Gary W Arendash

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    G W Arendash
    Alzheimer s Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Brain Res 891:42-53. 2001
  2. ncbi request reprint Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory
    G W Arendash
    The Alzheimer s Research Consortium, Department of Biology, University of South Florida, Tampa, Florida 33620, USA
    DNA Cell Biol 20:737-44. 2001
  3. ncbi request reprint Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    Gary W Arendash
    Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Physiol Behav 75:643-52. 2002
  4. ncbi request reprint Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain
    Gary W Arendash
    The Johnnie B Byrd Alzhimer s Center and Research Institute, Tampa, FL 33620, USA
    Brain Res 1012:29-41. 2004
  5. pmc Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice
    Chuanhai Cao
    The Byrd Alzheimer s Center and Research Institute, Tampa, FL, USA
    J Alzheimers Dis 17:681-97. 2009
  6. doi request reprint Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells
    Natasa Dragicevic
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E Fowler Ave, ISA 2015, Tampa, FL 33620, USA
    Neuropharmacology 63:1368-79. 2012
  7. ncbi request reprint Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
    Lars N G Nilsson
    Department of Biochemistry and Molecular Biology, Suncoast Gerontology Center, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Neurobiol Aging 25:1153-67. 2004
  8. ncbi request reprint Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
    Ralph E Leighty
    Memory and Aging Research Laboratory, SCA 110, University of South Florida, Tampa, FL 33620, USA
    Behav Brain Res 153:107-21. 2004
  9. pmc Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity
    Jennifer R Cracchiolo
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    Neurobiol Learn Mem 88:277-94. 2007
  10. doi request reprint Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
    Brain Res 1214:177-87. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    G W Arendash
    Alzheimer s Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Brain Res 891:42-53. 2001
    ..As such, the APP+PS1 transgenic mouse offers unique opportunities to develop therapeutics to treat or prevent Alzheimer's Disease through modulation of Abeta deposition/neuroinflammation...
  2. ncbi request reprint Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory
    G W Arendash
    The Alzheimer s Research Consortium, Department of Biology, University of South Florida, Tampa, Florida 33620, USA
    DNA Cell Biol 20:737-44. 2001
    ..In view of the early short-term memory deficits exhibited by AD patients, Abeta vaccination of presymptomatic AD patients could be an effective therapeutic to protect against such cognitive impairments...
  3. ncbi request reprint Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    Gary W Arendash
    Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Physiol Behav 75:643-52. 2002
    ....
  4. ncbi request reprint Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain
    Gary W Arendash
    The Johnnie B Byrd Alzhimer s Center and Research Institute, Tampa, FL 33620, USA
    Brain Res 1012:29-41. 2004
    ....
  5. pmc Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice
    Chuanhai Cao
    The Byrd Alzheimer s Center and Research Institute, Tampa, FL, USA
    J Alzheimers Dis 17:681-97. 2009
    ....
  6. doi request reprint Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells
    Natasa Dragicevic
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E Fowler Ave, ISA 2015, Tampa, FL 33620, USA
    Neuropharmacology 63:1368-79. 2012
    ..The results of this study indicate that melatonin restores mitochondrial function much more potently than caffeine in APP(sw) transgenic mouse and cell models of Alzheimer's disease...
  7. ncbi request reprint Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
    Lars N G Nilsson
    Department of Biochemistry and Molecular Biology, Suncoast Gerontology Center, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Neurobiol Aging 25:1153-67. 2004
    ....
  8. ncbi request reprint Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
    Ralph E Leighty
    Memory and Aging Research Laboratory, SCA 110, University of South Florida, Tampa, FL 33620, USA
    Behav Brain Res 153:107-21. 2004
    ..Analyses such as these will be very beneficial for the functional evaluation of therapeutic interventions against AD and for finding behavioral measures that can serve as predictors of pathology...
  9. pmc Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity
    Jennifer R Cracchiolo
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    Neurobiol Learn Mem 88:277-94. 2007
    ..Thus, our data suggest that humans who emphasize a high lifelong level of cognitive activity (over and above social and physical activities) will attain the maximal environmental protection against AD...
  10. doi request reprint Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
    Brain Res 1214:177-87. 2008
    ..Taken together, these data further the notion of EGCG dietary supplementation as a potentially safe and effective prophylaxis for Alzheimer's disease...
  11. ncbi request reprint Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
    David A Costa
    Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
    Neurobiol Aging 28:831-44. 2007
    ..These results indicate that EE protects against cognitive impairment in AD transgenic mice through a dual mechanism, including both amyloid dependent and independent mechanisms...
  12. ncbi request reprint Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
    David L King
    Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Physiol Behav 75:627-42. 2002
    ..This may reflect their predominant C57BL/6 background and an apparent inability of the mutant transgene to profoundly alter performance therein...
  13. doi request reprint Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice
    Gary W Arendash
    Department of Cell Biology, Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, FL 33620, USA
    J Alzheimers Dis 17:661-80. 2009
    ..Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD...
  14. doi request reprint Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice
    Gary W Arendash
    The Florida Alzheimer s Disease Research Center, Tampa, FL, USA
    J Alzheimers Dis 19:191-210. 2010
    ....
  15. ncbi request reprint Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
    Natasa Dragicevic
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
    J Alzheimers Dis 20:S535-50. 2010
    ..Therapeutics that target this cascade could be beneficial in the treatment of AD...
  16. doi request reprint Oxygen treatment triggers cognitive impairment in Alzheimer's transgenic mice
    Gary W Arendash
    Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, Florida 33620, USA
    Neuroreport 20:1087-92. 2009
    ..These results may suggest that exposure of elderly patients to excessive amounts of oxygen perioperatively hastens the development of Alzheimer's disease...
  17. doi request reprint GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice
    Tim D Boyd
    USF Health Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    J Alzheimers Dis 21:507-18. 2010
    ....
  18. doi request reprint Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS
    Chuanhai Cao
    The Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    Neurobiol Dis 34:63-70. 2009
    ..These results demonstrate that Abeta-specific Th2 cells are sufficient to reverse cognitive impairment and provide multiple pathological benefits in an Alzheimer's mouse model...
  19. ncbi request reprint Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition
    Gary W Arendash
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33620, USA
    Neuroreport 15:1751-4. 2004
    ..The results suggest that long-term EE/cognitive stimulation could provide cognitive stabilization or improvement to AD patients through mechanisms independent of A beta deposition and clearance...
  20. pmc Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice
    Briony J Catlow
    Department of Psychology, University of South Florida, Tampa, FL 33620, USA
    Brain Res 1256:173-9. 2009
    ....
  21. doi request reprint Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling
    Natasa Dragicevic
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
    J Pineal Res 51:75-86. 2011
    ....
  22. pmc Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit
    Gary W Arendash
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 7:e35751. 2012
    ..Results further underscore the potential for EMF treatment against AD...
  23. ncbi request reprint Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment
    David L King
    Memory and Aging Research Laboratory, SCA 110, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Brain Res 926:58-68. 2002
    ..The results of this study are consistent with the premise that maintained SYN-IR in Tg2576 mice during aging is associated with impaired synaptic function, resulting in cognitive deficits...
  24. doi request reprint High Blood caffeine levels in MCI linked to lack of progression to dementia
    Chuanhai Cao
    Department of Pharmaceutical Science, University of South Florida College of Pharmacy, Tampa, FL 33620, USA
    J Alzheimers Dis 30:559-72. 2012
    ..This case-control study provides the first direct evidence that caffeine/coffee intake is associated with a reduced risk of dementia or delayed onset, particularly for those who already have MCI...
  25. doi request reprint Caffeine and coffee as therapeutics against Alzheimer's disease
    Gary W Arendash
    The Florida Alzheimer s Disease Research Center, Tampa, FL, USA
    J Alzheimers Dis 20:S117-26. 2010
    ....
  26. ncbi request reprint ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    Demian F Obregon
    Neuroimmunology Laboratory, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, The Byrd Alzheimer s Center and Research Institute, 3515 E Fletcher Avenue, Tampa, FL 33647, USA
    J Biol Chem 281:16419-27. 2006
    ..Thus, ADAM10 represents an important pharmacotherapeutic target for the treatment of cerebral amyloidosis in Alzheimer disease...
  27. doi request reprint Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug development
    Gary W Arendash
    Department of Cell Biology, University of South Florida, Tampa, FL, USA
    J Alzheimers Dis 32:243-66. 2012
    ..TEMT's mechanisms of action provide extraordinary therapeutic potential against other neurologic disorders/injuries, such as Parkinson's disease, traumatic brain injury, and stroke...
  28. ncbi request reprint Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
    Douglas W Ethell
    Biomedical Sciences, University of California Riverside, 92521 0121, USA
    Neurobiol Dis 23:351-61. 2006
    ....
  29. ncbi request reprint Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice
    Ralph E Leighty
    The Byrd Alzheimer s Institute and The Florida Alzheimer s Disease Research Center, Tampa, FL 33647, United States
    J Neurosci Methods 167:358-66. 2008
    ..These results indicate that ANNs have an excellent capacity to discriminate cognitive impairment in AD transgenic mice and thus designate ANNs as a novel, sensitive method for cognitive assessment in Alzheimer's research...
  30. ncbi request reprint Intracerebroventricular infusions of gp120 inhibit weight gain and induce atrophy in the hippocampus and neostriatum without affecting cognition
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO, USA
    J NeuroAIDS 2:15-31. 2004
    ..Thus, gp120 alone can cause ADC-related neuropathologic and weight changes, but gp120 alone was not sufficient to induce impairments in spatial learning and memory...
  31. ncbi request reprint GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment
    Zhiming Suo
    Laboratory for Alzheimer s Disease and Aging Research, Veterans Affairs Medical Center, Kansas City, MO 64128, USA
    Neurobiol Aging 28:1873-88. 2007
    ..Taken together, these findings not only strongly support an important role of GRK5 deficiency in early Alzheimer's pathogenesis, but also promote the GRK5 knockout mouse as an additional model for early Alzheimer-related studies...
  32. pmc Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia
    Takashi Mori
    Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Stroke 39:2114-21. 2008
    ..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...