Donna K Arnett

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension
    Rikki M Tanner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e23609. 2011
  2. pmc Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy
    D Zhi
    Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 3:92. 2012
  3. pmc Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study
    Xue Zhang
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e34217. 2012
  4. pmc Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study
    Aurelian Bidulescu
    Department of Community Health and Preventive Medicine, Cardiovascular Research Institute, Morehouse School of Medicine, 30310, Atlanta, GA, USA
    BMC Cardiovasc Disord 13:9. 2013
  5. pmc Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BMC Med Genet 10:39. 2009
  6. pmc Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Genet 12:28. 2011
  7. pmc Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites
    Josiemer Mattei
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    BMC Genet 10:45. 2009
  8. ncbi request reprint Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980-1982 to 2000-2002
    Donna K Arnett
    Department of Epidemiology, University of Alabama, Birmingham, AL, USA
    Circulation 112:3884-91. 2005
  9. ncbi request reprint Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study
    Donna K Arnett
    University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama 55294 0022, USA
    J Hypertens 23:1141-7. 2005
  10. pmc Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA
    J Hypertens 27:1585-93. 2009

Detail Information

Publications129 found, 100 shown here

  1. pmc Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension
    Rikki M Tanner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e23609. 2011
    ..MMP-9 and -12 function in tissue remodeling and may play roles in cardiovascular disease (CVD). We assessed associations of four MMP polymorphisms and three antihypertensive drugs with cardiovascular outcomes...
  2. pmc Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy
    D Zhi
    Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 3:92. 2012
    ..Conclusion: Combining evidence from cutting-edge genetic and cellular experiments can enable identification of novel LVH risk loci...
  3. pmc Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study
    Xue Zhang
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e34217. 2012
    ..This suggests that NOS3 variants may potentially provide useful clinical information with respect to treatment decisions in the future...
  4. pmc Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study
    Aurelian Bidulescu
    Department of Community Health and Preventive Medicine, Cardiovascular Research Institute, Morehouse School of Medicine, 30310, Atlanta, GA, USA
    BMC Cardiovasc Disord 13:9. 2013
    ....
  5. pmc Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BMC Med Genet 10:39. 2009
    ..Variance components analysis was used to estimate heritability and to perform genome-wide scans. Adiponectin was adjusted for age, sex, and field center. Additional models also included BMI adjustment...
  6. pmc Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Genet 12:28. 2011
    ..We compare the agreement between SRE and genetic based measures of ancestry (GBMA), and conduct simulation studies based on observed MESA data to evaluate the performance of each measure under various conditions...
  7. pmc Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites
    Josiemer Mattei
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    BMC Genet 10:45. 2009
    ....
  8. ncbi request reprint Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980-1982 to 2000-2002
    Donna K Arnett
    Department of Epidemiology, University of Alabama, Birmingham, AL, USA
    Circulation 112:3884-91. 2005
    ..We assessed 20-year trends in cholesterol, hypercholesterolemia, lipid-lowering drug use, and cholesterol awareness, treatment, and control from Minnesota Heart Survey (MHS) data...
  9. ncbi request reprint Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study
    Donna K Arnett
    University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama 55294 0022, USA
    J Hypertens 23:1141-7. 2005
    ..To examine whether blood pressure (BP) differs between arms in hypertensive siblings and randomly selected volunteers, and whether this difference is explained by cardiovascular risk factors...
  10. pmc Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA
    J Hypertens 27:1585-93. 2009
    ..To identify genes contributing to variation in echocardiographic left ventricular mass and related traits using linkage and linkage disequilibrium analysis in sibships ascertained on hypertension...
  11. pmc Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 220E, 1530 3rd Ave South, Birmingham, AL 35294 0022, USA
    Circ Res 108:279-83. 2011
    ..Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals...
  12. pmc Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham AL 35294 0022, USA
    BMC Med Genet 10:43. 2009
    ..Eleven of 12 promising (Q < 0.8) single-nucleotide polymorphisms (SNPs) from the genome-wide study were successfully genotyped using quantitative real time PCR in a validation study...
  13. ncbi request reprint Pharmacogenetics of antihypertensive treatment
    Donna K Arnett
    Department of Epidemiology, University of Alabama, RPHB 220E, 1530 3rd Avenue South, Birmingham, 55294 0022, USA
    Vascul Pharmacol 44:107-18. 2006
    ..Caution regarding the future of hypertension pharmacogenetics is warranted...
  14. pmc Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 28:2076-83. 2010
    ..Several clinical studies report increased risk of diabetes mellitus with pharmacologic treatment for hypertension (HTN). HTN genes may modify glycemic response to antihypertensive treatment...
  15. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
    ....
  16. pmc High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional study
    Mary K Wojczynski
    Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
    Lipids Health Dis 10:181. 2011
    ..Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA...
  17. pmc Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Pharmacogenet Genomics 22:750-7. 2012
    ..Individual responses to fenofibrate vary, and we conducted a genome-wide association study to identify genetic differences that could contribute to such differences...
  18. pmc Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study
    Yongjun Liu
    Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pharmacogenet Genomics 19:161-9. 2009
    ..The apolipoproteins (APOA1/C3/A4/A5) are key components in modulating lipoprotein metabolism. It is unknown whether variants at the APOA1/C3/A4/A5 gene cluster are associated with lipid response to pharmacologic intervention...
  19. pmc Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study
    Amy I Lynch
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 55294 0022, USA
    Pharmacogenet Genomics 22:355-66. 2012
    ..The goal was to identify subgroups of individuals on the basis of their genetic profile who benefit most from a particular treatment...
  20. pmc Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate
    Stella Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e48663. 2012
    ..In conclusion, we present evidence linking several novel and biologically relevant genetic polymorphisms to lipid lowering drug response, as well as suggesting novel gene-gene interactions in fenofibrate pharmacogenetics...
  21. pmc VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham AL 35294 0021, USA
    Pharmacogenomics 9:1445-58. 2008
    ..However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort...
  22. pmc Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, USA
    Circ Cardiovasc Genet 3:462-7. 2010
    ..Although much is known about the effect of Apolipoprotein E (APOE) alleles on fasting lipid concentrations, less is known about the effect of APOE alleles on postprandial triglyceridemia or the triglyceride response to fenofibrate...
  23. pmc Comparison of the Framingham Heart Study hypertension model with blood pressure alone in the prediction of risk of hypertension: the Multi-Ethnic Study of Atherosclerosis
    Paul Muntner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 55:1339-45. 2010
    ..001); recalibrated and best-fit models produced a better model fit (P=0.064 and 0.245, respectively). In this multiethnic cohort of US adults, the FHS model was not substantially better than SBP alone for predicting hypertension...
  24. pmc Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Anke Hilse Maitland-van der Zee
    School of Public Health, University of Texas Health Science Center at Houston, 1200 Hermann Pressler, Houston TX, USA
    Am Heart J 153:54-8. 2007
    ....
  25. pmc Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN
    Wei Zhao
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
    Obesity (Silver Spring) 20:2431-7. 2012
    ..These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs...
  26. pmc Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e24052. 2011
    ....
  27. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
    ....
  28. ncbi request reprint Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks
    Kristin J Meyers
    Department of Epidemiology, University of Michigan, Ann Arbor, USA
    Hypertension 49:992-9. 2007
    ..We identified genetic variation that significantly influences left ventricular traits with replicable effects in a cohort of hypertensive, black siblings...
  29. pmc Kidney function influences warfarin responsiveness and hemorrhagic complications
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham, Alabama 35294 0021, USA
    J Am Soc Nephrol 20:912-21. 2009
    ..Diminished renal function may have implications for a larger proportion of warfarin users than previously estimated...
  30. ncbi request reprint Sibling resemblance for left ventricular structure, contractility, and diastolic filling
    Weihong Tang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Hypertension 40:233-8. 2002
    ..These data have potential importance in understanding heritability of LV diastolic function in hypertension...
  31. ncbi request reprint Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study
    James M Shikany
    Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Metabolism 56:1011-6. 2007
    ..The directions of the associations of plasma adiponectin with other factors were in agreement with results in other racial/ethnic groups...
  32. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  33. pmc Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Genet 132:405-13. 2013
    ..As lipoprotein diameters are modifiable, this may lead new strategies to modify lipoprotein profiles during the reduction of IR that are sensitive to race/ethnicity...
  34. pmc Smoking, inflammatory patterns and postprandial hypertriglyceridemia
    Edmond K Kabagambe
    Department of Epidemiology, University of Alabama at Birmingham, 35294, United States
    Atherosclerosis 203:633-9. 2009
    ..Inflammation and insulin resistance are potential "drivers" for this phenomenon. We tested whether inflammatory patterns and/or insulin resistance explain the effect of smoking on PPT...
  35. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
    ....
  36. pmc A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network
    Stella Aslibekyan
    Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 22:191-7. 2012
    ..This study provides the first genome-wide examination of fenofibrate effects on systemic inflammation...
  37. pmc Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study
    Marguerite R Irvin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Pharmacogenet Genomics 22:367-72. 2012
    ..Given significant interindividual variations in the TG response, we investigated the association of PPARA rare variants with treatment response in the Genetics of Lipid-Lowering Drugs and Diet Network study...
  38. pmc Preliminary evidence for an association between LRP-1 genotype and body mass index in humans
    Alexis C Frazier-Wood
    Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama, United States of America
    PLoS ONE 7:e30732. 2012
    ....
  39. ncbi request reprint Trends in blood pressure, hypertension control, and stroke mortality: the Minnesota Heart Survey
    Russell V Luepker
    University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, Minneapolis, Minn 55454 1015, USA
    Am J Med 119:42-9. 2006
    ..The study's objective was to determine population trends in blood pressure, hypertension prevalence, hypertension control, and stroke mortality...
  40. pmc Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, Washington 98101 1448, USA
    J Am Coll Cardiol 48:2285-92. 2006
    ....
  41. ncbi request reprint Left ventricular structure and systolic function in African Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Vuyisile T Nkomo
    University of Minnesota, School of Public Health, Division of Epidemiology, Minneapolis, Minnesota, 55454 1015, USA
    Ethn Dis 14:483-8. 2004
    ..To estimate prevalence of left ventricular (LV) hypertrophy and its relation to systolic function in a population-based sample of African Americans...
  42. pmc Association of low-grade albuminuria with adverse cardiac mechanics: findings from the hypertension genetic epidemiology network (HyperGEN) study
    Daniel H Katz
    Division of Cardiology, Department of Medicine D H K, S S, F G A, E E M, L B, S J S and Department of Preventive Medicine K Y A K, J P, Northwestern University Feinberg School of Medicine, Chicago, IL Departments of Epidemiology and Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL J S, M R I, D K A Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN J H E the Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN S T T and the Section of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC B I F
    Circulation 129:42-50. 2014
    ..The reasons for this association are unclear but may be attributable to the relationship between endothelial dysfunction and intrinsic myocardial dysfunction...
  43. ncbi request reprint Trends in cigarette smoking: the Minnesota Heart Survey, 1980-1982 through 2000-2002
    Sue Duval
    University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN 55454 1015, USA
    Nicotine Tob Res 10:827-32. 2008
    ..Focus on smoking cessation should continue, especially in the subpopulation that smokes more than the majority...
  44. ncbi request reprint Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study
    Joanlise M Leon
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Nephrol Dial Transplant 22:763-71. 2007
    ..We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study...
  45. ncbi request reprint Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study
    Weihong Tang
    Department of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Am J Hypertens 15:621-7. 2002
    ..The aim of this study was to identify chromosomal regions contributing to variation of LV transmitral early and late peak filling velocities (E and A velocities), Doppler echocardiographic measures of LV diastolic filling...
  46. pmc Association of adiponectin with left ventricular mass in blacks: the Jackson Heart Study
    Aurelian Bidulescu
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Circ Heart Fail 4:747-53. 2011
    ..The Jackson Heart Study cohort provides an opportunity to test the hypothesis that the inverse association between adiponectin and LVM may be modified by risk factors common among blacks...
  47. doi request reprint Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study
    Bertha Hidalgo
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL
    Diabetes 63:801-7. 2014
    ..75 × 10(-3) and P = 3.35 × 10(-2), respectively). Our findings suggest that methylation of a CpG site within ABCG1 is associated with fasting insulin and merits further evaluation as a novel disease risk marker. ..
  48. pmc Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study
    Mary K Wojczynski
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    J Lipid Res 51:3316-23. 2010
    ..0017). We conclude the rs676210 variant may identify individuals who respond best to fenofibrate for TG reduction...
  49. pmc The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Eur J Hum Genet 16:603-13. 2008
    ..These results yield insight into the complex biology of fenofibrate response, which can be used to target fenofibrate therapy to individuals who are most likely to benefit from the drug...
  50. pmc Association between family risk of stroke and myocardial infarction with prevalent risk factors and coexisting diseases
    Richard E Kennedy
    Department of Biostatistics, School of Public Health, 1665 University Boulevard, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Stroke 43:974-9. 2012
    ..We examined relationships between family risk of stroke and MI with risk factors for these phenotypes...
  51. pmc Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study
    Nathan E Wineinger
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Hum Genet 19:1271-5. 2011
    ..We identified 1541 unique copy-number variable regions, 309 of which did not overlap with the Database of Genomic Variants. These results provide further insight into the distribution of CNV in African Americans...
  52. pmc Generalized bone loss as a predictor of three-year radiographic damage in African American patients with recent-onset rheumatoid arthritis
    Jie Zhang
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    Arthritis Rheum 62:2219-26. 2010
    ..To examine the association between baseline bone mineral density (BMD) and radiographic damage at 3 years of disease duration in a longitudinal cohort of African Americans with recent-onset rheumatoid arthritis (RA)...
  53. doi request reprint The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994
    Paul Muntner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 57:160-6. 2011
    ..In this population-based study of US adults, higher levels of short-term visit-to-visit variability in systolic blood pressure were associated with increased all-cause mortality...
  54. ncbi request reprint Fifteen-year trends in cardiovascular risk factors (1980-1982 through 1995-1997): the Minnesota Heart Survey
    Donna K Arnett
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Am J Epidemiol 156:929-35. 2002
    ..Paul from 1980-1982 to 1995-1997 were paralleled by less favorable recent trends in total cholesterol, hypercholesterolemia, adiposity, and physical activity...
  55. ncbi request reprint Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension?
    Donna K Arnett
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Curr Opin Cardiol 24:333-9. 2009
    ..To describe recent advances in antihypertensive pharmacogenetics and discuss challenges related to translating this knowledge into 'personalized medicine' for the initial drug treatment of hypertension...
  56. doi request reprint Barriers to hospice care in Alabama: provider-based perceptions
    Todd M Jenkins
    Division of Pediatric General and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Hosp Palliat Care 28:153-60. 2011
    ..Our findings were similar to previous investigations assessing provider perceptions. Future studies should explore how reimbursement cap issues affect the receipt and delivery of hospice care...
  57. pmc The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions
    Yongjun Liu
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Genet 53:709-17. 2008
    ..In summary, our study suggested that the SCARB1 gene may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention...
  58. doi request reprint Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies
    Stella Aslibekyan
    Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Expert Rev Cardiovasc Ther 11:355-64. 2013
    ..However, few of the pharmacogenomic findings have been independently validated, precluding the development of clinical tools that can be used to predict HDL-C response and leaving the goal of personalized medicine to future efforts...
  59. pmc The relation between erythrocyte trans fat and triglyceride, VLDL- and HDL-cholesterol concentrations depends on polyunsaturated fat
    Edmond K Kabagambe
    Department of Epidemiology and the Nutrition Obesity Research Center, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e47430. 2012
    ..The effect of the interaction between trans fat and PUFA on lipids is uncertain...
  60. ncbi request reprint Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Diabetes 56:137-42. 2007
    ..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes...
  61. pmc Pharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: the genetics of hypertension associated treatment study
    Richard Sherva
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 32594, USA
    Stroke 42:330-5. 2011
    ....
  62. ncbi request reprint Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study
    Weihong Tang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am Heart J 143:854-60. 2002
    ..We investigated whether 2 tightly linked polymorphisms of angiotensinogen gene, M235T and G-6A, are associated with LV mass and function in a large population-based sample, composed mostly of patients with hypertension...
  63. ncbi request reprint Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study
    Marguerite R Irvin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 9:e99509. 2014
    ..We hypothesized that detailed lipid profiles (eg, sterols and fatty acids) may help elucidate specific genetic and dietary pathways contributing to the PPL response...
  64. pmc Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites
    Sadeep Shrestha
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    AIDS 26:1571-3. 2012
    ..SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals...
  65. pmc Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men
    Marguerite Ryan Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 21:798-807. 2011
    ..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)...
  66. pmc TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
    Edmond K Kabagambe
    Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
    Diabetol Metab Syndr 1:16. 2009
    ....
  67. ncbi request reprint Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study
    Edmond K Kabagambe
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL 35294, USA
    Clin Chem 54:154-62. 2008
    ..Different fatty acids may vary in their effect on the metabolic syndrome (MetS). We tested whether fatty acid classes measured in erythrocytes are associated with the MetS or its components...
  68. pmc Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations
    Caren E Smith
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA 4Department of Health Sciences, Northeastern University, Boston, MA 5Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 6Genetic and Molecular Epidemiology Unit and Center for Biomedical Research Network Physiopathology of Obesity and Nutrition, School of Medicine, University of Valencia, Valencia, Spain 7Division of Statistical Genomics in the Center for Genome Sciences of the Washington University, St Louis, MO 8Department of Epidemiology, National Center of Cardiovascular Investigations, Madrid, Spain 9Madrid Institute of Advanced Studies Food, Madrid, Spain
    J Nutr 143:1865-71. 2013
    ..Moreover, these findings suggest that other strongly demonstrated gene-nutrient relations might be investigated through appropriate food-based, translatable avenues and may be relevant to dietary management of obesity...
  69. pmc Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed
    Michael I Falola
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e64813. 2013
    ..We have tested this hypothesis in two study populations from a clinical trial of anthrax vaccination...
  70. ncbi request reprint Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance
    Donna K Arnett
    University of Alabama at Birmingham, Birmingham AL 55294 0022, USA
    Pharmacogenomics 10:1295-307. 2009
    ..Progress in the future will depend upon our ability to launch large studies using high-fidelity phenotyping with multiple drugs and multiple ethnic groups...
  71. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
    ..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis...
  72. ncbi request reprint Genes for left ventricular hypertrophy
    Donna K Arnett
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Curr Hypertens Rep 6:36-41. 2004
    ..An overview of the pathophysiology of LV hypertrophy and dysfunction is provided, in addition to evidence of the genetic basis for LV hypertrophy in humans and animal models...
  73. pmc Markers of treatment response to methotrexate in rheumatoid arthritis: where do we stand?
    Karina I Halilova
    Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Rheumatol 2012:978396. 2012
    ..This paper provides an update on the current data regarding biomarkers of treatment response to MTX...
  74. ncbi request reprint Arterial stiffness is greater in African Americans than in whites: evidence from the Forsyth County, North Carolina, ARIC cohort
    Rebecca Din-Dzietham
    School of Public Health, Division of Cardiovascular Epidemiology, University of North Carolina at Chapel Hill, North Carolina, USA
    Am J Hypertens 17:304-13. 2004
    ....
  75. ncbi request reprint Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Donna K Arnett
    University of Minnesota, Division of Epidemiology, Minneapolis, USA
    Circulation 111:3374-83. 2005
    ....
  76. pmc Comparison of m-mode echocardiographic left ventricular mass measured using digital and strip chart readings: the Atherosclerosis Risk in Communities (ARIC) study
    Donna K Arnett
    Division of Epidemiology, University of Minnesota, School of Public Health, Minneapolis, MN, USA
    Cardiovasc Ultrasound 1:8. 2003
    ..We sought to determine if systematic differences in LV mass occur between the two methods by comparing LV mass measured from simultaneous M-mode strip chart recordings and digitized recordings...
  77. doi request reprint Vascular stiffness and the "chicken-or-the-egg" question
    Stephen P Glasser
    Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, 1717 11th Ave S, Birmingham, AL 35216, USA
    Hypertension 51:177-8. 2008
  78. pmc Health-related quality of life and survival in liver transplant candidates
    Rajasekhar Tanikella
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Liver Transpl 16:238-45. 2010
    ..53). In conclusion, PCS significantly predicts survival in liver transplant candidates, and interventions directed toward improving the physical status may be helpful in improving outcomes in liver transplant candidates...
  79. ncbi request reprint Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Kidney Dis 43:836-45. 2004
    ..It is unknown whether kidney function and lower hemoglobin levels are associated with LV morphological characteristics among African Americans with moderate kidney dysfunction, independent of blood pressure...
  80. pmc Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
    Nita A Limdi
    University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35294 0021, USA
    Pharmacogenomics 9:511-26. 2008
    ....
  81. pmc A genome-wide association study of carotid atherosclerosis in HIV-infected men
    Sadeep Shrestha
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, AL 35294 0022, USA
    AIDS 24:583-92. 2010
    ..The role of host genetics in the development of subclinical atherosclerosis in the context of HIV-infected persons who are being treated with highly active antiretroviral therapy (HAART) is not well understood...
  82. pmc Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis?
    Maria I Danila
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1530 3rd Avenue South, 178 SHEL, Birmingham, AL 35294 2182, USA
    Curr Rheumatol Rep 12:342-7. 2010
    ....
  83. pmc Short-term effect of fenofibrate on C-reactive protein: A meta-analysis of randomized controlled trials
    Jiatao Ye
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Diabetol Metab Syndr 3:24. 2011
    ..abstract:..
  84. pmc Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study
    Shia T Kent
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
    Environ Health 8:34. 2009
    ..We evaluated whether the amount of sunlight exposure (i.e. insolation) affects cognitive function and examined the effect of season on this relationship...
  85. ncbi request reprint Gender difference in diastolic function in hypertension (the HyperGEN study)
    Jonathan N Bella
    Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 89:1052-6. 2002
    ..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
  86. ncbi request reprint Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, University of Minnesota, Minneapolis, USA
    Am J Clin Nutr 80:1639-44. 2004
    ....
  87. ncbi request reprint Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Hypertension 45:368-73. 2005
    ..These data suggest that dietary linolenic acid is associated with a lower prevalence of hypertension and lower systolic blood pressure in white subjects...
  88. ncbi request reprint Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans
    Herman A Taylor
    University of Mississippi Medical Center, Jackson, Mississippi, USA Jackson State University, Jackson, Mississippi, USA
    Am J Cardiol 95:401-4. 2005
    ....
  89. ncbi request reprint Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:323-31. 2002
    ..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
  90. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group
    Ivor J Benjamin
    Circulation 111:e120-3. 2005
  91. ncbi request reprint Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Felizen S Agno
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 23:867-73. 2005
    ..However, whether AVS is associated with preclinical cardiovascular disease among adults at high risk because of hypertension has not been determined in a population-based sample...
  92. ncbi request reprint A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study
    Amy I Lynch
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hypertens 18:627-32. 2005
    ..Aortic root dilation is a prominent feature in several cardiovascular diseases. This study seeks to identify genomic regions linked to variation in the aortic root diameter (ARD) in hypertensive African American and white individuals...
  93. ncbi request reprint Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:899-905. 2005
    ..This study analyzes the association of increased LASF to LV geometry and function in hypertensive patients from a population study...
  94. ncbi request reprint Optimal threshold value for left ventricular hypertrophy in blacks: the Atherosclerosis Risk in Communities study
    Eduardo Nunez
    Division of Epidemiology, University of Minnesota, Minneapolis, Minn 55454, USA
    Hypertension 45:58-63. 2005
    ..Because these values are close to the 51 g/m(2.7) established from predominantly white populations, this cutpoint is appropriate for both groups...
  95. ncbi request reprint Comparison of the prognostic value of left ventricular hypertrophy in African-American men versus women
    Eduardo Nunez
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Cardiol 94:1383-90. 2004
    ..66 vs 2.09, p = 0.55 for men; population-attributable risk 0.24 vs 0.32, p <0.07 for women). Thus, LV hypertrophy is a strong predictor of CVD in African-Americans, and the effect of LV hypertrophy on CVD is similar in men and women...
  96. ncbi request reprint Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Jorge R Kizer
    Division of Cardiology, Weill Medical College of Cornell University, New York, USA
    Hypertension 43:1182-8. 2004
    ..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
  97. ncbi request reprint Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study
    Richard B Devereux
    Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 15:1029-35. 2002
    ....
  98. pmc Regarding "Testing for population subdivision and association in four case-control studies"
    James S Pankow
    Am J Hum Genet 71:1478-80. 2002
  99. ncbi request reprint A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network
    Dabeeru C Rao
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:148-50. 2003
    ..Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes...
  100. ncbi request reprint Echocardiographic left ventricular mass in African-Americans: the Jackson cohort of the Atherosclerosis Risk in Communities Study
    Thomas N Skelton
    University of Mississippi Medical Center, Jackson, MS, USA
    Echocardiography 20:111-20. 2003
    ..4%). The findings confirm previous suggestions from electrocardiographic investigations that cardiac hypertrophy is common, if not epidemic in middle-aged African-American men and women, whether or not they have hypertension...