Michelle R Arkin
Affiliation: University of California
- The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactionsMichelle R Arkin
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States
Curr Opin Chem Biol 13:284-90. 2009..However, the hypothesis that targeting such sites might confer on the resulting inhibitors improved properties of efficacy and/or tolerability, while appealing, remains largely untested...
- Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseasesJohn A Flygare
Small Molecule Discovery Center, University of California San Francisco, San Francisco, CA, 94158, USA
Curr Top Med Chem 14:319-25. 2014..The successful structure of the agreement serves as a model for future collaborations at both institutions. ..
- Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' diseaseJuan C Engel
Sandler Center for Basic Research in Parasitic Diseases and Department of Pathology, University of California, San Francisco, UCSF MC 2550, Room 501E, 1700 4th St, San Francisco, CA 94158 2330, USA
Antimicrob Agents Chemother 54:3326-34. 2010..This high-throughput assay will have an important impact in antiparasitic drug discovery...
- An image-based assay for high throughput screening of Giardia lambliaJiri Gut
Sandler Center for Drug Discovery, University of California, San Francisco, USA
J Microbiol Methods 84:398-405. 2011..lamblia at low- or sub-micromolar concentrations. Our high throughput assay should facilitate evaluation of available chemical libraries for novel drugs to treat giardiasis...
- A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hitGéraldine De Muylder
Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
PLoS Negl Trop Dis 5:e1253. 2011..This compound affects intracellular but not axenic parasites, suggesting a host cell-dependent mechanism of action, opening new avenues for anti-leishmanial chemotherapy...
- Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteasesClifford Bryant
Small Molecule Discovery Center, University of California, San Francisco, CA 94158, USA
Bioorg Med Chem Lett 19:6218-21. 2009....