Research Topics
Species | Saman ArbabiSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Priming interleukin 8 production: role of platelet-activating factor and p38S Arbabi
Department of Surgery, University of Washington, Seattle 98195, USA
Arch Surg 134:1348-53. 1999..Platelet-activating factor (PAF) activates p38, an important intracellular signal transduction kinase, and primes human mononuclear cells for the production of interleukin 8 (IL-8), a potent chemoattractant and activator of neutrophils...- Beta-blocker use is associated with improved outcomes in adult trauma patientsSaman Arbabi
Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
J Trauma 62:56-61; discussion 61-2. 2007..We hypothesized that beta-blockers are safe in trauma patients, even if they have suffered a significant head injury... - Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancerS Arbabi
Department of Surgery, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Surg Res 97:60-4. 2001..We further investigated the transduction cascades mediating COX-2 expression, focusing upon the mitogen-activated protein kinase pathways p38 and extracellular signal-regulated kinase (ERK)... - Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiologyMark R Hemmila
Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
J Trauma 61:598-605; discussion 605-6. 2006..We postulate that LBP knockout mice will develop derangements in lung physiology from gram-negative pneumonia and that these changes can be reversed with systemic LBP gene therapy... 
Topical p38 MAPK inhibition reduces bacterial growth in an in vivo burn wound modelKyros Ipaktchi
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Surgery 142:86-93. 2007..We now question whether attenuating local inflammation would weaken bacterial wound resistance and compromise host defense...- Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injuryKyros Ipaktchi
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 177:8065-71. 2006..Attenuating local inflammatory signaling appears effective in reducing SIRS and subsequent systemic complications after burn injury... 
Intensive insulin therapy is associated with reduced infectious complications in burn patientsMark R Hemmila
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 5033, USA
Surgery 144:629-35; discussion 635-7. 2008..We sought to evaluate our experience with intensive insulin therapy in burn-injured ICU patients with regard to mortality, morbidity, and use of hospital resources...- A comparison of prehospital and hospital data in trauma patientsSaman Arbabi
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
J Trauma 56:1029-32. 2004..We hypothesized that ED and Fd physiologic parameters are equally valid predictors of outcomes. In addition, we hypothesized that early field intubation will improve survival compared with later ED intubation... - Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia modelKyros Ipaktchi
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Crit Care Med 35:2139-44. 2007..We hypothesized that this topical intervention would attenuate burn-induced lung injury, improve pulmonary function, protect lungs from bacterial invasion, and reduce mortality... - Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficitsAndreas D Niederbichler
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 5033, USA
J Surg Res 165:128-35. 2011..In this study, we sought to determine the effect of recombinant rat LBP (rLBP) on cardiomyocyte sarcomere function after burn or sham injury in the presence or absence of bacterial endotoxin... - Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injuryMark R Hemmila
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5033, USA
Surgery 148:499-509. 2010..In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following thermal injury... - Altered Kupffer cell function in biliary obstructionRebecca M Minter
Veterans Administration Ann Arbor Healthcare Systems, Department of Surgery, University of Michigan Medical School, 48109 0331, USA
Surgery 138:236-45. 2005..Few studies, however, have directly examined KC function. We have sought to define the specific alterations in function and phenotype that occur in the KC after biliary obstruction... - Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunctionLaszlo M Hoesel
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
Surgery 146:775-85; discussion 785-6. 2009..Topical inhibition of activated p38 MAPK within burn wounds attenuates the local and systemic inflammatory response. In this study, we investigated the effects of local activated p38 MAPK inhibition on burn-induced cardiac dysfunction... - Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn woundsKyros Ipaktchi
Department of Surgery, Burn Center, University of Michigan Medical School, Ann Arbor, MI 48109-0033, USA
Shock 26:201-9. 2006..Blunting early excessive inflammatory signaling may be an efficient strategy to improve patient outcomes after burn injury... - National variation in outcomes and costs for splenic injury and the impact of trauma systems: a population-based cohort studyChristian A Hamlat
Harborview Injury Prevention and Research Center, Department of Surgery, University of Washington and Harborview Medical Center, Seattle, WA, USA
Ann Surg 255:165-70. 2012..To measure national variation in splenectomy rates, mortality, and costs for hospitalized patients with splenic injury and the impact of state trauma systems on these outcomes... - Beta-blocker use is associated with improved outcomes in adult burn patientsSaman Arbabi
Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
J Trauma 56:265-9; discussion 269-71. 2004..However, beta-blockers decrease cardiac output and may decrease oxygen delivery, and theoretically may increase mortality. What is the effect of beta-blockers on healing time and mortality in burn patients?.. - Detecting the blind spot: complications in the trauma registry and trauma quality improvementMark R Hemmila
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0033, USA
Surgery 142:439-48; discussion 448-9. 2007..We sought to apply the NSQIP methodology to collect comorbidity and outcome data for trauma patients. Data were compared to the NTDB to determine the benefit and validity of using the NSQIP methodology for trauma... - Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profileAndreas D Niederbichler
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Shock 25:176-83. 2006..These results demonstrate that LPS exposure and burn injury independently decrease peak cardiac shortening. These decreases did not directly correlate with the levels of cytokines released in response to each stressor... - Does bronchoalveolar lavage enhance our ability to treat ventilator-associated pneumonia in a trauma-burn intensive care unit?Wendy L Wahl
Department of Surgery, University of Michigan Health System, Ann Arbor 48109 0033, USA
J Trauma 54:633-8; discussion 638-9. 2003..We hypothesized that BAL would decrease the number of cases of VAP diagnosed and impact our antibiotic use and ventilator days... - Effect of patient load on trauma outcomes in a Level I trauma centerSaman Arbabi
Department of Surgery, University of Michigan, Ann Arbor, USA
J Trauma 59:815-8; discussion 819-20. 2005..The goal of the study was to see whether trauma patients admitted during 'high' patient-load periods, at night, or on weekends had worse outcomes... - The cushion effectSaman Arbabi
Department of Surgery, University of Michigan Health System, Ann Arbor, USA
J Trauma 54:1090-3. 2003..Human body characteristics such as height and weight may play an important role. We hypothesized that body mass index (BMI) will influence crash injury patterns... - Angioembolization reduces operative intervention for blunt splenic injuryBenjamin Wei
Department of Surgery, Henry Ford Health System Detroit, Michigan, USA
J Trauma 64:1472-7. 2008..We postulated that splenic AE for BSI would have superior outcomes compared with operation and increase our splenic salvage rate... - Delayed repair for blunt thoracic aortic injury: is it really equivalent to early repair?Mark R Hemmila
Department of Surgery, University of Michigan Health System, Ann Arbor, 48109 0033, USA
J Trauma 56:13-23. 2004.... - Impact of operative intervention delay on pediatric trauma outcomesGiana H Davidson
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, WA, USA
J Trauma Acute Care Surg 73:162-7. 2012.... - Intensive care unit core measures improve infectious complications in burn patientsWendy L Wahl
Department of Surgery, Trauma Burn Center, University of Michigan Health System, Ann Arbor, MI 481099, USA
J Burn Care Res 31:190-5. 2010.... - Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activationRichard P Darveau
Department of Periodontics, University of Washington, Seattle, Washington 98181, USA
Infect Immun 70:1867-73. 2002..These data also suggest that although LPS is generally considered a bacterial component that alerts the host to infection, LPS from P. gingivalis may selectively modify the host response as a means to facilitate colonization... - Long-term survival of adult trauma patientsGiana H Davidson
Harborview Injury Prevention and Research Center, and Department of Surgery, University of Washington, Seattle, USA
JAMA 305:1001-7. 2011..To date, there have been few large studies evaluating long-term mortality in trauma patients and identifying predictors that increase risk for death following hospital discharge... - Mitogen-activated protein kinases in the intensive care unit: prognostic potentialMatthew R Rosengart
Department of Surgery, University of Washington, Seattle, USA
Ann Surg 237:94-100. 2003..To evaluate the prognostic significance of the activational status of p38, specifically progression to multiple organ dysfunction syndrome (MODS), in a group of severely injured trauma patients... - Duration of antibiotic therapy for ventilator-associated pneumonia in burn patientsWendy L Wahl
University of Michigan Health System, Department of Surgery, Ann Arbor, MI 48109, USA
J Burn Care Res 30:801-6. 2009..In patients without virulent pathogens, a shorter antibiotic course was well-tolerated without recurrences... - Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic salineValerie Schaeffer
Harborview Medical Center, University of Washington, Seattle, Washington 98109, USA
J Surg Res 171:769-76. 2011..In addition, we studied the effect of hypertonic saline solution (HTS) on the mTOR cascade in peripheral blood mononuclear cells (PBMCs)... - The macrophage response to endotoxin requires platelet activating factorEileen M Bulger
Department of Surgery, University of Washington, Seattle, USA
Shock 17:173-9. 2002..Macrophage cytokine production in response to endotoxin is PAF dependent. This effect involves the inhibition of TNF gene transcription and concomitant inhibition of NF-kappaB... - Compliance with Centers for Disease Control and Prevention field triage guidelines in an established trauma systemAlexis M Gage
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
J Am Coll Surg 215:148-54; discussion 154-6. 2012..Regionalization of trauma care reduces mortality and has clear guidelines for transport to the highest level of trauma care. Whether prehospital providers follow the CDC triage algorithm remains to be determined... - Normal D-dimer levels do not exclude thrombotic complications in trauma patientsWendy L Wahl
Department of Surgery, Trauma Burn Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0033, USA
Surgery 134:529-32; discussion 532-3. 2003..Patients with clinical signs and symptoms of DVT or PE in the immediate postinjury phase should undergo further screening to exclude thromboembolic complications... - Patient outcomes in academic medical centers: influence of fellowship programs and in-house on-call attending surgeonSaman Arbabi
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Arch Surg 138:47-51; discussion 51. 2003..We were interested in 2 such policies or characteristics that are commonly implemented in academic centers: an in-house on-call attending physician policy and the existence of postgraduate medical education... - Drotrecogin alfa in patients with burns and soft tissue injuryMelissa E Brunsvold
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
J Burn Care Res 29:676-8. 2008 - Oxidant alterations in CD16 expression are cytoskeletal inducedJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
Shock 32:572-7. 2009.... - Introduction to propensity scores: A case study on the comparative effectiveness of laparoscopic vs open appendectomyMark R Hemmila
Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109 5033, USA
Arch Surg 145:939-45. 2010..To demonstrate the use of propensity scores to evaluate the comparative effectiveness of laparoscopic and open appendectomy... - Improved survival in mice given systemic gene therapy in a gram negative pneumonia modelMark R Hemmila
Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
J Trauma 58:1110-8; discussion 1118. 2005..We postulate that systemic LBP gene therapy will reconstitute a protective innate immune response in LBP knockout mice and that overexpression of LBP in wild-type mice may offer a survival advantage... - Extracorporeal life support for severe acute respiratory distress syndrome in adultsMark R Hemmila
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Ann Surg 240:595-605; discussion 605-7. 2004..The objective of this study was to evaluate our experience with ECLS in adult patients with severe ARDS with respect to mortality and morbidity... - Active surveillance cultures of methicillin-resistant Staphylococcus aureus as a tool to predict methicillin-resistant S. aureus ventilator-associated pneumoniaJeannie D Chan
Department of Pharmacy, Harborview Medical Center and School of Pharmacy, University of Washington, Seattle, WA, USA
Crit Care Med 40:1437-42. 2012..aureus colonization in predicting the development of methicillin-resistant S. aureus ventilator-associated pneumonia... 
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunctionAndreas D Niederbichler
Department of Surgery, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Exp Med 203:53-61. 2006..These data suggest that CLP induces C5aR on cardiomyocytes and that in vivo generation of C5a causes C5a-C5aR interaction, causing dysfunction of cardiomyocytes, resulting in compromise of cardiac performance...- The actin cytoskeleton: an essential component for enhanced TNFalpha production by adherent monocytesMatthew R Rosengart
Department of Surgery, University of Washington, Seattle 98104, USA
Shock 17:109-13. 2002..In conclusion, the actin cytoskeleton is integral in the reprogramming of the monocyte for enhanced cytokine production and in maintaining this "primed" state... - Identifying survivors with traumatic craniocervical dissociation: a retrospective studyZara Cooper
Department of Surgery, Brigham and Women s Medical Center, Harvard University, Boston, Massachusetts 02115, USA
J Surg Res 160:3-8. 2010..Our aim was to identify survivors of CCD based on clinical presentation... - Decreased juvenile arson and firesetting recidivism after implementation of a multidisciplinary prevention programGlen A Franklin
Department of Surgery, Division of Trauma, Burn and Emergency Surgery, University of Michigan, Ann Arbor, Michigan, USA
J Trauma 53:260-4; discussion 264-6. 2002..The purpose of this study was to determine the value of this trauma burn center prevention program from a financial, clinical, and recidivism perspective... - Possibilities and challenges in occupational injury surveillance of day laborersSarah J Lowry
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
Am J Ind Med 53:126-34. 2010..We sought to determine the degree of completeness of work information in the medical records, and to identify day laborers and contingent workers to the extent possible... - Mitogen-activated protein kinasesSaman Arbabi
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Crit Care Med 30:S74-9. 2002..A major challenge is to elucidate the principles by which the network is assembled, so a more tissue- and temporal-specific approach can be used... - Re-laparotomy for severe intra-abdominal infectionsKatherine Mandell
Department of Surgery, University of Washington and Harborview Medical Center, Seattle, Washington 98104, USA
Surg Infect (Larchmt) 11:307-10. 2010..The role of re-laparotomy in the management of intra-abdominal infection remains controversial. Two strategies have been used: Planned re-laparotomy or laparotomy on demand... - Restrictive red blood cell transfusion: not just for the stable intensive care unit patientWendy L Wahl
Trauma Burn Center, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48190 5539, USA
Am J Surg 195:803-6. 2008..We hypothesized that a RBC transfusion guideline would safely decrease our use of RBC transfusions in the ICU and lower the hematocrit at which our trauma and burn patients were transfused, both in the stable and symptomatic patient... - Mean glucose values predict trauma patient mortalityWendy L Wahl
Trauma Burn Center, University of Michigan Health System, Ann Arbor, Michigan, USA
J Trauma 65:42-7; discussion 47-8. 2008..We postulated targeted therapy to achieve glucose levels <140 mg/dL would reduce infectious complications and mortality in trauma patients admitted to the intensive care unit (ICU)... - Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in miceGrace L Su
Medical Service, Department of Veterans Affairs Medical Center and the Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Hepatology 41:187-95. 2005..This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/O270-9139/suppmat/index.html)... - Evaluation of hyaluronan from different sources: Streptococcus zooepidemicus, rooster comb, bovine vitreous, and human umbilical cordAviva Shiedlin
Genzyme Corporation, Cambridge, Massachusetts 02139, USA
Biomacromolecules 5:2122-7. 2004..These results indicate that the source of HA should be considered due to differences in the amounts and types of contaminants that could lead to widely different behaviors in vitro and in vivo... - Advances in burn critical careKyros Ipaktchi
University of Michigan Burn Center, Ann Arbor, MI, USA
Crit Care Med 34:S239-44. 2006..Although immunomodulation therapy is promising, currently most of these treatments are not clinically viable, and further clinical and translational research is warranted... - Use of computerized ICU documentation to capture ICU core measuresWendy Lynn Wahl
Trauma Burn Center, University of Michigan Health System, Ann Arbor, Mich, USA
Surgery 140:684-9; discussion 690. 2006..We hypothesized that use of our current computerized ICU flowsheet could provide timely, accurate data on ICU core measures without additional personnel dedicated to data capture... - C5a-blockade improves burn-induced cardiac dysfunctionLaszlo M Hoesel
Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
J Immunol 178:7902-10. 2007..These results suggest a linkage between C5a and burn-induced cardiac dysfunction and a possible contribution of LPS to these events...
Research Grants
- Role of Signal Transduction in Burn and Wound HealingSaman Arbabi; Fiscal Year: 2006..The candidate will gain knowledge of advanced techniques under the tutlelage of Dr. Stewart C. Wang, while working on the research proposal. The goal is for the candidate to become an independent researcher with his own grants. ..
- Controlling the Source of Inflammatory Signaling in a Burn ModelSaman Arbabi; Fiscal Year: 2009..This promising therapy may have a significant impact in decreasing the morbidity and mortality of these victims. ..
- Controlling the Source of Inflammatory Signaling in a Burn ModelSaman Arbabi; Fiscal Year: 2010..This promising therapy may have a significant impact in decreasing the morbidity and mortality of these victims. ..