Carmen Andreescu

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
  2. pmc Twelve-year depressive symptom trajectories and their predictors in a community sample of older adults
    Carmen Andreescu
    Department of Psychiatry University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int Psychogeriatr 20:221-36. 2008
  3. pmc Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management
    Charles F Reynolds
    Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1134-41. 2010
  4. ncbi request reprint Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA Electronic address
    Am J Geriatr Psychiatry 22:274-84. 2014
  5. pmc Comorbid anxiety and depression: bête noire or quick fix?
    Carmen Andreescu
    Br J Psychiatry 200:179-81. 2012
  6. pmc Generalized anxiety disorder severity scale validation in older adults
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:813-8. 2008
  7. pmc Altered cerebral blood flow patterns associated with pathologic worry in the elderly
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Depress Anxiety 28:202-9. 2011
  8. pmc High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression
    Carmen Andreescu
    The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:266-72. 2009
  9. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
  10. doi request reprint Treatment-related alteration of cortisol predicts change in neuropsychological function during acute treatment of late-life anxiety disorder
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Int J Geriatr Psychiatry 27:454-62. 2012

Detail Information

Publications31

  1. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  2. pmc Twelve-year depressive symptom trajectories and their predictors in a community sample of older adults
    Carmen Andreescu
    Department of Psychiatry University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int Psychogeriatr 20:221-36. 2008
    ....
  3. pmc Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management
    Charles F Reynolds
    Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1134-41. 2010
    ....
  4. ncbi request reprint Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA Electronic address
    Am J Geriatr Psychiatry 22:274-84. 2014
    ..We examined subgroups of anxiety symptoms and depression symptom profiles in relation to MCI, which we defined using both cognitive and functional approaches...
  5. pmc Comorbid anxiety and depression: bête noire or quick fix?
    Carmen Andreescu
    Br J Psychiatry 200:179-81. 2012
    ..The most recent evidence from genetics, neuropeptide systems and functional neuroimaging suggests a valid diagnostic construct...
  6. pmc Generalized anxiety disorder severity scale validation in older adults
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:813-8. 2008
    ..Given the high prevalence of GAD in the elderly and the need for a validated scale to assess GAD severity in this age group, the authors examined the psychometric properties of the GADSS in the elderly...
  7. pmc Altered cerebral blood flow patterns associated with pathologic worry in the elderly
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Depress Anxiety 28:202-9. 2011
    ..The aim of this study was to examine the neural correlates of emotion regulation in late-life GAD...
  8. pmc High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression
    Carmen Andreescu
    The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:266-72. 2009
    ..We explored the impact of the dimensions of worry and panic on acute and maintenance treatment outcomes in LLD...
  9. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  10. doi request reprint Treatment-related alteration of cortisol predicts change in neuropsychological function during acute treatment of late-life anxiety disorder
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Int J Geriatr Psychiatry 27:454-62. 2012
    ....
  11. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  12. pmc The default mode network in late-life anxious depression
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Geriatr Psychiatry 19:980-3. 2011
    ..The aim of this exploratory study is to examine the default mode network (DMN) functional connectivity pattern in elderly depressed subjects with and without comorbid anxiety...
  13. pmc Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Geriatr Psychiatry 19:482-90. 2011
    ..The authors examined whether treatment of GAD in older adults with a selective serotonin reuptake inhibitor (SSRI) corrects this HPA axis hyperactivity...
  14. pmc Anxiety impairs depression remission in partial responders during extended treatment in late-life
    Adam Greenlee
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Depress Anxiety 27:451-6. 2010
    ..This study characterizes the effect of anxiety on remission during extended treatment for partial responders...
  15. pmc Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder
    Meryl A Butters
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Br J Psychiatry 199:211-8. 2011
    ..Aims We examined neuropsychological functioning in older adults with GAD in comparison with psychiatrically healthy older adults at baseline, and we examined changes following a 12-week placebo-controlled trial of escitalopram...
  16. pmc Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    JAMA 301:295-303. 2009
    ..Selective serotonin reuptake inhibitors (SSRIs) are efficacious for younger adults with GAD, but benefits and risks may be different in older adults...
  17. pmc Empirically derived decision trees for the treatment of late-life depression
    Carmen Andreescu
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:855-62. 2008
    ..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making...
  18. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  19. pmc Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    J Clin Psychopharmacol 30:672-7. 2010
    ..We hypothesized that GAD patients with no La haplotypes (La⁻) have lower SSRI treatment efficacy than those with 1 to 2 La haplotypes (La+)...
  20. pmc Default-mode network connectivity and white matter burden in late-life depression
    Minjie Wu
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatry Res 194:39-46. 2011
    ..The correlation between white-matter hyperintensities burden and default-mode network connectivity emphasizes the role of vascular changes in late-life depression etiopathogenesis...
  21. ncbi request reprint Magnetic resonance imaging predictors of treatment response in late-life depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Geriatr Psychiatry Neurol 27:24-32. 2014
    ..These imaging markers may be integrated into clinical decision making to attain better treatment outcomes in the future. ..
  22. pmc Resting state functional connectivity and treatment response in late-life depression
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Psychiatry Res 214:313-21. 2013
    ..The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity. ..
  23. pmc fMRI correlates of white matter hyperintensities in late-life depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, USA
    Am J Psychiatry 168:1075-82. 2011
    ..This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions...
  24. pmc Gray matter changes in late life depression--a structural MRI analysis
    Carmen Andreescu
    The Advanced Center for Interventions and Services Research for Late life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:2566-72. 2008
    ..However, it remains likely that both processes as well as other factors contribute to the heterogeneity of volumetric brain changes in LLD...
  25. ncbi request reprint Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
    ..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
  26. doi request reprint Acupuncture for the treatment of major depressive disorder: a randomized controlled trial
    Carmen Andreescu
    Department of Psychiatry University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Psychiatry 72:1129-35. 2011
    ..We sought to determine whether a 2-point electroacupuncture protocol (verum acupuncture) would be beneficial for MDD, in comparison to needling at nonchannel scalp points with sham electrostimulation (control acupuncture)...
  27. pmc fMRI activation in late-life anxious depression: a potential biomarker
    Carmen Andreescu
    Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:820-8. 2009
    ..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit...
  28. doi request reprint Late-life depression: evidence-based treatment and promising new directions for research and clinical practice
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, 247 Sterling Plaza, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 34:335-55, vii-iii. 2011
    ..Treatment algorithms are also reviewed based on predictors of response and promising novel treatment options...
  29. ncbi request reprint The ages of anxiety-differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 29:704-12. 2014
    ..This study aims to characterize the functional connectivity in the default mode network (DMN) in GAD across the lifespan...
  30. pmc MRI studies in late-life mood disorders
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Curr Top Behav Neurosci 11:269-87. 2012
    ..In this chapter, we will review the contribution of MRI studies to late-life mood and anxiety disorders: major depression, bipolar disorder and anxiety disorders in late-life...
  31. doi request reprint Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence
    Carmen Andreescu
    The Advanced Center for Interventions and Services Research for Late life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    J Affect Disord 110:16-26. 2008
    ..In the meantime, patients need to be informed about the possible risks associated with the use of these interventions...