Christian C Apfel

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Supplemental intravenous crystalloids for the prevention of postoperative nausea and vomiting: quantitative review
    C C Apfel
    Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California San Francisco, UCSF Medical Center at Mt Zion, 1600 Divisadero, C 447, San Francisco, CA 94115, USA
    Br J Anaesth 108:893-902. 2012
  2. ncbi [Postoperative nausea and vomiting]
    C C Apfel
    Department of Anesthesiology and Perioperative Medicine, Outcomes Research Institute, University of Louisville, KY 40202, USA
    Anaesthesist 53:377-89; quiz 390-1. 2004
  3. ncbi [Nausea and vomiting in the postoperative phase. Expert- and evidence-based recommendations for prophylaxis and therapy]
    C C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California, San Francisco, UCSF Medical Center at Mt Zion, 1600 Divisadero, C 355, San Francisco, California 94115 1605, USA
    Anaesthesist 56:1170-80. 2007
  4. doi The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting
    Christian C Apfel
    Perioperative Clinical Research Core, Department of Anesthesiology and Perioperative Care, University of California, San Francisco, California, USA
    Curr Opin Anaesthesiol 21:427-32. 2008
  5. pmc Restoration of disk height through non-surgical spinal decompression is associated with decreased discogenic low back pain: a retrospective cohort study
    Christian C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
    BMC Musculoskelet Disord 11:155. 2010
  6. ncbi PONV: a problem of inhalational anaesthesia?
    Christian C Apfel
    Department of Anesthesiology and Perioperative Medicine, and Outcomes Research Institute, University of Louisville, 501 E Broadway, Suite 210, Louisville, KY 40202, USA
    Best Pract Res Clin Anaesthesiol 19:485-500. 2005
  7. ncbi [A factorial trial of six interventions for the prevention of postoperative nausea and vomiting]
    C C Apfel
    Klinik und Poliklinik für Anaesthesiologie, Julius Maximilians Universitat, Wurzburg
    Anaesthesist 54:201-9. 2005
  8. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
  9. ncbi An international multicenter protocol to assess the single and combined benefits of antiemetic interventions in a controlled clinical trial of a 2x2x2x2x2x2 factorial design (IMPACT)
    Christian C Apfel
    Department of Anesthesiology, University of Wuerzburg, Wuerzburg, Germany
    Control Clin Trials 24:736-51. 2003
  10. doi The effect of postoperative fasting on vomiting in children and their assessment of pain
    Oliver C Radke
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California at San Francisco, UCSF Medical Center at Mount Zion, San Francisco, CA 94115, USA
    Paediatr Anaesth 19:494-9. 2009

Collaborators

Detail Information

Publications45

  1. doi Supplemental intravenous crystalloids for the prevention of postoperative nausea and vomiting: quantitative review
    C C Apfel
    Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California San Francisco, UCSF Medical Center at Mt Zion, 1600 Divisadero, C 447, San Francisco, CA 94115, USA
    Br J Anaesth 108:893-902. 2012
    ..However, a number of PONV outcomes failed to reach statistical significance, perhaps due to the lack of power. Thus, studies sufficiently powered for the less frequent outcomes (e.g. POV) are required...
  2. ncbi [Postoperative nausea and vomiting]
    C C Apfel
    Department of Anesthesiology and Perioperative Medicine, Outcomes Research Institute, University of Louisville, KY 40202, USA
    Anaesthesist 53:377-89; quiz 390-1. 2004
    ..For the treatment of PONV an antiemetic should be chosen which has not been used prophylactically. The necessary doses are usually a quarter of those needed for prophylaxis...
  3. ncbi [Nausea and vomiting in the postoperative phase. Expert- and evidence-based recommendations for prophylaxis and therapy]
    C C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California, San Francisco, UCSF Medical Center at Mt Zion, 1600 Divisadero, C 355, San Francisco, California 94115 1605, USA
    Anaesthesist 56:1170-80. 2007
    ..These algorithms should provide evidence-based guidelines allowing the development of SOPs/policies which take local circumstances into account...
  4. doi The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting
    Christian C Apfel
    Perioperative Clinical Research Core, Department of Anesthesiology and Perioperative Care, University of California, San Francisco, California, USA
    Curr Opin Anaesthesiol 21:427-32. 2008
    ..To review the characteristics of neurokinin-1 receptor antagonists and their potential role in the management of postoperative nausea and vomiting...
  5. pmc Restoration of disk height through non-surgical spinal decompression is associated with decreased discogenic low back pain: a retrospective cohort study
    Christian C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
    BMC Musculoskelet Disord 11:155. 2010
    ....
  6. ncbi PONV: a problem of inhalational anaesthesia?
    Christian C Apfel
    Department of Anesthesiology and Perioperative Medicine, and Outcomes Research Institute, University of Louisville, 501 E Broadway, Suite 210, Louisville, KY 40202, USA
    Best Pract Res Clin Anaesthesiol 19:485-500. 2005
    ..However, since volatile anaesthetics are probably not the most important risk factors, it might be even better--if appropriate--to avoid general anaesthesia by using a regional, opioid-free anaesthesia if PONV is a serious problem...
  7. ncbi [A factorial trial of six interventions for the prevention of postoperative nausea and vomiting]
    C C Apfel
    Klinik und Poliklinik für Anaesthesiologie, Julius Maximilians Universitat, Wurzburg
    Anaesthesist 54:201-9. 2005
    ..Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown...
  8. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
    ..Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown...
  9. ncbi An international multicenter protocol to assess the single and combined benefits of antiemetic interventions in a controlled clinical trial of a 2x2x2x2x2x2 factorial design (IMPACT)
    Christian C Apfel
    Department of Anesthesiology, University of Wuerzburg, Wuerzburg, Germany
    Control Clin Trials 24:736-51. 2003
    ..To the best of our knowledge this is the first randomized controlled trial of a six-way factorial design that may serve as an example for numerous other medical specialties...
  10. doi The effect of postoperative fasting on vomiting in children and their assessment of pain
    Oliver C Radke
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California at San Francisco, UCSF Medical Center at Mount Zion, San Francisco, CA 94115, USA
    Paediatr Anaesth 19:494-9. 2009
    ..Mandatory postoperative food intake has been shown to increase nausea and vomiting, and so postoperative fasting has become common practice even if patients request food or drink...
  11. ncbi Consensus guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    From the Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina Service d Anesthésiologie Réanimation Chirurgicale, CHU de Hautepierre, and EA 3072, Faculte de Medecine, Strasbourg, France Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas Department of Anesthesiology, University of Wuerzburg, Wuerzburg, Germany Department of Pharmacy Anesthesiology, BaylorScott and White Health, Temple, Texas Department of Anesthesiology and Pediatrics, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada Department of Anesthesiology and Perioperative Medicine, Case Western Reserve University School of Medicine, Washington, District of Columbia Department of Anesthesia and Perioperative Care, UCSF Medical Center at Mt Zion, San Francisco, California Department of Anesthesiology, Wexner Medical Center, Ohio State University, Columbus, Ohio Department of Anesthesiology, Perioperative Medicine, and Pain Management, University of Miami, Miami, Florida Department of Anaesthesia and Intensive Care, Canada
    Anesth Analg 118:85-113. 2014
    ....
  12. ncbi Who is at risk for postdischarge nausea and vomiting after ambulatory surgery?
    Christian C Apfel
    Epidemiology and Biostatistics, Mt Zion Medical Center, San Francisco General Hospital, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94115, USA
    Anesthesiology 117:475-86. 2012
    ..Fortunately, risk scores have been developed to better manage this outcome in hospitalized patients, but there is currently no risk score for postdischarge nausea and vomiting (PDNV) in ambulatory surgical patients...
  13. doi Neurokinin-1 and novel serotonin antagonists for postoperative and postdischarge nausea and vomiting
    Elizabeth George
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94115, USA
    Curr Opin Anaesthesiol 23:714-21. 2010
    ..Finally, we will discuss strategies for prophylaxis and treatment of PONV and PDNV that address the unique concerns in ambulatory surgery patients...
  14. ncbi Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1615-28, table of contents. 2007
    ....
  15. doi Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis
    Christian C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94115, USA or
    Clin Ther 32:1987-2002. 2010
    ....
  16. ncbi A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Centre, Durham, North Carolina 27710, USA
    Anesth Analg 104:1082-9, tables of contents. 2007
    ..This is the first study evaluating the efficacy and tolerability of the neurokinin-1 receptor antagonist, aprepitant, for the prevention of postoperative nausea and vomiting...
  17. doi Intravenous buspirone for the prevention of postoperative nausea and vomiting
    Peter Kranke
    Department of Anaesthesiology and Critical Care, University Hospitals of Würzburg, 97080, Wurzburg, Germany
    Eur J Clin Pharmacol 68:1465-72. 2012
    ..Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown...
  18. doi Pharmacologic management of postoperative nausea and vomiting
    Katherine E Fero
    University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C 447, San Francisco, CA 94115, USA
    Expert Opin Pharmacother 12:2283-96. 2011
    ..PONV occurs after 30% of all surgeries, and incidences as high as 80% have been reported among patients at high risk...
  19. doi Nausea and vomiting after office-based anesthesia
    Kerstin Kolodzie
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94115, USA
    Curr Opin Anaesthesiol 22:532-8. 2009
    ..This article reviews the incidences and risk factors for PDNV as well as medications and concepts for prophylaxis and treatment...
  20. doi Prevention of pain on injection of propofol: systematic review and meta-analysis
    Leena Jalota
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, 94115 CA, USA
    BMJ 342:d1110. 2011
    ..To systematically determine the most efficacious approach for preventing pain on injection of propofol...
  21. doi Does supplemental oxygen reduce postoperative nausea and vomiting? A meta-analysis of randomized controlled trials
    Mukadder Orhan-Sungur
    Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, Kentucky, USA
    Anesth Analg 106:1733-8. 2008
    ..Studies on the ability of supplemental oxygen to decrease the incidence of postoperative nausea and vomiting (PONV) are inconsistent, with initial studies suggesting benefit while subsequent trials demonstrate no decrease in PONV...
  22. doi Droperidol has comparable clinical efficacy against both nausea and vomiting
    C C Apfel
    Clinical Research Core, Department of Anesthesia and Perioperative Care, UCSF Mount Zion Hospital, University of California San Francisco, 1600 Divisadero Street, C 447, San Francisco, CA 94115, USA
    Br J Anaesth 103:359-63. 2009
    ..This may be relevant for clinical decisions, especially for designing multiple-drug antiemetic regimens...
  23. ncbi Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis
    Christian C Apfel
    Department of Anesthesia and Perioperative Care, UCSF Medical Center at Mt Zion, San Francisco, CA 94115, USA
    Pain 154:677-89. 2013
    ..66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22). Prophylactically administered i.v. acetaminophen reduced PONV, mainly mediated through superior pain control...
  24. pmc Does neostigmine administration produce a clinically important increase in postoperative nausea and vomiting?
    Ching Rong Cheng
    Outcomes Research Institute and Department of Anesthesiology and Preoperative Medicine, University of Louisville, KY, 40202, USA
    Anesth Analg 101:1349-55. 2005
    ..Contrasting a previous analysis, we conclude that there is insufficient evidence to conclude that neostigmine increases the risk of postoperative nausea and vomiting...
  25. ncbi Consensus guidelines for managing postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 97:62-71, table of contents. 2003
    ..We present evidence-based guidelines developed by an international panel of experts for the management of postoperative nausea and vomiting...
  26. ncbi Risk assessment of postoperative nausea and vomiting
    Christian C Apfel
    Department of Anesthesiology, Outcomes Research Institute, 501 E Broadway, Suite 201, Louisville, KY 40202, USA
    Int Anesthesiol Clin 41:13-32. 2003
  27. ncbi The influence of a dominating centre on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting
    P Kranke
    Department of Anaesthesiology, University of Wuerzburg, Germany
    Acta Anaesthesiol Scand 45:659-70. 2001
    ....
  28. doi An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling
    Vincent Degos
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 43:1253-9. 2012
    ..Our goal was to develop, compare, and validate a predictive score for 1-year outcomes in patients with coiled subarachnoid hemorrhage...
  29. doi A simple clinical maneuver to reduce laparoscopy-induced shoulder pain: a randomized controlled trial
    Paul Phelps
    Department of Anesthesia, Southwest Healthcare System, Murrieta, California, USA
    Obstet Gynecol 111:1155-60. 2008
    ..To estimate the efficacy of a simple clinical maneuver that facilitates removal of residual abdominal carbon dioxide (CO2) after laparoscopic surgery to reduce shoulder pain...
  30. ncbi A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers
    C C Apfel
    Department of Anesthesiology, University of Wuerzburg, Germany
    Anesthesiology 91:693-700. 1999
    ..This study investigated (1) whether risk scores are valid across centers and (2) whether risk scores based on logistic regression coefficients can be simplified without loss of discriminating power...
  31. ncbi Comparison of predictive models for postoperative nausea and vomiting
    C C Apfel
    Department of Anaesthesiology, Julius Maximilians University, Wurzburg, Germany
    Br J Anaesth 88:234-40. 2002
    ..This study compared the validity and practicability of these models in patients undergoing general anaesthesia...
  32. ncbi How to study postoperative nausea and vomiting
    C C Apfel
    Department of Anesthesiology, Julius Maximilians University, Wuerzburg, Germany
    Acta Anaesthesiol Scand 46:921-8. 2002
    ..Lastly, interpretation of results should take into account the study hypothesis, sources of potential bias or imprecision, and the difficulties associated with multiplicity of analysis and outcomes...
  33. ncbi Comparison of surgical site and patient's history with a simplified risk score for the prediction of postoperative nausea and vomiting
    C C Apfel
    Department of Anaesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40202, USA
    Anaesthesia 59:1078-82. 2004
    ..56-0.61) while for risk score it was 0.68 (95% CI 0.66-0.71; P < 0.001). Prediction using surgical site or patient's history alone was poor while the simplified risk score provided clinically useful sensitivity and specificity...
  34. ncbi [Pathophysiology, risk factors and assessment for nausea and vomiting in the postoperative phase]
    C C Apfel
    Department of Anesthesiology, University of Louisville, Louisville, KY 40202, USA edu
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:497-503. 2005
  35. doi Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane
    R E McKay
    Department of Anaesthesia and Perioperative Care, C 450, University of California San Francisco, San Francisco, CA 94143 0648, USA
    Br J Anaesth 104:175-82. 2010
    ..Increased BMI may increase the body's capacity to store potent inhaled anaesthetics, more so with more soluble agents. Accordingly, we asked whether increased BMI and longer anaesthesia prolonged airway reflex recovery...
  36. doi Prevention of postdural puncture headache after accidental dural puncture: a quantitative systematic review
    C C Apfel
    Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California at San Francisco, 1600 Divisadero St, San Francisco, CA, USA
    Br J Anaesth 105:255-63. 2010
    ..Thus, a large multicentre RCT is needed to determine the best preventative practices...
  37. ncbi The influence of the weather and the phase of the moon on post-operative nausea and vomiting
    M Kredel
    Department of Anaesthesiology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany
    Acta Anaesthesiol Scand 50:488-94. 2006
    ..We therefore determined the effects of specific and general weather patterns as well as the lunar phase on PONV in adults undergoing balanced inhalation anaesthesia...
  38. ncbi A risk adapted approach reduces the overall institutional incidence of postoperative nausea and vomiting
    Andreas Biedler
    Klinik für Anaesthesiologie und Intensivmedizin, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Can J Anaesth 51:13-9. 2004
    ..The objective of this investigation was to assess the feasibility and efficacy of a dichotomized risk score adapted management of PONV based on ondansetron prophylaxis and treatment with respect to the overall institutional rate of PONV...
  39. ncbi A risk score-dependent antiemetic approach effectively reduces postoperative nausea and vomiting--a continuous quality improvement initiative
    Sébastien Pierre
    Department of Anesthesiology, Institut Claudius Regaud, Toulouse, France
    Can J Anaesth 51:320-5. 2004
    ..Consequently, we investigated whether a risk score-dependent antiemetic strategy could effectively reduce the incidence of PONV in our department...
  40. ncbi Prospective application of a simplified risk score to prevent postoperative nausea and vomiting
    Dirk Rüsch
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Can J Anaesth 52:478-84. 2005
    ..To compare the risk-adapted approach with ondansetron against ondansetron plus dexamethasone to prevent postoperative nausea and vomiting (PONV) in a randomized clinical trial...
  41. ncbi The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting
    Matthew T V Chan
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region
    Anesth Analg 103:1155-62. 2006
    ..Both drugs acted independently of each other through their specific mechanisms of action. The incidence of QTc prolongation did not increase with the drug combination...
  42. ncbi Identification of risk factors for postoperative nausea and vomiting in the perianesthesia adult patient
    Marguerite J Murphy
    School of Nursing, Medical College of Georgia, Augusta, GA, USA
    J Perianesth Nurs 21:377-84. 2006
    ..The identification of risk factors associated with PONV and the factors that are independent predictors of PONV preoperatively can facilitate the effective prophylactic treatment and management of PONV in adult surgical patients...
  43. ncbi Transdermal nicotine patch failed to improve postoperative pain management
    Alparslan Turan
    Department of Anesthesiology, Trakya University, Turkey
    Anesth Analg 107:1011-7. 2008
    ....
  44. ncbi Influence of intraoperative conversion from off-pump to on-pump coronary artery bypass grafting on costs and quality of life: a cost-effectiveness analysis
    Toshiya Shiga
    Second Department of Anesthesiology, Toho University School of Medicine, Meguro ku, Tokyo, Japan
    J Cardiothorac Vasc Anesth 21:793-9. 2007
    ..The objective of this study was to determine whether intraoperative conversion affects costs and quality of life...
  45. doi Comparative pharmacodynamic modeling using bispectral and narcotrend-index with and without a pharmacodynamic plateau during sevoflurane anesthesia
    Sascha Kreuer
    Department of Anesthesiology and Intensive Care Medicine, University of Saarland, 66421 Homburg Saar, Germany
    Anesth Analg 106:1171-81, table of contents. 2008
    ..0) were used as an electroencephalographic measure of sevoflurane drug effect. In addition, we tried to analyze the origin of the plateau...