D A Arenberg

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi Bronchioloalveolar carcinoma
    Douglas Arenberg
    Division of Pulmonary Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Semin Respir Crit Care Med 32:52-61. 2011
  2. ncbi Chemokines in the biology of lung cancer
    Douglas Arenberg
    University of Michigan, Ann Arbor, Michigan, USA
    J Thorac Oncol 1:287-8. 2006
  3. ncbi Bronchioloalveolar lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Douglas Arenberg
    University of Michigan, Pulmonary and Critical Care Medicine, 6301 MSRB III, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Chest 132:306S-13S. 2007
  4. pmc Electromagnetic navigation guided bronchoscopy
    Douglas Arenberg
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Cancer Imaging 9:89-95. 2009
  5. ncbi Improved survival in tumor-bearing SCID mice treated with interferon-gamma-inducible protein 10 (IP-10/CXCL10)
    D A Arenberg
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cancer Immunol Immunother 50:533-8. 2001
  6. pmc Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair
    Douglas Arenberg
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 182:1030-7. 2010
  7. ncbi The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model
    D A Arenberg
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cancer Immunol Immunother 49:587-92. 2001
  8. ncbi Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines
    D A Arenberg
    University of Michigan Medical Center, Division of Pulmonary and Critical Care, Ann Arbor 48109, USA
    Cancer Immunol Immunother 49:63-70. 2000
  9. ncbi Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity
    E S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:7549-55. 2001
  10. ncbi Chemokines as therapeutic targets in non-small cell lung cancer
    E S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Curr Med Chem Anticancer Agents 2:403-17. 2002

Research Grants

  1. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas Arenberg; Fiscal Year: 2006
  2. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas Arenberg; Fiscal Year: 2009
  3. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas A Arenberg; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. doi Bronchioloalveolar carcinoma
    Douglas Arenberg
    Division of Pulmonary Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Semin Respir Crit Care Med 32:52-61. 2011
    ..Additional clinical trials are needed on patients with BAC, employing strict definitions and enrollment criteria to allow the results to be applied to appropriate patient populations...
  2. ncbi Chemokines in the biology of lung cancer
    Douglas Arenberg
    University of Michigan, Ann Arbor, Michigan, USA
    J Thorac Oncol 1:287-8. 2006
    ..This is a brief review of some of the mechanisms by which members of the large family of chemotactic cytokines (known as chemokines) participate in critical features of lung cancer biology...
  3. ncbi Bronchioloalveolar lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Douglas Arenberg
    University of Michigan, Pulmonary and Critical Care Medicine, 6301 MSRB III, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Chest 132:306S-13S. 2007
    ..To review the current evidence on special issues relating to the diagnosis, imaging, prognosis, and treatment of bronchioloalveolar carcinoma (BAC)...
  4. pmc Electromagnetic navigation guided bronchoscopy
    Douglas Arenberg
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Cancer Imaging 9:89-95. 2009
    ..This technique offers some potential advantages over other forms of biopsy. The design, application, relative advantages and pitfalls of this system are the subject of this review...
  5. ncbi Improved survival in tumor-bearing SCID mice treated with interferon-gamma-inducible protein 10 (IP-10/CXCL10)
    D A Arenberg
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cancer Immunol Immunother 50:533-8. 2001
    ..These data suggest that anti-angiogenic therapy of human lung cancer should be continued indefinitely to realize persistent benefit, and confirms the anti-metastatic capacity of localized angiostatic therapy...
  6. pmc Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair
    Douglas Arenberg
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 182:1030-7. 2010
    ..We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth...
  7. ncbi The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model
    D A Arenberg
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cancer Immunol Immunother 49:587-92. 2001
    ..Furthermore, while not confirmatory, these data lend further support to the fact that CXCR3 may be the receptor for angiostatic CXC chemokines...
  8. ncbi Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines
    D A Arenberg
    University of Michigan Medical Center, Division of Pulmonary and Critical Care, Ann Arbor 48109, USA
    Cancer Immunol Immunother 49:63-70. 2000
    ..However, the functional significance of CC-chemokine-mediated macrophage infiltration into NSCLC remains to be determined...
  9. ncbi Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity
    E S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:7549-55. 2001
    ..These data suggest that the interaction between host macrophages and NSCLC cells synergistically increases angiogenic potential, and that this is due to an increased elaboration of angiogenic CXC chemokines...
  10. ncbi Chemokines as therapeutic targets in non-small cell lung cancer
    E S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Curr Med Chem Anticancer Agents 2:403-17. 2002
    ..This review will focus on the evidence supporting the central role of these molecules in lung cancer angiogenesis, and focus on potential novel means of targeting this family of angiogenic regulators...
  11. pmc PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer
    Venkateshwar G Keshamouni
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neoplasia 7:294-301. 2005
    ..These antiangiogenic effects likely contribute to the inhibition of primary tumor growth by PPAR-gamma ligands...
  12. pmc Diversity of the angiogenic phenotype in non-small cell lung cancer
    Marc R McClelland
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 36:343-50. 2007
    ..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway...
  13. ncbi Overexpression of CXC chemokines by an adrenocortical carcinoma: a novel clinical syndrome
    D E Schteingart
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 86:3968-74. 2001
    ..Through their angiogenic and chemotactic properties these chemokines may play an important role in adrenal tumorigenesis...
  14. ncbi Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype
    Venkateshwar G Keshamouni
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Proteomics Consortium, National Resource for Proteomics and Pathways, University of Michigan, Ann Arbor, Michigan, 48109, USA
    J Proteome Res 5:1143-54. 2006
    ....
  15. ncbi The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
    ..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)...
  16. ncbi Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
    Arterioscler Thromb Vasc Biol 24:1130-7. 2004
    ..To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution...
  17. pmc Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 168:436-42. 2003
    ..Furthermore, this study implicates a loss of PTEN function in the pathophysiology of idiopathic pulmonary fibrosis...
  18. ncbi Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis
    Eric S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Clin Cancer Res 9:853-60. 2003
    ..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis...
  19. ncbi Monocyte-fibronectin interactions, via alpha(5)beta(1) integrin, induce expression of CXC chemokine-dependent angiogenic activity
    E S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 167:5362-6. 2001
    ..These data suggest that fibronectin, via alpha(5)beta(1) integrin, promotes CXC chemokine-dependent angiogenic activity from monocytes...
  20. ncbi Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysis
    D R Smith
    Department of Medicine, University of Michigan Medical School, Ann Arbor, USA
    Am J Respir Crit Care Med 151:1965-73. 1995
    ....
  21. ncbi RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
    ..The purpose of this study was to identify differences in global gene expression profiles between stage I NSCLC tumors with ALR (ALR+) and those without ALR (ALR-)...
  22. pmc Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 180:1179-88. 2009
    ..Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis...
  23. doi Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48105 2303, USA
    J Immunol 184:6504-13. 2010
    ..These findings suggest that the production of proinflammatory cytokines and cytotoxic molecules by lung-resident CD8(+) T cells contributes to COPD pathogenesis...
  24. ncbi Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer
    Venkateshwar G Keshamouni
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Oncogene 23:100-8. 2004
    ..Collectively, our data demonstrate that activation of PPAR-gamma impedes lung tumor progression and suggest that PPAR-gamma ligands may serve as potential therapeutic agents for NSCLC...
  25. pmc Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation
    Priya Kulasekaran
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 5642, USA
    Am J Respir Cell Mol Biol 41:484-93. 2009
    ..These findings suggest the potential for novel therapies targeting the convergence of prosurvival signaling pathways activated by these two profibrotic mediators...

Research Grants7

  1. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas Arenberg; Fiscal Year: 2006
    ..monocytes?) 2) Does MIF correlate with vascularity of human tumors? 3) Does MIF correlate with levels of angiogenic CXC chemokines in human tumors? 4) Does high expression of MIF predict poor clinical outcomes? ..
  2. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas Arenberg; Fiscal Year: 2009
    ..Specific aim: a) Determine the role of CD74 in the promotion of lung tumor growth by MIF, and b) to determine the role myeloid cells in the MIF-CD74 axis in lung cancer. ..
  3. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas A Arenberg; Fiscal Year: 2010
    ..Specific aim: a) Determine the role of CD74 in the promotion of lung tumor growth by MIF, and b) to determine the role myeloid cells in the MIF-CD74 axis in lung cancer. ..