Michelle R Arkin

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions
    Michelle R Arkin
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States
    Curr Opin Chem Biol 13:284-90. 2009
  2. ncbi request reprint Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases
    John A Flygare
    Small Molecule Discovery Center, University of California San Francisco, San Francisco, CA, 94158, USA
    Curr Top Med Chem 14:319-25. 2014
  3. pmc Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease
    Juan C Engel
    Sandler Center for Basic Research in Parasitic Diseases and Department of Pathology, University of California, San Francisco, UCSF MC 2550, Room 501E, 1700 4th St, San Francisco, CA 94158 2330, USA
    Antimicrob Agents Chemother 54:3326-34. 2010
  4. doi request reprint An image-based assay for high throughput screening of Giardia lamblia
    Jiri Gut
    Sandler Center for Drug Discovery, University of California, San Francisco, USA
    J Microbiol Methods 84:398-405. 2011
  5. pmc A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit
    Géraldine De Muylder
    Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 5:e1253. 2011
  6. pmc Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases
    Clifford Bryant
    Small Molecule Discovery Center, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem Lett 19:6218-21. 2009

Collaborators

  • Juan C Engel
  • James McKerrow
  • Kenny K H Ang
  • John A Flygare
  • Géraldine De Muylder
  • Jiri Gut
  • Clifford Bryant
  • Jennifer Legac
  • Steven Chen
  • Philip J Rosenthal
  • Linda S Brinen
  • Joseline Ratnam
  • Adam R Renslo
  • Priyadarshini Jaishankar
  • Moumita Debnath
  • Rafaela S Ferreira
  • Dongmei Zhao
  • Iain D Kerr

Detail Information

Publications6

  1. doi request reprint The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions
    Michelle R Arkin
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States
    Curr Opin Chem Biol 13:284-90. 2009
    ..However, the hypothesis that targeting such sites might confer on the resulting inhibitors improved properties of efficacy and/or tolerability, while appealing, remains largely untested...
  2. ncbi request reprint Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases
    John A Flygare
    Small Molecule Discovery Center, University of California San Francisco, San Francisco, CA, 94158, USA
    Curr Top Med Chem 14:319-25. 2014
    ..The successful structure of the agreement serves as a model for future collaborations at both institutions. ..
  3. pmc Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease
    Juan C Engel
    Sandler Center for Basic Research in Parasitic Diseases and Department of Pathology, University of California, San Francisco, UCSF MC 2550, Room 501E, 1700 4th St, San Francisco, CA 94158 2330, USA
    Antimicrob Agents Chemother 54:3326-34. 2010
    ..This high-throughput assay will have an important impact in antiparasitic drug discovery...
  4. doi request reprint An image-based assay for high throughput screening of Giardia lamblia
    Jiri Gut
    Sandler Center for Drug Discovery, University of California, San Francisco, USA
    J Microbiol Methods 84:398-405. 2011
    ..lamblia at low- or sub-micromolar concentrations. Our high throughput assay should facilitate evaluation of available chemical libraries for novel drugs to treat giardiasis...
  5. pmc A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit
    Géraldine De Muylder
    Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 5:e1253. 2011
    ..This compound affects intracellular but not axenic parasites, suggesting a host cell-dependent mechanism of action, opening new avenues for anti-leishmanial chemotherapy...
  6. pmc Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases
    Clifford Bryant
    Small Molecule Discovery Center, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem Lett 19:6218-21. 2009
    ....