Blake D Anson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block
    Sridharan Rajamani
    Department of Medicine, University of Wisconsin, Madison, USA
    Circulation 105:2830-5. 2002
  2. ncbi Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels
    Blake D Anson
    Department of Medicine, University of Wisconsin, 1300 University Ave, Madison, WI 53711, USA
    Am J Physiol Heart Circ Physiol 286:H2434-41. 2004
  3. ncbi Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
    Corey L Anderson
    Department of Medicine, University of Wisconsin Madison, WI, USA
    Circulation 113:365-73. 2006
  4. pmc Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes
    Eric C Lin
    Section of Cardiovascular Medicine, Departments of Medicine and Physiology, University of Wisconsin, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 298:H1842-9. 2010
  5. ncbi Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome
    Brian P Delisle
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Mol Pharmacol 68:233-40. 2005
  6. ncbi Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C
    Brian P Delisle
    Department of Medicine Cardiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:35749-54. 2003
  7. ncbi Blockade of HERG channels by HIV protease inhibitors
    Blake D Anson
    Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
    Lancet 365:682-6. 2005
  8. doi High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
    Junyi Ma
    Cellular Dynamics International, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 301:H2006-17. 2011
  9. ncbi Biology of cardiac arrhythmias: ion channel protein trafficking
    Brian P Delisle
    Section of Cardiovascular Medicine, Department of Medicine, University of Wisconsin Madison, USA
    Circ Res 94:1418-28. 2004
  10. ncbi Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr)
    Sridharan Rajamani
    Department of Medicine Cardiology, University of Wisconsin, Madison 53792, USA
    Am J Physiol Heart Circ Physiol 290:H1278-88. 2006

Collaborators

  • Brian P Delisle
  • Sridharan Rajamani
  • Liang Guo
  • MICHAEL JOHN ACKERMAN
  • G M Vincent
  • Igor Splawski
  • Jonathan Makielski
  • Craig T January
  • Junyi Ma
  • Eric C Lin
  • David J Tester
  • Kazunobu Kawakami
  • Corey L Anderson
  • Li Zhang
  • Matthew R Keyser
  • Mackenzi Mbai
  • Steve J Fiene
  • Timothy J Kamp
  • Bradley J Swanson
  • James A Thomson
  • Kyle L Kolaja
  • Katherine M Holzem
  • Ravi C Balijepalli
  • Sadguna Y Balijepalli
  • Brooke M Moungey
  • Toshihisa Nagatomo
  • Melissa L Will
  • Hiroko Takemasa
  • Jennifer A Kilby
  • Yasuhide Nakashima
  • Qiuming Gong
  • Zhengfeng Zhou
  • Kan Kikuchi
  • Haruhiko Abe
  • John Carlquist
  • Marco Baralle
  • Mark T Keating
  • D Woodrow Benson
  • Francisco E Baralle
  • Katherine W Timothy
  • Bryant Whiting
  • Jane L Witten
  • Steven A Titus
  • Barry Ganetzky
  • Corey Anderson

Detail Information

Publications14

  1. ncbi Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block
    Sridharan Rajamani
    Department of Medicine, University of Wisconsin, Madison, USA
    Circulation 105:2830-5. 2002
    ..The G601S mutation was also rescued without channel block...
  2. ncbi Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels
    Blake D Anson
    Department of Medicine, University of Wisconsin, 1300 University Ave, Madison, WI 53711, USA
    Am J Physiol Heart Circ Physiol 286:H2434-41. 2004
    ..All HERG channels had similar sensitivity to block by cisapride. Therefore, some HERG polymorphic channels are electrophysiologically different from WT channels...
  3. ncbi Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
    Corey L Anderson
    Department of Medicine, University of Wisconsin Madison, WI, USA
    Circulation 113:365-73. 2006
    ..1 current (IKv11.1). We tested the hypotheses that (1) most LQT2 missense mutations generate trafficking-deficient Kv11.1 channels, and (2) their trafficking-deficient phenotype can be corrected...
  4. pmc Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes
    Eric C Lin
    Section of Cardiovascular Medicine, Departments of Medicine and Physiology, University of Wisconsin, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 298:H1842-9. 2010
    ..An important finding of this work is that pharmacological correction of trafficking-deficient LQT2 mutations, as a potential innovative approach to therapy, is possible in native cardiac tissue...
  5. ncbi Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome
    Brian P Delisle
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Mol Pharmacol 68:233-40. 2005
    ..These are the first findings to demonstrate that a single amino acid substitution in the putative KCNH2 drug binding domain can cause intragenic suppression of several LQT2 mutations...
  6. ncbi Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C
    Brian P Delisle
    Department of Medicine Cardiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:35749-54. 2003
    ..e. LQT2 and cystic fibrosis)...
  7. ncbi Blockade of HERG channels by HIV protease inhibitors
    Blake D Anson
    Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
    Lancet 365:682-6. 2005
    ..Our data show that four protease inhibitors block HERG channels, suggesting that protease inhibitors could predispose individuals to QT prolongation and torsade de pointes...
  8. doi High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
    Junyi Ma
    Cellular Dynamics International, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 301:H2006-17. 2011
    ..These hiPSC-derived cardiomyocytes have the added advantage that they can be used in high-throughput assays, and they have the potential to impact multiple areas of cardiovascular research and therapeutic applications...
  9. ncbi Biology of cardiac arrhythmias: ion channel protein trafficking
    Brian P Delisle
    Section of Cardiovascular Medicine, Department of Medicine, University of Wisconsin Madison, USA
    Circ Res 94:1418-28. 2004
    ..As a scientist and physician, his writings and mentorship have served to foster a generation of investigators who continue to bring this complex field toward greater scientific understanding and impact on humankind...
  10. ncbi Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr)
    Sridharan Rajamani
    Department of Medicine Cardiology, University of Wisconsin, Madison 53792, USA
    Am J Physiol Heart Circ Physiol 290:H1278-88. 2006
    ....
  11. ncbi Genetic basis for the origin of cardiac arrhythmias: implications for therapy
    Mackenzi Mbai
    University of Wisconsin Hospitals and Clinics, Section of Cardiovascular Medicine, Room H6 354 CSC 3248, 600 Highland Avenue, Madison, WI 53792, USA
    Curr Cardiol Rep 4:411-7. 2002
    ..New therapies based on this evolving insight are being developed. This review summarizes recent discoveries with a focus on the genetic basis of cardiac arrhythmias and their implications for new therapies...
  12. ncbi An intronic mutation causes long QT syndrome
    Li Zhang
    LDS Hospital, Salt Lake City, Utah 84103, USA
    J Am Coll Cardiol 44:1283-91. 2004
    ..The purpose of this research was to determine whether an intronic variant (T1945+6C) in KCNH2 is a disease-causing mutation, and if expanded phenotyping criteria produce improved identification of long QT syndrome (LQTS) patients...
  13. pmc Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy
    Kazunobu Kawakami
    Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Br J Pharmacol 147:642-52. 2006
    ..Carvedilol has a class III antiarrhythmic effect, which may provide the rationale for a favourable clinical outcome compared with other beta-blockers as suggested in the recent COMET (Carvedilol Or Metoprolol European Trial) substudy...
  14. ncbi Molecular characterization, functional expression, and developmental profile of an ether à-go-go K+ channel in the tobacco hornworm Manduca sexta
    Matthew R Keyser
    Department of Biological Sciences, P O Box 413, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    J Neurobiol 55:73-85. 2003
    ..These results provide the foundation for functional and modulatory studies of the Eag family of K+ channels in Manduca, which will complement the genetic analysis in Drosophila...