G K Andrews

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. request reprint
    Andrews G. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals. 2001;14:223-37 pubmed
    ..Furthermore, the mouse MTF-1 gene is essential for development of the embryo, thus underscoring the importance of this transcription factor. ..
  2. Andrews G, Lee D, Ravindra R, Lichtlen P, Sirito M, Sawadogo M, et al. The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 2001;20:1114-22 pubmed
    ..Expression of MT-I in visceral endoderm cells was dependent on maternal dietary zinc. Thus, the essential metal, zinc, apparently provides the signaling ligand that activates cell-specific MT-I expression in visceral endoderm cells. ..
  3. request reprint
    Andrews G, Wang H, Dey S, Palmiter R. Mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis. 2004;40:74-81 pubmed
  4. Weaver B, Dufner Beattie J, Kambe T, Andrews G. Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). Biol Chem. 2007;388:1301-12 pubmed
    ..After zinc-gavage, ZIP5 is rapidly resynthesized and targeted to the basolateral membranes of these cell types...
  5. Andrews G. Regulation and function of Zip4, the acrodermatitis enteropathica gene. Biochem Soc Trans. 2008;36:1242-6 pubmed publisher
    ..Mice heterozygous for Zip4-knockout are hypersensitive to zinc deficiency, which suggests that humans heterozygous for this gene may also be very sensitive to zinc deficiency. ..