Takashi Angata

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint [Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins]
    Takashi Angata
    Tanpakushitsu Kakusan Koso 53:733-8. 2008
  2. ncbi request reprint I-type lectins
    Takashi Angata
    Glycobiology Research and Training Center, University of California, San Diego, 9500 Gilman Drive, 0687, La Jolla CA 92093 0687, USA
    Biochim Biophys Acta 1572:294-316. 2002
  3. pmc Evolution of siglec-11 and siglec-16 genes in hominins
    Xiaoxia Wang
    Glycobiology Research and Training Center, University of California at San Diego, San Diego, CA, USA
    Mol Biol Evol 29:2073-86. 2012
  4. ncbi request reprint A human-specific gene in microglia
    Toshiyuki Hayakawa
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093, USA
    Science 309:1693. 2005
  5. pmc Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
    Mai Zhang
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Blood 109:4280-7. 2007
  6. pmc SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas
    Nivedita Mitra
    Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:23003-11. 2011
  7. ncbi request reprint Siglecs--the major subfamily of I-type lectins
    Ajit Varki
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 16:1R-27R. 2006
  8. pmc CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice
    Els C M Brinkman-Van der Linden
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    Mol Cell Biol 23:4199-206. 2003
  9. pmc Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
    Takashi Angata
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 101:13251-6. 2004
  10. ncbi request reprint Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia
    Takashi Angata
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 277:24466-74. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint [Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins]
    Takashi Angata
    Tanpakushitsu Kakusan Koso 53:733-8. 2008
  2. ncbi request reprint I-type lectins
    Takashi Angata
    Glycobiology Research and Training Center, University of California, San Diego, 9500 Gilman Drive, 0687, La Jolla CA 92093 0687, USA
    Biochim Biophys Acta 1572:294-316. 2002
    ..There are I-type lectins recognizing sialic acids, other sugars and glycosaminoglycans. The occurrence, structure, binding properties and (potential) biological functions of the I-type lectins are reviewed here...
  3. pmc Evolution of siglec-11 and siglec-16 genes in hominins
    Xiaoxia Wang
    Glycobiology Research and Training Center, University of California at San Diego, San Diego, CA, USA
    Mol Biol Evol 29:2073-86. 2012
    ....
  4. ncbi request reprint A human-specific gene in microglia
    Toshiyuki Hayakawa
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093, USA
    Science 309:1693. 2005
    ..SIGLEC11 is expressed in human but not in chimpanzee brain microglia. Further studies will determine if this event was related to the evolution of Homo...
  5. pmc Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
    Mai Zhang
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Blood 109:4280-7. 2007
    ....
  6. pmc SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas
    Nivedita Mitra
    Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:23003-11. 2011
    ..Polymorphic expression of Siglec-XII in humans thus has implications for prostate cancer biology and therapeutics...
  7. ncbi request reprint Siglecs--the major subfamily of I-type lectins
    Ajit Varki
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 16:1R-27R. 2006
    ..This article provides an overview of historical and current information about the Siglecs...
  8. pmc CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice
    Els C M Brinkman-Van der Linden
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    Mol Cell Biol 23:4199-206. 2003
    ....
  9. pmc Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
    Takashi Angata
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 101:13251-6. 2004
    ....
  10. ncbi request reprint Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia
    Takashi Angata
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 277:24466-74. 2002
    ....
  11. ncbi request reprint Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective
    Takashi Angata
    Glycobiology Research and Training Center, Department of Medicine, University of California San Diego, La Jolla, California 92093 0687, USA
    Chem Rev 102:439-69. 2002
  12. ncbi request reprint Molecular diversity and evolution of the Siglec family of cell-surface lectins
    Takashi Angata
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Umezono, Tsukuba, Ibaraki, Japan
    Mol Divers 10:555-66. 2006
    ....
  13. ncbi request reprint Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
    Takashi Angata
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 17:838-46. 2007
    ..Thus, Siglec-15 probably plays a conserved, regulatory role in the immune system of vertebrates...
  14. ncbi request reprint Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates
    Takashi Angata
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    FASEB J 20:1964-73. 2006
    ..The "essential arginine" critical for sialic acid recognition in both Siglec-14 and Siglec-5 is present in humans but mutated in almost all great ape alleles...
  15. ncbi request reprint [Functions and evolution of siglecs, a family of endogenous sialic acid receptors of vertebrates]
    Takashi Angata
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba, Ibaraki 3058562, Japan
    Seikagaku 76:1224-8. 2004