D C Angus

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Translating research evidence into clinical practice: new challenges for critical care
    Kenneth G Kalassian
    Department of Critical Care Medicine, School of Medicine and Department of Health Services Administration, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 6:11-4. 2002
  2. pmc The PIRO concept: P is for predisposition
    Derek C Angus
    CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:248-51. 2003
  3. ncbi request reprint Epidemiology of neonatal respiratory failure in the United States: projections from California and New York
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 164:1154-60. 2001
  4. ncbi request reprint Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  5. ncbi request reprint Quality-adjusted survival in the first year after the acute respiratory distress syndrome
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 163:1389-94. 2001
  6. ncbi request reprint Caring for the critically ill patient. Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease: can we meet the requirements of an aging population?
    D C Angus
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    JAMA 284:2762-70. 2000
  7. ncbi request reprint E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, and Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
    JAMA 283:1723-30. 2000
  8. ncbi request reprint Short-term and long-term outcome prediction with the Acute Physiology and Chronic Health Evaluation II system after orthotopic liver transplantation
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
    Crit Care Med 28:150-6. 2000
  9. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
  10. ncbi request reprint Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002

Collaborators

Detail Information

Publications94

  1. pmc Translating research evidence into clinical practice: new challenges for critical care
    Kenneth G Kalassian
    Department of Critical Care Medicine, School of Medicine and Department of Health Services Administration, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 6:11-4. 2002
  2. pmc The PIRO concept: P is for predisposition
    Derek C Angus
    CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:248-51. 2003
  3. ncbi request reprint Epidemiology of neonatal respiratory failure in the United States: projections from California and New York
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 164:1154-60. 2001
    ..4 billion. We conclude neonatal respiratory failure is common, expensive, and frequently fatal. There are a surprisingly large number of normal BW cases and there are large racial differences...
  4. ncbi request reprint Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  5. ncbi request reprint Quality-adjusted survival in the first year after the acute respiratory distress syndrome
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 163:1389-94. 2001
    ..We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care...
  6. ncbi request reprint Caring for the critically ill patient. Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease: can we meet the requirements of an aging population?
    D C Angus
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    JAMA 284:2762-70. 2000
    ..Two important areas of medicine, care of the critically ill and management of pulmonary disease, are likely to be influenced by the aging of the US population...
  7. ncbi request reprint E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, and Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
    JAMA 283:1723-30. 2000
    ..Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not...
  8. ncbi request reprint Short-term and long-term outcome prediction with the Acute Physiology and Chronic Health Evaluation II system after orthotopic liver transplantation
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
    Crit Care Med 28:150-6. 2000
    ..To evaluate the relationship between the postoperative Acute Physiology and Chronic Health Evaluation (APACHE) II score and mortality at hospital discharge and at 1 yr in liver transplant recipients...
  9. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
    ..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response...
  10. ncbi request reprint Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
    ..The sex differences are of concern and require further investigation...
  11. ncbi request reprint Predicting hospital mortality for patients in the intensive care unit: a comparison of artificial neural networks with logistic regression models
    G Clermont
    Critical Care Medicine Division, the Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:291-6. 2001
    ..However, development sets of < or = 800 were generally inadequate. This is concerning, given typical sample sizes used for individual ICU mortality prediction...
  12. ncbi request reprint Epidemiology of sepsis: an update
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 29:S109-16. 2001
    ..To place new information, such as the role of genetic predisposition, in the correct context, it is essential that such studies be conducted...
  13. pmc Is survival better at hospitals with higher "end-of-life" treatment intensity?
    Amber E Barnato
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Med Care 48:125-32. 2010
    ..Concern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit...
  14. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
    ..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals...
  15. ncbi request reprint The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2199-206. 2004
    ..To determine long-term survival for subjects with severe sepsis enrolled in the previous multiple-center trial (PROWESS) of drotrecogin alfa (activated) (DrotAA) vs. placebo...
  16. ncbi request reprint The epidemiology of severe sepsis in children in the United States
    R Scott Watson
    Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 167:695-701. 2003
    ..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight...
  17. ncbi request reprint Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  18. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  19. ncbi request reprint Incidence and definition of sepsis and associated organ dysfunction
    T T Dremsizov
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Artif Organs 27:352-9. 2004
    ..To discuss the incidence, outcome and predisposing factors to systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ failure...
  20. ncbi request reprint Community-wide assessment of intensive care outcomes using a physiologically based prognostic measure: implications for critical care delivery from Cleveland Health Quality Choice
    C A Sirio
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Chest 115:793-801. 1999
    ..To examine the applicability of a previously developed intensive care prognostic measure to a community-based sample of hospitals, and assess variations in severity-adjusted mortality across a major metropolitan region...
  21. doi request reprint Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
    ..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear...
  22. pmc Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics
    Amber E Barnato
    Center for Research on Health Care, 200 Meyran Ave, Suite 200, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 177:279-84. 2008
    ..Higher rates of sepsis have been reported in minorities...
  23. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  24. ncbi request reprint A clinically based discrete-event simulation of end-stage liver disease and the organ allocation process
    Steven M Shechter
    Department of Industrial Engineering, University of Pittsburgh, Pennsylvania, USA
    Med Decis Making 25:199-209. 2005
    ..The objective of this article was to design a biologically based discrete-event simulation to test proposed changes in allocation policies...
  25. pmc The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia
    Michael C Reade
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 10:15. 2010
    ..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals...
  26. doi request reprint Acute care practices relevant to quality end-of-life care: a survey of Pennsylvania hospitals
    C Y Lin
    Center for Research on Health Care and the Institute for Clinical Research Education, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Suite 200, Pittsburgh, PA 15213, USA
    Qual Saf Health Care 19:e12. 2010
    ..Improving end-of-life care in the hospital is a national priority...
  27. ncbi request reprint Use of intensive care at the end of life in the United States: an epidemiologic study
    Derek C Angus
    Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:638-43. 2004
    ..We sought to describe the use of ICU care at the end of life in the United States using hospital discharge data from 1999 for six states and the National Death Index...
  28. pmc Organizational determinants of hospital end-of-life treatment intensity
    Caroline Y Lin
    Center for Research on Health Care, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh, PA 15213, USA
    Med Care 47:524-30. 2009
    ..There is substantial hospital-level variation in end-of-life (EOL) treatment intensity...
  29. pmc Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsis
    Gorkem Saka
    Department of Industrial Engineering, University of Pittsburgh, 3700 Ohara St, 3700 Benedum Hall, Pittsburgh, PA 15261, USA
    Crit Care 11:R65. 2007
    ....
  30. ncbi request reprint Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide
    Derek C Angus
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 34:2883-90. 2006
    ..To determine the costs and long-term outcomes of acute respiratory distress syndrome (ARDS) in previously healthy adults. To determine whether treatment with inhaled nitric oxide affects these costs and outcomes...
  31. doi request reprint Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
    ..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO...
  32. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  33. ncbi request reprint Perceptions of safety culture vary across the intensive care units of a single institution
    David T Huang
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:165-76. 2007
    ..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes...
  34. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  35. ncbi request reprint Influence of comorbid conditions on long-term mortality after pneumonia in older people
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:518-25. 2007
    ..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions...
  36. ncbi request reprint The Acute Physiology and Chronic Health Evaluation II. Article of Knaus et al with expert commentary by Dr Derek Angus
    Ali Al-Khafaji
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Crit Care 22:85-8. 2007
  37. pmc Genetics and proteomics: deciphering gene association studies in critical illness
    Sachin Yende
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 10:227. 2006
    ....
  38. pmc Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics
    Eric B Milbrandt
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 641 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Crit Care 10:238. 2006
    ....
  39. ncbi request reprint Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:1061-7. 2007
    ....
  40. ncbi request reprint Improving care of the critically ill: institutional and health-care system approaches
    Derek C Angus
    Clinical Research, Investigation and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lancet 363:1314-20. 2004
    ....
  41. pmc Racial variation in end-of-life intensive care use: a race or hospital effect?
    Amber E Barnato
    Department of Medicine, School of Medicine, Graduate School of Public Health, Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Health Serv Res 41:2219-37. 2006
    ....
  42. ncbi request reprint National estimates of severe sepsis in United States emergency departments
    Henry E Wang
    Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 35:1928-36. 2007
    ..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis...
  43. pmc Intensive care unit safety culture and outcomes: a US multicenter study
    David T Huang
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Int J Qual Health Care 22:151-61. 2010
    ..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes...
  44. doi request reprint Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreach
    Yên Lan Nguyen
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 181:1164-9. 2010
    ....
  45. pmc Prevalence and significance of coagulation abnormalities in community-acquired pneumonia
    Eric B Milbrandt
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Med 15:438-45. 2009
    ..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials...
  46. pmc Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia
    David T Huang
    Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 136:823-31. 2009
    ..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection...
  47. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
    ..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear...
  48. doi request reprint Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
    ..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs...
  49. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  50. doi request reprint Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsis
    Derek C Angus
    The CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 614 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 305:1469-77. 2011
    ..Although advances in understanding the host immune response have fueled considerable interest in immunomodulatory therapy, the role of such agents in clinical practice remains limited and controversial...
  51. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  52. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  53. ncbi request reprint Designing clinical trials in acute lung injury/acute respiratory distress syndrome
    David T Huang
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 12:32-6. 2006
    ..To review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS)...
  54. ncbi request reprint Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004
    ..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing...
  55. pmc Severe sepsis epidemiology: sampling, selection, and society
    Walter T Linde-Zwirble
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 8:222-6. 2004
    ..In the future, we must focus on whether all severe sepsis should be treated, and, consequently, what level of ICU services is optimal...
  56. ncbi request reprint Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database
    Mark S Roberts
    Section of Decision Sciences and Clinical Systems Modeling, Division of General Medicine, University of Pittsburgh School of Medicine, Center for Research on Health Care, Pittsburgh, PA 15213, USA
    Liver Transpl 10:886-97. 2004
    ..However, a significant portion of the difference in survival between diseases arises from differences in clinical characteristics at the time of transplantation...
  57. ncbi request reprint Value and role of intensive care unit outcome prediction models in end-of-life decision making
    Amber E Barnato
    Center for Research on Health Care, Department of Medicine, University of Pittsburgh, 230 McKee Place, Suite 600, Pittsburgh, PA 15213, USA
    Crit Care Clin 20:345-62, vii-viii. 2004
    ....
  58. ncbi request reprint Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  59. ncbi request reprint Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003
    ..Our objective was to estimate the cost-effectiveness ratio of iNO in this population...
  60. ncbi request reprint Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  61. ncbi request reprint Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unit
    Cindy L Bryce
    Department of Medicine, Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Med Care 42:423-31. 2004
    ..This issue is particularly problematic in the intensive-care unit (ICU) where death is frequent, care is difficult, and costs are high...
  62. pmc Understanding the lingering consequences of what we treat and what we do
    Derek C Angus
    Department of Critical Care Medicine, The CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 8:103-4. 2004
    ..In the meantime, we can hope that this quality of follow-up will move from the research arena to become a part of routine clinical care...
  63. ncbi request reprint Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    Derek C Angus
    Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 166:717-23. 2002
    ..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time...
  64. ncbi request reprint The future of critical care
    Derek C Angus
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care Clin 21:163-9, x. 2005
    ....
  65. ncbi request reprint Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 112:3745-53. 2005
    ..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population...
  66. pmc Variation in sepsis care: a wake-up call
    Mary E Hartman
    CRISMA Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:211-3. 2003
  67. ncbi request reprint Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 31:1746-51. 2003
    ..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions...
  68. ncbi request reprint Critical care medicine training and certification for emergency physicians
    David T Huang
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Emerg Med 46:217-23. 2005
    ..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship...
  69. ncbi request reprint Potential mechanisms and markers of critical illness-associated cognitive dysfunction
    Eric B Milbrandt
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:355-9. 2005
    ....
  70. ncbi request reprint Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
    ..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival...
  71. ncbi request reprint Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 33:226-9; discussion 263-5. 2005
    ..To determine whether haloperidol use is associated with lower mortality in mechanically ventilated patients...
  72. ncbi request reprint Pneumonia: still the old man's friend?
    Vladimir Kaplan
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:317-23. 2003
    ..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP...
  73. ncbi request reprint Surviving intensive care: a report from the 2002 Brussels Roundtable
    Derek C Angus
    CRISMA, Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:368-77. 2003
    ..Specific interventions that show promise for improving care include ICU discharge screening tools and ICU follow-up clinics...
  74. ncbi request reprint The first international consensus conference on continuous renal replacement therapy
    John A Kellum
    Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Kidney Int 62:1855-63. 2002
    ..We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study...
  75. ncbi request reprint Economics of end-of-life care in the intensive care unit
    P Pronovost
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 29:N46-51. 2001
    ..We must be aware of the limitations of cost-effectiveness analyses and the need for value judgments when using cost-effectiveness analyses to inform healthcare decisions...
  76. ncbi request reprint Genetic variation and risk of sepsis
    J A Kellum
    The CRISMA Laboratory Clinical Research, Investigation and Systems Modeling of Acute illness, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine Pittsburgh, Pennsylvania 15261, USA
    Minerva Anestesiol 69:245-53. 2003
    ..g. tumor necrosis factor) has lent credence to this hypothesis. Yet discovery of the actual relationship between risks of infection / severe sepsis and individual genotypes will require larger, more rigorously designed studies...
  77. ncbi request reprint Epidemiologic assessment of mortality, building collapse pattern, and medical response after the 1992 earthquake in Turkey. Disaster Reanimatology Study Group (DRSG)
    D C Angus
    Department of Anesthesiology CCM, University of Pittsburgh, PA 15213, USA
    Prehosp Disaster Med 12:222-31. 1997
    ..This paper describes mortality and its relationship to building collapse patterns and initial medical responses following the 1992 earthquake in Erzincan, Turkey...
  78. pmc Sociodemographic differences in early access to liver transplantation services
    C L Bryce
    Division of General Internal Medicine, Department of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 9:2092-101. 2009
    ..For early management and treatment decisions of patients with ESLD to be better understood, more comprehensive data concerning referral and listing practices are needed...
  79. ncbi request reprint Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review
    Peter J Pronovost
    Department of Critical Care Medicine, Hopkins University, Baltimore, MD, USA
    JAMA 288:2151-62. 2002
    ..Intensive care unit (ICU) physician staffing varies widely, and its association with patient outcomes remains unclear...
  80. ncbi request reprint Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
    Crit Care Med 31:12-9. 2003
    ....
  81. ncbi request reprint Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 31:834-40. 2003
    ..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)...
  82. pmc Potential value of regionalized intensive care for mechanically ventilated medical patients
    Jeremy M Kahn
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:285-91. 2008
    ..Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit...
  83. ncbi request reprint Drotrecogin alfa (activated) treatment of older patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Clin Infect Dis 37:187-95. 2003
    ..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related...
  84. ncbi request reprint End-of-life care for the critically ill: A national intensive care unit survey
    Judith E Nelson
    Department of Medicine, Hertzberg Palliative Care Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Crit Care Med 34:2547-53. 2006
    ..We conducted this study to elicit the views and experiences of ICU directors regarding barriers to optimal end-of-life care and to identify the type, availability, and perceived benefit of specific strategies that may improve this care...
  85. ncbi request reprint Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial
    Pierre Francois Laterre
    Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
    Crit Care Med 32:2207-18. 2004
    ..To compare differences in hospital mortality and resource use in adult severe sepsis subjects randomized to receive drotrecogin alfa (activated) (DrotAA) or placebo in the PROWESS trial...
  86. ncbi request reprint Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team
    J Randall Curtis
    University of Washington, Seattle, Washington, USA
    Crit Care Med 34:211-8. 2006
    ....
  87. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  88. ncbi request reprint Health policy and future planning for survivors of critical illness
    Jeremy M Kahn
    Division of Pulmonary, Allergy and Critical Care, Leonard Davis Institute of Health Economics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA
    Curr Opin Crit Care 13:514-8. 2007
    ..This review will assess some of the health system-level barriers to effective post-intensive care unit care and provide a framework for policy decisions directed at improving outcomes for survivors of critical illness...
  89. ncbi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  90. ncbi request reprint Health status versus utilities of patients with end-stage liver disease
    Cindy L Bryce
    Division of General Internal Medicine, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Qual Life Res 13:773-82. 2004
    ..The two approaches have never been compared in terms of the values they assign to health prior to liver transplantation...
  91. ncbi request reprint Community-acquired pneumonia in the elderly
    Vladimir Kaplan
    Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, CJ 8091, Zurich, Switzerland
    Crit Care Clin 19:729-48. 2003
    ..Future efforts in the management of CAP need to consider the postdischarge period where most deaths occur. Prevention is an important issue especially for those at high risk for CAP...
  92. doi request reprint Variation in critical care services across North America and Western Europe
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York, NY, USA
    Crit Care Med 36:2787-93, e1-9. 2008
    ..Yet, little is known regarding international variation in critical care services. We sought to understand differences in critical care delivery by comparing data on the distribution of services in eight countries...
  93. ncbi request reprint Long-term mortality and medical care charges in patients with severe sepsis
    Derek Weycker
    Policy Analysis Inc, Brookline, MA, USA
    Crit Care Med 31:2316-23. 2003
    ..To estimate long-term mortality and medical care charges among patients with severe sepsis...
  94. ncbi request reprint How does lack of insurance affect use of intensive care? A population-based study
    Marion Danis
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 34:2043-8. 2006
    ..We sought to compare the use of intensive care by insured and uninsured populations...