Donna Arnett

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study
    A I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    J Hum Hypertens 26:133-40. 2012
  2. pmc Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    Nutr Metab (Lond) 4:28. 2007
  3. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
  4. pmc Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
    Catherine R Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Information Research Center MAVERIC, Boston VA Healthcare, Boston, Massachusetts, USA
    Lipids Health Dis 10:167. 2011
  5. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
  6. pmc Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study
    Shia T Kent
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
    Environ Health 8:34. 2009
  7. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
  8. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
  9. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
  10. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007

Detail Information

Publications87

  1. pmc Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study
    A I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    J Hum Hypertens 26:133-40. 2012
    ..2, 'ID/AC':43.4, 'ID/AA':42.6; 'II/CC': NA, 'II/AC':41.3, 'II/AA':43.1). These findings indicate that renin-angiotensin system variants in at least two genes may interact to modulate LVM...
  2. pmc Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    Nutr Metab (Lond) 4:28. 2007
    ..However, the relationship of inflammatory biomarkers to MetS is not clear...
  3. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
    ....
  4. pmc Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
    Catherine R Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Information Research Center MAVERIC, Boston VA Healthcare, Boston, Massachusetts, USA
    Lipids Health Dis 10:167. 2011
    ....
  5. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
    ....
  6. pmc Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study
    Shia T Kent
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
    Environ Health 8:34. 2009
    ..We evaluated whether the amount of sunlight exposure (i.e. insolation) affects cognitive function and examined the effect of season on this relationship...
  7. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  8. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
    ....
  9. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
    ....
  10. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  11. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
    ..We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis...
  12. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
    ..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis...
  13. pmc Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension?
    Donna K Arnett
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Curr Opin Cardiol 24:333-9. 2009
    ..To describe recent advances in antihypertensive pharmacogenetics and discuss challenges related to translating this knowledge into 'personalized medicine' for the initial drug treatment of hypertension...
  14. pmc Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance
    Donna K Arnett
    University of Alabama at Birmingham, Birmingham AL 55294 0022, USA
    Pharmacogenomics 10:1295-307. 2009
    ..Progress in the future will depend upon our ability to launch large studies using high-fidelity phenotyping with multiple drugs and multiple ethnic groups...
  15. ncbi request reprint Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Donna K Arnett
    University of Minnesota, Division of Epidemiology, Minneapolis, USA
    Circulation 111:3374-83. 2005
    ....
  16. pmc The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hypertens 22:552-8. 2009
    ..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease...
  17. pmc Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Mol Genet Metab 100:118-22. 2010
    ....
  18. pmc Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participants
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Transl Res 158:99-105. 2011
    ..The greatest reductions in Lp-PLA(2) levels were observed in individuals with Lp-PLA(2) concentrations indicative of increased cardiovascular disease risk (>200 ng/mL)...
  19. pmc Isolated systolic hypertension and incident heart failure in older adults: a propensity-matched study
    O James Ekundayo
    University of Alabama at Birmingham, Birmingham, AL 35294 2041, USA
    Hypertension 53:458-65. 2009
    ..In conclusion, in a propensity-matched cohort of community-dwelling older adults who were well balanced in 64 baseline covariates, ISH was associated with increased risk of incident HF but had no association with all-cause mortality...
  20. ncbi request reprint Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Clin Chem 55:481-8. 2009
    ..The associations of ABCA1 and CETP polymorphisms with lipoprotein subclasses have not been extensively studied...
  21. pmc Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants
    Yan Dong
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 214:422-5. 2011
    ....
  22. pmc Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 200:359-67. 2008
    ..8%, 19.8%, and 18.4%, respectively; p<0.001) and higher HDL-C concentration (9.7%, 11.5%, and 10.4%, respectively; p<0.01). However, we did not find any associations between these non-coding polymorphisms and subclinical CVD...
  23. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  24. ncbi request reprint Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study
    - Juhaeri
    Department of Epidemiology, School of Public Health, CB 7400 McGavran Greenberg Hall, University of North Carolina Chapel Hill, 27599 740, USA
    Prev Med 36:330-9. 2003
    ..To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample...
  25. pmc Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:545-54. 2013
    ....
  26. pmc Value of orthopnea, paroxysmal nocturnal dyspnea, and medications in prospective population studies of incident heart failure
    O James Ekundayo
    University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Cardiol 104:259-64. 2009
    ....
  27. pmc ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Atherosclerosis 201:339-44. 2008
    ..Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis...
  28. ncbi request reprint Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study
    Christy L Avery
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Diabetes 53:3307-12. 2004
    ..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility...
  29. pmc A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study
    Richard Sherva
    University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hypertens 20:398-402. 2007
    ..Linkage analysis has identified genomic regions that likely harbor genes contributing to its phenotypic expression. We sought to identify loci contributing to arterial stiffness in a large group of African-American hypertensive families...
  30. ncbi request reprint Summary of the American Heart Association's scientific statement on the relevance of genetics and genomics for prevention and treatment of cardiovascular disease
    Donna K Arnett
    Arterioscler Thromb Vasc Biol 27:1682-6. 2007
  31. ncbi request reprint Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome
    Jian Shen
    Nutrition and Genomics Laboratory, JM U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 137:1846-51. 2007
    ..These results suggested that IL1beta genetic variants were associated with measures of chronic inflammation and the MetS risk, and that genetic influences were more evident among subjects with low (n-3) PUFA intake...
  32. ncbi request reprint Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study
    James M Shikany
    Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Metabolism 56:1011-6. 2007
    ..The directions of the associations of plasma adiponectin with other factors were in agreement with results in other racial/ethnic groups...
  33. ncbi request reprint Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    J Hypertens 25:1397-402. 2007
    ..Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance...
  34. ncbi request reprint Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Hum Genet 122:33-40. 2007
    ..This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes...
  35. ncbi request reprint The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    Clin Chem 53:1144-52. 2007
    ..Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis...
  36. ncbi request reprint Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study
    Edmond K Kabagambe
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL 35294, USA
    Clin Chem 54:154-62. 2008
    ..Different fatty acids may vary in their effect on the metabolic syndrome (MetS). We tested whether fatty acid classes measured in erythrocytes are associated with the MetS or its components...
  37. ncbi request reprint Echocardiographic left ventricular mass in African-Americans: the Jackson cohort of the Atherosclerosis Risk in Communities Study
    Thomas N Skelton
    University of Mississippi Medical Center, Jackson, MS, USA
    Echocardiography 20:111-20. 2003
    ..4%). The findings confirm previous suggestions from electrocardiographic investigations that cardiac hypertrophy is common, if not epidemic in middle-aged African-American men and women, whether or not they have hypertension...
  38. ncbi request reprint Trends in cigarette smoking: the Minnesota Heart Survey, 1980-1982 through 2000-2002
    Sue Duval
    University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN 55454 1015, USA
    Nicotine Tob Res 10:827-32. 2008
    ..Focus on smoking cessation should continue, especially in the subpopulation that smokes more than the majority...
  39. pmc Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study
    Pinchia Huang
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hypertens 26:1360-6. 2008
    ..Metabolic syndrome and its risk factors are predictors of cardiovascular events. Metabolic syndrome is also directly associated with echocardiographic phenotypes...
  40. pmc The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 49:1839-45. 2008
    ..This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk...
  41. ncbi request reprint Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1524, USA
    Diabetes Care 31:910-5. 2008
    ..We investigated the influences of CRP polymorphisms on baseline CRP levels and fenofibrate-induced CRP changes in subjects with the metabolic syndrome...
  42. ncbi request reprint Retinal arteriolar narrowing and left ventricular hypertrophy in African Americans. the Atherosclerosis Risk in Communities (ARIC) study
    Gabriella Tikellis
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Am J Hypertens 21:352-9. 2008
    ..Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population...
  43. doi request reprint Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA
    JAMA 299:296-307. 2008
    ..The NPPA gene codes for the precursor of atrial natriuretic polypeptide, suggesting that NPPA may modulate the efficacy of some antihypertensive drugs...
  44. doi request reprint Vascular stiffness and the "chicken-or-the-egg" question
    Stephen P Glasser
    Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, 1717 11th Ave S, Birmingham, AL 35216, USA
    Hypertension 51:177-8. 2008
  45. pmc Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
    Nita A Limdi
    University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35294 0021, USA
    Pharmacogenomics 9:511-26. 2008
    ....
  46. ncbi request reprint Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks
    Kristin J Meyers
    Department of Epidemiology, University of Michigan, Ann Arbor, USA
    Hypertension 49:992-9. 2007
    ..We identified genetic variation that significantly influences left ventricular traits with replicable effects in a cohort of hypertensive, black siblings...
  47. ncbi request reprint Gender difference in diastolic function in hypertension (the HyperGEN study)
    Jonathan N Bella
    Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 89:1052-6. 2002
    ..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
  48. ncbi request reprint Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Hypertension 45:368-73. 2005
    ..These data suggest that dietary linolenic acid is associated with a lower prevalence of hypertension and lower systolic blood pressure in white subjects...
  49. ncbi request reprint Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, University of Minnesota, Minneapolis, USA
    Am J Clin Nutr 80:1639-44. 2004
    ....
  50. ncbi request reprint Optimal threshold value for left ventricular hypertrophy in blacks: the Atherosclerosis Risk in Communities study
    Eduardo Nunez
    Division of Epidemiology, University of Minnesota, Minneapolis, Minn 55454, USA
    Hypertension 45:58-63. 2005
    ..Because these values are close to the 51 g/m(2.7) established from predominantly white populations, this cutpoint is appropriate for both groups...
  51. ncbi request reprint Comparison of the prognostic value of left ventricular hypertrophy in African-American men versus women
    Eduardo Nunez
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Cardiol 94:1383-90. 2004
    ..66 vs 2.09, p = 0.55 for men; population-attributable risk 0.24 vs 0.32, p <0.07 for women). Thus, LV hypertrophy is a strong predictor of CVD in African-Americans, and the effect of LV hypertrophy on CVD is similar in men and women...
  52. ncbi request reprint Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Jorge R Kizer
    Division of Cardiology, Weill Medical College of Cornell University, New York, USA
    Hypertension 43:1182-8. 2004
    ..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
  53. ncbi request reprint Arterial stiffness is greater in African Americans than in whites: evidence from the Forsyth County, North Carolina, ARIC cohort
    Rebecca Din-Dzietham
    School of Public Health, Division of Cardiovascular Epidemiology, University of North Carolina at Chapel Hill, North Carolina, USA
    Am J Hypertens 17:304-13. 2004
    ....
  54. ncbi request reprint Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Room B 612, 715 Albany Street, Boston, MA 02118, USA
    Am J Clin Nutr 78:1098-102. 2003
    ..Dietary intake of linolenic acid is associated with a decreased risk of cardiovascular disease mortality. However, the mechanisms by which dietary linolenic acid affects cardiovascular disease risk are not clearly understood...
  55. ncbi request reprint Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Diabetes 52:2840-7. 2003
    ..34 at 240 cM. Suggestive linkage was also observed for regions on chromosomes 7, 12, 14, and 15. In summary, a genomic region on chromosome 2 may contain a pleiotropic locus contributing to the clustering of MMS-related phenotypes...
  56. ncbi request reprint The Arg16Gly polymorphism of the beta2-adrenergic receptor and left ventricular systolic function
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hypertens 16:945-51. 2003
    ..This study examined the association of the beta2-AR Arg16Gly polymorphism with left ventricular (LV) systolic function in a biethnic population-based sample...
  57. ncbi request reprint Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN Study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    J Hypertens 21:1747-52. 2003
    ....
  58. ncbi request reprint A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network
    Dabeeru C Rao
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:148-50. 2003
    ..Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes...
  59. pmc Regarding "Testing for population subdivision and association in four case-control studies"
    James S Pankow
    Am J Hum Genet 71:1478-80. 2002
  60. ncbi request reprint Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study
    Richard B Devereux
    Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 15:1029-35. 2002
    ....
  61. ncbi request reprint Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:323-31. 2002
    ..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
  62. ncbi request reprint Fifteen-year trends in cardiovascular risk factors (1980-1982 through 1995-1997): the Minnesota Heart Survey
    Donna K Arnett
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Am J Epidemiol 156:929-35. 2002
    ..Paul from 1980-1982 to 1995-1997 were paralleled by less favorable recent trends in total cholesterol, hypercholesterolemia, adiposity, and physical activity...
  63. ncbi request reprint Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study
    Weihong Tang
    Department of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Am J Hypertens 15:621-7. 2002
    ..The aim of this study was to identify chromosomal regions contributing to variation of LV transmitral early and late peak filling velocities (E and A velocities), Doppler echocardiographic measures of LV diastolic filling...
  64. ncbi request reprint Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study
    Weihong Tang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am Heart J 143:854-60. 2002
    ..We investigated whether 2 tightly linked polymorphisms of angiotensinogen gene, M235T and G-6A, are associated with LV mass and function in a large population-based sample, composed mostly of patients with hypertension...
  65. ncbi request reprint Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans
    Herman A Taylor
    University of Mississippi Medical Center, Jackson, Mississippi, USA Jackson State University, Jackson, Mississippi, USA
    Am J Cardiol 95:401-4. 2005
    ....
  66. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group
    Ivor J Benjamin
    Circulation 111:e120-3. 2005
  67. ncbi request reprint Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Felizen S Agno
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 23:867-73. 2005
    ..However, whether AVS is associated with preclinical cardiovascular disease among adults at high risk because of hypertension has not been determined in a population-based sample...
  68. ncbi request reprint Trends in blood pressure, hypertension control, and stroke mortality: the Minnesota Heart Survey
    Russell V Luepker
    University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, Minneapolis, Minn 55454 1015, USA
    Am J Med 119:42-9. 2006
    ..The study's objective was to determine population trends in blood pressure, hypertension prevalence, hypertension control, and stroke mortality...
  69. ncbi request reprint Blood pressure stress reactivity and left ventricular mass in a random community sample of African-American and caucasian men and women
    Mustafa al'Absi
    Department of Behavioral Sciences, University of Minnesota Medical School, Duluth, Minnesota, USA
    Am J Cardiol 97:240-4. 2006
    ..05). In conclusion, BP reactivity is not related to LV mass, but may be related to concentric remodeling...
  70. ncbi request reprint Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (Hy
    Ping An
    Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:551-8. 2006
    ..These regions replicate previous reports for type 2 diabetes-associated traits...
  71. ncbi request reprint Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second St, Suite 300, Minneapolis, MN 55454, USA
    Diabetes Care 29:631-6. 2006
    ..We present a bivariate genetic analysis of MetS-related traits including both traditional and novel risk factors...
  72. pmc Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cardiovasc Ultrasound 4:43. 2006
    ..However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans...
  73. pmc Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, Washington 98101 1448, USA
    J Am Coll Cardiol 48:2285-92. 2006
    ....
  74. pmc Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Anke Hilse Maitland-van der Zee
    School of Public Health, University of Texas Health Science Center at Houston, 1200 Hermann Pressler, Houston TX, USA
    Am Heart J 153:54-8. 2007
    ....
  75. ncbi request reprint Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study
    Jonathan N Bella
    Weill Medical College, Cornell University, New York, NY, USA
    Hypertension 49:453-60. 2007
    ..1-q22.3 and suggestive linkage to chromosome 19p13.11-p11 and identifies several other promising genomic regions that may contain specific susceptibility loci for valve calcification...
  76. ncbi request reprint Pharmacogenetics of antihypertensive treatment
    Donna K Arnett
    Department of Epidemiology, University of Alabama, RPHB 220E, 1530 3rd Avenue South, Birmingham, 55294 0022, USA
    Vascul Pharmacol 44:107-18. 2006
    ..Caution regarding the future of hypertension pharmacogenetics is warranted...
  77. ncbi request reprint Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980-1982 to 2000-2002
    Donna K Arnett
    Department of Epidemiology, University of Alabama, Birmingham, AL, USA
    Circulation 112:3884-91. 2005
    ..We assessed 20-year trends in cholesterol, hypercholesterolemia, lipid-lowering drug use, and cholesterol awareness, treatment, and control from Minnesota Heart Survey (MHS) data...
  78. ncbi request reprint A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study
    Amy I Lynch
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hypertens 18:627-32. 2005
    ..Aortic root dilation is a prominent feature in several cardiovascular diseases. This study seeks to identify genomic regions linked to variation in the aortic root diameter (ARD) in hypertensive African American and white individuals...
  79. ncbi request reprint Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study
    Donna K Arnett
    University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama 55294 0022, USA
    J Hypertens 23:1141-7. 2005
    ..To examine whether blood pressure (BP) differs between arms in hypertensive siblings and randomly selected volunteers, and whether this difference is explained by cardiovascular risk factors...
  80. ncbi request reprint Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:899-905. 2005
    ..This study analyzes the association of increased LASF to LV geometry and function in hypertensive patients from a population study...
  81. ncbi request reprint A summary of the effects of antihypertensive medications on measured blood pressure
    Jun Wu
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110 1093, USA
    Am J Hypertens 18:935-42. 2005
    ..A review of numerous clinical trials that investigated the effects of BP-lowering medications is summarized here...
  82. ncbi request reprint The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ....
  83. ncbi request reprint Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota, USA
    Am Heart J 150:845-51. 2005
    ..Calcineurin B (CnB) is a regulatory subunit of calcineurin and is important for the phosphatase activity...
  84. ncbi request reprint A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Hypertension 46:1294-9. 2005
    ..The single SNP association was driven by a large group of SNPs in high linkage disequilibrium that includes the promoter SNP rs5051...
  85. ncbi request reprint Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Kidney Dis 43:836-45. 2004
    ..It is unknown whether kidney function and lower hemoglobin levels are associated with LV morphological characteristics among African Americans with moderate kidney dysfunction, independent of blood pressure...
  86. ncbi request reprint Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:1417-25. 2007
    ..Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy...
  87. ncbi request reprint Task Force on Strategic Research Direction: Population/Outcomes/Epidemiology/Social Science Subgroup key science topics report
    Lori Mosca
    Circulation 106:e167-72. 2002

Research Grants33

  1. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2000
    ..Overall, the study represents a complementary approach, from animal to human, to further understanding of the genetic architecture of LV hypertrophy. ..
  2. Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate
    Donna K Arnett; Fiscal Year: 2010
    ....
  3. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2009
    ..We hypothesize that we will identify genetic variants that play clinically significant roles in LVH, and that will suggest novel pathways for LVH preventive or therapeutic interventions. ..
  4. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2002
    ..Overall, the study represents a complementary approach, from animal to human, to further understanding of the genetic architecture of LV hypertrophy. ..
  5. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2003
    ..Overall, the study represents a complementary approach, from animal to human, to further understanding of the genetic architecture of LV hypertrophy. ..
  6. GENHAT-GENETICS OF HYPERTENSION ASSOCIATED TREATMENTS
    Donna Arnett; Fiscal Year: 2003
    ..Boerwinkle and Eckfeldt) and clinical trials (Drs. Davis and Ford). It will, therefore, provide an important and cost-efficient contribution to the knowledge and understanding of the treatment of hypertension. ..
  7. Genetics of Hypertension Associated Treatment (GENHAT)
    Donna Arnett; Fiscal Year: 2009
    ..GenHAT offers an unparalleled opportunity to determine the pharmacogenetic basis of antihypertensive treatment. ..
  8. COMMUNITY SURVEILLANCE OF CARDIOVASCULAR DISEASE--RISK F
    Donna Arnett; Fiscal Year: 2002
    ..The Minnesota Heart Survey has been, and continues to offer, a powerful resource to examine long-term trends in cardiovascular disease risk factors. ..
  9. Genetic and Environmental Determinants of Triglycerides
    Donna Arnett; Fiscal Year: 2007
    ..Genotypic characterization of individuals who respond favorably to fenofibrate may enable targeted interventions to reduce TGs and identify the most effective treatments in clinical practice. ..
  10. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2004
    ..Overall, the study represents a complementary approach, from animal to human, to further understanding of the genetic architecture of LV hypertrophy. ..
  11. GENHAT-GENETICS OF HYPERTENSION ASSOCIATED TREATMENTS
    Donna Arnett; Fiscal Year: 2002
    ..Boerwinkle and Eckfeldt) and clinical trials (Drs. Davis and Ford). It will, therefore, provide an important and cost-efficient contribution to the knowledge and understanding of the treatment of hypertension. ..
  12. HYPERGEN--GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 1999
    ..D. C. Rao), and genetic testing by a state-of-the-art laboratory(directed by Dr. Lalouel). It will, therefore, be an important and cost-effective contribution to the knowledge and understanding about the genetics of LV hypertrophy. ..
  13. MESA Family Study
    Donna Arnett; Fiscal Year: 2004
    ..abstract_text> ..
  14. Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat
    Donna K Arnett; Fiscal Year: 2010
    ....
  15. Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat
    Donna Arnett; Fiscal Year: 2009
    ....
  16. GENHAT-GENETICS OF HYPERTENSION ASSOCIATED TREATMENTS
    Donna Arnett; Fiscal Year: 2001
    ..Boerwinkle and Eckfeldt) and clinical trials (Drs. Davis and Ford). It will, therefore, provide an important and cost-efficient contribution to the knowledge and understanding of the treatment of hypertension. ..
  17. MESA Family Study
    Donna Arnett; Fiscal Year: 2003
    ....
  18. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2007
    ..We hypothesize that we will identify genetic variants that play clinically significant roles in LVH, and that will suggest novel pathways for LVH preventive or therapeutic interventions. ..
  19. COMMUNITY SURVEILLANCE OF CARDIOVASCULAR DISEASE--RISK F
    Donna Arnett; Fiscal Year: 2000
    ..The Minnesota Heart Survey has been, and continues to offer, a powerful resource to examine long-term trends in cardiovascular disease risk factors. ..
  20. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2006
    ..We hypothesize that we will identify genetic variants that play clinically significant roles in LVH, and that will suggest novel pathways for LVH preventive or therapeutic interventions. ..
  21. Genetics of Hypertension Associated Treatment (GENHAT)
    Donna Arnett; Fiscal Year: 2007
    ..GenHAT offers an unparalleled opportunity to determine the pharmacogenetic basis of antihypertensive treatment. ..
  22. COMMUNITY SURVEILLANCE OF CARDIOVASCULAR DISEASE--RISK F
    Donna Arnett; Fiscal Year: 2001
    ..The Minnesota Heart Survey has been, and continues to offer, a powerful resource to examine long-term trends in cardiovascular disease risk factors. ..
  23. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna K Arnett; Fiscal Year: 2010
    ..We hypothesize that we will identify genetic variants that play clinically significant roles in LVH, and that will suggest novel pathways for LVH preventive or therapeutic interventions. ..
  24. GENHAT
    Donna Arnett; Fiscal Year: 2000
    ..Boerwinkle and Eckfeldt) and clinical trials (Drs. Davis and Ford). It will, therefore, provide an important and cost-efficient contribution to the knowledge and understanding of the treatment of hypertension. ..
  25. GENHAT--GENETICS OF HYPERTENSION ASSOCIATED TREATMENTS
    Donna Arnett; Fiscal Year: 1999
    ..Boerwinkle and Eckfeldt) and clinical trials (Drs. Davis and Ford). It will, therefore, provide an important and cost-efficient contribution to the knowledge and understanding of the treatment of hypertension. ..
  26. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna Arnett; Fiscal Year: 2001
    ..Overall, the study represents a complementary approach, from animal to human, to further understanding of the genetic architecture of LV hypertrophy. ..