D J Angiolillo

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Shands Jacksonville, Jacksonville, Florida
    J Am Coll Cardiol 50:1541-7. 2007
  2. doi request reprint Atopaxar: a review of its mechanism of action and role in patients with coronary artery disease
    Fabiana Rollini
    University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Future Cardiol 8:503-11. 2012
  3. ncbi request reprint Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: an analysis from 5 Phase III studies
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, ACC Building 5th Floor, 655 West 8th Street, Jacksonville, FL, 32209, USA
    J Thromb Thrombolysis 38:11-23. 2014
  4. pmc Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar
    Jung Rae Cho
    University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA
    Vasc Health Risk Manag 10:177-88. 2014
  5. ncbi request reprint Pharmacodynamic evaluation of switching from ticagrelor to prasugrel in patients with stable coronary artery disease: Results of the SWAP-2 Study (Switching Anti Platelet-2)
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida Electronic address
    J Am Coll Cardiol 63:1500-9. 2014
  6. doi request reprint Pharmacodynamic effects of standard dose prasugrel versus high dose clopidogrel in non-diabetic obese patients with coronary artery disease
    Andrew Darlington
    Dominick J Angiolillo MD, PhD, University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA, Tel 1 904 244 3933, Fax 1 904 244 3102, E mail
    Thromb Haemost 111:258-65. 2014
  7. ncbi request reprint Impact of aspirin dose on adenosine diphosphate-mediated platelet activities. Results of an in vitro pilot investigation
    Antonio Tello-Montoliu
    Dominick J Angiolillo, MD, PhD, University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA, Tel 1 904 244 3933, Fax 1 904 244 3102, E mail
    Thromb Haemost 110:777-84. 2013
  8. doi request reprint Antiplatelet and anticoagulant therapy for atherothrombotic disease: the role of current and emerging agents
    Dominick J Angiolillo
    Division of Cardiology, Department of Medicine, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Am J Cardiovasc Drugs 13:233-50. 2013
  9. doi request reprint The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day
    Dominick J Angiolillo
    Department of Medicine, Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Drugs 72:2087-116. 2012
  10. ncbi request reprint Challenges and perspectives of antiplatelet therapy in patients with diabetes mellitus and coronary artery disease
    Jose Luis Ferreiro
    Cardiovascular Research Lab, Heart Diseases Institute, Hospital Universitari de Bellvitge IDIBELL, University of Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    Curr Pharm Des 18:5273-93. 2012

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Shands Jacksonville, Jacksonville, Florida
    J Am Coll Cardiol 50:1541-7. 2007
    ..This study sought to determine the prognostic implications of high platelet reactivity (HPR) assessed in type 2 diabetes mellitus (T2DM) patients while in their steady-state phase of dual antiplatelet therapy...
  2. doi request reprint Atopaxar: a review of its mechanism of action and role in patients with coronary artery disease
    Fabiana Rollini
    University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Future Cardiol 8:503-11. 2012
    ..This article provides an overview on atopaxar (E5555), an orally active protease-activated receptor-1 antagonist that has recently completed Phase II clinical investigation...
  3. ncbi request reprint Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: an analysis from 5 Phase III studies
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, ACC Building 5th Floor, 655 West 8th Street, Jacksonville, FL, 32209, USA
    J Thromb Thrombolysis 38:11-23. 2014
    ..For LDA users, AE incidence was less than that observed for EC naproxen. For most AE categories, incidences were similar among NAP/ESO, celecoxib and placebo groups. The safety of NAP/ESO appeared similar regardless of LDA use...
  4. pmc Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar
    Jung Rae Cho
    University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA
    Vasc Health Risk Manag 10:177-88. 2014
    ..The present manuscript will provide an overview on the role of thrombin-mediated signaling, the impact of PAR-1 blockade with vorapaxar on ischemic and bleeding outcomes, and the potential role for vorapaxar in clinical practice. ..
  5. ncbi request reprint Pharmacodynamic evaluation of switching from ticagrelor to prasugrel in patients with stable coronary artery disease: Results of the SWAP-2 Study (Switching Anti Platelet-2)
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida Electronic address
    J Am Coll Cardiol 63:1500-9. 2014
    ..The goal of this study was to evaluate the pharmacodynamic effects of switching patients from ticagrelor to prasugrel...
  6. doi request reprint Pharmacodynamic effects of standard dose prasugrel versus high dose clopidogrel in non-diabetic obese patients with coronary artery disease
    Andrew Darlington
    Dominick J Angiolillo MD, PhD, University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA, Tel 1 904 244 3933, Fax 1 904 244 3102, E mail
    Thromb Haemost 111:258-65. 2014
    ..Whether an intensified prasugrel regimen is required in obese patients warrants investigation...
  7. ncbi request reprint Impact of aspirin dose on adenosine diphosphate-mediated platelet activities. Results of an in vitro pilot investigation
    Antonio Tello-Montoliu
    Dominick J Angiolillo, MD, PhD, University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA, Tel 1 904 244 3933, Fax 1 904 244 3102, E mail
    Thromb Haemost 110:777-84. 2013
    ..P2Y12 receptor blockade modulates platelet reactivity mediated by alternative activators. ..
  8. doi request reprint Antiplatelet and anticoagulant therapy for atherothrombotic disease: the role of current and emerging agents
    Dominick J Angiolillo
    Division of Cardiology, Department of Medicine, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Am J Cardiovasc Drugs 13:233-50. 2013
    ..The role of emerging antiplatelet agents and anticoagulants in the long-term management of patients with atherothrombotic disease will be determined by the balance of efficacy and safety in large ongoing clinical trials. ..
  9. doi request reprint The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day
    Dominick J Angiolillo
    Department of Medicine, Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Drugs 72:2087-116. 2012
    ..This review highlights the mechanisms of action of these agents, and the continuing evolution of ACS therapy...
  10. ncbi request reprint Challenges and perspectives of antiplatelet therapy in patients with diabetes mellitus and coronary artery disease
    Jose Luis Ferreiro
    Cardiovascular Research Lab, Heart Diseases Institute, Hospital Universitari de Bellvitge IDIBELL, University of Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    Curr Pharm Des 18:5273-93. 2012
    ....
  11. doi request reprint Effects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patients with type 2 diabetes mellitus
    Siva Suryadevara
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    Thromb Haemost 108:930-6. 2012
    ..In conclusion, in patients with T2DM on maintenance aspirin and clopidogrel therapy, the adjunctive use of pioglitazone does not result in enhanced inhibition of platelet P2Y12 mediated signalling...
  12. ncbi request reprint Prasugrel
    Antonio Tello-Montoliu
    University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA
    Adv Cardiol 47:39-63. 2012
    ..Ongoing clinical studies with prasugrel will better define the safety and efficacy profiles of this agent and potentially set the basis for new indications for use...
  13. doi request reprint Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (I
    Dominick J Angiolillo
    University of Florida Shands Jacksonville, Jacksonville, FL 32209, USA
    Circ Cardiovasc Interv 5:347-56. 2012
    ..Elinogrel is the only selective, competitive and reversible platelet P2Y(12) inhibitor available in both intravenous (IV) and oral formulations...
  14. doi request reprint Pharmacodynamic effects of cangrelor and clopidogrel: the platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials
    Dominick J Angiolillo
    University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    J Thromb Thrombolysis 34:44-55. 2012
    ..Although there was no significant pharmacodynamic interaction when transitioning to clopidogrel therapy, further studies are warranted given that enrollment in this study was limited due to premature interruption of the main trial...
  15. pmc Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
    Ugo Cavallari
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    BMC Med Genet 8:59. 2007
    ..No data are available on its association with coronary artery disease (CAD)...
  16. ncbi request reprint Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine at Shands, Jacksonville, FL 32209, USA
    Circulation 115:708-16. 2007
    ..The aim of this pilot study was to assess the functional impact of a high maintenance dose in T2DM patients with suboptimal clopidogrel-induced antiplatelet effects...
  17. doi request reprint Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapy
    Dominick J Angiolillo
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 55:1139-46. 2010
    ..We sought to assess the impact of renal function on platelet reactivity in patients with diabetes mellitus (DM) and coronary artery disease on aspirin and clopidogrel therapy...
  18. doi request reprint Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Shands Jacksonville, Jacksonville, FL 32209, USA
    Thromb Haemost 99:161-8. 2008
    ....
  19. ncbi request reprint Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives
    Dominick J Angiolillo
    Division of Cardiology, University of Florida Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 49:1505-16. 2007
    ..This paper reviews the impact of individual response variability to clopidogrel on clinical outcomes and current and future directions for its management...
  20. doi request reprint Mechanism of action and clinical development of ticagrelor, a novel platelet ADP P2Y12 receptor antagonist
    Davide Capodanno
    University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 8:151-8. 2010
    ..This article provides an overview of the pharmacologic properties and clinical development of ticagrelor...
  21. ncbi request reprint Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions
    Dominick J Angiolillo
    University of Florida, College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    Rev Esp Cardiol 63:60-76. 2010
    ....
  22. pmc Platelet thrombin receptor antagonism and atherothrombosis
    Dominick J Angiolillo
    Division of Cardiology, Department of Medicine, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Eur Heart J 31:17-28. 2010
    ..Thus PAR-1 antagonism coupled with existing dual oral antiplatelet therapy may potentially offer more comprehensive platelet inhibition without the liability of increased bleeding...
  23. ncbi request reprint Basic principles of platelet biology and clinical implications
    Dominick J Angiolillo
    Department of Medicine, Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Circ J 74:597-607. 2010
    ..An overview of the basic principles of platelet biology is given and currently available antiplatelet agents, as well as those under clinical development, are reviewed...
  24. doi request reprint Aspirin and clopidogrel: efficacy and resistance in diabetes mellitus
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Best Pract Res Clin Endocrinol Metab 23:375-88. 2009
    ..Finally, future developments in the field directed towards individualized treatment strategies and novel antiplatelet agents are examined...
  25. doi request reprint Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Thromb Res 124:318-22. 2009
    ....
  26. doi request reprint Clinical overview of promising nonthienopyridine antiplatelet agents
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL FL32209, USA
    Am Heart J 156:S23-8. 2008
    ..We review the clinical features of these new platelet inhibition therapies...
  27. doi request reprint Clinical profile of prasugrel, a novel thienopyridine
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL32209, USA
    Am Heart J 156:S16-22. 2008
    ....
  28. doi request reprint Platelet inhibitor therapy: current perspectives and emerging novel agents: introduction
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Am Heart J 156:S1-2. 2008
    ..Several novel antiplatelet medications are currently under advanced clinical testing. Results from ongoing clinical studies will determine the efficacy and safety of these novel agents compared to those currently available...
  29. doi request reprint A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, FL 32209, USA
    Eur Heart J 29:2202-11. 2008
    ..The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clopidogrel treatment...
  30. ncbi request reprint Prasugrel: a novel platelet ADP P2Y12 receptor antagonist. A review on its mechanism of action and clinical development
    Dominick J Angiolillo
    University of Florida College of Medicine Shands Jacksonville, Division of Cardiology, 655 West 8th Street, Jacksonville, FL 32209, USA
    Expert Opin Pharmacother 9:2893-900. 2008
    ..This article reviews the currently available data regarding the efficacy and safety of prasugrel...
  31. ncbi request reprint Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, Florida, USA
    Am J Cardiol 101:440-5. 2008
    ..However, the antiplatelet effects achieved are nonuniform, and a considerable number of patients persist with inadequate platelet inhibition...
  32. doi request reprint Antiplatelet drug response variability and the role of platelet function testing: a practical guide for interventional cardiologists
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    Catheter Cardiovasc Interv 73:1-14. 2009
    ....
  33. ncbi request reprint ADP receptor antagonism: what's in the pipeline?
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Shands, Jacksonville, Florida, USA
    Am J Cardiovasc Drugs 7:423-32. 2007
    ..This article reviews the current knowledge of platelet ADP P2Y(12) receptor antagonism and the projected developments in this field...
  34. ncbi request reprint Antiplatelet therapy in type 2 diabetes mellitus
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Shands, Jacksonville, Florida 32209, USA
    Curr Opin Endocrinol Diabetes Obes 14:124-31. 2007
    ..This review summarizes the current knowledge on how antiplatelet therapy affects this high-risk patient population...
  35. doi request reprint Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies
    D J Angiolillo
    Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA
    Clin Pharmacol Ther 89:65-74. 2011
    ..7, 27.1, 19.0 (P < 0.0001), and 3.9% (P = 0.3319), respectively. The results suggest that a metabolic drug-drug interaction exists between clopidogrel and omeprazole but not between clopidogrel and pantoprazole...
  36. doi request reprint Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study
    Dominick J Angiolillo
    University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 56:1017-23. 2010
    ..The objective was to evaluate the pharmacodynamic response of switching patients on maintenance phase clopidogrel therapy after an acute coronary syndrome (ACS) to prasugrel...
  37. ncbi request reprint Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Diabetes 55:780-4. 2006
    ..In conclusion, clopidogrel withdrawal is associated with an increase in platelet and inflammatory biomarkers in diabetic patients, supporting pleiotropic effects coupled with P2Y12 receptor antagonism...
  38. doi request reprint Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease
    Dominick J Angiolillo
    Division of Cardiology, College ofMedicine, University of Florida Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    J Am Coll Cardiol 58:30-9. 2011
    ....
  39. ncbi request reprint Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention
    Dominick J Angiolillo
    Division of Cardiology, University of Florida Shands Jacksonville, Jacksonville, Florida, USA
    Am J Cardiol 97:38-43. 2006
    ..25) in patient response to treatment was observed in ASA-resistant and -sensitive patients. In conclusion, ASA resistance is associated with increased platelet reactivity in patients on long-term dual antiplatelet treatment...
  40. ncbi request reprint Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Jacksonville, Florida, USA
    Am J Cardiol 96:1095-9. 2005
    ..These findings may contribute to the increased ischemic risk observed in these patients...
  41. doi request reprint Tackling the thrombotic burden in patients with acute coronary syndrome and diabetes mellitus
    Dominick J Angiolillo
    University of Florida College of Medicine Jacksonville, Division of Cardiology ACC Building 5th floor, 655 West 8th Street, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 9:697-710. 2011
    ..In particular, strategies to enhance platelet P2Y(12) receptor inhibition, a key factor to improve outcomes in this patient population, are reviewed...
  42. ncbi request reprint Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease
    Dominick J Angiolillo
    Division of Cardiology, University of Florida Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Thromb Res 116:491-7. 2005
    ..However, the role of gene sequence variations of the P2Y(12) receptor in patients treated with clopidogrel has not yet been assessed...
  43. ncbi request reprint Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Diabetes 54:2430-5. 2005
    ..Reduced sensitivity to antiplatelet drugs may contribute to the increased atherothombotic risk in diabetic patients...
  44. pmc Antiplatelet therapy: thrombin receptor antagonists
    Antonio Tello-Montoliu
    University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Br J Clin Pharmacol 72:658-71. 2011
    ....
  45. doi request reprint Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial
    Dominick J Angiolillo
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    Clin Ther 33:1883-93. 2011
    ..Low-dose aspirin (LDA) and nonsteroidal anti-inflammatory drugs (NSAIDs) are often used concomitantly; however, some NSAIDs may interfere with LDA antiplatelet activity...
  46. ncbi request reprint Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Thromb Res 115:101-8. 2005
    ..In the present study, platelet function profiles were assessed in patients undergoing coronary stenting receiving a standard 300-mg clopidogrel loading dose with the aim to identify low clopidogrel responders...
  47. ncbi request reprint High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, FL 32209, USA
    Eur Heart J 25:1903-10. 2004
    ..To assess platelet inhibitory effects, interindividual variability in platelet inhibition as well as response to a 600 mg, compared to a standard 300 mg, clopidogrel loading dose (LD) after coronary stenting..
  48. ncbi request reprint Tackling the diabetic platelet: is high clopidogrel dosing the answer?
    D J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Thromb Haemost 4:2563-5. 2006
  49. ncbi request reprint Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Arterioscler Thromb Vasc Biol 26:1895-900. 2006
    ..Because metabolic activity of CYP3A4 is genetically regulated, we hypothesized that genetic variations of this enzyme may contribute to clopidogrel response variability...
  50. doi request reprint Haemostatic profiles assessed by thromboelastography in patients with end-stage renal disease
    Andrew Darlington
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida, 32209, USA
    Thromb Haemost 106:67-74. 2011
    ..005). In conclusion, patients with ESRD have an elevated prevalence of abnormal haemostatic profiles, which may contribute to their elevated risk of bleeding and thrombotic complications...
  51. pmc A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial
    Dominick J Angiolillo
    University of Florida College of Medicine Jacksonville, 655 W Eighth Street, Jacksonville, FL 32209, USA
    Eur Heart J 32:838-46. 2011
    ..The aim of this study was to perform serial pharmacodynamic assessments of prasugrel with high-dose clopidogrel in patients with DM...
  52. doi request reprint Prasugrel for the treatment of coronary thrombosis: a review of pharmacological properties, indications for use and future development
    Salvatore D Tomasello
    University of Florida College of Medicine Jacksonville, 655 West 8th Street, Jacksonville, Florida 32209, USA
    Expert Opin Investig Drugs 20:119-33. 2011
    ..Investigations have shown that this may be in part related to the broad range in pharmacodynamic response to clopidogrel, which includes patients with poor platelet inhibitory effects who have an increased risk of events...
  53. doi request reprint Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Thromb Haemost 106:253-62. 2011
    ..Despite the marked platelet inhibition, cilostazol does not alter thrombin-mediated haemostatic processes, which may explain its ischaemic benefit without the increased risk of bleeding...
  54. ncbi request reprint Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 48:298-304. 2006
    ..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
  55. ncbi request reprint Stent thrombosis in the era of drug eluting stents
    R Kawaguchi
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, FL 32209, USA
    Minerva Cardioangiol 55:199-211. 2007
    ..The topic of stent thrombosis in the era of DES will be reviewed in this article...
  56. ncbi request reprint Angiographic and 3D intravascular ultrasound assessment of overlapping bare metal stent and three different formulations of drug-eluting stents in patients with diabetes mellitus
    Ren Kawaguchi
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida Shands Jacksonville, Jacksonville, FL 32209, USA
    Int J Cardiovasc Imaging 24:125-32. 2008
    ..The aim of this study was to examine the impact of overlapping bare-metal stent (BMS) and three different formulations of drug-eluting stent (DES) on intimal hyperplasia (IH) response of patients with diabetes mellitus (DM)...
  57. doi request reprint Pharmacology of emerging novel platelet inhibitors
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL
    Am Heart J 156:S10-5. 2008
    ..We review the preclinical pharmacology and selected ongoing clinical trials of promising novel platelet inhibitor therapies...
  58. ncbi request reprint Characterization of plaque prolapse after drug-eluting stent implantation in diabetic patients: a three-dimensional volumetric intravascular ultrasound outcome study
    Hideki Futamatsu
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 48:1139-45. 2006
    ..The aim of this research was to evaluate the plaque prolapse (PP) phenomenon after bare-metal (BMS) and drug-eluting stent (DES) implantation in patients with diabetes mellitus using 3-dimensional volumetric intravascular ultrasound (IVUS)...
  59. doi request reprint Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial I
    Stephen D Wiviott
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 118:1626-36. 2008
    ..We compared prasugrel with clopidogrel among subjects with DM in TRITON-TIMI 38...
  60. ncbi request reprint Assessment of potential relationship between wall shear stress and arterial wall response after bare metal stent and sirolimus-eluting stent implantation in patients with diabetes mellitus
    Nobuaki Suzuki
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, FL, USA
    Int J Cardiovasc Imaging 24:357-64. 2008
    ..Drug-eluting stents (DES) almost abolish NIH. Conversely, diabetes mellitus amplifies NIH response. The association between WSS and arterial wall response following DES and BMS implantation in diabetic patients remains to be evaluated...
  61. ncbi request reprint Platelet monitoring for PCI: which test is the one to choose?
    D Capodanno
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    Hamostaseologie 29:376-80. 2009
    ..This manuscript will review the state of the art on the most commonly available platelet functional tests, describing their advantages and disadvantages and exploring their applicability in clinical practice...
  62. ncbi request reprint Usefulness of cardiac magnetic resonance imaging for coronary artery disease detection
    H Futamatsu
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, FL 32209, USA
    Minerva Cardioangiol 55:105-14. 2007
    ..Such comprehensive information would require the performance of multiple tests if other modalities were used. This article describes current applications of cMRI for evaluation of patients with CAD...
  63. ncbi request reprint Sirolimus-eluting stents for treatment of complex bypass graft disease: insights from the SECURE registry
    Marco Costa
    Department of Cardiology, University of Florida, Shands, Jacksonville, FL 32209, USA
    J Invasive Cardiol 17:396-8. 2005
    ..The aim of this study was to evaluate the safety and feasibility of SES to treat patients with high-risk bypass graft disease...
  64. ncbi request reprint Percutaneous coronary intervention of bifurcation coronary disease
    N Suzuki
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida College of Medicine Shands, Jacksonville, FL 32209, USA
    Minerva Cardioangiol 55:57-71. 2007
    ..In this review, we attempted to describe the current understanding of bifurcation anatomy and corresponding PCI strategies...
  65. doi request reprint Current antiplatelet therapies: benefits and limitations
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Am Heart J 156:S3-9. 2008
    ..This article summarizes the current understanding of the benefits and limitations of the commonly used antiplatelet therapies...
  66. doi request reprint Advances in antiplatelet therapy: agents in clinical development
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, Florida, USA
    Am J Cardiol 103:40A-51A. 2009
    ....
  67. doi request reprint Prasugrel in acute coronary syndrome patients undergoing percutaneous coronary intervention
    Piera Capranzano
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 7:361-9. 2009
    ..Recent clinical trial data analyses have led to a better understanding of the efficacy and safety of prasugrel. This article reviews the currently available data regarding the efficacy and safety of prasugrel in ACS patients...
  68. ncbi request reprint Mechanism of action and clinical development of platelet thrombin receptor antagonists
    Masafumi Ueno
    Division of Cardiology, Department of Medicine, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 8:1191-200. 2010
    ..This article provides an overview of the current status of knowledge on platelet thrombin receptor antagonists, focusing on pharmacologic properties and clinical development...
  69. ncbi request reprint Platelet P2Y₁₂ receptor inhibition: an update on clinical drug development
    David Vivas
    Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    Am J Cardiovasc Drugs 10:217-26. 2010
    ..This article provides an overview of ADP P2Y₁₂ receptor-inhibiting strategies, including high clopidogrel dosing regimens and novel agents under advanced clinical development...
  70. ncbi request reprint Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development
    Marlene S Williams
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Arterioscler Thromb Vasc Biol 30:2372-84. 2010
    ....
  71. doi request reprint Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial
    Alan D Michelson
    Department of Medicine, Children s Hospital Boston, Center for Platelet Research Studies, Division of Hematology Oncology, Boston, MA 02115, USA
    Eur Heart J 30:1753-63. 2009
    ..To examine the extent of platelet inhibition by prasugrel vs. clopidogrel in a TRITON-TIMI 38 substudy...
  72. doi request reprint Hypertriglyceridemia and ischemic stroke
    Nader Antonios
    Department of Neurology, Division of Cardiology, University of Florida College of Medicine, Jacksonville, Fla 32209, USA
    Eur Neurol 60:269-78. 2008
    ..The aim of this review is to critically analyze the contribution of hypertriglyceridemia to the occurrence of IS...
  73. ncbi request reprint Quantitative magnetic resonance perfusion imaging detects anatomic and physiologic coronary artery disease as measured by coronary angiography and fractional flow reserve
    Marco A Costa
    Division of Cardiology, University of Florida Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 50:514-22. 2007
    ..To evaluate the ability of quantitative perfusion cardiac magnetic resonance (CMR) to assess the hemodynamic significance of coronary artery disease (CAD) compared with well-established anatomic and physiologic techniques...
  74. ncbi request reprint Relocation of minimal luminal diameter after bare metal and drug-eluting stent implantation: incidence and impact on angiographic late loss
    Marco A Costa
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida Shands Jacksonville, Jacksonville, Florida 32209, USA
    Catheter Cardiovasc Interv 69:181-8. 2007
    ..Comprehensive LL analyses, including MaxLL and AvgLL, provides a better appraisal of the biological and clinical effectiveness of DES...
  75. ncbi request reprint Anatomical and physiologic assessments in patients with small coronary artery disease: final results of the Physiologic and Anatomical Evaluation Prior to and After Stent Implantation in Small Coronary Vessels (PHANTOM) trial
    Marco A Costa
    University of Florida, Shands Jacksonville, Cardiovascular Center, Jacksonville, FL 32209, USA
    Am Heart J 153:296.e1-7. 2007
    ..The objective of our study was to investigate the correlation between angiography, intravascular ultrasound (IVUS), and fractional flow reserve (FFR) in patients with moderate stenoses in small (<2.8 mm) coronary arteries...
  76. doi request reprint A systematic review of outcomes in patients with staged carotid artery stenting and coronary artery bypass graft surgery
    Luis A Guzman
    Division of Cardiology, University of Florida College of Medicine Jacksonville, FL, USA
    Stroke 39:361-5. 2008
    ..The aim of this study was to define, based on the published information, if carotid artery stenting is beneficial in this setting...
  77. ncbi request reprint Intravascular ultrasound characterization of the "black hole" phenomenon after drug-eluting stent implantation
    Marco A Costa
    Division of Cardiology, University of Florida, Shands Jacksonville, Florida, USA
    Am J Cardiol 97:203-6. 2006
    ..Black holes were also identified in a nonirradiated population, although the incidence was lower than in the post-brachytherapy patients. Bare metal stents were not associated with this phenomenon...
  78. doi request reprint Variability in responsiveness to oral antiplatelet therapy
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, Florida, USA
    Am J Cardiol 103:27A-34A. 2009
    ..This article discusses variability in individual responses to oral antiplatelet therapy and its implications for clinical outcomes...
  79. ncbi request reprint Impact of race and gender on antithrombotic therapy
    Davide Capodanno
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    Thromb Haemost 104:471-84. 2010
    ....
  80. doi request reprint Strategies for drug-eluting stent treatment of bifurcation coronary artery disease in the United States: insights from the e-Cypher S.T.L.L.R.trial
    Nobuaki Suzuki
    Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, Florida, USA
    Catheter Cardiovasc Interv 73:890-7. 2009
    ..Our goal is to report the first large multicenter data for percutaneous coronary intervention (PCI) of bifurcation disease with drug-eluting stents (DES) in the United States...
  81. ncbi request reprint Diagnostic accuracy of quantitative cardiac MRI evaluation compared to stress single-photon-emission computed tomography
    Hideki Futamatsu
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, 655 West 8th Street, Jacksonville, FL 32209, USA
    Int J Cardiovasc Imaging 24:293-9. 2008
    ..The aim of this study was to evaluate the diagnostic accuracy of myocardial perfusion reserve (MPR) based on cMRI compared with SPECT...
  82. ncbi request reprint Cangrelor: a review on its mechanism of action and clinical development
    Jose Luis Ferreiro
    University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 7:1195-201. 2009
    ..This article provides an overview of the current status of knowledge on cangrelor, focusing on its pharmacologic properties, clinical development and potential future applications...
  83. ncbi request reprint Saphenous vein graft disease
    S Peykar
    Division of Cardiology and Cardiovascular Imaging Core, Laboratories University of Florida, Shands Jacksonville, Jacksonville, FL 32209, USA
    Minerva Cardioangiol 52:379-90. 2004
    ..The pathogenesis and therapeutic options for SVG disease is reviewed in this article...
  84. doi request reprint Antiplatelet therapy: new pharmacological agents and changing paradigms
    D Capodanno
    Ferrarotto Hospital, University of Catania, Catania, Italy
    J Thromb Haemost 11:316-29. 2013
    ....
  85. doi request reprint Safety and efficacy of protease-activated receptor-1 antagonists in patients with coronary artery disease: a meta-analysis of randomized clinical trials
    D Capodanno
    Ferrarotto Hospital, Catania, Italy
    J Thromb Haemost 10:2006-15. 2012
    ..Thrombin receptor antagonists blocking protease-activated receptor-1 (PAR-1) on platelets represent a new class of oral antiplatelet agents for patients with atherothrombotic disease manifestations...
  86. ncbi request reprint Update on the clinical development of cangrelor
    Masafumi Ueno
    Department of Medicine, Division of Cardiology, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA
    Expert Rev Cardiovasc Ther 8:1069-77. 2010
    ..This article provides an overview of the current status of knowledge on cangrelor, focusing on its pharmacologic properties and clinical development...
  87. doi request reprint Elinogrel: pharmacological principles, preclinical and early phase clinical testing
    Masafumi Ueno
    Department of Medicine Division of Cardiology, University of Florida College of Medicine Jacksonville, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Future Cardiol 6:445-53. 2010
    ..This article provides an overview of the current level of knowledge regarding elinogrel, focusing on its pharmacologic properties and preclinical and early-phase clinical development...
  88. ncbi request reprint Quantitative contrast enhanced magnetic resonance imaging for the evaluation of peripheral arterial disease: a comparative study versus standard digital angiography
    Chris Pavlovic
    Division of Cardiology and Cardiovascular Imaging Core Laboratory, University of Florida, Shands Jacksonville, 655 West Eighth Street, 5th Floor ACC, Jacksonville, FL 32209, USA
    Int J Cardiovasc Imaging 23:225-32. 2007
    ..The purpose of this study is to evaluate the accuracy of semiautomated analysis of contrast enhanced magnetic resonance angiography (MRA) in patients who have undergone standard angiographic evaluation for peripheral vascular disease (PVD)...
  89. ncbi request reprint Platelet function testing and risk of bleeding complications
    Jose Luis Ferreiro
    University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Thromb Haemost 103:1128-35. 2010
    ....
  90. ncbi request reprint Imaging of atherosclerotic plaque
    Mario A Pulido
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, The Cardiovascular Center, University of Florida, Shands Jacksonville, FL 32209, USA
    Int J Cardiovasc Imaging 20:553-9. 2004
    ..This manuscript will review the more recent data concerning these interventions and their individual characteristics...
  91. ncbi request reprint Evaluation of cardiac magnetic resonance imaging parameters to detect anatomically and hemodynamically significant coronary artery disease
    Hideki Futamatsu
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, FL 32209, USA
    Am Heart J 154:298-305. 2007
    ..Our objective was to evaluate accuracy of various cMR imaging parameters to detect significant CAD as compared with angiography or fractional flow reserve (FFR)...
  92. ncbi request reprint Heterogeneity of atherosclerotic plaque characteristics in human coronary artery disease: a three-dimensional intravascular ultrasound study
    Lyndon C Box
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Jacksonville, Florida 32209, USA
    Catheter Cardiovasc Interv 70:349-56. 2007
    ..The objective of this study was to describe the intraplaque variability of coronary atherosclerosis in humans...
  93. ncbi request reprint Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies
    Raul Moreno
    Division of Interventional Cardiology, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    J Am Coll Cardiol 45:954-9. 2005
    ..We compared the risk of stent thrombosis (ST) after drug-eluting stents (DES) versus bare-metal stents (BMS), and tested the hypothesis that the risk of DES thrombosis is related to stent length...
  94. ncbi request reprint Intracoronary brachytherapy following drug-eluting stent failure. It's still not time to hang up the spikes!
    Dominick J Angiolillo
    Interventional Cardiology Unit, San Carlos University Hospital planta 2N, Plaza Cristo Rey s n, 28040 Madrid, Spain
    Cardiovasc Radiat Med 4:171-5. 2003
    ..IBT for treatment of DES failure was shown to be both safe and efficient and, therefore, until ISR exists, IBT still remains an important player in this growing and even more challenging setting...
  95. ncbi request reprint [Past, present, and future of intracoronary brachytherapy]
    Dominick J Angiolillo
    U O di Cardiologia Invasiva, Istituto Cardiovascolare, Ospedale Universitario San Carlos, Madrid, Spagna
    Ital Heart J Suppl 4:794-806. 2003
    ..In this manuscript, principles of radiation therapy, results of clinical trials, current clinical practice, and future perspectives of intracoronary brachytherapy are summarized...
  96. ncbi request reprint Intracoronary brachytherapy after stenting de novo lesions in diabetic patients: results of a randomized intravascular ultrasound study
    Manel Sabate
    San Carlos University Hospital, Madrid, Spain
    J Am Coll Cardiol 44:520-7. 2004
    ..We studied the efficacy of intracoronary brachytherapy (ICB) after successful coronary stenting in diabetic patients with de novo lesions...
  97. ncbi request reprint "Candy wrapper" effect after drug-eluting stent implantation: déjà vu or stumbling over the same stone again?
    Dominick J Angiolillo
    Interventional Cardiology Unit, San Carlos University Hospital, Madrid, Spain
    Catheter Cardiovasc Interv 61:387-91. 2004
    ..However, DESs are not immune from restenosis and we describe a case of "candy wrapper" effect, commonly observed with intracoronary brachytherapy (IBT). In this article, we review the common drawbacks of DES and IBT and their prevention...
  98. ncbi request reprint Late stent thrombosis (> 1 year) following clopidogrel withdrawal after brachytherapy treatment: need to assess aspirin resistance?
    Pilar Jimenez-Quevedo
    Instituto Cardiovascular Servicio de Cardiología Intervencionista, Hospital Clinico San Carlos, Madrid, Spain
    Catheter Cardiovasc Interv 62:39-42. 2004
    ..At the time of stent thrombosis, evaluation of platelet aggregation was performed, revealing a suboptimal response to aspirin. Pathophysiological insights of aspirin resistance and clinical implications are reviewed...
  99. ncbi request reprint 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment
    Dominick J Angiolillo
    Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain
    Blood Coagul Fibrinolysis 15:427-33. 2004
    ....
  100. ncbi request reprint Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted?
    Dominick J Angiolillo
    Interventional Cardiology Unit Cardiovascular Institute, San Carlos University Hospital, Plaza Cristo Rey s n planta 2N, 28040 Madrid, Spain
    J Invasive Cardiol 16:169-74. 2004
    ..The aim of this study was to assess whether body mass index (BMI) influenced platelet response to clopidogrel LD in patients undergoing CS...
  101. ncbi request reprint Coronary stenting versus balloon angioplasty in small vessels: a meta-analysis from 11 randomized studies
    Raul Moreno
    Division of Interventional Cardiology, Instituto Cardiovascular, Hospital Clinico San Carlos, Madrid, Spain
    J Am Coll Cardiol 43:1964-72. 2004
    ..A meta-analysis of 11 randomized trials was done to compare stenting versus balloon angioplasty (BA) in small coronary vessels...