Research Topics
Genomes and Genes | Hoda Anton-CulverSummaryAffiliation: University of California Country: USA Publications
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Publications
The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohortEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Breast Cancer Res 13:R37. 2011..It therefore seems plausible that variation in genes involved in metabolism of these hormones may affect breast cancer risk, and that these associations may vary depending on menopausal status and use of hormone therapy...- Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control studyRoger L Milne
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
Breast Cancer Res 12:R110. 2010.... - Risk of second primary cancer in men with breast cancerSacha Satram Hoang
Epidemiology Division, School of Medicine, University of California, Irvine, CA 92697, USA
Breast Cancer Res 9:R10. 2007..A retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breast cancer in males... - Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancerNigel P S Crawford
Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, Bethesda, Maryland, USA
Breast Cancer Res 8:R16. 2006..The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) within the human SIPA1 gene are associated with metastasis and other disease characteristics in breast cancer... - The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancerEsther M John
Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
Breast Cancer Res 6:R375-89. 2004.... - Activating mutation in MET oncogene in familial colorectal cancerDeborah W Neklason
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
BMC Cancer 11:424. 2011..Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility... - Cancer prevention strategies: use of cancer prevention research registriesH Anton-Culver
Department of Medicine, University of California, Irvine, USA
Environ Health Perspect 103:237-9. 1995..Regardless of what we do in the future, we must now promote healthier lifestyles, prevent exposure to known carcinogens, and improve early detection procedures... 
The Cancer Genetics Network: recruitment results and pilot studiesHoda Anton-Culver
Epidemiology Division, College of Medicine, University of California, Irvine, 92697 7550, USA
Community Genet 6:171-7. 2003....- Characteristics of BRCA1 mutations in a population-based case series of breast and ovarian cancerH Anton-Culver
Epidemiology Division, College of Medicine, 224 Irvine Hall, University of California, Irvine, CA 92697 7550, USA
Eur J Cancer 36:1200-8. 2000..The results indicate that, using a conservative approach to targeted genotyping of BRCA1, the frequency of mutations was consistent with those reported using similar methods of population-based case ascertainment... - Prognostic factors for survival of stage I nonsmall cell lung cancer patients : a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003S H Ignatius Ou
Division of Hematology Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, Orange, California 92868, USA
Cancer 110:1532-41. 2007.... - Risk of pancreatic adenocarcinoma: disparity between African Americans and other race/ethnic groupsKenneth J Chang
Division of Gastroenterology, Department of Medicine, University of California, Irvine Medical Center, Orange, California 92868 3298, USA
Cancer 103:349-57. 2005..African Americans have a higher incidence of pancreatic adenocarcinoma compared with non-Hispanic whites. Whether other clinical differences exist between these two groups is not well known... - Validation of the proposed International Association for the Study of Lung Cancer non-small cell lung cancer staging system revisions for advanced bronchioloalveolar carcinoma using data from the California Cancer RegistryJason A Zell
Genetic Epidemiology Research Institute, Department of Epidemiology, University of California Irvine, Irvine, California, USA
J Thorac Oncol 2:1078-85. 2007..We set out to validate this staging system for bronchioloalveolar carcinoma (BAC) cases using data from the California Cancer Registry (CCR)... 
Survival for patients with invasive cutaneous melanoma among ethnic groups: the effects of socioeconomic status and treatmentJason A Zell
Division of Hematology Oncology, Department of Internal Medicine, Chao Family Comprehensive Cancer Center, University of California, Irvine 92697, USA
J Clin Oncol 26:66-75. 2008..We set out to determine this by using the large, population-based California Cancer Registry (CCR) database as a model...- Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancerDan J Raz
Department of Surgery, Division of Cardiothoracic Surgery and the UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94131, USA
J Thorac Oncol 1:943-8. 2006..The aims of this study were to calculate the sensitivity and specificity of cytologic diagnosis of BAC and to estimate the misclassification of BAC as other subtypes of NSCLC... - Epidemiology of bronchioloalveolar carcinoma: improvement in survival after release of the 1999 WHO classification of lung tumorsJason A Zell
The Chao Family Comprehensive Cancer Center, Division of Hematology, Department of Medicine, University of California, Irvine, CA, USA
J Clin Oncol 23:8396-405. 2005..Classification changes for bronchioloalveolar carcinoma (BAC) by the WHO in May 1999 narrowed its definition. This study was undertaken in an attempt to characterize the impact of these changes on the epidemiology of BAC... - Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in CaliforniaJason A Zell
Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, University of California, Irvine Medical Center, 101 The City Drive South, Orange, CA 92868, USA
Cancer Epidemiol Biomarkers Prev 16:546-52. 2007..We set out to determine this using the large, population-based California Cancer Registry (CCR) database as a model... - How valid is using cancer registries' data to identify acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma?Catherine Diamond
Department of Medicine, UCI Medical Center, University of California Irvine, Orange, CA 92868, USA
Cancer Causes Control 18:135-42. 2007..We sought to determine the accuracy of cancer registry data regarding the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) status of patients with non-Hodgkin's lymphoma (NHL)... - Natural history of stage I non-small cell lung cancer: implications for early detectionDan J Raz
University of California, San Francisco, 513 Parnassus Ave, S 321, San Francisco, CA 94131, USA
Chest 132:193-9. 2007..Our hypothesis is that long-term survival in patients with untreated stage I non-small cell lung cancer (NSCLC) is uncommon... - Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapyCatherine Diamond
Department of Medicine, Epidemiology Division, University of California Irvine, Orange, California 92868, USA
Sex Transm Dis 32:314-20. 2005..We sought to determine if the introduction of highly active antiretroviral therapy (HAART) corresponded with changes in anal squamous cell cancer rates among men with AIDS... - Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohortJoan A Largent
Department of Epidemiology, College of Health Sciences, University of California Irvine, Irvine, CA 92697 7555, USA
Cancer Causes Control 21:1615-24. 2010..We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS)... - Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survivalJason A Zell
Department of Epidemiology, University of California, Irvine, California 92697, USA
Clin Cancer Res 15:6208-16. 2009..We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer-specific survival among colorectal cancer cases, and then investigated its functional significance in colon cancer cells... - Improved survival and chemotherapy response among patients with AIDS-related non-Hodgkin's lymphoma receiving highly active antiretroviral therapyCatherine Diamond
University of California, Irvine Department of Medicine, CA, USA
Hematol Oncol 24:139-45. 2006..We conclude that HAART should be initiated or continued after NHL diagnosis, including during the period of chemotherapy administration... - Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer typesAmanda Ewart-Toland
UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
Carcinogenesis 26:1368-73. 2005..The data also underline the advantages of comparative association studies involving study populations from different ethnic groups for determination of disease risk... - Feasibility of management of high-grade cervical lesions in a single visit: a randomized controlled trialWendy R Brewster
Department of Medicine, School of Medicine, University of California, Irvine 92868 3200, USA
JAMA 294:2182-7. 2005..Screening has been shown to reduce cervical cancer incidence rates... - Differential effects of wine consumption on colorectal cancer outcomes based on family history of the diseaseJason A Zell
Genetic Epidemiology Research Institute, University of California UC Irvine, Irvine, CA 92697, USA
Nutr Cancer 59:36-45. 2007..50, 95% confidence interval = 0.25-0.99). Our findings implicate favorable effects of wine consumption on stage at presentation and survival in CRC, selectively among familial CRC cases... - Presentation and outcomes of systemic non-Hodgkin's lymphoma: a comparison between patients with acquired immunodeficiency syndrome (AIDS) treated with highly active antiretroviral therapy and patients without AIDSCatherine Diamond
Department of Medicine, University of California Irvine, 101 The City Drive, Orange, CA 92868, USA
Leuk Lymphoma 47:1822-9. 2006.... - Prognostic significance of the non-size-based AJCC T2 descriptors: visceral pleura invasion, hilar atelectasis, or obstructive pneumonitis in stage IB non-small cell lung cancer is dependent on tumor sizeSai Hong Ignatius Ou
Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of California Irvine Medical Center, Orange, CA 92868 3298, USA
Chest 133:662-9. 2008..The T2 descriptor for staging non-small cell lung cancer (NSCLC) contains several non-size-based criteria. It remains unknown whether the prognostic significance of these non-size-based criteria is dependent on tumor size... - Survival improvements for advanced stage nonbronchioloalveolar carcinoma-type nonsmall cell lung cancer cases with ipsilateral intrapulmonary nodulesJason A Zell
Division of Hematology Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of California at Irvine School of Medicine, Irvine, California 92697, USA
Cancer 112:136-43. 2008..However, it is not known whether these differences are observed in patients with non-BAC NSCLC... - Changes in acquired immunodeficiency syndrome-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: incidence, presentation, treatment, and survivalCatherine Diamond
Department of Medicine, Divisions of Epidemiology and Infectious Diseases, University of California Irvine, Irvine, California 92868, USA
Cancer 106:128-35. 2006..The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in the epidemiology of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL)... - Low socioeconomic status is a poor prognostic factor for survival in stage I nonsmall cell lung cancer and is independent of surgical treatment, race, and marital statusS H Ignatius Ou
Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of California Irvine Medical Center, Orange, CA 92868 3298, USA
Cancer 112:2011-20. 2008..In this study, the authors investigated the role of SES in this survival disparity among patients with stage I NSCLC... - Effect of reproductive factors on stage, grade and hormone receptor status in early-onset breast cancerJoan A Largent
Epidemiology Division, Department of Medicine, University of California, Irvine, California, USA
Breast Cancer Res 7:R541-54. 2005..The objective of the present study was to examine the relationship between reproductive events and tumor stage, grade, estrogen receptor and progesterone receptor status, and survival in women diagnosed with early-onset breast cancer... - Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patientsBrian Y Shin
Division of Hematology Oncology, Department of Medicine, University of California Irvine, 92697, USA
Dis Colon Rectum 48:1723-7. 2005.... - The association of body mass index with mortality in the California Teachers StudyLeona Bessonova
Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92697 7550, USA
Int J Cancer 129:2492-501. 2011..These findings help to identify groups at risk for BMI-related poor health outcomes... - Risk of a second breast cancer associated with hormone-receptor and HER2/neu status of the first breast cancerLeona Bessonova
Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA
Cancer Epidemiol Biomarkers Prev 20:389-96. 2011..Hormone-receptor (HR) and HER2/neu-receptor (HER2) status of breast tumors are important indicators for targeted therapies. We examine the association of receptor status and risk for a second breast cancer... - Highly active antiretroviral therapy is associated with improved survival among patients with AIDS-related primary central nervous system non-Hodgkin's lymphomaCatherine Diamond
University of California, Irvine, Department of Medicine, USA
Curr HIV Res 4:375-8. 2006..HAART, radiation therapy, and better performance status were associated with improved survival. We conclude that HAART prolongs survival in AIDS-related CNS NHL... - Reproductive history and risk of second primary breast cancer: the WECARE studyJoan A Largent
Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
Cancer Epidemiol Biomarkers Prev 16:906-11. 2007..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results... - Malignancies following in situ cervical cancer in Hispanic Americans and non-Hispanic WhitesThomas H Taylor
Epidemiology Division, Department of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
Gynecol Oncol 103:1012-6. 2006..Some risk factors for cervical cancer in situ convey risk for malignancies of the cervix and other sites. We estimate risk of several malignancies following in situ cancer of the cervix for Hispanic Americans and non-Hispanic Whites... - "You're too young for this": adolescent and young adults' perspectives on cancer survivorshipErin E Kent
Cancer Prevention Fellowship Program and Office of Cancer Survivorship, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
J Psychosoc Oncol 30:260-79. 2012..Future intervention development for adolescent and young adult survivors should involve patient voices at each stage of the research process... - Gender and race/ethnicity affect the cost-effectiveness of colorectal cancer screeningCharles P Theuer
Department of Surgery, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
J Natl Med Assoc 98:51-7. 2006..We determined the influence of gender and race/ethnicity on the cost-effectiveness of recommended colorectal cancer screening regimens... - Prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (IBC): analysis of 2,014 IBC patient cases from the California Cancer RegistryJason A Zell
Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA
Breast Cancer Res 11:R9. 2009.... - New perspectives on melanoma pathogenesis and chemopreventionFrank L Meyskens
University of California, Irvine, Orange 92868, USA
Recent Results Cancer Res 174:191-5. 2007..These observations offer a new paradigm for the development of preventive (and therapeutic) approaches to this disease... - Nonsteroidal anti-inflammatory drugs: effects on mortality after colorectal cancer diagnosisJason A Zell
Genetic Epidemiology Research Institute and Department of Epidemiology, University of California at Irvine, Irvine, California 92697 7550, USA
Cancer 115:5662-71. 2009..The authors investigated the association between prediagnosis NSAID use and mortality after CRC diagnosis among women in the California Teachers Study cohort... - Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survivalJason A Zell
Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92697 7550, USA
Int J Cancer 120:459-68. 2007..Our results suggest important roles for arginine and meat consumption in CRC pathogenesis, and have implications for CRC prevention... - Five polymorphisms and breast cancer risk: results from the Breast Cancer Association ConsortiumMia M Gaudet
Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Epidemiol Biomarkers Prev 18:1610-6. 2009.... - Quality of life, characteristics and survival of patients with HIV and lymphomaCatherine Diamond
Department of Epidemiology, University of California Irvine, Irvine, CA 92697 7555, USA
Qual Life Res 19:149-55. 2010..We sought to compare the quality of life (QOL), characteristics, and survival of patients with non-Hodgkin lymphoma (NHL) with and without human immunodeficiency virus (HIV) infection... - Socioeconomic Impacts on Survival Differ by Race/Ethnicity among Adolescents and Young Adults with Non-Hodgkin's LymphomaErin E Kent
Department of Epidemiology, University of California, Irvine, CA 92697 7550, USA
J Cancer Epidemiol 2010:824691. 2010..001). Reduced overall and lymphoma-specific survival was associated with lower SES in AYAs with NHL, although a significant trend was only observed for NHWs... - Leukemia survival in children, adolescents, and young adults: influence of socioeconomic status and other demographic factorsErin E Kent
Department of Epidemiology, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697 7555, USA
Cancer Causes Control 20:1409-20. 2009..We explored the relationship between SES and survival as modified by age and race/ethnicity using data from the California Cancer Registry... - A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are importantFeng Liu
Department of Medicine, University of California, Irvine, CA, USA
Pigment Cell Melanoma Res 26:128-35. 2013..We conclude that exposure to solar ultraviolet (UV) radiation is the major causative factor for melanoma at older age (>44 yr), but that other factors may play a role in early onset melanomas, particularly in females... - Validation of family history data in cancer family registriesArgyrios Ziogas
Epidemiology Division, Department of Medicine, University of California-Irvine, 224 Irvine Hall, Irvine, CA 92697-7550, USA
Am J Prev Med 24:190-8. 2003..However, degree of relationship to the proband, type of cancer, age at diagnosis of the proband, and source of ascertainment of probands were statistically significant predictors of accuracy of reporting... - Testing targeted approaches to enhance Cancer Genetics Network minority recruitment within Asian populationsLari Wenzel
Center for Health Policy Research, University of California, Irvine, CA 92697, USA
Community Genet 11:234-40. 2008..Asian Americans have been underrepresented in cancer research. The purpose of this study was to evaluate the efficacy of a multiple arm recruitment approach in improving Asian recruitment into the Cancer Genetics Network (CGN)... - Quality of life in long-term cervical cancer survivorsLari Wenzel
Department of Medicine and Center for Health Policy Research, University of California Irvine, 111 Academy Way, Suite 220, Irvine, CA 92697 5800, USA
Gynecol Oncol 97:310-7. 2005..To describe the quality of life (QOL) and long-term psychosocial sequelae of women of childbearing age diagnosed with cervical cancer 5-10 years earlier... - Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers StudyJason A Zell
Genetic Epidemiology Research Institute, Department of Epidemiology, University of California at Irvine, 92697, USA
Cancer Prev Res (Phila) 3:865-75. 2010..These findings have implications for CRC survivorship and tertiary CRC prevention... - Survival after colorectal cancer diagnosis is associated with colorectal cancer family historyJason A Zell
Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA
Cancer Epidemiol Biomarkers Prev 17:3134-40. 2008..Our population-based analysis investigates whether familial CRC cases exhibit improved survival compared with sporadic CRC cases... - Pilot study of blood biomarker candidates for detection of pancreatic cancerRu Chen
GI Division, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Pancreas 39:981-8. 2010..Biomarkers that detect pancreatic cancer at earlier stages could improve the outcome of this deadly disease... - Risk factors for acute myeloid leukemia and multiple myeloma: a combination of GIS and case-control studiesSteven A Speer
Epidemiology Division, Department of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697-7550, USA
J Environ Health 64:9-16; quiz 35-6. 2002..The case-control study identified occupational and lifestyle risk factors for AML and MM that were not apparent from census-tract-level data... - Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosisJason A Zell
Department of Epidemiology, California, University of California, USA Genetic Epidemiology Research Institute, University of California, Irvine, California, USA Chao Family Comprehensive Cancer Center, University of California, Irvine, California, USA Division of Hematology Oncology, University of California, Irvine, California, USA
J Carcinog 11:17. 2012..Polymorphism in the polyamine-regulatory gene, ornithine decarboxylase 1 (Odc1, rs2302615) is prognostic for CRC-specific mortality. Here, we examined joint effects of meat consumption and Odc1 polymorphism on CRC-specific mortality... - Etiologic pathogenesis of melanoma: a unifying hypothesis for the missing attributable riskFrank L Meyskens
Department of Medicine, Hematology/Oncology, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California
Clin Cancer Res 10:2581-3. 2004 - Kids, adolescents, and young adult cancer study-a methodologic approach in cancer epidemiology researchNancy J Link
Department of Epidemiology, School of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
J Cancer Epidemiol 2009:354257. 2009..8% and varies by age and tumor type. The study included patients, mothers, and fathers. The methods used to establish this resource are described, and the values of the resource in studies of childhood and young adult cancer are outlined... - The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trialAnne R Simoneau
Department of Medicine, University of California, Irvine, 101 The City Drive, Route 81, Building 55, Room 304, Orange, CA 92868, USA
Cancer Epidemiol Biomarkers Prev 17:292-9. 2008..The prostate has high levels of tissue polyamines and has shown sensitivity to DFMO both in vitro and in vivo... - Prevalence and clinical correlates of isolated mitral, isolated aortic regurgitation, and both in adults aged 21 to 35 years (from the CARDIA study)Cheryl L Reid
Department of Medicine, Division of Epidemiology, University of California, Irvine, Irvine, California, USA
Am J Cardiol 99:830-4. 2007..In conclusion, MR and AR detected by color Doppler echocardiography are relatively uncommon in a healthy young adult population, but both are associated with evidence of increased left ventricular dimensions and mass... - A pilot study of male breast cancer in the Veterans Affairs healthcare systemSacha Satram-Hoang
Division of Epidemiology, School of Medicine, University of California, Irvine, USA
J Environ Pathol Toxicol Oncol 29:235-44. 2010..We report our findings on a hospital-based retrospective pilot cohort with case-controls study, which we carried out to examine genetic, environmental, and occupational risk factors in men with breast cancer... - Enhanced Expression of Radiation-induced Leukocyte CDKN1A mRNA in Multiple Primary Breast Cancer Patients: Potential New Marker of Cancer SusceptibilityMasato Mitsuhashi
Hitachi Chemical Research Center, Inc, Irvine, CA, USA
Biomark Insights 4:201-9. 2009..The study also suggests that ex vivo gene expression analysis could potentially be used as a new tool in epidemiological studies for cancer and radiation sensitivity research... - Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasiaItzel Calleja-Macias
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
Life Sci 91:1099-102. 2012..Recent literature suggests that single nucleotide polymorphisms (SNPs) of some of these subunits, notably alpha5, are risk factors for developing lung cancer in smokers as well as in non-smokers... - Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)Elizabeth C Chao
Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, California, USA
Hum Mutat 29:852-60. 2008..MAPP-MMR is an effective bioinformatic tool for missense variant interpretation that accurately distinguishes MLH1/MSH2 deleterious variants from neutral variants... - Genotype determination for polymorphisms in linkage disequilibriumZhaoxia Yu
Department of Statistics, University of California, Irvine, CA, USA
BMC Bioinformatics 10:63. 2009..Although many statistical methods have been developed to improve either genotype calling or imputation of missing genotypes, treating the two steps independently can lead to loss of genetic information... - Characteristics and survival of patients with non-Hodgkin's lymphoma with and without acquired immunodeficiency syndromeCatherine Diamond
Department of Medicine, Epidemiology Division, University of California, Irvine 92679, USA
Hematol Oncol 20:177-87. 2002..001). Although these patients with AIDS-related NHL were unlikely to survive, the highly active antiretroviral agents currently used may improve outcomes in future patients... - Self-sampling for human papillomavirus in a community setting: feasibility in Hispanic womenIsrael De Alba
Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, USA
Cancer Epidemiol Biomarkers Prev 17:2163-8. 2008.... - TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylasesWill Yarosh
Department of Pediatrics, Division of Human Genetics, University of California, Irvine, California 92697, USA
Cancer Res 68:693-9. 2008..TBX3 repression to its targets is dependent on HDAC activity. TBX3 may serve as a biomarker for breast cancer and have significant applications in both breast cancer diagnosis and treatment... - Dynamical interactions between multiple cancersDominik Wodarz
Department of Ecology and Evolution, University of California, Irvine, California 92697, USA
Cell Cycle 4:764-71. 2005..We further discuss the inefficiency of metastatic cells to grow successfully, and suggest an explanation for the occurrence of multiple metastases with an unknown primary cancer...
Research Grants
- Hereditary Breast Cancer: Genetic and Molecular StudiesHoda Anton Culver; Fiscal Year: 2007..abstract_text> ..
- Enhanced Single-Visit Cervical Cancer Screening ProgramHoda Anton Culver; Fiscal Year: 2007..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. ..
- UCI UCSD CANCER GENETICS NETWORKHoda Anton Culver; Fiscal Year: 2006..The majority of the elements of the proposed network have already been established by our group and communications among them are in place. ..
- NCI CANCER GENETICS NETWORK INFORMATICS CENTER AT UCIHoda Anton Culver; Fiscal Year: 2006..The design of the Cancer Genetics Network CIMS architecture is a very cost-effective solution without compromising performance and scalability and prepares for the challenges of the next millennium. ..
- NCI CFRBCCS INFORMATICS CENTER AT UCIHoda Anton Culver; Fiscal Year: 2005....
- CARCR Confrence SupportHoda Anton Culver; Fiscal Year: 2005..The March 2005 conference, which is the first to be covered by this proposal, will be held at a still to be determined site in Northern California. ..