Veena B Antony
Affiliation: University of Alabama at Birmingham
Karki S, Surolia R, Hock T, Guroji P, Zolak J, Duggal R, et al
. Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. FASEB J. 2014;28:1122-31 pubmed publisher
..Our results, for the first time, demonstrate that Wt1 is necessary for the morphologic integrity of pleural membrane and that loss of Wt1 contributes to IPF via MMT of PMCs into a myofibroblast phenotype. ..
Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov S, et al
. Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol. 2015;309:L280-92 pubmed publisher
..Induction of autophagy following CdCl2 treatment was found to be protective from apoptotic cell death. HO-1 induced protective autophagy in PECs and mitigated cadmium-induced emphysema. ..
Li F, Surolia R, Li H, Wang Z, Liu G, Liu R, et al
. Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin. Am J Physiol Lung Cell Mol Physiol. 2017;313:L80-L91 pubmed publisher
Li F, Surolia R, Li H, Wang Z, Kulkarni T, Liu G, et al
. Autoimmunity to Vimentin Is Associated with Outcomes of Patients with Idiopathic Pulmonary Fibrosis. J Immunol. 2017;199:1596-1605 pubmed publisher
..These findings have implications with regard to the pathogenesis of this enigmatic disease and raise the possibility that therapies specifically directed at these autoimmune processes could have therapeutic efficacy. ..