Clay M Armstrong

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Resolving the gating charge movement associated with late transitions in K channel activation
    A Loboda
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Biophys J 81:905-16. 2001
  2. ncbi request reprint Voltage-gated K channels
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Sci STKE 2003:re10. 2003
  3. ncbi request reprint Life among the axons
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 69:1-18. 2007
  4. pmc A model for 4-aminopyridine action on K channels: similarities to tetraethylammonium ion action
    C M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:895-904. 2001
  5. pmc The Na/K pump, Cl ion, and osmotic stabilization of cells
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, B 701 Richards Building, Philadelphia 19104 6085, USA
    Proc Natl Acad Sci U S A 100:6257-62. 2003
  6. pmc Charge immobilization caused by modification of internal cysteines in squid Na channels
    K Khodakhah
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Marine Biological Laboratory, Woods Hole, Massachusetts 02543 USA
    Biophys J 75:2821-9. 1998
  7. pmc Loss of shaker K channel conductance in 0 K+ solutions: role of the voltage sensor
    A Melishchuk
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 75:1828-35. 1998
  8. pmc Inositol trisphosphate and ryanodine receptors share a common functional Ca2+ pool in cerebellar Purkinje neurons
    K Khodakhah
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085, USA
    Biophys J 73:3349-57. 1997
  9. pmc Induction of long-term depression and rebound potentiation by inositol trisphosphate in cerebellar Purkinje neurons
    K Khodakhah
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Proc Natl Acad Sci U S A 94:14009-14. 1997
  10. pmc Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel
    A Melishchuk
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 80:2167-75. 2001

Collaborators

Detail Information

Publications14

  1. pmc Resolving the gating charge movement associated with late transitions in K channel activation
    A Loboda
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Biophys J 81:905-16. 2001
    ..The effect of 4AP is well modeled as a selective block of the final gating transition, which opens the channel. The final transition contributes approximately 5% of the total gating charge...
  2. ncbi request reprint Voltage-gated K channels
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Sci STKE 2003:re10. 2003
    ..More complex channels have evolved molecular "gatekeepers," allowing them to respond to appropriate stimuli by opening, closing, and inactivating...
  3. ncbi request reprint Life among the axons
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 69:1-18. 2007
    ..This chapter gives a personal account of a small part of this story, the transformation of the rather abstract electrical conductances of Hodgkin & Huxley into the more tangible gated ion channel...
  4. pmc A model for 4-aminopyridine action on K channels: similarities to tetraethylammonium ion action
    C M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:895-904. 2001
    ..The model is qualitatively the same as the one used for many years to explain the action of quaternary ammonium ions...
  5. pmc The Na/K pump, Cl ion, and osmotic stabilization of cells
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, B 701 Richards Building, Philadelphia 19104 6085, USA
    Proc Natl Acad Sci U S A 100:6257-62. 2003
    ..The results emphasize the role of the pump and membrane voltage in lowering internal Cl(-) concentration, thus making osmotic room for vital substances that must be sequestered in the cell...
  6. pmc Charge immobilization caused by modification of internal cysteines in squid Na channels
    K Khodakhah
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Marine Biological Laboratory, Woods Hole, Massachusetts 02543 USA
    Biophys J 75:2821-9. 1998
    ....
  7. pmc Loss of shaker K channel conductance in 0 K+ solutions: role of the voltage sensor
    A Melishchuk
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 75:1828-35. 1998
    ..Several mutations that removed C-type inactivation also made the channels resistant to becoming defunct. Our results show that normal gating current cannot be stably recorded in the absence of K+...
  8. pmc Inositol trisphosphate and ryanodine receptors share a common functional Ca2+ pool in cerebellar Purkinje neurons
    K Khodakhah
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085, USA
    Biophys J 73:3349-57. 1997
    ..It is concluded that InsP3 receptors use the same functional Ca2+ pool as that utilized by Ry receptors in Purkinje neurons...
  9. pmc Induction of long-term depression and rebound potentiation by inositol trisphosphate in cerebellar Purkinje neurons
    K Khodakhah
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Proc Natl Acad Sci U S A 94:14009-14. 1997
    ..In the presence of heparin, an InsP3 receptor antagonist, repeated activation of PF+DeltaV failed to induce LTD, suggesting that InsP3 receptors play an important role in LTD induction under physiological conditions...
  10. pmc Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel
    A Melishchuk
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 80:2167-75. 2001
    ..Our results suggest that the cavity in Shaker is so small that even permeant cations like Rb+ or Cs+ must leave the cavity before the channel gate can close...
  11. pmc Do voltage-dependent K+ channels require Ca2+? A critical test employing a heterologous expression system
    C M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Proc Natl Acad Sci U S A 87:7579-82. 1990
    ..These results show that Ca2+ is essential for proper function of voltage-dependent K+ channels and is required to stabilize the native conformations of these membrane proteins...
  12. pmc Initial steps in the opening of a Shaker potassium channel
    Toshinori Hoshi
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:12800-4. 2012
    ..The results give strong support to the closed state model of the K(V) channel and a clear explanation of the effect of multivalent cations on cellular excitability...
  13. pmc Na channel inactivation from open and closed states
    Clay M Armstrong
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Proc Natl Acad Sci U S A 103:17991-6. 2006
    ..Csi requires only S4 activation of domains 3 and 4, which does not open the a gate...
  14. pmc Block of Shaker potassium channels by external calcium ions
    Froylan Gomez-Lagunas
    School of Medicine, National University of Mexico, Mexico City, 04510, Mexico
    Proc Natl Acad Sci U S A 100:347-51. 2003
    ..When combined, the results suggest that calcium accelerates the first step in closing of the channel gate, perhaps by changing the channel's ion-occupancy state...