Research Topics
Genomes and GenesSpecies | Gary W ArendashSummaryAffiliation: University of South Florida Country: USA Publications
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Publications
Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug developmentGary W Arendash
Department of Cell Biology, University of South Florida, Tampa, FL, USA
J Alzheimers Dis 32:243-66. 2012..TEMT's mechanisms of action provide extraordinary therapeutic potential against other neurologic disorders/injuries, such as Parkinson's disease, traumatic brain injury, and stroke...
Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefitGary W Arendash
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, United States of America
PLoS ONE 7:e35751. 2012..Results further underscore the potential for EMF treatment against AD...- The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-reviewJuan Sanchez-Ramos
Department of Neurology, University of South Florida, Tampa, FL 33612, USA
BMC Neurosci 9:S3. 2008..In addition, neuronal hematopoietic growth factor receptors provide novel targets for the discovery of peptide-mimetic drugs that can forestall or reverse the pathological progression of Alzheimer's disease... 
A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic miceG W Arendash
The Florida Alzheimer s Disease Research Center and The Byrd Alzheimer s Institute, Tampa, FL 33613, USA
Neuroscience 149:286-302. 2007..Alternatively, dietary fish may contain nutrients, other than DHA and EPA, that could provide some protection against AD...- Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid productionG W Arendash
The Byrd Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
Neuroscience 142:941-52. 2006..Our data demonstrate that moderate daily intake of caffeine may delay or reduce the risk of AD... - Oxygen treatment triggers cognitive impairment in Alzheimer's transgenic miceGary W Arendash
Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, Florida 33620, USA
Neuroreport 20:1087-92. 2009..These results may suggest that exposure of elderly patients to excessive amounts of oxygen perioperatively hastens the development of Alzheimer's disease... - Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid depositionGary W Arendash
The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33620, USA
Neuroreport 15:1751-4. 2004..The results suggest that long-term EE/cognitive stimulation could provide cognitive stabilization or improvement to AD patients through mechanisms independent of A beta deposition and clearance... - Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease miceGary W Arendash
Department of Cell Biology, Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, FL 33620, USA
J Alzheimers Dis 17:661-80. 2009..Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD... - Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease miceGary W Arendash
The Florida Alzheimer s Disease Research Center, Tampa, FL, USA
J Alzheimers Dis 19:191-210. 2010.... - Caffeine and coffee as therapeutics against Alzheimer's diseaseGary W Arendash
The Florida Alzheimer s Disease Research Center, Tampa, FL, USA
J Alzheimers Dis 20:S117-26. 2010.... - Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic miceChuanhai Cao
The Byrd Alzheimer s Center and Research Institute, Tampa, FL, USA
J Alzheimers Dis 17:681-97. 2009.... - Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cellsNatasa Dragicevic
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E Fowler Ave, ISA 2015, Tampa, FL 33620, USA
Neuropharmacology 63:1368-79. 2012..The results of this study indicate that melatonin restores mitochondrial function much more potently than caffeine in APP(sw) transgenic mouse and cell models of Alzheimer's disease... - Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivityJennifer R Cracchiolo
The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
Neurobiol Learn Mem 88:277-94. 2007..Thus, our data suggest that humans who emphasize a high lifelong level of cognitive activity (over and above social and physical activities) will attain the maximal environmental protection against AD... - Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic miceKavon Rezai-Zadeh
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
Brain Res 1214:177-87. 2008..Taken together, these data further the notion of EGCG dietary supplementation as a potentially safe and effective prophylaxis for Alzheimer's disease... - Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanismsDavid A Costa
Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
Neurobiol Aging 28:831-44. 2007..These results indicate that EE protects against cognitive impairment in AD transgenic mice through a dual mechanism, including both amyloid dependent and independent mechanisms... - Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formationLars N G Nilsson
Department of Biochemistry and Molecular Biology, Suncoast Gerontology Center, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
Neurobiol Aging 25:1153-67. 2004.... - Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta depositionRalph E Leighty
Memory and Aging Research Laboratory, SCA 110, University of South Florida, Tampa, FL 33620, USA
Behav Brain Res 153:107-21. 2004..Analyses such as these will be very beneficial for the functional evaluation of therapeutic interventions against AD and for finding behavioral measures that can serve as predictors of pathology... - Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer diseaseJames M Olcese
Florida State University College of Medicine, Tallahassee, FL, USA
J Pineal Res 47:82-96. 2009..Our findings provide support for long-term melatonin therapy as a primary or complementary strategy for abating the progression of Alzheimer disease... - Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic miceNatasa Dragicevic
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
J Alzheimers Dis 20:S535-50. 2010..Therapeutics that target this cascade could be beneficial in the treatment of AD... - Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic miceRalph E Leighty
The Byrd Alzheimer s Institute and The Florida Alzheimer s Disease Research Center, Tampa, FL 33647, United States
J Neurosci Methods 167:358-66. 2008..These results indicate that ANNs have an excellent capacity to discriminate cognitive impairment in AD transgenic mice and thus designate ANNs as a novel, sensitive method for cognitive assessment in Alzheimer's research... - Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controlsGary W Arendash
Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
Physiol Behav 75:643-52. 2002.... - Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNSChuanhai Cao
The Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
Neurobiol Dis 34:63-70. 2009..These results demonstrate that Abeta-specific Th2 cells are sufficient to reverse cognitive impairment and provide multiple pathological benefits in an Alzheimer's mouse model... - Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout agingM T Jensen
The Johnnie B. Byrd Alzheimer's Center and Research Institute, Tampa, FL 33620, USA
Neuroscience 130:667-84. 2005.... - GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer miceTim D Boyd
USF Health Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
J Alzheimers Dis 21:507-18. 2010.... - Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signalingNatasa Dragicevic
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
J Pineal Res 51:75-86. 2011.... - Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP miceBriony J Catlow
Department of Psychology, University of South Florida, Tampa, FL 33620, USA
Brain Res 1256:173-9. 2009.... - Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 monthsDavid L King
Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
Physiol Behav 75:627-42. 2002..This may reflect their predominant C57BL/6 background and an apparent inability of the mutant transgene to profoundly alter performance therein... - Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 miceM N Gordon
Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, 33612, Tampa, FL, USA
Neurobiol Aging 22:377-85. 2001..These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Abeta load... - Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrainGary W Arendash
The Johnnie B Byrd Alzhimer s Center and Research Institute, Tampa, FL 33620, USA
Brain Res 1012:29-41. 2004.... - Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairmentDavid L King
Memory and Aging Research Laboratory, SCA 110, Department of Biology, University of South Florida, Tampa, FL 33620, USA
Brain Res 926:58-68. 2002..The results of this study are consistent with the premise that maintained SYN-IR in Tg2576 mice during aging is associated with impaired synaptic function, resulting in cognitive deficits... - High Blood caffeine levels in MCI linked to lack of progression to dementiaChuanhai Cao
Department of Pharmaceutical Science, University of South Florida College of Pharmacy, Tampa, FL 33620, USA
J Alzheimers Dis 30:559-72. 2012..This case-control study provides the first direct evidence that caffeine/coffee intake is associated with a reduced risk of dementia or delayed onset, particularly for those who already have MCI... - Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 miceL Austin
Department of Biology and Memory, Aging Research Laboratory, University of South Florida, Tampa, Florida, USA
Behav Neurosci 117:478-84. 2003..A beta-based immunotherapy for Alzheimer's disease will likely be more successful prophylactically than therapeutically... - ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor proteinDemian F Obregon
Neuroimmunology Laboratory, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, The Byrd Alzheimer s Center and Research Institute, 3515 E Fletcher Avenue, Tampa, FL 33647, USA
J Biol Chem 281:16419-27. 2006..Thus, ADAM10 represents an important pharmacotherapeutic target for the treatment of cerebral amyloidosis in Alzheimer disease... - The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic miceM F Garcia
Memory and Aging Research Laboratory, SCA110, University of South Florida, Tampa, FL 33620, USA
Neuroreport 15:73-7. 2004..Our results strongly encourage rd screening of genetically manipulated mouse lines produced from rd-carrying strain backgrounds to avoid serious potential confounds in the interpretation of spatially based cognitive performance... - Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease miceValentina Echeverria
Bay Pines VA Healthcare System, Bay Pines, FL, USA
J Alzheimers Dis 24:817-35. 2011..The good safety profile in humans and its beneficial effects suggest that cotinine may be an excellent therapeutic candidate for the treatment of AD... - Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memoryG W Arendash
The Alzheimer s Research Consortium, Department of Biology, University of South Florida, Tampa, Florida 33620, USA
DNA Cell Biol 20:737-44. 2001..In view of the early short-term memory deficits exhibited by AD patients, Abeta vaccination of presymptomatic AD patients could be an effective therapeutic to protect against such cognitive impairments... - Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's miceJ Sanchez-Ramos
Department of Neurology MDC55, University of South Florida, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
Neuroscience 163:55-72. 2009..4) To learn whether enhanced hippocampal neurogenesis was induced by G-CSF treatment, numbers of calretinin-expressing cells were determined in dentate gyrus... - Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenesG W Arendash
Alzheimer s Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
Brain Res 891:42-53. 2001..As such, the APP+PS1 transgenic mouse offers unique opportunities to develop therapeutics to treat or prevent Alzheimer's Disease through modulation of Abeta deposition/neuroinflammation... - A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseD Morgan
Department of Pharmacology, University of South Florida, Tampa 33612, USA
Nature 408:982-5. 2000..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia... - Peptide T prevents NBM lesion-induced cortical atrophy in aged ratsD J Socci
Department of Biology and Institute on Aging, University of South Florida, Tampa 33620, USA
Peptides 17:831-7. 1996..These results provide evidence that PT1 perhaps acting via VIP receptor stimulation, is neurotrophic and important for the integrity of brain tissue following denervation... - Intracerebroventricular infusions of gp120 inhibit weight gain and induce atrophy in the hippocampus and neostriatum without affecting cognitionKimberly B Bjugstad
Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO, USA
J NeuroAIDS 2:15-31. 2004..Thus, gp120 alone can cause ADC-related neuropathologic and weight changes, but gp120 alone was not sufficient to induce impairments in spatial learning and memory... - GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairmentZhiming Suo
Laboratory for Alzheimer s Disease and Aging Research, Veterans Affairs Medical Center, Kansas City, MO 64128, USA
Neurobiol Aging 28:1873-88. 2007..Taken together, these findings not only strongly support an important role of GRK5 deficiency in early Alzheimer's pathogenesis, but also promote the GRK5 knockout mouse as an additional model for early Alzheimer-related studies... - Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's miceDouglas W Ethell
Biomedical Sciences, University of California Riverside, 92521 0121, USA
Neurobiol Dis 23:351-61. 2006.... - Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemiaTakashi Mori
Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
Stroke 39:2114-21. 2008..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...