Stephen Lawrence Archer
Affiliation: University of Chicago
- A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletionThenappan Thenappan
Section of Cardiology, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Am J Respir Crit Care Med 183:1080-91. 2011..Inflammation and macrophage accumulation occur in HPS; however, their importance is unclear. Common bile duct ligation (CBDL) creates an accepted model of HPS, allowing us to investigate the cause of HPS...
- GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertensionLin Piao
Section of Cardiology, Department of Medicine, University of Chicago Medical Center, University of Chicago, Chicago, IL 60637, USA
Circulation 126:2859-69. 2012..The implications of right ventricular (RV) adrenergic remodeling for inotrope selection and the therapeutic benefit of interrupting Gβγ-GRK2 interaction, using gallein, were tested...
- Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertensionBenjamin H Freed
Section of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
J Cardiovasc Magn Reson 14:11. 2012..However, the prognostic role of RVIP-LGE and other CMR-derived parameters of RV function are not well established. Our aim was to evaluate the predictive value of contrast-enhanced CMR in patients with PH...
- Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertensionGlenn Marsboom
Department of Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago, IL, USA
Circ Res 110:1484-97. 2012..Dynamin-related protein-1 (DRP1) is a GTPase that, when activated by kinases that phosphorylate serine 616, causes mitochondrial fission. It is, however, unknown whether mitochondrial fission is a prerequisite for proliferation...
- Inhibition of mitochondrial fission prevents cell cycle progression in lung cancerJalees Rehman
Section of Cardiology, University of Chicago, 5841 South Maryland Ave, MC6080, Chicago, IL 60637, USA
FASEB J 26:2175-86. 2012..0 ± 19 to 87.0 ± 6 mm(3) (P<0.01) with therapeutic Drp-1 inhibition. Impaired fusion and enhanced fission contribute fundamentally to the proliferation/apoptosis imbalance in cancer and constitute promising novel therapeutic targets...
- Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertensionGlenn Marsboom
Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Am J Respir Crit Care Med 185:670-9. 2012..Glycolytic metabolism can be detected with the positron emission tomography (PET) tracer (18)F-fluorodeoxyglucose (FDG)...
- Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case reportElaine Lin
Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
J Med Case Reports 4:246. 2010..However, the signs, symptoms and laboratory findings of pericarditis related to chronic lymphocytic leukemia can mimic tuberculosis...
- Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic targetStephen L Archer
Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Circulation 121:2661-71. 2010..Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), the major generator of H(2)O(2), is known to be reduced in PAH; however, the mechanism and therapeutic relevance of this are unknown...
- Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancerStephen L Archer
University of Chicago, Section of Cardiology, IL 60637, USA
Am J Physiol Heart Circ Physiol 294:H570-8. 2008..Mitochondrial abnormalities that disturb the ROS-HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of PAH and cancer and constitute promising therapeutic targets...
- Dilated cardiomyopathy and left bundle branch block associated with ingestion of colloidal gold and silver is reversed by British antiLewisite and vitamin E: the potential toxicity of metals used as health supplementsStephen Lawrence Archer
Section of Cardiology, University of Chicago, Chicago, Illinois 60637, USA
Can J Cardiol 24:397-9. 2008..This is the first case of gold and silver cardiomyopathy in humans, and highlights the risks of these colloidal metal 'health supplements'...
- A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertensionJalees Rehman
Section of Cardiology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC6080, Chicago, IL, 60637, USA
Adv Exp Med Biol 661:171-85. 2010..This book chapter will review the role of such a metabolic shift in the pathophysiology of PAH and also highlight emerging anti-proliferative PAH therapies that correct the metabolic dysregulation in PAH...
- Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertensionStuart Rich
Department of Medicine, University of Chicago, Section of Cardiology, 5841 S Maryland Ave, Ste LO 8 MC 5403, Chicago, IL 60637, USA
Chest 138:1234-9. 2010..Remarkably, the RV was able to sustain a normal cardiac output in the face of advanced vascular pathology. The mechanisms by which the RV adapts to chronic PAH need further study...
- The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent mannerDaniel I Levy
Department of Medicine, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
J Physiol 588:2657-68. 2010..Thus, regional heterogeneity in cardiac expression of MiRP3, Kv4.2 and KChIP2 in health and disease may establish the local attributes and magnitude of cardiac I(to)...
- Acute oxygen-sensing mechanismsE Kenneth Weir
Department of Medicine, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA
N Engl J Med 353:2042-55. 2005
- Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertensionDalia Urboniene
Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol Lung Cell Mol Physiol 299:L401-12. 2010..These tools are useful for assessment of the rodent pulmonary circulation and RVH...
- Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertensionSonal Chandra
Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois
J Heart Lung Transplant 29:181-7. 2010..Little is known of its prognostic utility in World Health Organization (WHO) Group I PAH...
- Value of exercise treadmill testing in the risk stratification of patients with pulmonary hypertensionSanjiv J Shah
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Circ Heart Fail 2:278-86. 2009..The ability of the Naughton-Balke exercise treadmill test, an objective indicator of exercise capacity, to predict abnormal hemodynamics and mortality in pulmonary hypertension is unknown...
- Association of serum creatinine with abnormal hemodynamics and mortality in pulmonary arterial hypertensionSanjiv J Shah
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60637, USA
Circulation 117:2475-83. 2008..Renal dysfunction predicts mortality in patients with cardiovascular disease. How renal dysfunction relates to hemodynamics and mortality in pulmonary arterial hypertension (PAH) remains unclear...
- Diagnosis and management of pulmonary hypertension in systemic sclerosisNadera J Sweiss
Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue MC6080, Chicago, IL 60637, USA
Curr Rheumatol Rep 12:8-18. 2010..Approved therapies include prostacyclins, endothelin antagonists, and phosphodiesterase type 5 inhibitors. Research is needed to define disease mechanisms and develop effective therapies...
- Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen speciesE Kenneth Weir
Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, USA
J Appl Physiol 101:995-8; discussion 998. 2006
- O2 Sensing in the Ductus ArteriosusStephen Archer; Fiscal Year: 2007..3) Augmenting expression of O2-sensitive, DASMC Kv channels in preterm or ionically remodeled DA (using an SMC-specific adenovirus) will enhance 02 constriction. ..
- O2 sensing in the human and rabbit ductus arteriosusStephen L Archer; Fiscal Year: 2010..Hidden by its complex encoding mechanism within the collagen a2(1) gene HOSK has a unique structure and explain how O2 causes functional closure of the DA and extend our basic knowledge of K+ channel structure/function. ..