Research Topics
Species | L G ApostolovaSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairmentLiana Apostolova
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Neurobiol Aging 33:2113-24. 2012..Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD...
Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer DiseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Alzheimer Dis Assoc Disord 26:17-27. 2012..Aging affects both the hippocampus and lateral ventricles independent of AD pathology, and should be included as covariate in all structural, hippocampal, and ventricular analyses when possible...- Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairmentLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, CA, United States
Neuropsychologia 46:1597-612. 2008..We give an overview of some recent neuroimaging advances in AD and MCI and discuss strengths and weaknesses of the various analytic approaches... 
Deep white matter pathologic features in watershed regions: a novel pattern of central nervous system involvement in MELASLiana G Apostolova
Department of Neurology, University of California, Los Angeles, USA
Arch Neurol 62:1154-6. 2005..Magnetic resonance imaging (MRI) abnormalities typically involve the cortical gray and the adjacent subcortical white matter...- Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normalLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
Neurobiol Aging 31:1077-88. 2010.... - Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderlyLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 10911 Weyburn Avenue, Los Angeles, CA 90095, USA
Mol Imaging Biol 12:218-24. 2010..The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly... - Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjectsLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Neuroimage 51:488-99. 2010..After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution... - 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCILiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
Hum Brain Mapp 31:786-97. 2010..Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses... - Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementiaLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, California, USA
Mov Disord 25:687-95. 2010..Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement... - 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjectsLiana G Apostolova
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Neurobiol Aging 31:1284-303. 2010..p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy... - Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literatureLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, USA
Dement Geriatr Cogn Disord 25:115-26. 2008..MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI... - Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer diseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 10911 Westwood Blvd, Second Floor, Los Angeles, CA 90095, USA
Arch Neurol 64:1489-95. 2007..Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to dementia at a rate of 10% to 15% per year. Patients with AD and MCI experience progressive brain atrophy... - 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer diseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Alzheimer Dis Assoc Disord 20:224-31. 2006..As a global cognitive measure, MMSE depends on the integrity of widely distributed cortical areas in both brain hemispheres with left-sided predominance... - 3D mapping of language networks in clinical and pre-clinical Alzheimer's diseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
Brain Lang 104:33-41. 2008..Using a novel 3D mapping technique, we demonstrated that in AD language abilities are strongly influenced by the integrity of the perisylvian cortical regions... - Multiple system atrophy presenting with language impairmentL G Apostolova
Department of Neurology, University of California Los Angeles, USA
Neurology 67:726-7. 2006 - 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's diseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine UCLA, CA, USA
Brain 129:2867-73. 2006..Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool... - Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy mapsLiana G Apostolova
Laboratory of Neuro Imaging, Department of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA
Arch Neurol 63:693-9. 2006..While most patients with mild cognitive impairment (MCI) transition to Alzheimer disease (AD), others develop non-AD dementia, remain in the MCI state, or improve... - Structural correlates of apathy in Alzheimer's diseaseLiana G Apostolova
Department of Neurology, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Dement Geriatr Cogn Disord 24:91-7. 2007..Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described... - Brain mapping as a tool to study neurodegenerationLiana G Apostolova
Department of Neurology and Laboratory of NeuroImaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
Neurotherapeutics 4:387-400. 2007..Applications to AD and other dementias are discussed, with a brief review of related findings in other neurological and neuropsychiatric illnesses, including epilepsy, HIV/AIDS, schizophrenia, and disorders of brain development... - Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Hum Brain Mapp 30:2766-88. 2009..Forty subjects were sufficient to discriminate AD from normal and correlate atrophy with CDR scores; 104, 200, and 304 subjects, respectively, were required to correlate MMSE with atrophy, to distinguish MCI from normal, and MCI from AD... - Computational anatomical methods as applied to ageing and dementiaP M Thompson
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Br J Radiol 80:S78-91. 2007..Finally, we indicate which computational methods are powerful enough to track dementia in clinical trials, on the basis of their efficiency and sensitivity to early change, and the detail in the measures they provide... - Automatic subcortical segmentation using a contextual modelJonathan H Morra
Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
Med Image Comput Comput Assist Interv 11:194-201. 2008.... - Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 45:S3-15. 2009..They also reveal genetically greater atrophy in cognitively intact subjects... - Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 43:59-68. 2008..Our error metrics compare favorably with those previously reported for other automated hippocampal segmentations, suggesting the utility of the approach for large-scale studies... - Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?Bernhard H Monien
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Neuroscience Research Building 1, Room 455, 635 Charles E Young Drive South Los Angeles, CA 90095 7334, USA
Expert Rev Neurother 6:1293-306. 2006..Nevertheless, new insights into the earliest events that lead to development of AD increase hope that reliable diagnostics and efficacious therapies may emerge... - Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutationsJohn M Ringman
UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
Brain 130:1767-76. 2007..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease... - Comparison of AdaBoost and support vector machines for detecting Alzheimer's disease through automated hippocampal segmentationJonathan H Morra
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095, USA
IEEE Trans Med Imaging 29:30-43. 2010..We also evaluated how segmentation accuracy depended on the size of the training set, providing practical information for future users of this technique... - Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutationJohn M Ringman
Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
Neurosci Lett 487:287-92. 2011..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...
Research Grants
- Structural MRI outcome predictors in MCILiana Apostolova; Fiscal Year: 2007....