
    Y Chen
    Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neurology 77:1977-85. 2011
    ..We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls...
  27. ncbi request reprint A comparative volumetric analysis of the prefrontal cortex in human and baboon MRI
    T McBride
    Brain Behavior Laboratory, Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Behav Evol 54:159-66. 1999
    ..On the other hand, the small magnitude of the difference might underlie similarities between the species and should encourage a search for other structures that are disproportionately larger in humans...
  28. ncbi request reprint Recent advances in defining the neuropathology of schizophrenia
    S E Arnold
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Acta Neuropathol 92:217-31. 1996
    ....
  29. pmc Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background
    M M Cox
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Brain Behav 8:390-7. 2009
    ....
  30. ncbi request reprint Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue
    G Smutzer
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Brain Res Mol Brain Res 44:347-54. 1997
    ..These results demonstrate the co-expression of multiple IP3 receptor subtypes in olfactory cells, and suggest multiple functions for IP3 receptors in this tissue...