Research Topics
| D A ArenbergSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Bronchioloalveolar carcinomaDouglas Arenberg
Division of Pulmonary Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Semin Respir Crit Care Med 32:52-61. 2011..Additional clinical trials are needed on patients with BAC, employing strict definitions and enrollment criteria to allow the results to be applied to appropriate patient populations...
Chemokines in the biology of lung cancerDouglas Arenberg
University of Michigan, Ann Arbor, Michigan, USA
J Thorac Oncol 1:287-8. 2006..This is a brief review of some of the mechanisms by which members of the large family of chemotactic cytokines (known as chemokines) participate in critical features of lung cancer biology...- Bronchioloalveolar lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)Douglas Arenberg
University of Michigan, Pulmonary and Critical Care Medicine, 6301 MSRB III, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
Chest 132:306S-13S. 2007..To review the current evidence on special issues relating to the diagnosis, imaging, prognosis, and treatment of bronchioloalveolar carcinoma (BAC)... 
Electromagnetic navigation guided bronchoscopyDouglas Arenberg
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
Cancer Imaging 9:89-95. 2009..This technique offers some potential advantages over other forms of biopsy. The design, application, relative advantages and pitfalls of this system are the subject of this review...- Improved survival in tumor-bearing SCID mice treated with interferon-gamma-inducible protein 10 (IP-10/CXCL10)D A Arenberg
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
Cancer Immunol Immunother 50:533-8. 2001..These data suggest that anti-angiogenic therapy of human lung cancer should be continued indefinitely to realize persistent benefit, and confirms the anti-metastatic capacity of localized angiostatic therapy... - Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repairDouglas Arenberg
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
Am J Respir Crit Care Med 182:1030-7. 2010..We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth... - The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse modelD A Arenberg
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
Cancer Immunol Immunother 49:587-92. 2001..Furthermore, while not confirmatory, these data lend further support to the fact that CXCR3 may be the receptor for angiostatic CXC chemokines... - Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokinesD A Arenberg
University of Michigan Medical Center, Division of Pulmonary and Critical Care, Ann Arbor 48109, USA
Cancer Immunol Immunother 49:63-70. 2000..However, the functional significance of CC-chemokine-mediated macrophage infiltration into NSCLC remains to be determined... - Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activityE S White
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 166:7549-55. 2001..These data suggest that the interaction between host macrophages and NSCLC cells synergistically increases angiogenic potential, and that this is due to an increased elaboration of angiogenic CXC chemokines... - Chemokines as therapeutic targets in non-small cell lung cancerE S White
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Curr Med Chem Anticancer Agents 2:403-17. 2002..This review will focus on the evidence supporting the central role of these molecules in lung cancer angiogenesis, and focus on potential novel means of targeting this family of angiogenic regulators... - PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancerVenkateshwar G Keshamouni
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Neoplasia 7:294-301. 2005..These antiangiogenic effects likely contribute to the inhibition of primary tumor growth by PPAR-gamma ligands... - Diversity of the angiogenic phenotype in non-small cell lung cancerMarc R McClelland
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
Am J Respir Cell Mol Biol 36:343-50. 2007..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway... - Overexpression of CXC chemokines by an adrenocortical carcinoma: a novel clinical syndromeD E Schteingart
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Clin Endocrinol Metab 86:3968-74. 2001..Through their angiogenic and chemotactic properties these chemokines may play an important role in adrenal tumorigenesis... - Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotypeVenkateshwar G Keshamouni
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Proteomics Consortium, National Resource for Proteomics and Pathways, University of Michigan, Ann Arbor, Michigan, 48109, USA
J Proteome Res 5:1143-54. 2006.... - The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neckTheodoros N Teknos
Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
Arch Otolaryngol Head Neck Surg 131:204-11. 2005..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)... - Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse modelPeter K Henke
Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
Arterioscler Thromb Vasc Biol 24:1130-7. 2004..To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution... - Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10Eric S White
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Crit Care Med 168:436-42. 2003..Furthermore, this study implicates a loss of PTEN function in the pathophysiology of idiopathic pulmonary fibrosis... - Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosisEric S White
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
Clin Cancer Res 9:853-60. 2003..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis... - Monocyte-fibronectin interactions, via alpha(5)beta(1) integrin, induce expression of CXC chemokine-dependent angiogenic activityE S White
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 167:5362-6. 2001..These data suggest that fibronectin, via alpha(5)beta(1) integrin, promotes CXC chemokine-dependent angiogenic activity from monocytes... - Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysisD R Smith
Department of Medicine, University of Michigan Medical School, Ann Arbor, USA
Am J Respir Crit Care Med 151:1965-73. 1995.... - RANTES expression is a predictor of survival in stage I lung adenocarcinomaChristopher J Moran
Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 8:3803-12. 2002..002). CONCLUSION: When tested in the Cox univariate proportional hazards model, RANTES expression by lung adenocarcinoma cells is a predictor of survival in stage I NSCLC patients and may be useful as a prognostic factor in lung cancer... - Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary diseaseChristine M Freeman
Pulmonary and Critical Care Medicine Section, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Am J Respir Crit Care Med 180:1179-88. 2009..Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis... - Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15Christine M Freeman
Pulmonary and Critical Care Medicine Section, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48105 2303, USA
J Immunol 184:6504-13. 2010..These findings suggest that the production of proinflammatory cytokines and cytotoxic molecules by lung-resident CD8(+) T cells contributes to COPD pathogenesis... - Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancerVenkateshwar G Keshamouni
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA
Oncogene 23:100-8. 2004..Collectively, our data demonstrate that activation of PPAR-gamma impedes lung tumor progression and suggest that PPAR-gamma ligands may serve as potential therapeutic agents for NSCLC... - Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activationPriya Kulasekaran
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 5642, USA
Am J Respir Cell Mol Biol 41:484-93. 2009..These findings suggest the potential for novel therapies targeting the convergence of prosurvival signaling pathways activated by these two profibrotic mediators...
Research Grants
- Promotion of Angiogenesis in Lung Cancer by MIFDouglas Arenberg; Fiscal Year: 2006..monocytes?) 2) Does MIF correlate with vascularity of human tumors? 3) Does MIF correlate with levels of angiogenic CXC chemokines in human tumors? 4) Does high expression of MIF predict poor clinical outcomes? ..
- Promotion of Angiogenesis in Lung Cancer by MIFDouglas Arenberg; Fiscal Year: 2009..Specific aim: a) Determine the role of CD74 in the promotion of lung tumor growth by MIF, and b) to determine the role myeloid cells in the MIF-CD74 axis in lung cancer. ..
- Promotion of Angiogenesis in Lung Cancer by MIFDouglas A Arenberg; Fiscal Year: 2010..Specific aim: a) Determine the role of CD74 in the promotion of lung tumor growth by MIF, and b) to determine the role myeloid cells in the MIF-CD74 axis in lung cancer. ..