Research Topics
| Justin J AnkerSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Escalation of methamphetamine self-administration in adolescent and adult ratsJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Drug Alcohol Depend 124:149-53. 2012..In the present study, the effect of age on the vulnerability to METH abuse was examined using a rat model of bingeing (i.e., escalation)...
Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 monthsJustin J Anker
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Biol Psychiatry 71:700-5. 2012..In the present experiments, these results were extended to achieve a long-duration blockade of cocaine seeking with a gene transfer paradigm using a related butyrylcholinesterase-based cocaine hydrolase (CocH)...- Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intakeJustin J Anker
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Behav Pharmacol 23:205-10. 2012..These results suggest that genetic differences in drug abuse vulnerability contribute differentially to treatment outcomes during escalation, a critical phase of the drug abuse process... - Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult ratsJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 208:211-22. 2010..However, little is known of how vulnerability factors such as adolescence are related to conditions that induce relapse, triggered by the drug itself, drug-associated cues, or stress... - Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in ratsJustin J Anker
University of Minnesota, Department of Psychiatry, MMC 392, 420 Delaware St SE, Minneapolis, MN 55455, USA
Drug Alcohol Depend 107:264-7. 2010..These results suggest that females may be more sensitive than males to stress-induced reinstatement of cocaine-seeking behavior, and the progesterone metabolite, allopregnanolone, offers protection against this vulnerability... - Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormonesJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Curr Top Behav Neurosci 8:73-96. 2011..This chapter discusses sex differences in and hormonal effects on drug-seeking behaviors in animal models of drug abuse. The neurobiological basis of these differences and effects are also discussed... - Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intakeJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Drug Alcohol Depend 118:68-72. 2011..The purpose of the present study was to determine whether environmental and genetic factors interact to produce additive drug abuse vulnerability... - The role of progestins in the behavioral effects of cocaine and other drugs of abuse: human and animal researchJustin J Anker
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Neurosci Biobehav Rev 35:315-33. 2010..The findings discussed here highlight the complexity of progestin-drug interactions, and they suggest a possible use for these agents in understanding the etiology of and developing treatments for drug abuse... - Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female ratsJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 212:419-29. 2010..Evidence suggests that the progesterone metabolite allopregnanolone (ALLO) decreases cocaine seeking in animal models of relapse... - Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differencesJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 215:785-99. 2011..Research suggests that age and sex are vulnerability factors for drug abuse. However, few studies have systematically examined their interaction... - Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedureJustin J Anker
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
Behav Pharmacol 20:406-14. 2009..These results indicate that the effects of cocaine on measures of impulsivity may be determined by a preexisting level of impulsive behavior... - Impulsivity predicts the escalation of cocaine self-administration in ratsJustin J Anker
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Pharmacol Biochem Behav 93:343-8. 2009..This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women... - Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female ratsJustin J Anker
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
Psychopharmacology (Berl) 203:63-72. 2009..This effect of PROG may be in part due to its metabolite allopregnanolone (ALLO), which has been shown to decrease the sensitizing effects of cocaine and reduce lethality associated with cocaine overdose in mice... - Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intakeJustin J Anker
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
Behav Pharmacol 19:615-29. 2008..The results indicate that HiS rats and females are more prone than LoS rats and males to impulsive drug-seeking behavior... 
Effects of progesterone on the reinstatement of cocaine-seeking behavior in female ratsJustin J Anker
Department of Psychiatry, Division of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Exp Clin Psychopharmacol 15:472-80. 2007..The suppression of cocaine-induced reinstatement following P treatment suggests a role for P in the prevention of relapse to cocaine self-administration in female cocaine users...- Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended accessErin B Larson
Department of Psychiatry, University of Texas Southwestern Medical Center, Texas, USA
Exp Clin Psychopharmacol 15:461-71. 2007..Estrogen promoted and progesterone inhibited escalation of cocaine self-administration, illustrating the importance of female gonadal hormones in drug-seeking behavior... - Selective breeding for differential saccharin intake as an animal model of drug abuseMarilyn E Carroll
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Behav Pharmacol 19:435-60. 2008.... - Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotionMarilyn E Carroll
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS ONE 7:e43536. 2012..A similar combination therapy in human cocaine users might provide a robust therapy to help maintain abstinence... - Operant responding for sucrose by rats bred for high or low saccharin consumptionBlake A Gosnell
Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108, USA
Physiol Behav 99:529-33. 2010..These studies provide further characterization of the HiS and LoS rat lines by demonstrating that motivation to consume sucrose is greater in HiS than in LoS rats... - Reduction of extinction and reinstatement of cocaine seeking by wheel running in female ratsNatalie E Zlebnik
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 209:113-25. 2010..WE and WR were retested later to examine the effect of one session of wheel access on cocaine-primed reinstatement... - Exercise to reduce the escalation of cocaine self-administration in adolescent and adult ratsNatalie E Zlebnik
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 224:387-400. 2012..Concurrent access to an exercise wheel decreases cocaine self-administration under short access (5 h/day for 5 days) conditions and suppresses cocaine-primed reinstatement in adult rats... - Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in ratsMarilyn E Carroll
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 213:817-29. 2011..In the present study, rats were treated with Albu-CocH while self-administering cocaine under a progressive ratio (PR) schedule during 2-h sessions and under a fixed-ratio 1 (FR 1) schedule during 6-h sessions... - Modeling risk factors for nicotine and other drug abuse in the preclinical laboratoryMarilyn E Carroll
University of Minnesota, Department of Psychiatry, Minneapolis, MN 55455, USA
Drug Alcohol Depend 104:S70-8. 2009..The models offer valuable information that has been transferred to effective prevention and treatment strategies for smoking and other drug abuse in humans... - Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intakeJennifer L Perry
Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 186:235-45. 2006..v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self-administration than their low saccharin-consuming (LoS) counterparts... - Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female ratsErin B Larson
Graduate Program in Neuroscience, University of Minnesota, MMC 392 Minneapolis, MN 55455, USA
Pharmacol Biochem Behav 82:98-108. 2005.... - Sex differences and ovarian hormones in animal models of drug dependenceMarilyn E Carroll
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA
Horm Behav 58:44-56. 2010..Overall, sex and hormonal status along with other biological risk factors account for a continuum of addiction-prone and -resistant animal models that are valuable for studying drug abuse prevention and treatment strategies...
Research Grants
- Progesterone as a Treatment for Cocaine Abuse in Rats with Differing VulnerabilitJUSTIN ANKER; Fiscal Year: 2007..The proposed research will also assess the effectiveness of progesterone and allopregnanolone as potential treatments for cocaine abuse in more and less vulnerable phenotypes. ..