Mark A Arnold

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Pure component selectivity analysis of multivariate calibration models from near-infrared spectra
    Mark A Arnold
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:2583-90. 2004
  2. ncbi request reprint Noninvasive glucose sensing
    Mark A Arnold
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:5429-39. 2005
  3. ncbi request reprint Phantom glucose calibration models from simulated noninvasive human near-infrared spectra
    M A Arnold
    Department of Chemistry, University of Iowa, Iowa City 52242, USA
    Anal Chem 70:1773-81. 1998
  4. ncbi request reprint Comparison of multivariate calibration models for glucose, urea, and lactate from near-infrared and Raman spectra
    Min Ren
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, IA 52242, USA
    Anal Bioanal Chem 387:879-88. 2007
  5. ncbi request reprint On-line monitoring of human prostate cancer cells in a perfusion rotating wall vessel by near-infrared spectroscopy
    Martin H Rhiel
    Department of Chemical and Biochemical Engineering, 4133 Seamens Center, University of Iowa, Iowa City, IA 52242, USA
    Biotechnol Bioeng 86:852-61. 2004
  6. ncbi request reprint Monitoring and controlling the dissolved oxygen (DO) concentration within the high aspect ratio vessel (HARV)
    Mark A Saarinen
    Department of Chemical and Biochemical Engineering and Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Biotechnol Prog 19:1335-41. 2003
  7. doi request reprint Selectivity for glucose, glucose-6-phosphate, and pyruvate in ternary mixtures from the multivariate analysis of near-infrared spectra
    Lingzhi Liu
    Department of Chemistry and Optical Science Technology Center, University of Iowa, Iowa City, IA 52242, USA
    Anal Bioanal Chem 393:669-77. 2009
  8. doi request reprint On-line near-infrared spectrometer to monitor urea removal in real time during hemodialysis
    David S Cho
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 62:866-72. 2008
  9. ncbi request reprint Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopy
    Airat K Amerov
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:4587-94. 2005
  10. ncbi request reprint Evaluating prostate cancer cell culturing methods: a comparison of cell morphologies and metabolic activity
    Jennifer J Winkenwerder
    Department of Chemistry, The University of Iowa, Iowa City, IA 52242, USA
    Oncol Rep 10:783-9. 2003

Collaborators

  • Jonathon T Olesberg
  • Jun Chen
  • Michael B Cohen
  • Michael J Flanigan
  • Dong Xiang
  • Lingzhi Liu
  • J M Wiencek
  • S Y Hu
  • Natalia V Alexeeva
  • Airat K Amerov
  • David W Murhammer
  • Gary W Small
  • Julie S Reece
  • Lin Zhang
  • Jiang Qiu
  • Mark A Saarinen
  • Toshiyasu Tarumi
  • David S Cho
  • Min Ren
  • Martin H Rhiel
  • Christopher V Eddy
  • Jennifer J Winkenwerder
  • Carolyn E Green
  • Martin Rhiel
  • C V Eddy
  • R G Wolcott
  • M J Mattu
  • Laura Cohn
  • G W Small
  • Michael J Miller
  • Tom Cannon
  • Cris Waterhouse
  • Ted Delaplaine
  • Patricia L Palechek
  • S Pan
  • L R Snyder
  • J A Nichols
  • S R Bakalyar
  • J W Dolan
  • H Chung

Detail Information

Publications31

  1. ncbi request reprint Pure component selectivity analysis of multivariate calibration models from near-infrared spectra
    Mark A Arnold
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:2583-90. 2004
    ..The proposed procedure demonstrates conclusively that no component of the sucrose or maltose spectrum contributes to the selective measurement of glucose. Analogous conclusions are possible for the sucrose and maltose calibration models...
  2. ncbi request reprint Noninvasive glucose sensing
    Mark A Arnold
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:5429-39. 2005
    ..A set of publication standards is recommended as a means to enhance progress toward a successful noninvasive monitor...
  3. ncbi request reprint Phantom glucose calibration models from simulated noninvasive human near-infrared spectra
    M A Arnold
    Department of Chemistry, University of Iowa, Iowa City 52242, USA
    Anal Chem 70:1773-81. 1998
    ..Chance temporal correlations between assigned glucose concentrations and some uncontrolled experimental parameter are responsible for this apparent model functionality...
  4. ncbi request reprint Comparison of multivariate calibration models for glucose, urea, and lactate from near-infrared and Raman spectra
    Min Ren
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, IA 52242, USA
    Anal Bioanal Chem 387:879-88. 2007
    ..The net analyte signal analysis also revealed that analytical sensitivity was higher for the models generated from near-IR spectra. This is consistent with the lower standard errors of prediction...
  5. ncbi request reprint On-line monitoring of human prostate cancer cells in a perfusion rotating wall vessel by near-infrared spectroscopy
    Martin H Rhiel
    Department of Chemical and Biochemical Engineering, 4133 Seamens Center, University of Iowa, Iowa City, IA 52242, USA
    Biotechnol Bioeng 86:852-61. 2004
    ..The resulting concentration information can be incorporated into closed-loop control schemes, thereby leading to better in vitro models of in vivo behavior...
  6. ncbi request reprint Monitoring and controlling the dissolved oxygen (DO) concentration within the high aspect ratio vessel (HARV)
    Mark A Saarinen
    Department of Chemical and Biochemical Engineering and Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Biotechnol Prog 19:1335-41. 2003
    ..The ability for DO concentration control within the vessel was demonstrated by using this sensor to monitor the DO concentration inside the HARV...
  7. doi request reprint Selectivity for glucose, glucose-6-phosphate, and pyruvate in ternary mixtures from the multivariate analysis of near-infrared spectra
    Lingzhi Liu
    Department of Chemistry and Optical Science Technology Center, University of Iowa, Iowa City, IA 52242, USA
    Anal Bioanal Chem 393:669-77. 2009
    ..Overall, selectivity is demonstrated for each solute with an order of sensitivity of pyruvate > glucose-6-phosphate > glucose...
  8. doi request reprint On-line near-infrared spectrometer to monitor urea removal in real time during hemodialysis
    David S Cho
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 62:866-72. 2008
    ..Selectivity for urea is demonstrated and the selectivity properties of the PLS calibration models are characterized with a pure component selectivity analysis...
  9. ncbi request reprint Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopy
    Airat K Amerov
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:4587-94. 2005
    ..This result provides evidence that absorption information is needed in order to obtain a glucose calibration model with acceptable performance...
  10. ncbi request reprint Evaluating prostate cancer cell culturing methods: a comparison of cell morphologies and metabolic activity
    Jennifer J Winkenwerder
    Department of Chemistry, The University of Iowa, Iowa City, IA 52242, USA
    Oncol Rep 10:783-9. 2003
    ..Results demonstrate that use of the perfusion-RWV bioreactor is advantageous in obtaining spherical aggregates, while grown in a controlled environment...
  11. ncbi request reprint Nondestructive near-infrared spectroscopic measurement of multiple analytes in undiluted samples of serum-based cell culture media
    Martin Rhiel
    Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, USA
    Biotechnol Bioeng 77:73-82. 2002
    ....
  12. doi request reprint Solid-state digital micro-mirror array spectrometer for Hadamard transform measurements of glucose and lactate in aqueous solutions
    Dong Xiang
    Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 65:1170-80. 2011
    ..These quantitative results from the DMD Hadamard transform spectrometer compare favorably to similar measurements performed with a commercial Fourier transform spectrometer...
  13. ncbi request reprint Molar absorptivities of glucose and other biological molecules in aqueous solutions over the first overtone and combination regions of the near-infrared spectrum
    Airat K Amerov
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa, USA
    Appl Spectrosc 58:1195-204. 2004
    ..It is shown that the net absorbance of light is controlled by the magnitude of the absorptivity of glucose compared to the product of the absorptivity of water and the water displacement coefficient for glucose...
  14. pmc Impact of tissue heterogeneity on noninvasive near-infrared glucose measurements in interstitial fluid of rat skin
    Natalia V Alexeeva
    Department of Chemistry, Optical Science and Technology Center, University of Iowa, Iowa City, Iowa, USA
    J Diabetes Sci Technol 4:1041-54. 2010
    ..Chemical heterogeneity of the skin matrix is examined as a possible mechanism for the strong sensitivity to the interface placement during noninvasive measurements conducted from transmission near-infrared absorption spectroscopy...
  15. ncbi request reprint Online measurement of urea concentration in spent dialysate during hemodialysis
    Jonathon T Olesberg
    Optical Science and Technology Center and the Department of Chemistry, The University of Iowa, Iowa City, IA 52242, USA
    Clin Chem 50:175-81. 2004
    ..We describe online optical measurements of urea in the effluent dialysate line during regular hemodialysis treatment of several patients. Monitoring urea removal can provide valuable information about dialysis efficiency...
  16. ncbi request reprint Tunable laser diode system for noninvasive blood glucose measurements
    Jonathon T Olesberg
    Optical Science and Technology Center and the Department of Chemistry, 100 IATL, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 59:1480-4. 2005
    ..Because the tunable filter has no moving parts, scans can be completed very quickly, typically in less than 10 ms. We describe the performance of the present laser system and avenues for extending the tuning range beyond 400 nm...
  17. doi request reprint Design considerations for near-infrared filter photometry: effects of noise sources and selectivity
    Toshiyasu Tarumi
    Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 63:700-8. 2009
    ..For the source noise limited case, the best quantitative results are obtained with the use of narrow-band non-overlapping optical filters...
  18. pmc Near-infrared microspectroscopic analysis of rat skin tissue heterogeneity in relation to noninvasive glucose sensing
    Natalia V Alexeeva
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa, USA
    J Diabetes Sci Technol 3:219-32. 2009
    ..Microscopic spectral mapping is used to map the chemical distribution for a set of excised sections of rat skin...
  19. ncbi request reprint Application of near-infrared spectra on temperature-controlled protein crystallization: a simulation study
    S Y Hu
    Department of Chemical and Biochemical Engineering and Center of Optical Science and Technology University of Iowa, Iowa City 52242, USA
    Appl Biochem Biotechnol 94:179-96. 2001
    ..Through simulations, it is shown that the proposed design is practical and represents a significant improvement over the commonly used isothermal crystallization technique...
  20. ncbi request reprint Comparison of combination and first overtone spectral regions for near-infrared calibration models for glucose and other biomolecules in aqueous solutions
    Jun Chen
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:5405-13. 2004
    ..The superior selectivity of combination spectra is confirmed by comparing the length of the NAS vectors for each matrix component...
  21. ncbi request reprint In vivo near-infrared spectroscopy of rat skin tissue with varying blood glucose levels
    Jonathon T Olesberg
    Optical Science and Technology Center and the Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 78:215-23. 2006
    ..The analysis described here provides a procedure by which the analytical significance of a multivariate calibration can be evaluated...
  22. doi request reprint On-line near infrared bioreactor monitoring of cell density and concentrations of glucose and lactate during insect cell cultivation
    Jiang Qiu
    Department of Chemical and Biochemical Engineering, Optical Science and Technology Center, University of Iowa, Iowa City, IA 52242, United States Electronic address
    J Biotechnol 173:106-11. 2014
    ..The standard errors of prediction are 1.54mM, 0.83mM, and 0.38×10(6)cells/mL for the glucose, lactate, and cell density models, respectively. ..
  23. ncbi request reprint Near-infrared spectroscopic measurement of urea in dialysate samples collected during hemodialysis treatments
    Christopher V Eddy
    Department of Chemistry, Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 57:1230-5. 2003
    ..5 mm and spectral noise levels on the order of 25 micro-absorbance units when measured as the root-mean-square (RMS) noise of 100% lines...
  24. ncbi request reprint Continuous oxygen monitoring of mammalian cell growth on space shuttle mission STS-93 with a novel radioluminescent oxygen sensor
    Julie S Reece
    Department of Chemistry, 230 IATL, The University of Iowa, Iowa City, IA 52242, USA
    Appl Biochem Biotechnol 104:1-11. 2003
    ..In addition, the sensor provided physically meaningful oxygen predictions...
  25. ncbi request reprint Determination of glucose in a biological matrix by multivariate analysis of multiple band-pass-filtered Fourier transform near-infrared interferograms
    M J Mattu
    Department of Chemistry, Ohio University, Athens 45701, USA
    Anal Chem 69:4695-702. 1997
    ..The interferogram-based method operates without the use of a separate background measurement and employs only a short section of the interferogram...
  26. ncbi request reprint Near-infrared spectroscopy for measuring urea in hemodialysis fluids
    C V Eddy
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, IA 52242, USA
    Clin Chem 47:1279-86. 2001
    ..CONCLUSIONS: Urea can be determined with sufficient sensitivity and selectivity for clinical measurements within the matrix of the hemodialysis fluid...
  27. ncbi request reprint Near-infrared spectroscopic measurement of physiological glucose levels in variable matrices of protein and triglycerides
    S Pan
    Department of Chemistry, University of Iowa, Iowa City 52242, USA
    Anal Chem 68:1124-35. 1996
    ..Lastly, digital Fourier filtering alone is shown to have only limited ability to isolate glucose signals from those of BSA and triacetin due to similarities in the widths of the absorption bands of the three species...
  28. ncbi request reprint Control of column temperature in reversed-phase liquid chromatography
    R G Wolcott
    Department of Chemistry, Linfield College, McMinnville, OR 97128, USA
    J Chromatogr A 869:211-30. 2000
    ..Means for correcting for such effects and thereby ensuring method transferability are described...
  29. ncbi request reprint Calibration standardization algorithm for partial least-squares regression: application to the determination of physiological levels of glucose by near-infrared spectroscopy
    Lin Zhang
    Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens 45701, USA
    Anal Chem 74:4097-108. 2002
    ..A similar improvement in the prediction performance of the 2000 test set is obtained after standardization with the 1996 database (SEP = 0.70 mM)...
  30. ncbi request reprint Multivariate calibration standardization across instruments for the determination of glucose by Fourier transform near-infrared spectrometry
    Lin Zhang
    Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, USA
    Anal Chem 75:5905-15. 2003
    ..Diagnostic procedures are presented for use with the GMR algorithm that forecasts the successful calibration transfer with spectrometer C and the unsatisfactory results with spectrometer B...
  31. ncbi request reprint Multivariate calibration models for lysozyme from near-infrared transmission spectra in scattering solutions of monodisperse microspheres
    Carolyn E Green
    Anal Chem 74:3392-9. 2002
    ..Differences in the prediction ability are noted between the 6.4- and 0.6-microm data sets...

Research Grants17

  1. Noninvasive Spectroscopic Sensors for Glucose and Urea
    Mark Arnold; Fiscal Year: 2002
    ..Success will provide tremendous healthcare benefits arising from an improvement in the treatment and management of diabetes and end stage renal disease. ..
  2. Continuous Near Infrared Glucose Sensor
    Mark Arnold; Fiscal Year: 2009
    ..The overall objective is to measure clinically relevant levels of glucose in one minute under non- laboratory conditions. Analytical properties will be validated in laboratory animals. ..
  3. Instrumental Designs for Near Infrared Glucose Monitors
    Mark Arnold; Fiscal Year: 2007
    ..The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm. ..
  4. Noninvasive Nocturnal Hypoglycemic Alarm
    Mark Arnold; Fiscal Year: 2007
    ..Our approach is noninvasive, thereby avoiding confounding issues associated with biocompatibility and infection that plague implantable biosensor technologies. ..
  5. Instrumental Designs for Near Infrared Glucose Monitors
    Mark Arnold; Fiscal Year: 2006
    ..The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm. ..
  6. Noninvasive Spectroscopic Sensors for Glucose and Urea
    Mark Arnold; Fiscal Year: 2005
    ..Success will provide tremendous healthcare benefits arising from an improvement in the treatment and management of diabetes and end stage renal disease. ..
  7. Instrumental Designs for Near Infrared Glucose Monitors
    Mark Arnold; Fiscal Year: 2005
    ..The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm. ..
  8. Noninvasive Spectroscopic Sensors for Glucose and Urea
    Mark Arnold; Fiscal Year: 2004
    ..Success will provide tremendous healthcare benefits arising from an improvement in the treatment and management of diabetes and end stage renal disease. ..
  9. Instrumental Designs for Near Infrared Glucose Monitors
    Mark Arnold; Fiscal Year: 2004
    ..The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm. ..
  10. Noninvasive Spectroscopic Sensors for Glucose and Urea
    Mark Arnold; Fiscal Year: 2003
    ..Success will provide tremendous healthcare benefits arising from an improvement in the treatment and management of diabetes and end stage renal disease. ..
  11. Continuous Near Infrared Glucose Sensor
    Mark Arnold; Fiscal Year: 2002
    ....
  12. Continuous Near Infrared Glucose Sensor
    Mark A Arnold; Fiscal Year: 2010
    ..The overall objective is to measure clinically relevant levels of glucose in one minute under non- laboratory conditions. Analytical properties will be validated in laboratory animals. ..