Research Topics
| Lesley ArnoldSummaryAffiliation: University of Cincinnati Country: USA Publications
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Detail Information
Publications
Advances in the management of fibromyalgiaLesley M Arnold
Women s Health Research Program, University of Cincinnati College of Medicine, Ohio, USA
CNS Spectr 14:12-6; discussion 17-8. 2009..CNS targets have proven to be effective in the treatment of FM. However, treatment must be individualized and the integration of various pharmacologic and nonpharmacologic treatments may be the best approach...
The fibromyalgia family study: a genome-wide linkage scan studyLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio
Arthritis Rheum 65:1122-8. 2013..Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia...- Relationships among pain, depressed mood, and global status in fibromyalgia patients: post hoc analyses of a randomized, placebo-controlled trial of milnacipranLesley M Arnold
Women s Health Research Program, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Psychosomatics 53:371-9. 2012..Patients with fibromyalgia often experience depressive symptoms in addition to chronic pain and other characteristic symptoms associated with this disorder... - Safety and efficacy of esreboxetine in patients with fibromyalgia: a fourteen-week, randomized, double-blind, placebo-controlled, multicenter clinical trialLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Arthritis Rheum 64:2387-97. 2012..To evaluate the efficacy, tolerability, and safety of multiple fixed dosages of esreboxetine for the treatment of fibromyalgia... - Safety profile and tolerability of up to 1 year of pregabalin treatment in 3 open-label extension studies in patients with fibromyalgiaLesley M Arnold
Women s Health Research Program, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Ohio, USA
Clin Ther 34:1092-102. 2012..Pain relief and an acceptable safety profile have been reported in randomized controlled trials (RCTs) of pregabalin in the treatment of fibromyalgia (FM) for up to 14 weeks... 
A framework for fibromyalgia management for primary care providersLesley M Arnold
Department of Psychiatry and Behavioral Neuroscience and the Women s Health Research Program, University of Cincinnati College of Medicine, OH 45219, USA
Mayo Clin Proc 87:488-96. 2012..This proactive and systematic treatment approach encourages ongoing education and patient self-management and is designed for use in the primary care setting...- Development and testing of the fibromyalgia diagnostic screen for primary careLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
J Womens Health (Larchmt) 21:231-9. 2012..The Fibromyalgia Diagnostic Screen was developed for use by primary care clinicians to assist in the diagnostic evaluation of fibromyalgia, a disorder that predominantly affects women... - Development of responder definitions for fibromyalgia clinical trialsLesley M Arnold
Women s Health Research Program, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Arthritis Rheum 64:885-94. 2012..To develop responder definitions for fibromyalgia (FM) clinical trials using key symptom and function domains... - Management of fibromyalgia and comorbid psychiatric disordersLesley M Arnold
Division of Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 69:14-9. 2008..The efficacy of pharmacologic and nonpharmacologic treatments is examined in this article, as well as the diagnostic difficulties that comorbid disorders present... - A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgiaLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
J Pain 9:792-805. 2008..These results provide evidence that pregabalin is an important treatment option for patients with fibromyalgia... - Understanding fatigue in major depressive disorder and other medical disordersLesley M Arnold
University of Cincinnati, Cincinnati, OH, USA
Psychosomatics 49:185-90. 2008..Although fatigue is a common symptom that occurs in many psychiatric and other medical disorders, the pathophysiological mechanisms of fatigue are still unclear... - The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgiaLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Pain Med 8:633-8. 2007..To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment... - Duloxetine for the treatment of fibromyalgia in women: pooled results from two randomized, placebo-controlled clinical trialsLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
J Womens Health (Larchmt) 16:1145-56. 2007.... - Duloxetine and other antidepressants in the treatment of patients with fibromyalgiaLesley M Arnold
Women s Health Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Pain Med 8:S63-74. 2007..To review the use of duloxetine, a new selective serotonin and norepinephrine reuptake inhibitor (SNRI), and other antidepressants in the treatment of patients with fibromyalgia... - Patient perspectives on the impact of fibromyalgiaLesley M Arnold
University of Cincinnati Medical Center, 222 Piedmont Avenue, Cincinnati, OH 45219, USA
Patient Educ Couns 73:114-20. 2008..The intention was to collect this information as part of an overall effort to overcome shortcomings of existing outcome measures in fibromyalgia... - Management of psychiatric comorbidity in fibromyalgiaLesley M Arnold
University of Cincinnati College of Medicine, 222 Piedmont Avenue, Suite 8200, Cincinnati, OH 45219, USA
Curr Psychiatry Rep 8:241-5. 2006..Many patients would likely benefit from combinations of pharmacologic and nonpharmacologic treatments... - Strategies for managing fibromyalgiaLesley M Arnold
Women s Health Research Program and Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Am J Med 122:S31-43. 2009..This report provides an in-depth review of randomized, controlled trials for pharmacologic and nonpharmacologic approaches to fibromyalgia therapy... - The pathophysiology, diagnosis and treatment of fibromyalgiaLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 222 Piedmont Avenue, Suite 8200, Cincinnati, OH 45219, USA
Psychiatr Clin North Am 33:375-408. 2010..The rapid growth of trials in fibromyalgia in recent years has resulted in new evidence-based approaches to pharmacological and nonpharmacological treatment... - Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: results of a randomized, double-blind, placebo-controlled trialLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Arthritis Rheum 62:2745-56. 2010..To assess the efficacy and safety of milnacipran at a dosage of 100 mg/day (50 mg twice daily) for monotherapy treatment of fibromyalgia... - Pregabalin: an alpha2-delta (alpha2-delta) ligand for the management of fibromyalgiaLesley Arnold
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Am J Manag Care 16:S138-43. 2010..To review the efficacy and safety of pregabalin, an alpha(2)-delta (alpha(2)-delta) ligand, for the management of fibromyalgia (FM)... - Safety and efficacy of esreboxetine in patients with fibromyalgia: An 8-week, multicenter, randomized, double-blind, placebo-controlled studyLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Clin Ther 32:1618-32. 2010..Esreboxetine is an investigational, highly selective norepinephrine reuptake inhibitor that has been reported to have antinociceptive effects in preclinical pain models... - Correlations between fibromyalgia symptom and function domains and patient global impression of change: a pooled analysis of three randomized, placebo-controlled trials of pregabalinLesley M Arnold
Women s Health Research Program, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Pain Med 12:260-7. 2011..The objective of the study was to conduct an analysis of pooled data from pregabalin fibromyalgia clinical trials to determine which fibromyalgia symptom and function domains drive patient perception of improvement... - The effect of pain on outcomes in a trial of duloxetine treatment of major depressive disorderLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Ann Clin Psychiatry 20:187-93. 2008..The primary objective was to test the hypothesis that a greater reduction in pain was associated with a higher probability of MDD remission... - Ethnicity and first-rank symptoms in patients with psychosisLesley M Arnold
Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Schizophr Res 67:207-12. 2004..These findings indicate that psychotic symptom presentation should be evaluated in the context of other symptoms (e.g., affective symptoms) in diagnostic assessments in order to prevent misdiagnoses of schizophrenia... - Improving the recognition and diagnosis of fibromyalgiaLesley M Arnold
Department of Psychiatry and Behavioral Neuroscience and the Women s Health Research Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Mayo Clin Proc 86:457-64. 2011..The hallmark symptoms used to identify FM are chronic widespread pain, fatigue, and sleep disturbances. Awareness of common mimics of FM and comorbid disorders will increase confidence in establishing a diagnosis of FM... - A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorderLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Pain 119:5-15. 2005..In conclusion, both duloxetine 60 mg QD and duloxetine 60 mg BID were effective and safe in the treatment of fibromyalgia in female patients with or without major depressive disorder... - Family study of fibromyalgiaLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
Arthritis Rheum 50:944-52. 2004..To assess for familial aggregation of fibromyalgia (FM) and measures of tenderness and pain, and for familial coaggregation of FM and major mood disorder (major depressive disorder or bipolar disorder)... - Gender differences in bipolar disorderLesley M Arnold
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
Psychiatr Clin North Am 26:595-620. 2003..Individualized risk/benefit assessments of pregnant and postpartum women with bipolar disorder are required to promote the health of the woman and avoid or limit exposure of the fetus or infant to potential adverse effects of medication... - A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorderLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Arthritis Rheum 50:2974-84. 2004..To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder... - A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorderLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
J Clin Psychiatry 63:1028-33. 2002..The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating disorder... - Biology and therapy of fibromyalgia. New therapies in fibromyalgiaLesley M Arnold
Women s Health Research Program, University of Cincinnati College of Medicine, Piedmont Avenue, Cincinnati, Ohio 45219, USA
Arthritis Res Ther 8:212. 2006..It is likely that many patients would benefit from combinations of pharmacological and non-pharmacological treatments, but more study is needed... - Comorbidity of fibromyalgia and psychiatric disordersLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
J Clin Psychiatry 67:1219-25. 2006..To assess the co-occurrence of fibromyalgia with psychiatric disorders in participants of a fibromyalgia family study... - Sex, ethnicity, and antipsychotic medication use in patients with psychosisLesley M Arnold
Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
Schizophr Res 66:169-75. 2004..There were no ethnic or sex differences in the dosing of antipsychotics for the treatment of schizophrenia spectrum disorders. There were also no ethnic or sex differences in the use of second-generation antipsychotics... - Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trialLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, and Newton Wellesley Hospital, Newton, MA, USA
Arthritis Rheum 56:1336-44. 2007..To assess the efficacy and safety of gabapentin in patients with fibromyalgia... - Ethnicity and diagnosis in patients with affective disordersStephen M Strakowski
Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 64:747-54. 2003..However, it may be due to a perception that psychotic symptoms are more chronic or persistent than affective symptoms in these patients... - Actigraphy-based physical activity monitoring in adolescents with juvenile primary fibromyalgia syndromeSusmita Kashikar-Zuck
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Pain 11:885-93. 2010..Results indicate that actigraphy provides a unique source of objective information that can advance our understanding of physical disability in JPFS and the factors associated with physical impairment... - Comparisons of the efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with versus without major depressive disorderLesley M Arnold
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Clin J Pain 25:461-8. 2009..To investigate whether comorbid major depressive disorder (MDD) influenced the efficacy and safety of duloxetine in treating fibromyalgia (FM)... - Pain and the brain: chronic widespread painLesley M Arnold
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 70:e10. 2009..A comprehensive disease management strategy including patient education, pharmacotherapy, cognitive-behavioral therapy, and aerobic and other forms of exercise can be beneficial for many patients with fibromyalgia... - Pain and the brainLesley M Arnold
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 69:e25. 2008.... - Use of a computerized evaluation system in a psychiatry clerkshipAurora J Bennett
University Psychiatric Services, 222 Piedmont Ave, Medical Arts Building, Suite 8500, Cincinnati, OH 45219, USA
Acad Psychiatry 28:197-203. 2004..Paper-based evaluations of medical students on clerkships are inefficient and time consuming to compile and analyze. To improve the evaluation process, the authors developed a web-based program... - Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trialSusan L McElroy
Division of Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
Am J Psychiatry 160:255-61. 2003..Binge eating disorder is associated with obesity. Topiramate is an antiepileptic agent associated with weight loss. The objective of this study was to evaluate topiramate in the treatment of binge eating disorder associated with obesity... - Professionalism deficits among medical students: models of identification and interventionAurora J Bennett
Department of Psychiatry, University of Cincinatti College of Medicine, Ohio, USA
Acad Psychiatry 29:426-32. 2005..This study compares the instruments and interventions utilized to identify and remediate unprofessional behaviors in medical students across U.S. psychiatry clerkships... - Topiramate in the long-term treatment of binge-eating disorder associated with obesitySusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
J Clin Psychiatry 65:1463-9. 2004..This study assessed the long-term effectiveness and tolerability of topiramate in binge-eating disorder (BED) with obesity... - A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgiaLesley M Arnold
Women's Health Research Program, Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0559, USA
Am J Med 112:191-7. 2002..CONCLUSIONS: In a 12-week, flexible-dose, placebo-controlled trial, fluoxetine was found to be effective on most outcome measures and generally well tolerated in women with fibromyalgia... - Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for maniaStephen M Strakowski
Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
Arch Gen Psychiatry 64:57-64. 2007..Cannabis use disorders commonly co-occur in bipolar disorder; however, the effects of cannabis abuse on outcome have been minimally studied... - Use of standardized patients during a psychiatry clerkshipAurora J Bennett
University of Cincinnati, 222 Piedmont Ave, Medical Arts Building, Ste 8500, Cincinnati, Ohio 45219, USA
Acad Psychiatry 30:185-90. 2006.... - Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for maniaStephen M Strakowski
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
Arch Gen Psychiatry 62:851-8. 2005..Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome... - Duloxetine versus escitalopram and placebo: an 8-month, double-blind trial in patients with major depressive disorderTeresa A Pigott
Department of Psychiatry, University of Florida, Gainesville, FL, USA
Curr Med Res Opin 23:1303-18. 2007..The current paper focuses on the longer-term (8-month) comparisons of efficacy and safety between duloxetine and escitalopram... - Relationships among pain and depressive and anxiety symptoms in clinical trials of pregabalin in fibromyalgiaLesley M Arnold
Women s Health Research Program, Departmentof Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA Lesley
Psychosomatics 51:489-97. 2010..Fibromyalgia, as defined by the American College of Rheumatology, is characterized by widespread pain lasting for at least 3 months, with pain in at least 11 out of 18 tender points when palpated with digital pressure... - Fibromyalgia syndrome: practical strategies for improving diagnosis and patient outcomesLesley M Arnold
Women s Health Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Am J Med 123:S2. 2010..Strategies to manage patients with comorbid conditions are explored, with an emphasis on the importance of a multidisciplinary approach to patient care. Online Access: http://www.cmeaccess.com/cme/ajm_fibro_program/.. - Multidisciplinary care and stepwise treatment for fibromyalgiaLesley M Arnold
Division of Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 69:e35. 2008..The development of a comprehensive, multidisciplinary disease management strategy is a difficult but essential challenge facing clinicians treating patients with fibromyalgia... - Evaluating and diagnosing fibromyalgia and comorbid psychiatric disordersLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Psychiatry 69:e28. 2008..In this activity, experts on fibromyalgia discuss the nature of the syndrome and its diagnosis and evaluation... - Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercisesPhillip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Arthritis Rheum 59:952-60. 2008.... - Family study of fibromyalgia and affective spectrum disorderJames I Hudson
Biological Psychiatry Laboratory, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Biol Psychiatry 56:884-91. 2004..Two predictions of the ASD hypothesis were tested: ASD, taken as a single entity, aggregates in families; and fibromyalgia coaggregates with other forms of ASD in families... - Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trialI Jon Russell
University of Texas Health Science Center, San Antonio, TX, USA
Pain 136:432-44. 2008..Study results demonstrated that duloxetine at doses of 60 mg/day and 120 mg/day appears to be safe and efficacious in patients with fibromyalgia... - A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgiaPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 35:502-14. 2008..To evaluate the efficacy and safety of pregabalin for symptomatic relief of pain associated with fibromyalgia (FM) and for management of FM... - Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part IIReva C Lawrence
NIH, Bethesda, Maryland, USA
Arthritis Rheum 58:26-35. 2008..A companion article (part I) addresses additional conditions... - Fibromyalgia syndromePhilip J Mease
Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
J Rheumatol 32:2270-7. 2005..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached... - Comment on: Familial aggregation of depression in fibromyalgia: a community-based test of alternative hypotheses, Raphael et al., Pain 110 (2004) 449-460Lesley M Arnold
Pain 112:409-10; author reply 410. 2004 - The nature of painful and somatic complaints in depressive disordersLesley M Arnold
CNS Spectr 10:4-5. 2005 - Fibromyalgia syndromePhilip Mease
Seattle Rhumatology Associates, Seattle, WA 98104, USA
J Rheumatol 34:1415-25. 2007..The OMERACT process has provided a framework for identification of key domains to be assessed and a path toward validation and standardization of outcome measures for clinical trials in FM...