Derek C Angus

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
  2. pmc The puzzle of long-term morbidity after critical illness
    Hannah Wunsch
    Division of Critical Care, Department of Anesthesiology, Columbia University, 622 West 168th St, New York, NY 10032, USA
    Crit Care 14:121. 2010
  3. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
  4. pmc Perceived barriers to the regionalization of adult critical care in the United States: a qualitative preliminary study
    Jeremy M Kahn
    Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    BMC Health Serv Res 8:239. 2008
  5. ncbi request reprint Surviving intensive care: a report from the 2002 Brussels Roundtable
    Derek C Angus
    CRISMA, Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:368-77. 2003
  6. ncbi request reprint Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
  7. pmc Revisiting Mars and Venus: understanding gender differences in critical illness
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and University of Melbourne, Melbourne, VIC 3084, Australia
    Crit Care 15:180. 2011
  8. ncbi request reprint Improving care of the critically ill: institutional and health-care system approaches
    Derek C Angus
    Clinical Research, Investigation and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lancet 363:1314-20. 2004
  9. ncbi request reprint Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    Derek C Angus
    Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 166:717-23. 2002
  10. ncbi request reprint Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
    ..The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia...
  2. pmc The puzzle of long-term morbidity after critical illness
    Hannah Wunsch
    Division of Critical Care, Department of Anesthesiology, Columbia University, 622 West 168th St, New York, NY 10032, USA
    Crit Care 14:121. 2010
    ..Such studies will likely need to incorporate extensive planning for data collection, as well as coordinated linkage with other available datasets that include substantial amounts of patient information from outside of the ICU...
  3. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
    ..These aspects of study design impact upon the evaluation of complex interventions in critical care. Clinicians should also consider these specific issues when implementing new complex interventions into their practice...
  4. pmc Perceived barriers to the regionalization of adult critical care in the United States: a qualitative preliminary study
    Jeremy M Kahn
    Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    BMC Health Serv Res 8:239. 2008
    ..We sought to develop a framework for understanding clinician attitudes toward regionalization and potential barriers to developing a tiered, regionalized system of care in the United States...
  5. ncbi request reprint Surviving intensive care: a report from the 2002 Brussels Roundtable
    Derek C Angus
    CRISMA, Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:368-77. 2003
    ..Specific interventions that show promise for improving care include ICU discharge screening tools and ICU follow-up clinics...
  6. ncbi request reprint Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  7. pmc Revisiting Mars and Venus: understanding gender differences in critical illness
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and University of Melbourne, Melbourne, VIC 3084, Australia
    Crit Care 15:180. 2011
    ..However, if true gender effects can be identified, examination of their biological or psychosocial causes will be warranted...
  8. ncbi request reprint Improving care of the critically ill: institutional and health-care system approaches
    Derek C Angus
    Clinical Research, Investigation and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lancet 363:1314-20. 2004
    ....
  9. ncbi request reprint Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    Derek C Angus
    Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 166:717-23. 2002
    ..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time...
  10. ncbi request reprint Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003
    ..Our objective was to estimate the cost-effectiveness ratio of iNO in this population...
  11. pmc Understanding the lingering consequences of what we treat and what we do
    Derek C Angus
    Department of Critical Care Medicine, The CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 8:103-4. 2004
    ..In the meantime, we can hope that this quality of follow-up will move from the research arena to become a part of routine clinical care...
  12. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
    ..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals...
  13. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
    ..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response...
  14. pmc Is survival better at hospitals with higher "end-of-life" treatment intensity?
    Amber E Barnato
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Med Care 48:125-32. 2010
    ..Concern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit...
  15. ncbi request reprint The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2199-206. 2004
    ..To determine long-term survival for subjects with severe sepsis enrolled in the previous multiple-center trial (PROWESS) of drotrecogin alfa (activated) (DrotAA) vs. placebo...
  16. pmc Intensive care unit safety culture and outcomes: a US multicenter study
    David T Huang
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Int J Qual Health Care 22:151-61. 2010
    ..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes...
  17. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  18. pmc Prevalence and significance of coagulation abnormalities in community-acquired pneumonia
    Eric B Milbrandt
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Med 15:438-45. 2009
    ..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials...
  19. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  20. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  21. doi request reprint Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
    ..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO...
  22. pmc Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia
    David T Huang
    Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 136:823-31. 2009
    ..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection...
  23. pmc Understanding the potential role of statins in pneumonia and sepsis
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 39:1871-8. 2011
    ..To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis...
  24. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  25. doi request reprint Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
    ..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear...
  26. ncbi request reprint Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004
    ..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing...
  27. ncbi request reprint Critical care medicine training and certification for emergency physicians
    David T Huang
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:2104-9. 2005
    ..We therefore propose that all accreditation bodies work cooperatively to create a route to CCM certification for emergency physicians who complete a critical care fellowship...
  28. doi request reprint Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
    ..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs...
  29. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
    ..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear...
  30. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  31. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  32. pmc The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia
    Michael C Reade
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 10:15. 2010
    ..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals...
  33. pmc A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancer
    Amber E Barnato
    Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 39:1663-9. 2011
    ..To test whether hospital-based physicians made different intensive care unit and life-sustaining treatment decisions for otherwise identical black and white patients with end-stage cancer and life-threatening hypoxia...
  34. pmc Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22847. 2011
    ....
  35. pmc Optimal approach to improving trauma triage decisions: a cost-effectiveness analysis
    Deepika Mohan
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Manag Care 18:e91-e100. 2012
    ..To identify the optimal target of a future intervention to improve physician decision making in trauma triage...
  36. pmc The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    Sachin Kale
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13852. 2010
    ..To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly...
  37. pmc The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22512. 2011
    ..central venous catheter (CVC). We explored if use of the PAC in ALI is justified by a beneficial cost-effectiveness profile...
  38. pmc Using simulation to isolate physician variation in intensive care unit admission decision making for critically ill elders with end-stage cancer: a pilot feasibility study
    Amber E Barnato
    University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:3156-63. 2008
    ..To determine the feasibility of high-fidelity simulation for studying variation in intensive care unit admission decision making for critically ill elders with end-stage cancer...
  39. doi request reprint Intensive care unit renal support therapy volume is not associated with patient outcome
    Yên Lan Nguyen
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 39:2470-7. 2011
    ..Our objective was to determine whether there is a volume-outcome relationship among intensive care unit patients receiving renal support therapy in two different healthcare systems (France and the United States)...
  40. ncbi request reprint Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 31:1746-51. 2003
    ..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions...
  41. ncbi request reprint Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
    ..The sex differences are of concern and require further investigation...
  42. pmc Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsis
    Gorkem Saka
    Department of Industrial Engineering, University of Pittsburgh, 3700 Ohara St, 3700 Benedum Hall, Pittsburgh, PA 15261, USA
    Crit Care 11:R65. 2007
    ....
  43. pmc Multidisciplinary acute care research organization (MACRO): if you build it, they will come
    Barbara J Early
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 75:106-9. 2013
    ..We sought to characterize the effects of implementation of a multidisciplinary acute care research organization (MACRO) at a busy tertiary referral university setting...
  44. pmc Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia
    Raghavan Murugan
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:895-905. 2012
    ..This study examined whether statin use was associated with a lower risk for pneumonia-induced AKI and 1-year and cause-specific mortality in patients with AKI...
  45. pmc Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 80:545-52. 2011
    ..Thus, in this cohort of patients with pneumonia-induced severe acute kidney injury, plasma NGAL appears to be a useful biomarker for predicting renal recovery...
  46. ncbi request reprint Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  47. pmc Informal caregiver burden among survivors of prolonged mechanical ventilation
    David C Van Pelt
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606D Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 175:167-73. 2007
    ..In existing studies, it is unclear whether the observed burden is a consequence of critical illness or of preexisting patient illness...
  48. ncbi request reprint Pneumonia: still the old man's friend?
    Vladimir Kaplan
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:317-23. 2003
    ..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP...
  49. ncbi request reprint Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide
    Derek C Angus
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 34:2883-90. 2006
    ..To determine the costs and long-term outcomes of acute respiratory distress syndrome (ARDS) in previously healthy adults. To determine whether treatment with inhaled nitric oxide affects these costs and outcomes...
  50. pmc Trauma triage in the emergency departments of nontrauma centers: an analysis of individual physician caseload on triage patterns
    Deepika Mohan
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Trauma Acute Care Surg 74:1541-7. 2013
    ..Little is known about the role of physicians' clinical judgment in triage at outlying hospitals. We assessed the association between physician caseload, case mix, and the triage of trauma patients presenting to nontrauma centers...
  51. doi request reprint Nighttime intensivist staffing and mortality among critically ill patients
    David J Wallace
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems of Modeling of Acute Illness Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    N Engl J Med 366:2093-101. 2012
    ..However, the degree to which nighttime intensivists are associated with improvements in the quality of ICU care is unknown...
  52. pmc Organizational determinants of hospital end-of-life treatment intensity
    Caroline Y Lin
    Center for Research on Health Care, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh, PA 15213, USA
    Med Care 47:524-30. 2009
    ..There is substantial hospital-level variation in end-of-life (EOL) treatment intensity...
  53. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  54. pmc Development and validation of hospital "end-of-life" treatment intensity measures
    Amber E Barnato
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Med Care 47:1098-105. 2009
    ..Health care utilization among decedents is increasingly used as a measure of health care efficiency, but decedent-based measures may be biased estimates of care received by "dying" patients...
  55. pmc Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics
    Amber E Barnato
    Center for Research on Health Care, 200 Meyran Ave, Suite 200, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 177:279-84. 2008
    ..Higher rates of sepsis have been reported in minorities...
  56. ncbi request reprint The epidemiology of severe sepsis in children in the United States
    R Scott Watson
    Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 167:695-701. 2003
    ..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight...
  57. doi request reprint Assessing the feasibility of the American College of Surgeons' benchmarks for the triage of trauma patients
    Deepika Mohan
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Surg 146:786-92. 2011
    ....
  58. ncbi request reprint Comparison of Cox and Gray's survival models in severe sepsis
    Jan Kasal
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:700-7. 2004
    ..Newer, more flexible models, such as Gray's model, may be more appropriate...
  59. ncbi request reprint Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  60. ncbi request reprint Value and role of intensive care unit outcome prediction models in end-of-life decision making
    Amber E Barnato
    Center for Research on Health Care, Department of Medicine, University of Pittsburgh, 230 McKee Place, Suite 600, Pittsburgh, PA 15213, USA
    Crit Care Clin 20:345-62, vii-viii. 2004
    ....
  61. doi request reprint Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreach
    Yên Lan Nguyen
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 181:1164-9. 2010
    ....
  62. pmc Racial variation in end-of-life intensive care use: a race or hospital effect?
    Amber E Barnato
    Department of Medicine, School of Medicine, Graduate School of Public Health, Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Health Serv Res 41:2219-37. 2006
    ....
  63. pmc Sources of non-compliance with clinical practice guidelines in trauma triage: a decision science study
    Deepika Mohan
    Department of Critical Care Medicine, The CRISMA Center Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, USA
    Implement Sci 7:103. 2012
    ..One possible reason is emergency physician decision-making. The objective of the study was to characterize sensory and decisional determinants of emergency physician trauma triage decision-making...
  64. pmc The research agenda in ICU telemedicine: a statement from the Critical Care Societies Collaborative
    Jeremy M Kahn
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 140:230-8. 2011
    ..We propose an agenda to advance the science of ICU telemedicine and generate research with the greatest potential to improve patient care...
  65. pmc Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome
    Christopher W Seymour
    Departments of Critical Care Medicine and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 186:1264-71. 2012
    ..Severe sepsis is common and highly morbid, yet the epidemiology of severe sepsis at the frontier of the health care system-pre-hospital emergency care-is unknown...
  66. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  67. ncbi request reprint A clinically based discrete-event simulation of end-stage liver disease and the organ allocation process
    Steven M Shechter
    Department of Industrial Engineering, University of Pittsburgh, Pennsylvania, USA
    Med Decis Making 25:199-209. 2005
    ..The objective of this article was to design a biologically based discrete-event simulation to test proposed changes in allocation policies...
  68. ncbi request reprint Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:1061-7. 2007
    ....
  69. pmc Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensity
    Amber E Barnato
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Palliat Med 10:1093-100. 2007
    ..Individual hospital microclimates must exist to perpetuate these practice variations...
  70. ncbi request reprint Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 33:226-9; discussion 263-5. 2005
    ..To determine whether haloperidol use is associated with lower mortality in mechanically ventilated patients...
  71. ncbi request reprint Use of intensive care at the end of life in the United States: an epidemiologic study
    Derek C Angus
    Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:638-43. 2004
    ..We sought to describe the use of ICU care at the end of life in the United States using hospital discharge data from 1999 for six states and the National Death Index...
  72. doi request reprint Physician attitudes toward regionalization of adult critical care: a national survey
    Jeremy M Kahn
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:2149-54. 2009
    ..Regionalization has been proposed as a method to improve outcomes for patients with critical illness. We sought to determine intensivist physician attitudes and potential barriers to the regionalization of adult critical care...
  73. doi request reprint Variability in management of early severe sepsis
    Michael C Reade
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA
    Emerg Med J 27:110-5. 2010
    ....
  74. ncbi request reprint Perceptions of safety culture vary across the intensive care units of a single institution
    David T Huang
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:165-76. 2007
    ..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes...
  75. ncbi request reprint Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory CRISMA, Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2090-100. 2007
    ..However, implementation of EGDT faces several barriers, including perceived costs and logistic difficulties. We conducted a decision analysis to explore the potential costs and consequences of EGDT implementation...
  76. ncbi request reprint Does acute organ dysfunction predict patient-centered outcomes?
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 121:1963-71. 2002
    ..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both...
  77. pmc Severe sepsis epidemiology: sampling, selection, and society
    Walter T Linde-Zwirble
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 8:222-6. 2004
    ..In the future, we must focus on whether all severe sepsis should be treated, and, consequently, what level of ICU services is optimal...
  78. pmc Predicting late anemia in critical illness
    Eric B Milbrandt
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 10:R39. 2006
    ..We sought to determine whether a predictive model could be constructed that would serve as a useful decision support tool for the pre-emptive management of intensive care unit (ICU)-related anemia...
  79. pmc Translating research evidence into clinical practice: new challenges for critical care
    Kenneth G Kalassian
    Department of Critical Care Medicine, School of Medicine and Department of Health Services Administration, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 6:11-4. 2002
  80. ncbi request reprint Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 112:3745-53. 2005
    ..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population...
  81. ncbi request reprint Influence of comorbid conditions on long-term mortality after pneumonia in older people
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:518-25. 2007
    ..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions...
  82. ncbi request reprint Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review
    Peter J Pronovost
    Department of Critical Care Medicine, Hopkins University, Baltimore, MD, USA
    JAMA 288:2151-62. 2002
    ..Intensive care unit (ICU) physician staffing varies widely, and its association with patient outcomes remains unclear...
  83. pmc Variation in sepsis care: a wake-up call
    Mary E Hartman
    CRISMA Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:211-3. 2003
  84. ncbi request reprint Critical care medicine training and certification for emergency physicians
    David T Huang
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Emerg Med 46:217-23. 2005
    ..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship...
  85. ncbi request reprint Potential mechanisms and markers of critical illness-associated cognitive dysfunction
    Eric B Milbrandt
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:355-9. 2005
    ....
  86. doi request reprint Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsis
    Derek C Angus
    The CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 614 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 305:1469-77. 2011
    ..Although advances in understanding the host immune response have fueled considerable interest in immunomodulatory therapy, the role of such agents in clinical practice remains limited and controversial...
  87. ncbi request reprint Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database
    Mark S Roberts
    Section of Decision Sciences and Clinical Systems Modeling, Division of General Medicine, University of Pittsburgh School of Medicine, Center for Research on Health Care, Pittsburgh, PA 15213, USA
    Liver Transpl 10:886-97. 2004
    ..However, a significant portion of the difference in survival between diseases arises from differences in clinical characteristics at the time of transplantation...
  88. ncbi request reprint Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
    ..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival...
  89. pmc Genetics and proteomics: deciphering gene association studies in critical illness
    Sachin Yende
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 10:227. 2006
    ....
  90. ncbi request reprint Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unit
    Cindy L Bryce
    Department of Medicine, Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Med Care 42:423-31. 2004
    ..This issue is particularly problematic in the intensive-care unit (ICU) where death is frequent, care is difficult, and costs are high...
  91. ncbi request reprint The Acute Physiology and Chronic Health Evaluation II. Article of Knaus et al with expert commentary by Dr Derek Angus
    Ali Al-Khafaji
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Crit Care 22:85-8. 2007
  92. ncbi request reprint National estimates of severe sepsis in United States emergency departments
    Henry E Wang
    Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 35:1928-36. 2007
    ..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis...
  93. pmc The PIRO concept: P is for predisposition
    Derek C Angus
    CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:248-51. 2003
  94. ncbi request reprint Designing clinical trials in acute lung injury/acute respiratory distress syndrome
    David T Huang
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 12:32-6. 2006
    ..To review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS)...
  95. ncbi request reprint The future of critical care
    Derek C Angus
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care Clin 21:163-9, x. 2005
    ....
  96. doi request reprint Comparison of medical admissions to intensive care units in the United States and United Kingdom
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York, New York, USA
    Am J Respir Crit Care Med 183:1666-73. 2011
    ..The United States has seven times as many intensive care unit (ICU) beds per capita as the United Kingdom; the effect on care of critically ill patients is unknown...
  97. pmc Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics
    Eric B Milbrandt
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 641 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Crit Care 10:238. 2006
    ....
  98. ncbi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  99. ncbi request reprint The first international consensus conference on continuous renal replacement therapy
    John A Kellum
    Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Kidney Int 62:1855-63. 2002
    ..We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study...
  100. pmc Potential value of regionalized intensive care for mechanically ventilated medical patients
    Jeremy M Kahn
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:285-91. 2008
    ..Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit...
  101. ncbi request reprint Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
    Crit Care Med 31:12-9. 2003
    ....

Research Grants14

  1. Long-Term Outcomes of NO for Ventilated Premature Babies
    Derek Angus; Fiscal Year: 2007
    ..Finally, our data will allow assessment of the robustness of early proxies for subsequent outcomes, key for future study design in this area. ..
  2. Long-Term Outcomes of NO for Ventilated Premature Babies
    Derek Angus; Fiscal Year: 2006
    ..Finally, our data will allow assessment of the robustness of early proxies for subsequent outcomes, key for future study design in this area. ..
  3. Economic Analysis of Pulmonary Artery Catheter Use
    Derek Angus; Fiscal Year: 2004
    ..abstract_text> ..
  4. Genetic And Inflammatory Markers Of Sepsis
    Derek Angus; Fiscal Year: 2004
    ....
  5. Long-Term Outcomes of NO for Ventilated Premature Babies
    Derek Angus; Fiscal Year: 2003
    ..Finally, our data will allow assessment of the robustness of early proxies for subsequent outcomes, key for future study design in this area. ..