Genomes and Genes
Affiliation: University of New Mexico
- GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancerHugo Arias-Pulido
Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM, USA
Breast Cancer Res Treat 123:51-8. 2010..These findings suggest potential new therapeutic targets for IBC such as novel endocrine agents or direct modulation of GPR30...
- Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patientsNabila Chaher
Department of Pathology, Centre Pierre et Marie Curie, 1, Avenue Battendier, Place May 1st, Algiers, Algeria
Breast Cancer Res Treat 131:437-44. 2012..Current therapeutic treatments were not very effective in this population and new approaches are much needed...
- Tumor stromal vascular endothelial growth factor A is predictive of poor outcome in inflammatory breast cancerHugo Arias-Pulido
Department of Internal Medicine, The University of New Mexico Cancer Center, Albuquerque, NM, USA
BMC Cancer 12:298. 2012....
- Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinomaPulivarthi H Rao
Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA
BMC Cancer 4:5. 2004..Therefore, genetic characterization is essential for understanding the biology and clinical heterogeneity in cervical cancer (CC)...
- Human papillomavirus type 18 variant lineages in United States populations characterized by sequence analysis of LCR-E6, E2, and L1 regionsHugo Arias-Pulido
Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, School of Medicine, Albuquerque, NM 87111, USA
Virology 338:22-34. 2005..Several novel HPV 18 nucleotide variations were identified in this study...
- Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumorsHugo Arias-Pulido
Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM 87131 5636, USA
Gynecol Oncol 114:480-5. 2009..This study was conducted to determine if ER and PR expression patterns are predictive of outcome in patients with epithelial ovarian cancer (EOC) or ovarian low malignant potential (LMP) tumors...
- Absence of epidermal growth factor receptor mutations in cervical cancerH Arias-Pulido
Department of Pathology, Division of Hematology Oncology, The University of New Mexico Cancer Center, Albuquerque, New Mexico
Int J Gynecol Cancer 18:749-54. 2008..Our results suggest, therefore, that treatment of CC patients with TKIs may not have the same efficacy as seen in patients with lung cancer, and that targeting the EGFR with other inhibitors may be more appropriate...
- Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including DroshaLuigi Scotto
Department of Pathology, Columbia University Medical Center, New York, New York, USA
Mol Cancer 7:58. 2008..These changes may possess oncogenic properties by deregulating tumor-related genes. Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC...
- Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancerGopeshwar Narayan
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
Genes Chromosomes Cancer 48:983-92. 2009..Our studies demonstrate that inactivation of PCDH10 may be a critical event in CC progression and form a potentially useful therapeutic target for CC...
- Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcomeGopeshwar Narayan
Department of Pathology, Columbia University, New York, New York 10032, USA
Mol Cancer 2:24. 2003..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
- Mapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesionsHugo Arias-Pulido
Department of Pathology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, 10032, USA
Mol Cancer 1:3. 2002..These data therefore suggest that loss of candidate tumor suppressor genes located on 5p is associated with the development of CC. However, the precise location of 5p deletions is not known...
- Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancerHugo Arias-Pulido
Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
J Clin Microbiol 44:1755-62. 2006..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
- Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancerGopeshwar Narayan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Cancer Res 64:2994-7. 2004..Thus, these results have important implications in understanding the molecular basis of CC tumorigenesis and clinical management in designing targeted experimental therapeutic protocols...
- Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progressionGopeshwar Narayan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Mol Cancer 5:16. 2006..Slit genes mediate their effect by binding to its receptor Roundabout (Robo). These genes have shown to be inactivated by promoter hypermethylation in a number of human cancers...
- Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genesGopeshwar Narayan
Department of Pathology, Columbia University Medical Center, NY 10032, USA
Genes Chromosomes Cancer 46:373-84. 2007..These data, thus, form an important step toward the identification of biologically relevant genes in CC pathogenesis. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
- A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancerJulie E Bauman
Department of Internal Medicine, Division of Hematology Oncology and Biostatistics, University of New Mexico Cancer Center, Albuquerque, New Mexico, USA
BMC Cancer 12:449. 2012..Antagonizing PDGFR with imatinib may improve intra-tumoral delivery of paclitaxel, increasing response rate (RR)...
- A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinomaJulie E Bauman
Department of Internal Medicine, Division of Hematology Oncology, University of Pittsburgh, Pittsburgh, PA, USA
Oral Oncol 49:461-7. 2013..Downstream activation of the PI3K/Akt/mTOR pathway is an established resistance mechanism. Concurrent mTOR blockade may improve efficacy of anti-EGFR therapy...
- Loss of heterozygosity on chromosome 6 in HPV-16 positive cervical carcinomas carrying the DRB1*1501-DQB1*0602 haplotypeHugo Arias-Pulido
Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, School of Medicine, Albuquerque, New Mexico 87131, USA
Genes Chromosomes Cancer 40:277-84. 2004..These losses may be a reflection of both an abnormal immune response and a general genome-wide instability resulting from virus persistence...
- Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasmsJoseph P Glass
University of New Mexico, Albuquerque, NM, USA
Int J Surg Pathol 19:588-96. 2011..Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology...
- Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progressionLuigi Scotto
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
Genes Chromosomes Cancer 47:755-65. 2008..Our findings implicate a role for these genes in CC tumorigenesis, represent an important step toward the development of clinically significant biomarkers, and form a framework for testing as molecular therapeutic targets...
- Novel chemotherapy approaches for cervical cancerSujana Movva
Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, USA
Cancer 115:3166-80. 2009..The use of novel therapeutic approaches targeted to the carcinogenic processes that leads to the ontogenesis of cervical cancer should be promoted in clinical studies to improve patient outcomes...