Genomes and Genes
Affiliation: University of California
- Messenger RNA targeting to endoplasmic reticulum stress signalling sitesTOMAS ARAGON
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158 2517, USA
Nature 457:736-40. 2009..Translational repression afforded by the intron fulfils this requirement for HAC1 mRNA. Recruitment of mRNA to signalling centres provides a new paradigm for the control of eukaryotic gene expression...
- BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein responseDavid Pincus
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, United States of America
PLoS Biol 8:e1000415. 2010..By contrast, BiP provides a buffer for inactive Ire1 molecules that ensures an appropriate response to restore protein folding homeostasis to the ER by modulating the sensitivity and dynamics of Ire1 activity...
- Clostridial myonecrosis cluster among injection drug users: a molecular epidemiology investigationDavid R Bangsberg
Epidemiology and Prevention Interventions Center, Box 1372, Room 301, Bldg 100, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
Arch Intern Med 162:517-22. 2002..Other C perfringens isolates from patients, heroin, and the environment were determined to be polyclonal. We postulate that rapid recognition and public health notification led to rapid resolution of the outbreak...
- The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasisPhilipp Kimmig
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States
elife 1:e00048. 2012..Thus, S. pombe uses a universally conserved stress-sensing machinery in novel ways to maintain homeostasis in the ER.DOI:http://dx.doi.org/10.7554/eLife.00048.001...