Justin J Anker

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Escalation of methamphetamine self-administration in adolescent and adult rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 124:149-53. 2012
  2. pmc Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Psychiatry 71:700-5. 2012
  3. pmc Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Behav Pharmacol 23:205-10. 2012
  4. pmc Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 208:211-22. 2010
  5. pmc Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats
    Justin J Anker
    University of Minnesota, Department of Psychiatry, MMC 392, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 107:264-7. 2010
  6. doi request reprint Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Curr Top Behav Neurosci 8:73-96. 2011
  7. doi request reprint Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 118:68-72. 2011
  8. pmc The role of progestins in the behavioral effects of cocaine and other drugs of abuse: human and animal research
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Neurosci Biobehav Rev 35:315-33. 2010
  9. pmc Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 212:419-29. 2010
  10. doi request reprint Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differences
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 215:785-99. 2011

Detail Information

Publications26

  1. pmc Escalation of methamphetamine self-administration in adolescent and adult rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 124:149-53. 2012
    ..In the present study, the effect of age on the vulnerability to METH abuse was examined using a rat model of bingeing (i.e., escalation)...
  2. pmc Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Psychiatry 71:700-5. 2012
    ..In the present experiments, these results were extended to achieve a long-duration blockade of cocaine seeking with a gene transfer paradigm using a related butyrylcholinesterase-based cocaine hydrolase (CocH)...
  3. pmc Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Behav Pharmacol 23:205-10. 2012
    ..These results suggest that genetic differences in drug abuse vulnerability contribute differentially to treatment outcomes during escalation, a critical phase of the drug abuse process...
  4. pmc Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 208:211-22. 2010
    ..However, little is known of how vulnerability factors such as adolescence are related to conditions that induce relapse, triggered by the drug itself, drug-associated cues, or stress...
  5. pmc Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats
    Justin J Anker
    University of Minnesota, Department of Psychiatry, MMC 392, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 107:264-7. 2010
    ..These results suggest that females may be more sensitive than males to stress-induced reinstatement of cocaine-seeking behavior, and the progesterone metabolite, allopregnanolone, offers protection against this vulnerability...
  6. doi request reprint Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Curr Top Behav Neurosci 8:73-96. 2011
    ..This chapter discusses sex differences in and hormonal effects on drug-seeking behaviors in animal models of drug abuse. The neurobiological basis of these differences and effects are also discussed...
  7. doi request reprint Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 118:68-72. 2011
    ..The purpose of the present study was to determine whether environmental and genetic factors interact to produce additive drug abuse vulnerability...
  8. pmc The role of progestins in the behavioral effects of cocaine and other drugs of abuse: human and animal research
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Neurosci Biobehav Rev 35:315-33. 2010
    ..The findings discussed here highlight the complexity of progestin-drug interactions, and they suggest a possible use for these agents in understanding the etiology of and developing treatments for drug abuse...
  9. pmc Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 212:419-29. 2010
    ..Evidence suggests that the progesterone metabolite allopregnanolone (ALLO) decreases cocaine seeking in animal models of relapse...
  10. doi request reprint Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differences
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 215:785-99. 2011
    ..Research suggests that age and sex are vulnerability factors for drug abuse. However, few studies have systematically examined their interaction...
  11. doi request reprint Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Behav Pharmacol 20:406-14. 2009
    ..These results indicate that the effects of cocaine on measures of impulsivity may be determined by a preexisting level of impulsive behavior...
  12. pmc Impulsivity predicts the escalation of cocaine self-administration in rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 93:343-8. 2009
    ..This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women...
  13. doi request reprint Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
    Psychopharmacology (Berl) 203:63-72. 2009
    ..This effect of PROG may be in part due to its metabolite allopregnanolone (ALLO), which has been shown to decrease the sensitizing effects of cocaine and reduce lethality associated with cocaine overdose in mice...
  14. doi request reprint Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Behav Pharmacol 19:615-29. 2008
    ..The results indicate that HiS rats and females are more prone than LoS rats and males to impulsive drug-seeking behavior...
  15. ncbi request reprint Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats
    Justin J Anker
    Department of Psychiatry, Division of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Clin Psychopharmacol 15:472-80. 2007
    ..The suppression of cocaine-induced reinstatement following P treatment suggests a role for P in the prevention of relapse to cocaine self-administration in female cocaine users...
  16. ncbi request reprint Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended access
    Erin B Larson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Texas, USA
    Exp Clin Psychopharmacol 15:461-71. 2007
    ..Estrogen promoted and progesterone inhibited escalation of cocaine self-administration, illustrating the importance of female gonadal hormones in drug-seeking behavior...
  17. doi request reprint Selective breeding for differential saccharin intake as an animal model of drug abuse
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Pharmacol 19:435-60. 2008
    ....
  18. pmc Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43536. 2012
    ..A similar combination therapy in human cocaine users might provide a robust therapy to help maintain abstinence...
  19. pmc Operant responding for sucrose by rats bred for high or low saccharin consumption
    Blake A Gosnell
    Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108, USA
    Physiol Behav 99:529-33. 2010
    ..These studies provide further characterization of the HiS and LoS rat lines by demonstrating that motivation to consume sucrose is greater in HiS than in LoS rats...
  20. pmc Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats
    Natalie E Zlebnik
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 209:113-25. 2010
    ..WE and WR were retested later to examine the effect of one session of wheel access on cocaine-primed reinstatement...
  21. pmc Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats
    Natalie E Zlebnik
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 224:387-400. 2012
    ..Concurrent access to an exercise wheel decreases cocaine self-administration under short access (5 h/day for 5 days) conditions and suppresses cocaine-primed reinstatement in adult rats...
  22. pmc Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 213:817-29. 2011
    ..In the present study, rats were treated with Albu-CocH while self-administering cocaine under a progressive ratio (PR) schedule during 2-h sessions and under a fixed-ratio 1 (FR 1) schedule during 6-h sessions...
  23. doi request reprint Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory
    Marilyn E Carroll
    University of Minnesota, Department of Psychiatry, Minneapolis, MN 55455, USA
    Drug Alcohol Depend 104:S70-8. 2009
    ..The models offer valuable information that has been transferred to effective prevention and treatment strategies for smoking and other drug abuse in humans...
  24. ncbi request reprint Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake
    Jennifer L Perry
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 186:235-45. 2006
    ..v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self-administration than their low saccharin-consuming (LoS) counterparts...
  25. ncbi request reprint Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats
    Erin B Larson
    Graduate Program in Neuroscience, University of Minnesota, MMC 392 Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 82:98-108. 2005
    ....
  26. doi request reprint Sex differences and ovarian hormones in animal models of drug dependence
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
    Horm Behav 58:44-56. 2010
    ..Overall, sex and hormonal status along with other biological risk factors account for a continuum of addiction-prone and -resistant animal models that are valuable for studying drug abuse prevention and treatment strategies...

Research Grants2

  1. Progesterone as a Treatment for Cocaine Abuse in Rats with Differing Vulnerabilit
    JUSTIN ANKER; Fiscal Year: 2007
    ..The proposed research will also assess the effectiveness of progesterone and allopregnanolone as potential treatments for cocaine abuse in more and less vulnerable phenotypes. ..