Research Topics
Species | D C AngusSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Translating research evidence into clinical practice: new challenges for critical careKenneth G Kalassian
Department of Critical Care Medicine, School of Medicine and Department of Health Services Administration, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 6:11-4. 2002- The PIRO concept: P is for predispositionDerek C Angus
CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 7:248-51. 2003 
Epidemiology of neonatal respiratory failure in the United States: projections from California and New YorkD C Angus
Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 164:1154-60. 2001..4 billion. We conclude neonatal respiratory failure is common, expensive, and frequently fatal. There are a surprisingly large number of normal BW cases and there are large racial differences...- Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careD C Angus
Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 29:1303-10. 2001..To determine the incidence, cost, and outcome of severe sepsis in the United States... - Quality-adjusted survival in the first year after the acute respiratory distress syndromeD C Angus
Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 163:1389-94. 2001..We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care... - Caring for the critically ill patient. Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease: can we meet the requirements of an aging population?D C Angus
Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
JAMA 284:2762-70. 2000..Two important areas of medicine, care of the critically ill and management of pulmonary disease, are likely to be influenced by the aging of the US population... - E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study InvestigatorsD C Angus
Department of Anesthesiology and Critical Care Medicine, and Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
JAMA 283:1723-30. 2000..Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not... - Short-term and long-term outcome prediction with the Acute Physiology and Chronic Health Evaluation II system after orthotopic liver transplantationD C Angus
Department of Anesthesiology and Critical Care Medicine, Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
Crit Care Med 28:150-6. 2000..To evaluate the relationship between the postoperative Acute Physiology and Chronic Health Evaluation (APACHE) II score and mortality at hospital discharge and at 1 yr in liver transplant recipients... - Differences in immune response may explain lower survival among older men with pneumoniaMichael C Reade
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 37:1655-62. 2009..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response... - Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United StatesVladimir Kaplan
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 165:766-72. 2002..The sex differences are of concern and require further investigation... - Predicting hospital mortality for patients in the intensive care unit: a comparison of artificial neural networks with logistic regression modelsG Clermont
Critical Care Medicine Division, the Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 29:291-6. 2001..However, development sets of < or = 800 were generally inadequate. This is concerning, given typical sample sizes used for individual ICU mortality prediction... - Epidemiology of sepsis: an updateD C Angus
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 29:S109-16. 2001..To place new information, such as the role of genetic predisposition, in the correct context, it is essential that such studies be conducted... 
Is survival better at hospitals with higher "end-of-life" treatment intensity?Amber E Barnato
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Med Care 48:125-32. 2010..Concern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit...- Do hospitals provide lower quality of care to black patients for pneumonia?Florian B Mayr
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 38:759-65. 2010..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals... - The effect of drotrecogin alfa (activated) on long-term survival after severe sepsisDerek C Angus
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 32:2199-206. 2004..Post hoc analysis suggests the effect of DrotAA varies by APACHE II score with improved long-term survival in subjects with APACHE II scores >/=25 but no benefit in those with lower scores... - The epidemiology of severe sepsis in children in the United StatesR Scott Watson
Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 167:695-701. 2003..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight... - Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomesGilles Clermont
Department of Critical Care Medicine and Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
Kidney Int 62:986-96. 2002..We were unable to identify a unique mortality associated with ARF, but the presence of measurable renal insufficiency continues to be a sensitive marker for poor outcome... - Risk prediction with procalcitonin and clinical rules in community-acquired pneumoniaDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Ann Emerg Med 52:48-58.e2. 2008..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65... - Incidence and definition of sepsis and associated organ dysfunctionT T Dremsizov
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Int J Artif Organs 27:352-9. 2004..CONCLUSION: Recently there has been an increasing amount of information enabling characterization of the epidemiology of sepsis, which may help to direct appropriate care in the coming years... - Community-wide assessment of intensive care outcomes using a physiologically based prognostic measure: implications for critical care delivery from Cleveland Health Quality ChoiceC A Sirio
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
Chest 115:793-801. 1999..To examine the applicability of a previously developed intensive care prognostic measure to a community-based sample of hospitals, and assess variations in severity-adjusted mortality across a major metropolitan region... - Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsisFlorian B Mayr
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
JAMA 303:2495-503. 2010..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear... - Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristicsAmber E Barnato
Center for Research on Health Care, 200 Meyran Ave, Suite 200, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 177:279-84. 2008..Higher rates of sepsis have been reported in minorities... - Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death... - A clinically based discrete-event simulation of end-stage liver disease and the organ allocation processSteven M Shechter
Department of Industrial Engineering, University of Pittsburgh, Pennsylvania, USA
Med Decis Making 25:199-209. 2005..CONCLUSION: The authors created a discrete-event simulation model that represents the biology of end-stage liver disease and the health care organization of transplantation in the United States... - The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumoniaMichael C Reade
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
BMC Pulm Med 10:15. 2010..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals... - Acute care practices relevant to quality end-of-life care: a survey of Pennsylvania hospitalsC Y Lin
Center for Research on Health Care and the Institute for Clinical Research Education, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Suite 200, Pittsburgh, PA 15213, USA
Qual Saf Health Care 19:e12. 2010..Improving end-of-life care in the hospital is a national priority... - Use of intensive care at the end of life in the United States: an epidemiologic studyDerek C Angus
Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 32:638-43. 2004.... - Organizational determinants of hospital end-of-life treatment intensityCaroline Y Lin
Center for Research on Health Care, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh, PA 15213, USA
Med Care 47:524-30. 2009..There is substantial hospital-level variation in end-of-life (EOL) treatment intensity... - Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsisGorkem Saka
Department of Industrial Engineering, University of Pittsburgh, 3700 Ohara St, 3700 Benedum Hall, Pittsburgh, PA 15261, USA
Crit Care 11:R65. 2007.... - Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxideDerek C Angus
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 34:2883-90. 2006..Inhaled nitric oxide at 5 ppm had no effect on these outcomes... - Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 yearR Scott Watson
Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 124:1333-43. 2009..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO... - The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumoniaSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
FASEB J 23:2403-11. 2009..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia... - Perceptions of safety culture vary across the intensive care units of a single institutionDavid T Huang
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:165-76. 2007..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes... - RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysisEric A J Hoste
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 10:R73. 2006.... - Influence of comorbid conditions on long-term mortality after pneumonia in older peopleSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:518-25. 2007..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions... - The Acute Physiology and Chronic Health Evaluation II. Article of Knaus et al with expert commentary by Dr Derek AngusAli Al-Khafaji
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Crit Care 22:85-8. 2007 - Genetics and proteomics: deciphering gene association studies in critical illnessSachin Yende
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care 10:227. 2006.... - Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeuticsEric B Milbrandt
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 641 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
Crit Care 10:238. 2006.... - Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsisDerek C Angus
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:1061-7. 2007.... - Improving care of the critically ill: institutional and health-care system approachesDerek C Angus
Clinical Research, Investigation and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lancet 363:1314-20. 2004.... - Racial variation in end-of-life intensive care use: a race or hospital effect?Amber E Barnato
Department of Medicine, School of Medicine, Graduate School of Public Health, Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213, USA
Health Serv Res 41:2219-37. 2006.... - National estimates of severe sepsis in United States emergency departmentsHenry E Wang
Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 35:1928-36. 2007..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis... - Intensive care unit safety culture and outcomes: a US multicenter studyDavid T Huang
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Int J Qual Health Care 22:151-61. 2010..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes... - Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreachYên Lan Nguyen
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Am J Respir Crit Care Med 181:1164-9. 2010.... - Prevalence and significance of coagulation abnormalities in community-acquired pneumoniaEric B Milbrandt
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mol Med 15:438-45. 2009..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials... - Midregional proadrenomedullin as a prognostic tool in community-acquired pneumoniaDavid T Huang
Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 136:823-31. 2009..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection... - The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studiesSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Thorax 65:870-7. 2010..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear... - Growth of intensive care unit resource use and its estimated cost in MedicareEric B Milbrandt
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:2504-10. 2008..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs... - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown... - Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsisDerek C Angus
The CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 614 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
JAMA 305:1469-77. 2011..Although advances in understanding the host immune response have fueled considerable interest in immunomodulatory therapy, the role of such agents in clinical practice remains limited and controversial... - 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown... - Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Tony Dremsizov
606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
Chest 129:968-78. 2006.... - Designing clinical trials in acute lung injury/acute respiratory distress syndromeDavid T Huang
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA
Curr Opin Crit Care 12:32-6. 2006..To review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS)... - Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patientsGilles Clermont
Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 30:2237-44. 2004..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing... - Severe sepsis epidemiology: sampling, selection, and societyWalter T Linde-Zwirble
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care 8:222-6. 2004..In the future, we must focus on whether all severe sepsis should be treated, and, consequently, what level of ICU services is optimal... - Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS databaseMark S Roberts
Section of Decision Sciences and Clinical Systems Modeling, Division of General Medicine, University of Pittsburgh School of Medicine, Center for Research on Health Care, Pittsburgh, PA 15213, USA
Liver Transpl 10:886-97. 2004..However, a significant portion of the difference in survival between diseases arises from differences in clinical characteristics at the time of transplantation... - Value and role of intensive care unit outcome prediction models in end-of-life decision makingAmber E Barnato
Center for Research on Health Care, Department of Medicine, University of Pittsburgh, 230 McKee Place, Suite 600, Pittsburgh, PA 15213, USA
Crit Care Clin 20:345-62, vii-viii. 2004.... - Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modelingGilles Clermont
Department of Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 31:2627-33. 2003..We encourage further evaluation of modeling in the search for more sensitive mortality end points... - Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United StatesDerek C Angus
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 112:1351-60. 2003..Our objective was to estimate the cost-effectiveness ratio of iNO in this population... - Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsisDerek C Angus
Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
Crit Care Med 31:1-11. 2003..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis... - Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unitCindy L Bryce
Department of Medicine, Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Med Care 42:423-31. 2004..This issue is particularly problematic in the intensive-care unit (ICU) where death is frequent, care is difficult, and costs are high... - Understanding the lingering consequences of what we treat and what we doDerek C Angus
Department of Critical Care Medicine, The CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 8:103-4. 2004..In the meantime, we can hope that this quality of follow-up will move from the research arena to become a part of routine clinical care... - Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteriaDerek C Angus
Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Respir Crit Care Med 166:717-23. 2002..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time... - The future of critical careDerek C Angus
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care Clin 21:163-9, x. 2005.... - Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failureDerek C Angus
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Circulation 112:3745-53. 2005..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population... - Variation in sepsis care: a wake-up callMary E Hartman
CRISMA (Clinical Research, Investigation and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 7:211-3. 2003 - Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?Lakshmipathi Chelluri
Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Crit Care Med 31:1746-51. 2003..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions... - Critical care medicine training and certification for emergency physiciansDavid T Huang
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Ann Emerg Med 46:217-23. 2005..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship... - Potential mechanisms and markers of critical illness-associated cognitive dysfunctionEric B Milbrandt
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Crit Care 11:355-9. 2005.... - Continuous versus intermittent renal replacement therapy: a meta-analysisJohn A Kellum
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Intensive Care Med 28:29-37. 2002..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival... - Haloperidol use is associated with lower hospital mortality in mechanically ventilated patientsEric B Milbrandt
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 33:226-9; discussion 263-5. 2005..Because of their observational nature and the potential risks associated with haloperidol use, they require confirmation in a randomized, controlled trial before being applied to routine patient care... - Pneumonia: still the old man's friend?Vladimir Kaplan
Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
Arch Intern Med 163:317-23. 2003..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP... - Surviving intensive care: a report from the 2002 Brussels RoundtableDerek C Angus
CRISMA, Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 29:368-77. 2003..Specific interventions that show promise for improving care include ICU discharge screening tools and ICU follow-up clinics... - The first international consensus conference on continuous renal replacement therapyJohn A Kellum
Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Kidney Int 62:1855-63. 2002..We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study... - Economics of end-of-life care in the intensive care unitP Pronovost
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 29:N46-51. 2001..We must be aware of the limitations of cost-effectiveness analyses and the need for value judgments when using cost-effectiveness analyses to inform healthcare decisions... - Genetic variation and risk of sepsisJ A Kellum
The CRISMA Laboratory Clinical Research, Investigation and Systems Modeling of Acute illness, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine Pittsburgh, Pennsylvania 15261, USA
Minerva Anestesiol 69:245-53. 2003..g. tumor necrosis factor) has lent credence to this hypothesis. Yet discovery of the actual relationship between risks of infection / severe sepsis and individual genotypes will require larger, more rigorously designed studies... - Epidemiologic assessment of mortality, building collapse pattern, and medical response after the 1992 earthquake in Turkey. Disaster Reanimatology Study Group (DRSG)D C Angus
Department of Anesthesiology CCM, University of Pittsburgh, PA 15213, USA
Prehosp Disaster Med 12:222-31. 1997..This paper describes mortality and its relationship to building collapse patterns and initial medical responses following the 1992 earthquake in Erzincan, Turkey... - Sociodemographic differences in early access to liver transplantation servicesC L Bryce
Division of General Internal Medicine, Department of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Am J Transplant 9:2092-101. 2009..For early management and treatment decisions of patients with ESLD to be better understood, more comprehensive data concerning referral and listing practices are needed... - Physician staffing patterns and clinical outcomes in critically ill patients: a systematic reviewPeter J Pronovost
Department of Critical Care Medicine, Hopkins University, Baltimore, MD, USA
JAMA 288:2151-62. 2002..No study found increased LOS with high-intensity staffing after case-mix adjustment. CONCLUSIONS: High-intensity vs low-intensity ICU physician staffing is associated with reduced hospital and ICU mortality and hospital and ICU LOS... - Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsisE Wesley Ely
Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
Crit Care Med 31:12-9. 2003.... - Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trialJean Louis Vincent
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
Crit Care Med 31:834-40. 2003..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)... - Potential value of regionalized intensive care for mechanically ventilated medical patientsJeremy M Kahn
Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 177:285-91. 2008..Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit... - Drotrecogin alfa (activated) treatment of older patients with severe sepsisE Wesley Ely
Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Clin Infect Dis 37:187-95. 2003..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related... - End-of-life care for the critically ill: A national intensive care unit surveyJudith E Nelson
Department of Medicine, Hertzberg Palliative Care Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Crit Care Med 34:2547-53. 2006..We conducted this study to elicit the views and experiences of ICU directors regarding barriers to optimal end-of-life care and to identify the type, availability, and perceived benefit of specific strategies that may improve this care... - Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trialPierre-Francois Laterre
Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
Crit Care Med 32:2207-18. 2004..Additional survivors created with DrotAA treatment did not increase per-patient resource use or intensive care unit or hospital length of stay... - Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary teamJ Randall Curtis
University of Washington, Seattle, Washington, USA
Crit Care Med 34:211-8. 2006..Further research is needed to refine the methods and identify the most cost-effective means of improving the quality of health care received by critically ill patients and their families... - Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) StudyJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
Arch Intern Med 167:1655-63. 2007..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death... - Health policy and future planning for survivors of critical illnessJeremy M Kahn
Division of Pulmonary, Allergy and Critical Care, Leonard Davis Institute of Health Economics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA
Curr Opin Crit Care 13:514-8. 2007..This review will assess some of the health system-level barriers to effective post-intensive care unit care and provide a framework for policy decisions directed at improving outcomes for survivors of critical illness... - Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, Camden, NJ, USA
Crit Care Med 36:296-327. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004... - Health status versus utilities of patients with end-stage liver diseaseCindy L Bryce
Division of General Internal Medicine, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
Qual Life Res 13:773-82. 2004..For formal economic evaluations such as cost effectiveness analyses, only direct measures of utility can be used to quantify health states... - Community-acquired pneumonia in the elderlyVladimir Kaplan
Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, CJ-8091, Zurich, Switzerland
Crit Care Clin 19:729-48. 2003..Future efforts in the management of CAP need to consider the postdischarge period where most deaths occur. Prevention is an important issue especially for those at high risk for CAP... - Variation in critical care services across North America and Western EuropeHannah Wunsch
Department of Anesthesiology, Columbia University, New York, NY, USA
Crit Care Med 36:2787-93, e1-9. 2008..Yet, little is known regarding international variation in critical care services. We sought to understand differences in critical care delivery by comparing data on the distribution of services in eight countries... - Long-term mortality and medical care charges in patients with severe sepsisDerek Weycker
Policy Analysis Inc, Brookline, MA, USA
Crit Care Med 31:2316-23. 2003..Hospitalization accounted for the largest component of total medical care charges. CONCLUSIONS: Mortality and economic costs are high in patients with severe sepsis, during the period of acute illness as well as subsequently... - How does lack of insurance affect use of intensive care? A population-based studyMarion Danis
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
Crit Care Med 34:2043-8. 2006..We sought to compare the use of intensive care by insured and uninsured populations...