L G Apostolova

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI donepezil/vitamin E study
    Liana G Apostolova
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 27:174-81. 2013
  2. doi request reprint Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment
    Liana Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurobiol Aging 33:2113-24. 2012
  3. pmc Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 26:17-27. 2012
  4. ncbi request reprint Deep white matter pathologic features in watershed regions: a novel pattern of central nervous system involvement in MELAS
    Liana G Apostolova
    Department of Neurology, University of California, Los Angeles, USA
    Arch Neurol 62:1154-6. 2005
  5. pmc Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Neurobiol Aging 31:1077-88. 2010
  6. pmc Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 10911 Weyburn Avenue, Los Angeles, CA 90095, USA
    Mol Imaging Biol 12:218-24. 2010
  7. pmc Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroimage 51:488-99. 2010
  8. pmc 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Hum Brain Mapp 31:786-97. 2010
  9. pmc Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, California, USA
    Mov Disord 25:687-95. 2010
  10. pmc 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Neurobiol Aging 31:1284-303. 2010

Research Grants

  1. Structural MRI outcome predictors in MCI
    Liana Apostolova; Fiscal Year: 2007

Detail Information

Publications29

  1. pmc Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI donepezil/vitamin E study
    Liana G Apostolova
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 27:174-81. 2013
    ..After correction for baseline hippocampal volume, decline in ADL showed a significant association with right frontal horn enlargement. Executive decline was associated with right frontal and left temporal horn enlargement...
  2. doi request reprint Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment
    Liana Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurobiol Aging 33:2113-24. 2012
    ..Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD...
  3. pmc Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 26:17-27. 2012
    ..Aging affects both the hippocampus and lateral ventricles independent of AD pathology, and should be included as covariate in all structural, hippocampal, and ventricular analyses when possible...
  4. ncbi request reprint Deep white matter pathologic features in watershed regions: a novel pattern of central nervous system involvement in MELAS
    Liana G Apostolova
    Department of Neurology, University of California, Los Angeles, USA
    Arch Neurol 62:1154-6. 2005
    ..Magnetic resonance imaging (MRI) abnormalities typically involve the cortical gray and the adjacent subcortical white matter...
  5. pmc Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Neurobiol Aging 31:1077-88. 2010
    ....
  6. pmc Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 10911 Weyburn Avenue, Los Angeles, CA 90095, USA
    Mol Imaging Biol 12:218-24. 2010
    ..The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly...
  7. pmc Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroimage 51:488-99. 2010
    ..After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution...
  8. pmc 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Hum Brain Mapp 31:786-97. 2010
    ..Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses...
  9. pmc Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, California, USA
    Mov Disord 25:687-95. 2010
    ..Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement...
  10. pmc 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Neurobiol Aging 31:1284-303. 2010
    ..p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy...
  11. pmc Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairment
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, United States
    Neuropsychologia 46:1597-612. 2008
    ..We give an overview of some recent neuroimaging advances in AD and MCI and discuss strengths and weaknesses of the various analytic approaches...
  12. ncbi request reprint Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, USA
    Dement Geriatr Cogn Disord 25:115-26. 2008
    ..MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI...
  13. pmc Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 10911 Westwood Blvd, Second Floor, Los Angeles, CA 90095, USA
    Arch Neurol 64:1489-95. 2007
    ..Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to dementia at a rate of 10% to 15% per year. Patients with AD and MCI experience progressive brain atrophy...
  14. ncbi request reprint 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 20:224-31. 2006
    ..As a global cognitive measure, MMSE depends on the integrity of widely distributed cortical areas in both brain hemispheres with left-sided predominance...
  15. pmc 3D mapping of language networks in clinical and pre-clinical Alzheimer's disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Brain Lang 104:33-41. 2008
    ..Using a novel 3D mapping technique, we demonstrated that in AD language abilities are strongly influenced by the integrity of the perisylvian cortical regions...
  16. ncbi request reprint Multiple system atrophy presenting with language impairment
    L G Apostolova
    Department of Neurology, University of California Los Angeles, USA
    Neurology 67:726-7. 2006
  17. ncbi request reprint Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps
    Liana G Apostolova
    Laboratory of Neuro Imaging, Department of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA
    Arch Neurol 63:693-9. 2006
    ..While most patients with mild cognitive impairment (MCI) transition to Alzheimer disease (AD), others develop non-AD dementia, remain in the MCI state, or improve...
  18. ncbi request reprint 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine UCLA, CA, USA
    Brain 129:2867-73. 2006
    ..Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool...
  19. ncbi request reprint Structural correlates of apathy in Alzheimer's disease
    Liana G Apostolova
    Department of Neurology, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Dement Geriatr Cogn Disord 24:91-7. 2007
    ..Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described...
  20. pmc Brain mapping as a tool to study neurodegeneration
    Liana G Apostolova
    Department of Neurology and Laboratory of NeuroImaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Neurotherapeutics 4:387-400. 2007
    ..Applications to AD and other dementias are discussed, with a brief review of related findings in other neurological and neuropsychiatric illnesses, including epilepsy, HIV/AIDS, schizophrenia, and disorders of brain development...
  21. pmc Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
    Jonathan H Morra
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Hum Brain Mapp 30:2766-88. 2009
    ..Forty subjects were sufficient to discriminate AD from normal and correlate atrophy with CDR scores; 104, 200, and 304 subjects, respectively, were required to correlate MMSE with atrophy, to distinguish MCI from normal, and MCI from AD...
  22. doi request reprint Computational anatomical methods as applied to ageing and dementia
    P M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Br J Radiol 80:S78-91. 2007
    ..Finally, we indicate which computational methods are powerful enough to track dementia in clinical trials, on the basis of their efficiency and sensitivity to early change, and the detail in the measures they provide...
  23. pmc Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
    Jonathan H Morra
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 45:S3-15. 2009
    ..They also reveal genetically greater atrophy in cognitively intact subjects...
  24. ncbi request reprint Automatic subcortical segmentation using a contextual model
    Jonathan H Morra
    Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
    Med Image Comput Comput Assist Interv 11:194-201. 2008
    ....
  25. pmc Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls
    Jonathan H Morra
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 43:59-68. 2008
    ..Our error metrics compare favorably with those previously reported for other automated hippocampal segmentations, suggesting the utility of the approach for large-scale studies...
  26. pmc Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?
    Bernhard H Monien
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Neuroscience Research Building 1, Room 455, 635 Charles E Young Drive South Los Angeles, CA 90095 7334, USA
    Expert Rev Neurother 6:1293-306. 2006
    ..Nevertheless, new insights into the earliest events that lead to development of AD increase hope that reliable diagnostics and efficacious therapies may emerge...
  27. pmc Comparison of AdaBoost and support vector machines for detecting Alzheimer's disease through automated hippocampal segmentation
    Jonathan H Morra
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095, USA
    IEEE Trans Med Imaging 29:30-43. 2010
    ..We also evaluated how segmentation accuracy depended on the size of the training set, providing practical information for future users of this technique...
  28. ncbi request reprint Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
    John M Ringman
    UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Brain 130:1767-76. 2007
    ..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease...
  29. pmc Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
    Neurosci Lett 487:287-92. 2011
    ..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...

Research Grants2

  1. Structural MRI outcome predictors in MCI
    Liana Apostolova; Fiscal Year: 2007
    ....