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Genomes and Genes | Derek C AngusSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary teamJ Randall Curtis
University of Washington, Seattle, Washington, USA
Crit Care Med 34:211-8. 2006..Further research is needed to refine the methods and identify the most cost-effective means of improving the quality of health care received by critically ill patients and their families...- The future of critical careDerek C Angus
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care Clin 21:163-9, x. 2005.... 
Variation in critical care services across North America and Western EuropeHannah Wunsch
Department of Anesthesiology, Columbia University, New York, NY, USA
Crit Care Med 36:2787-93, e1-9. 2008..Yet, little is known regarding international variation in critical care services. We sought to understand differences in critical care delivery by comparing data on the distribution of services in eight countries...
Drotrecogin alfa (activated)...a sad final fizzle to a roller-coaster partyDerek C Angus
Department of Critical Care Medicine, University of Pittsburgh, 614 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 16:107. 2012..At the same time, more sophisticated selection of patients seems key if we are to most wisely test agents designed to manipulate the septic host response...
Predicting late anemia in critical illnessEric B Milbrandt
The CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 10:R39. 2006..CONCLUSION: A rule-based decision support tool using information available within six hours of ICU admission may lead to earlier and more appropriate use of blood-sparing strategies...- Bench-to-bedside review: avoiding pitfalls in critical care meta-analysis--funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacyMichael C Reade
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 12:220. 2008..The present review explains these problems and the strategies by which they are overcome... - Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsisDerek C Angus
The CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 614 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
JAMA 305:1469-77. 2011..Although advances in understanding the host immune response have fueled considerable interest in immunomodulatory therapy, the role of such agents in clinical practice remains limited and controversial... - Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failureDerek C Angus
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Circulation 112:3745-53. 2005..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population... - Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsisDerek C Angus
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:1061-7. 2007.... - Differences in immune response may explain lower survival among older men with pneumoniaMichael C Reade
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 37:1655-62. 2009..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response... - Do hospitals provide lower quality of care to black patients for pneumonia?Florian B Mayr
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 38:759-65. 2010..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals... - The effect of drotrecogin alfa (activated) on long-term survival after severe sepsisDerek C Angus
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 32:2199-206. 2004..Post hoc analysis suggests the effect of DrotAA varies by APACHE II score with improved long-term survival in subjects with APACHE II scores >/=25 but no benefit in those with lower scores... - Is survival better at hospitals with higher "end-of-life" treatment intensity?Amber E Barnato
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Med Care 48:125-32. 2010..Concern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit... - Intensive care unit safety culture and outcomes: a US multicenter studyDavid T Huang
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Int J Qual Health Care 22:151-61. 2010..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes... - Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death... - Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Tony Dremsizov
606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
Chest 129:968-78. 2006.... - Prevalence and significance of coagulation abnormalities in community-acquired pneumoniaEric B Milbrandt
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mol Med 15:438-45. 2009..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials... - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown... - Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) StudyJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
Arch Intern Med 167:1655-63. 2007..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death... - Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsisFlorian B Mayr
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
JAMA 303:2495-503. 2010..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear... - Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patientsGilles Clermont
Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 30:2237-44. 2004..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing... - Midregional proadrenomedullin as a prognostic tool in community-acquired pneumoniaDavid T Huang
Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 136:823-31. 2009..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection... - Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 yearR Scott Watson
Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 124:1333-43. 2009..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO... - Understanding the potential role of statins in pneumonia and sepsisSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 39:1871-8. 2011..To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis... - The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumoniaMichael C Reade
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
BMC Pulm Med 10:15. 2010..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals... - Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deathsSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e22847. 2011.... - Critical care medicine training and certification for emergency physiciansDavid T Huang
The CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 33:2104-9. 2005..We therefore propose that all accreditation bodies work cooperatively to create a route to CCM certification for emergency physicians who complete a critical care fellowship... - The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studiesSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Thorax 65:870-7. 2010..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear... - Growth of intensive care unit resource use and its estimated cost in MedicareEric B Milbrandt
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:2504-10. 2008..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs... - Risk prediction with procalcitonin and clinical rules in community-acquired pneumoniaDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Ann Emerg Med 52:48-58.e2. 2008..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65... - The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumoniaSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
FASEB J 23:2403-11. 2009..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia... - Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteriaDerek C Angus
Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Respir Crit Care Med 166:717-23. 2002..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time... - A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancerAmber E Barnato
Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 39:1663-9. 2011..To test whether hospital-based physicians made different intensive care unit and life-sustaining treatment decisions for otherwise identical black and white patients with end-stage cancer and life-threatening hypoxia... - Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsisGorkem Saka
Department of Industrial Engineering, University of Pittsburgh, 3700 Ohara St, 3700 Benedum Hall, Pittsburgh, PA 15261, USA
Crit Care 11:R65. 2007.... - Optimal approach to improving trauma triage decisions: a cost-effectiveness analysisDeepika Mohan
The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Manag Care 18:e91-e100. 2012..To identify the optimal target of a future intervention to improve physician decision making in trauma triage... - Using simulation to isolate physician variation in intensive care unit admission decision making for critically ill elders with end-stage cancer: a pilot feasibility studyAmber E Barnato
University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:3156-63. 2008..To determine the feasibility of high-fidelity simulation for studying variation in intensive care unit admission decision making for critically ill elders with end-stage cancer... - Intensive care unit renal support therapy volume is not associated with patient outcomeYên Lan Nguyen
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Crit Care Med 39:2470-7. 2011..Our objective was to determine whether there is a volume-outcome relationship among intensive care unit patients receiving renal support therapy in two different healthcare systems (France and the United States)... - The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injuryGilles Clermont
Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e22512. 2011..central venous catheter (CVC). We explored if use of the PAC in ALI is justified by a beneficial cost-effectiveness profile... - Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?Lakshmipathi Chelluri
Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Crit Care Med 31:1746-51. 2003..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions... - The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumoniaSachin Kale
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e13852. 2010..To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly... - Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United StatesVladimir Kaplan
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 165:766-72. 2002..The sex differences are of concern and require further investigation... - Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumoniaRaghavan Murugan
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin J Am Soc Nephrol 7:895-905. 2012..This study examined whether statin use was associated with a lower risk for pneumonia-induced AKI and 1-year and cause-specific mortality in patients with AKI... - Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumoniaNattachai Srisawat
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 80:545-52. 2011..Thus, in this cohort of patients with pneumonia-induced severe acute kidney injury, plasma NGAL appears to be a useful biomarker for predicting renal recovery... - Pneumonia: still the old man's friend?Vladimir Kaplan
Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
Arch Intern Med 163:317-23. 2003..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP... - Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxideDerek C Angus
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 34:2883-90. 2006..Inhaled nitric oxide at 5 ppm had no effect on these outcomes... - Informal caregiver burden among survivors of prolonged mechanical ventilationDavid C Van Pelt
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606D Scaife Hall, Pittsburgh, PA 15261, USA
Am J Respir Crit Care Med 175:167-73. 2007..In existing studies, it is unclear whether the observed burden is a consequence of critical illness or of preexisting patient illness... - Nighttime intensivist staffing and mortality among critically ill patientsDavid J Wallace
Department of Critical Care Medicine, Clinical Research, Investigation, and Systems of Modeling of Acute Illness Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
N Engl J Med 366:2093-101. 2012..However, the degree to which nighttime intensivists are associated with improvements in the quality of ICU care is unknown... - 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown... - Development and validation of hospital "end-of-life" treatment intensity measuresAmber E Barnato
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Med Care 47:1098-105. 2009..Health care utilization among decedents is increasingly used as a measure of health care efficiency, but decedent-based measures may be biased estimates of care received by "dying" patients... - Haloperidol use is associated with lower hospital mortality in mechanically ventilated patientsEric B Milbrandt
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 33:226-9; discussion 263-5. 2005..Because of their observational nature and the potential risks associated with haloperidol use, they require confirmation in a randomized, controlled trial before being applied to routine patient care... - Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristicsAmber E Barnato
Center for Research on Health Care, 200 Meyran Ave, Suite 200, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 177:279-84. 2008..Higher rates of sepsis have been reported in minorities... - Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United StatesDerek C Angus
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 112:1351-60. 2003..Our objective was to estimate the cost-effectiveness ratio of iNO in this population... - Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreachYên Lan Nguyen
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Am J Respir Crit Care Med 181:1164-9. 2010.... - Racial variation in end-of-life intensive care use: a race or hospital effect?Amber E Barnato
Department of Medicine, School of Medicine, Graduate School of Public Health, Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213, USA
Health Serv Res 41:2219-37. 2006.... - Comparison of Cox and Gray's survival models in severe sepsisJan Kasal
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 32:700-7. 2004..CONCLUSION: We confirm that many of the important predictors of mortality in severe sepsis are nonproportional and find that Gray's model seems best suited for modeling survival in this condition... - Value and role of intensive care unit outcome prediction models in end-of-life decision makingAmber E Barnato
Center for Research on Health Care, Department of Medicine, University of Pittsburgh, 230 McKee Place, Suite 600, Pittsburgh, PA 15213, USA
Crit Care Clin 20:345-62, vii-viii. 2004.... - Organizational determinants of hospital end-of-life treatment intensityCaroline Y Lin
Center for Research on Health Care, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh, PA 15213, USA
Med Care 47:524-30. 2009..There is substantial hospital-level variation in end-of-life (EOL) treatment intensity... - Assessing the feasibility of the American College of Surgeons' benchmarks for the triage of trauma patientsDeepika Mohan
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
Arch Surg 146:786-92. 2011.... - Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modelingGilles Clermont
Department of Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 31:2627-33. 2003..We encourage further evaluation of modeling in the search for more sensitive mortality end points... - Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcomeChristopher W Seymour
Departments of Critical Care Medicine and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Respir Crit Care Med 186:1264-71. 2012..Severe sepsis is common and highly morbid, yet the epidemiology of severe sepsis at the frontier of the health care system-pre-hospital emergency care-is unknown... - Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensityAmber E Barnato
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Palliat Med 10:1093-100. 2007..Individual hospital microclimates must exist to perpetuate these practice variations... - A clinically based discrete-event simulation of end-stage liver disease and the organ allocation processSteven M Shechter
Department of Industrial Engineering, University of Pittsburgh, Pennsylvania, USA
Med Decis Making 25:199-209. 2005..CONCLUSION: The authors created a discrete-event simulation model that represents the biology of end-stage liver disease and the health care organization of transplantation in the United States... - Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsisDerek C Angus
Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
Crit Care Med 31:1-11. 2003..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis... - The epidemiology of severe sepsis in children in the United StatesR Scott Watson
Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 167:695-701. 2003..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight... - Use of intensive care at the end of life in the United States: an epidemiologic studyDerek C Angus
Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 32:638-43. 2004.... - Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomesGilles Clermont
Department of Critical Care Medicine and Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
Kidney Int 62:986-96. 2002..We were unable to identify a unique mortality associated with ARF, but the presence of measurable renal insufficiency continues to be a sensitive marker for poor outcome... - RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysisEric A J Hoste
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 10:R73. 2006.... - The research agenda in ICU telemedicine: a statement from the Critical Care Societies CollaborativeJeremy M Kahn
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 140:230-8. 2011..We propose an agenda to advance the science of ICU telemedicine and generate research with the greatest potential to improve patient care... - Variability in management of early severe sepsisMichael C Reade
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA
Emerg Med J 27:110-5. 2010.... - Physician attitudes toward regionalization of adult critical care: a national surveyJeremy M Kahn
Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 37:2149-54. 2009..Regionalization has been proposed as a method to improve outcomes for patients with critical illness. We sought to determine intensivist physician attitudes and potential barriers to the regionalization of adult critical care... - Perceptions of safety culture vary across the intensive care units of a single institutionDavid T Huang
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:165-76. 2007..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes... - Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysisDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory CRISMA, Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:2090-100. 2007..However, implementation of EGDT faces several barriers, including perceived costs and logistic difficulties. We conducted a decision analysis to explore the potential costs and consequences of EGDT implementation... - Translating research evidence into clinical practice: new challenges for critical careKenneth G Kalassian
Department of Critical Care Medicine, School of Medicine and Department of Health Services Administration, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 6:11-4. 2002 - Thought outside the box: intensive care unit freakonomics and decision making in the intensive care unitDeepika Mohan
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 38:S637-41. 2010.... - Physician staffing patterns and clinical outcomes in critically ill patients: a systematic reviewPeter J Pronovost
Department of Critical Care Medicine, Hopkins University, Baltimore, MD, USA
JAMA 288:2151-62. 2002..No study found increased LOS with high-intensity staffing after case-mix adjustment. CONCLUSIONS: High-intensity vs low-intensity ICU physician staffing is associated with reduced hospital and ICU mortality and hospital and ICU LOS... - Comparison of medical admissions to intensive care units in the United States and United KingdomHannah Wunsch
Department of Anesthesiology, Columbia University, New York, New York, USA
Am J Respir Crit Care Med 183:1666-73. 2011..The United States has seven times as many intensive care unit (ICU) beds per capita as the United Kingdom; the effect on care of critically ill patients is unknown... - Surviving intensive care: a report from the 2002 Brussels RoundtableDerek C Angus
CRISMA, Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 29:368-77. 2003..Specific interventions that show promise for improving care include ICU discharge screening tools and ICU follow-up clinics... - The Acute Physiology and Chronic Health Evaluation II. Article of Knaus et al with expert commentary by Dr Derek AngusAli Al-Khafaji
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Crit Care 22:85-8. 2007 - Genetics and proteomics: deciphering gene association studies in critical illnessSachin Yende
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care 10:227. 2006.... - Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unitCindy L Bryce
Department of Medicine, Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Med Care 42:423-31. 2004..This issue is particularly problematic in the intensive-care unit (ICU) where death is frequent, care is difficult, and costs are high... - Understanding the lingering consequences of what we treat and what we doDerek C Angus
Department of Critical Care Medicine, The CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 8:103-4. 2004..In the meantime, we can hope that this quality of follow-up will move from the research arena to become a part of routine clinical care... - Influence of comorbid conditions on long-term mortality after pneumonia in older peopleSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:518-25. 2007..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions... - Improving care of the critically ill: institutional and health-care system approachesDerek C Angus
Clinical Research, Investigation and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lancet 363:1314-20. 2004.... - National estimates of severe sepsis in United States emergency departmentsHenry E Wang
Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 35:1928-36. 2007..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis... - Severe sepsis epidemiology: sampling, selection, and societyWalter T Linde-Zwirble
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care 8:222-6. 2004..In the future, we must focus on whether all severe sepsis should be treated, and, consequently, what level of ICU services is optimal... - Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS databaseMark S Roberts
Section of Decision Sciences and Clinical Systems Modeling, Division of General Medicine, University of Pittsburgh School of Medicine, Center for Research on Health Care, Pittsburgh, PA 15213, USA
Liver Transpl 10:886-97. 2004..However, a significant portion of the difference in survival between diseases arises from differences in clinical characteristics at the time of transplantation... - Continuous versus intermittent renal replacement therapy: a meta-analysisJohn A Kellum
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Intensive Care Med 28:29-37. 2002..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival... - Variation in sepsis care: a wake-up callMary E Hartman
CRISMA (Clinical Research, Investigation and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 7:211-3. 2003 - The PIRO concept: P is for predispositionDerek C Angus
CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 7:248-51. 2003 - Potential mechanisms and markers of critical illness-associated cognitive dysfunctionEric B Milbrandt
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Crit Care 11:355-9. 2005.... - Critical care medicine training and certification for emergency physiciansDavid T Huang
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Ann Emerg Med 46:217-23. 2005..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship... - Designing clinical trials in acute lung injury/acute respiratory distress syndromeDavid T Huang
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA
Curr Opin Crit Care 12:32-6. 2006..To review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS)... - Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeuticsEric B Milbrandt
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 641 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
Crit Care 10:238. 2006.... - Health status versus utilities of patients with end-stage liver diseaseCindy L Bryce
Division of General Internal Medicine, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
Qual Life Res 13:773-82. 2004..For formal economic evaluations such as cost effectiveness analyses, only direct measures of utility can be used to quantify health states... - Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trialPierre-Francois Laterre
Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
Crit Care Med 32:2207-18. 2004..Additional survivors created with DrotAA treatment did not increase per-patient resource use or intensive care unit or hospital length of stay... - How does lack of insurance affect use of intensive care? A population-based studyMarion Danis
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
Crit Care Med 34:2043-8. 2006..We sought to compare the use of intensive care by insured and uninsured populations... - Drotrecogin alfa (activated) treatment of older patients with severe sepsisE Wesley Ely
Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Clin Infect Dis 37:187-95. 2003..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related... - Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, Camden, NJ, USA
Crit Care Med 36:296-327. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004... - Potential value of regionalized intensive care for mechanically ventilated medical patientsJeremy M Kahn
Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 177:285-91. 2008..Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit... - Community-acquired pneumonia in the elderlyVladimir Kaplan
Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, CJ-8091, Zurich, Switzerland
Crit Care Clin 19:729-48. 2003..Future efforts in the management of CAP need to consider the postdischarge period where most deaths occur. Prevention is an important issue especially for those at high risk for CAP... - Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trialJean Louis Vincent
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
Crit Care Med 31:834-40. 2003..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)...