Richard Aplenc

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study
    Priya P Gor
    Center for Cancer and Hematologic Disease, 1930 E Route 70, Cherry Hill, NJ 08003, USA
    Breast Cancer Res 12:R26. 2010
  2. doi request reprint Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group
    Richard Aplenc
    Children s Hospital of Philadelphia, Center for Clinical Epidemiology Biostatistic, 3615 Civic Center Blvd, 916G ARC, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 26:2390-3295. 2008
  3. pmc Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium
    Richard Aplenc
    MSCE, The Children s Hospital of Philadelphia, Pediatric Oncology Stem Cell Transplant, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 29:839-44. 2011
  4. pmc Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States
    Marko Kavcic
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Cancer 119:1916-23. 2013
  5. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
  6. pmc SNP-set analysis replicates acute lung injury genetic risk factors
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
    BMC Med Genet 13:52. 2012
  7. pmc IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:950-9. 2013
  8. pmc Low-dose, high-frequency CPR training improves skill retention of in-hospital pediatric providers
    Robert M Sutton
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, 7th Floor, Central Wing 7C09 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 128:e145-51. 2011
  9. doi request reprint Induction mortality, ATRA administration, and resource utilization in a nationally representative cohort of children with acute promyelocytic leukemia in the United States from 1999 to 2009
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 61:68-73. 2014
  10. ncbi request reprint Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941
    Beverly J Lange
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Oncol 22:150-6. 2004

Research Grants

  1. GENETIC PREDICTORS OF LEUKEMIA THERAPY RESPONSE
    Richard Aplenc; Fiscal Year: 2009
  2. Genetic Predictors of AML Treatment Response
    Richard Aplenc; Fiscal Year: 2010

Detail Information

Publications47

  1. pmc Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study
    Priya P Gor
    Center for Cancer and Hematologic Disease, 1930 E Route 70, Cherry Hill, NJ 08003, USA
    Breast Cancer Res 12:R26. 2010
    ..We hypothesize that functional single nucleotide polymorphisms (SNPs) in drug metabolizing enzymes (DMEs) that activate (CYPs) or metabolize (GSTs) cyclophosphamide account for some of the observed variability in disease outcomes...
  2. doi request reprint Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group
    Richard Aplenc
    Children s Hospital of Philadelphia, Center for Clinical Epidemiology Biostatistic, 3615 Civic Center Blvd, 916G ARC, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 26:2390-3295. 2008
    ....
  3. pmc Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium
    Richard Aplenc
    MSCE, The Children s Hospital of Philadelphia, Pediatric Oncology Stem Cell Transplant, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 29:839-44. 2011
    ..Dose levels of 50, 65, 85, and 110 mg/m²/dose, administered orally twice daily for 28 days, with courses repeated without interruption, were studied. Pharmacokinetic studies were performed with the initial dose...
  4. pmc Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States
    Marko Kavcic
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Cancer 119:1916-23. 2013
    ..Moreover, these trials likely underreport the clinical toxicities experienced by patients...
  5. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
    ..Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma...
  6. pmc SNP-set analysis replicates acute lung injury genetic risk factors
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
    BMC Med Genet 13:52. 2012
    ..We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations...
  7. pmc IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:950-9. 2013
    ..Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete...
  8. pmc Low-dose, high-frequency CPR training improves skill retention of in-hospital pediatric providers
    Robert M Sutton
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, 7th Floor, Central Wing 7C09 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 128:e145-51. 2011
    ..We hypothesized that a low-dose, high-frequency training program (booster training) would improve CPR skill retention...
  9. doi request reprint Induction mortality, ATRA administration, and resource utilization in a nationally representative cohort of children with acute promyelocytic leukemia in the United States from 1999 to 2009
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 61:68-73. 2014
    ....
  10. ncbi request reprint Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941
    Beverly J Lange
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Oncol 22:150-6. 2004
    ..In Children's Cancer Group Pilot Study CCG-2941, we assessed toxicity and feasibility of substituting 4 mg of DNR with 1 mg of IDA in intensive-timing daunorubicin-based induction therapy (DNR/DNR) used in CCG-2891...
  11. doi request reprint Leveraging administrative data to monitor rituximab use in 2875 patients at 42 freestanding children's hospitals across the United States
    Marko Kavcic
    Division of Oncology, Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, and Department of Pediatrics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 162:1252-8, 1258.e1. 2013
    ..To describe the pharmacoepidemiology of rituximab use in children and to estimate the frequency of infectious events within a 1-year period after rituximab exposure...
  12. pmc Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group
    Richard Aplenc
    Pediatric Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 108:74-80. 2006
    ..Fewer black children than expected had an available family marrow donor...
  13. doi request reprint Dexrazoxane use in pediatric patients with acute lymphoblastic or myeloid leukemia from 1999 and 2009: analysis of a national cohort of patients in the Pediatric Health Information Systems database
    Dana M Walker
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 60:616-20. 2013
    ....
  14. doi request reprint Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 55:655-61. 2010
    ..This study aims to evaluate the rate of ARF in AML patients and to delineate the impact of age, race, various co-morbid conditions and antimicrobial agents on the development of ARF...
  15. doi request reprint Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
    David T Teachey
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 121:5154-7. 2013
    ..This trial was registered at www.clinicaltrials.gov as #NCT00103285. ..
  16. doi request reprint Variation in hospital antibiotic prescribing practices for children with acute lymphoblastic leukemia
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA fi
    Leuk Lymphoma 54:1633-9. 2013
    ..Antibiotic use for children with newly diagnosed ALL varies widely across children's hospitals and is not explained by demographics or illness severity...
  17. pmc Germline genetic variation and treatment response on CCG-1891
    Dana M Sepe
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Pediatr Blood Cancer 58:695-700. 2012
    ..We sought to extend current knowledge by using standard and novel statistical methodology to examine polymorphic variants of genes and relapse risk, toxicity, and drug dose delivery in standard risk ALL...
  18. pmc Unrelated donor bone marrow transplantation for children with acute myeloid leukemia beyond first remission or refractory to chemotherapy
    Nancy J Bunin
    Children s Hospital of Philadelphia, Philadelphia, USA
    J Clin Oncol 26:4326-32. 2008
    ..Identify prognostic factors that influence outcome after unrelated donor bone marrow transplantation in children with acute myeloid leukemia (AML)...
  19. ncbi request reprint Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:2794-800. 2008
    ..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients...
  20. ncbi request reprint CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer
    Charnita Zeigler-Johnson
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 64:8461-7. 2004
    ....
  21. ncbi request reprint CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia
    Richard Aplenc
    Children s Hospital of Philadelphia, Philadelphia, University of Pennsylvania, PA, Children s Cancer Study Group, Arcadia, CA, USA
    Br J Haematol 122:240-4. 2003
    ..CYP3 genotypes may not significantly modify the risk of relapse in childhood ALL, but may modify the risk of toxicity...
  22. ncbi request reprint Genetic polymorphisms of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian children
    Richard Aplenc
    Pediatric Oncology Stem Cell Transplant, Children s Hospital of Philadelphia, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 43:539-41. 2004
  23. ncbi request reprint Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort
    Angela DeMichele
    Department of Biostatistics and Epidemiology, Abramson Cancer Center, PA, USA
    J Clin Oncol 23:5552-9. 2005
    ..Genotypes in drug-metabolizing enzymes, including functional polymorphisms in cytochrome P450 (CYP) and glutathione S-transferases (GST), may predict treatment-related outcomes...
  24. pmc Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database
    Marko Kavcic
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 60:508-11. 2013
    ..7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML...
  25. doi request reprint Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
    Angela DeMichele
    Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cancer Res 69:4184-91. 2009
    ..Kaplan-Meier plots show that all patients in this group relapsed by 24 months from diagnosis. This poor-risk haplotype was quite common overall (estimated frequency, 0.20) and twice as frequent among Blacks (estimated frequency, 0.41)...
  26. ncbi request reprint Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia
    Richard Aplenc
    Children s Hospital of Philadelphia, PA 19104, USA
    Cancer Res 65:2482-7. 2005
    ..These data provide evidence that the MTHFR C677T polymorphism is a common genetic variant conferring a moderate relative risk and a high attributable risk for relapse in pediatric ALL patients...
  27. doi request reprint Pre-transplant lung function is predictive of survival following pediatric bone marrow transplantation
    Jill P Ginsberg
    Division of Oncology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 54:454-60. 2010
    ..We hypothesized that in children, as in adults, pre-transplant pulmonary function would also be predictive of outcome post-transplantation morbidity...
  28. pmc A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors
    Elizabeth Fox
    The Children s Hospital of Philadelphia, Division of Oncology CTRB4016, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Clin Oncol 28:5174-81. 2010
    ....
  29. doi request reprint Survival by race among children with extracranial solid tumors in the United States between 1985 and 2005
    Kelsey A Johnson
    School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 56:425-31. 2011
    ..The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was used to compare survival rates by race among children with common extracranial solid tumors between 1985 and 2005...
  30. pmc ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 183:1344-53. 2011
    ..Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI...
  31. doi request reprint The use of palliative chemotherapy in pediatric oncology patients: a national survey of pediatric oncologists
    Tammy I Kang
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Blood Cancer 60:88-94. 2013
    ..One factor that influences parental decisions to pursue medical therapies is physician preference. To date, no studies have described pediatric oncologists' perspectives and practices regarding palliative chemotherapy (PC)...
  32. pmc Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors
    Jun J Mao
    Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 3400 Spruce Street 2 Gates, Philadelphia, PA 19104, USA
    Breast Cancer Res 13:R8. 2011
    ....
  33. pmc Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  34. ncbi request reprint Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia
    Richard Aplenc
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Br J Haematol 125:421-34. 2004
    ..This review summarizes current research on the impact of genetic variation in drug-processing genes in paediatric ALL and reviews important methodological and statistical issues presently challenging the field of pharmacogenetics...
  35. doi request reprint Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    Stephan A Grupp
    Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    N Engl J Med 368:1509-18. 2013
    ..The emergence of tumor cells that no longer express the target indicates a need to target other molecules in addition to CD19 in some patients with ALL...
  36. doi request reprint Acceptability and feasibility of family use of The Cellie Cancer Coping Kit
    Meghan L Marsac
    Center for Injury Research and Prevention, The Children s Hospital of Philadelphia, 3535 Market, Suite 1150, Philadelphia, PA 19104, USA
    Support Care Cancer 20:3315-24. 2012
    ..The Cellie kit is designed to promote coping and decrease distress in children undergoing pediatric cancer treatment. It includes a plush toy, coping cards, and book for caregivers...
  37. ncbi request reprint Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancer
    Dimitri S Monos
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hum Immunol 66:554-62. 2005
    ....
  38. ncbi request reprint Pharmacogenetics of gemtuzumab-associated hepatic sinusoidal occlusion syndrome after hematopoietic stem cell transplant
    Richard Aplenc
    Pediatric Oncology, Children s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acta Haematol 110:207-10. 2003
  39. ncbi request reprint Pharmacogenetics of acute lymphoblastic leukemia treatment response
    Lea Cunningham
    Children s Hospital of Philadelphia, University of Pennsylvania, 916G ARC, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 8:2519-31. 2007
    ..Despite these recent advances, further work is needed to develop clinically useful genetic predictors of leukemia treatment response...
  40. doi request reprint Cefepime and mortality in pediatric acute myelogenous leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 28:971-5. 2009
    ..We evaluated the association of cefepime and other beta-lactam antibiotic exposures with all cause in-hospital mortality in pediatric AML patients...
  41. pmc "Booster" training: evaluation of instructor-led bedside cardiopulmonary resuscitation skill training and automated corrective feedback to improve cardiopulmonary resuscitation compliance of Pediatric Basic Life Support providers during simulated cardiac
    Robert M Sutton
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 12:e116-21. 2011
    ..To investigate the effectiveness of brief bedside "booster" cardiopulmonary resuscitation (CPR) training to improve CPR guideline compliance of hospital-based pediatric providers...
  42. pmc Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia
    Parinda A Mehta
    Division of Haematology Oncology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 137:152-7. 2007
    ..We did not observe an association with IL-1alpha genotype in donor and/or recipient and transplant-outcome. These data suggest that the outcome of unrelated donor transplant for CML is not influenced by IL-1alpha genotype...
  43. ncbi request reprint Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
    Jacqui M Marzec
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 21:2237-46. 2007
    ..Furthermore, these findings may have important implications in other oxidative stress related illnesses...
  44. ncbi request reprint No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia
    Janez Jazbec
    Department of Pediatrics, Unit of Oncology and Haematology, Medical Centre Ljubljana, Ljubljana, Slovenia
    Leuk Lymphoma 46:893-7. 2005
    ..43-5.31] or one polymorphic A1298C allele (OR 1; 95% CI 0.29?-?3.46). Our study suggests that MTHFR polymorphisms are not associated with increased risk of second cancer in children treated with high-dose methotrexate...
  45. ncbi request reprint Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia
    Robert J Arceci
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 2M51, Bunting Blaustein Cancer Research Bldg, 1650 Orleans St, Baltimore, MD 21231, USA
    Blood 106:1183-8. 2005
    ..Further studies in combination with standard induction therapy for childhood AML are warranted...
  46. ncbi request reprint In response to "Drug metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort"
    Angela DeMichele
    J Clin Oncol 25:5675-7. 2007
  47. ncbi request reprint Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation
    Sean Bulley
    Division of Haematology Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
    Br J Haematol 140:214-7. 2008
    ..5 +/- 3.2% in the non-overweight group (P = 0.02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight...

Research Grants6

  1. GENETIC PREDICTORS OF LEUKEMIA THERAPY RESPONSE
    Richard Aplenc; Fiscal Year: 2009
    ..This application will identify and validate polymorphisms that modify ALL therapy outcome and will rigorously evaluate the additional predictive information captured in genotype data. ..
  2. Genetic Predictors of AML Treatment Response
    Richard Aplenc; Fiscal Year: 2010
    ..Thus, this application may not only inform the care of adult and pediatric AML patients, but may also provide important insights into the translation of genotype data into patient care. ..