Research Topics
Genomes and GenesSpecies | Richard AplencSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort studyPriya P Gor
Center for Cancer and Hematologic Disease, 1930 E Route 70, Cherry Hill, NJ 08003, USA
Breast Cancer Res 12:R26. 2010..We hypothesize that functional single nucleotide polymorphisms (SNPs) in drug metabolizing enzymes (DMEs) that activate (CYPs) or metabolize (GSTs) cyclophosphamide account for some of the observed variability in disease outcomes...
Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology GroupRichard Aplenc
Children s Hospital of Philadelphia, Center for Clinical Epidemiology Biostatistic, 3615 Civic Center Blvd, 916G ARC, Philadelphia, PA 19104 4318, USA
J Clin Oncol 26:2390-3295. 2008....- Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortiumRichard Aplenc
MSCE, The Children s Hospital of Philadelphia, Pediatric Oncology Stem Cell Transplant, Philadelphia, PA 19104 4318, USA
J Clin Oncol 29:839-44. 2011..CONCLUSION Overall, drug disposition and tolerability of dasatinib were similar to those observed in adult patients... - Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major traumaMelanie Rushefski
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
BMC Med Genet 12:77. 2011..Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma... - Low-dose, high-frequency CPR training improves skill retention of in-hospital pediatric providersRobert M Sutton
Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, 7th Floor, Central Wing 7C09 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatrics 128:e145-51. 2011..We hypothesized that a low-dose, high-frequency training program (booster training) would improve CPR skill retention... 
Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941Beverly J Lange
Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Clin Oncol 22:150-6. 2004..Remission induction, survival, and event-free survival rates were not significantly different from those of CCG-2891. CONCLUSION: In CCG-2941, excessive toxicity and withdrawals outweighed potential benefits of early response with IDA...- Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology GroupRichard Aplenc
Pediatric Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Blood 108:74-80. 2006..Fewer black children than expected had an available family marrow donor... - Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort studyBrian T Fisher
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatr Blood Cancer 55:655-61. 2010..This study aims to evaluate the rate of ARF in AML patients and to delineate the impact of age, race, various co-morbid conditions and antimicrobial agents on the development of ARF... - SNP-set analysis replicates acute lung injury genetic risk factorsNuala J Meyer
Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
BMC Med Genet 13:52. 2012..We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations... - Germline genetic variation and treatment response on CCG-1891Dana M Sepe
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
Pediatr Blood Cancer 58:695-700. 2012..We sought to extend current knowledge by using standard and novel statistical methodology to examine polymorphic variants of genes and relapse risk, toxicity, and drug dose delivery in standard risk ALL... - Unrelated donor bone marrow transplantation for children with acute myeloid leukemia beyond first remission or refractory to chemotherapyNancy J Bunin
Children s Hospital of Philadelphia, Philadelphia, USA
J Clin Oncol 26:4326-32. 2008..Identify prognostic factors that influence outcome after unrelated donor bone marrow transplantation in children with acute myeloid leukemia (AML)... - Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major traumaJason D Christie
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 36:2794-800. 2008..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients... - CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemiaRichard Aplenc
Children s Hospital of Philadelphia, Philadelphia, University of Pennsylvania, PA, Children s Cancer Study Group, Arcadia, CA, USA
Br J Haematol 122:240-4. 2003..CYP3 genotypes may not significantly modify the risk of relapse in childhood ALL, but may modify the risk of toxicity... - CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancerCharnita Zeigler-Johnson
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Cancer Res 64:8461-7. 2004.... - Genetic polymorphisms of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian childrenRichard Aplenc
Pediatric Oncology/Stem Cell Transplant, Children's Hospital of Philadelphia, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Philadelphia, Pennsylvania, USA
Pediatr Blood Cancer 43:539-41. 2004 - Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohortAngela DeMichele
Department of Biostatistics and Epidemiology, Abramson Cancer Center, PA, USA
J Clin Oncol 23:5552-9. 2005..Genotypes in drug-metabolizing enzymes, including functional polymorphisms in cytochrome P450 (CYP) and glutathione S-transferases (GST), may predict treatment-related outcomes... - Pre-transplant lung function is predictive of survival following pediatric bone marrow transplantationJill P Ginsberg
Division of Oncology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
Pediatr Blood Cancer 54:454-60. 2010..We hypothesized that in children, as in adults, pre-transplant pulmonary function would also be predictive of outcome post-transplantation morbidity... - A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumorsElizabeth Fox
The Children s Hospital of Philadelphia, Division of Oncology CTRB4016, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA
J Clin Oncol 28:5174-81. 2010.... - Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancerAngela DeMichele
Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Cancer Res 69:4184-91. 2009..Kaplan-Meier plots show that all patients in this group relapsed by 24 months from diagnosis. This poor-risk haplotype was quite common overall (estimated frequency, 0.20) and twice as frequent among Blacks (estimated frequency, 0.41)... - ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratioNuala J Meyer
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 183:1344-53. 2011..Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI... - Survival by race among children with extracranial solid tumors in the United States between 1985 and 2005Kelsey A Johnson
School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pediatr Blood Cancer 56:425-31. 2011..The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was used to compare survival rates by race among children with common extracranial solid tumors between 1985 and 2005... - Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemiaRichard Aplenc
Children s Hospital of Philadelphia, PA 19104, USA
Cancer Res 65:2482-7. 2005..These data provide evidence that the MTHFR C677T polymorphism is a common genetic variant conferring a moderate relative risk and a high attributable risk for relapse in pediatric ALL patients... - Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivorsJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 3400 Spruce Street 2 Gates, Philadelphia, PA 19104, USA
Breast Cancer Res 13:R8. 2011.... - Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemiaRichard Aplenc
Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Br J Haematol 125:421-34. 2004..This review summarizes current research on the impact of genetic variation in drug-processing genes in paediatric ALL and reviews important methodological and statistical issues presently challenging the field of pharmacogenetics... - Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunctionJason D Christie
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 180:1010-5. 2009..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD... - The use of palliative chemotherapy in pediatric oncology patients: a national survey of pediatric oncologistsTammy I Kang
The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatr Blood Cancer 60:88-94. 2013..One factor that influences parental decisions to pursue medical therapies is physician preference. To date, no studies have described pediatric oncologists' perspectives and practices regarding palliative chemotherapy (PC)... - Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancerDimitri S Monos
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Hum Immunol 66:554-62. 2005.... - "Booster" training: evaluation of instructor-led bedside cardiopulmonary resuscitation skill training and automated corrective feedback to improve cardiopulmonary resuscitation compliance of Pediatric Basic Life Support providers during simulateRobert M Sutton
Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Pediatr Crit Care Med 12:e116-21. 2011..To investigate the effectiveness of brief bedside "booster" cardiopulmonary resuscitation (CPR) training to improve CPR guideline compliance of hospital-based pediatric providers... - Pharmacogenetics of gemtuzumab-associated hepatic sinusoidal occlusion syndrome after hematopoietic stem cell transplantRichard Aplenc
Pediatric Oncology, Children's Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
Acta Haematol 110:207-10. 2003 - Pharmacogenetics of acute lymphoblastic leukemia treatment responseLea Cunningham
Children s Hospital of Philadelphia, University of Pennsylvania, 916G ARC, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
Expert Opin Pharmacother 8:2519-31. 2007..Despite these recent advances, further work is needed to develop clinically useful genetic predictors of leukemia treatment response... - Cefepime and mortality in pediatric acute myelogenous leukemia: a retrospective cohort studyBrian T Fisher
Division of Infectious Diseases, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pediatr Infect Dis J 28:971-5. 2009..We evaluated the association of cefepime and other beta-lactam antibiotic exposures with all cause in-hospital mortality in pediatric AML patients... - Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemiaRobert J Arceci
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 2M51, Bunting Blaustein Cancer Research Bldg, 1650 Orleans St, Baltimore, MD 21231, USA
Blood 106:1183-8. 2005..Further studies in combination with standard induction therapy for childhood AML are warranted... - No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemiaJanez Jazbec
Department of Pediatrics, Unit of Oncology and Haematology, Medical Centre Ljubljana, Ljubljana, Slovenia
Leuk Lymphoma 46:893-7. 2005..43-5.31] or one polymorphic A1298C allele (OR 1; 95% CI 0.29?-?3.46). Our study suggests that MTHFR polymorphisms are not associated with increased risk of second cancer in children treated with high-dose methotrexate... - Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injuryJacqui M Marzec
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 21:2237-46. 2007..Furthermore, these findings may have important implications in other oxidative stress related illnesses... - In response to "Drug metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort"Angela DeMichele
J Clin Oncol 25:5675-7. 2007 - Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemiaParinda A Mehta
Division of Haematology Oncology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
Br J Haematol 137:152-7. 2007..We did not observe an association with IL-1alpha genotype in donor and/or recipient and transplant-outcome. These data suggest that the outcome of unrelated donor transplant for CML is not influenced by IL-1alpha genotype... - Inferior outcomes for overweight children undergoing allogeneic stem cell transplantationSean Bulley
Division of Haematology Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
Br J Haematol 140:214-7. 2008..5 +/- 3.2% in the non-overweight group (P = 0.02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight...
Research Grants
- GENETIC PREDICTORS OF LEUKEMIA THERAPY RESPONSERichard Aplenc; Fiscal Year: 2009..This application will identify and validate polymorphisms that modify ALL therapy outcome and will rigorously evaluate the additional predictive information captured in genotype data. ..
- Genetic Predictors of AML Treatment ResponseRichard Aplenc; Fiscal Year: 2010..Thus, this application may not only inform the care of adult and pediatric AML patients, but may also provide important insights into the translation of genotype data into patient care. ..