Nancy C Andreasen

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc A journey into chaos: creativity and the unconscious
    Nancy C Andreasen
    Andrew H Woods Chair of Psychiatry, W278GH, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Mens Sana Monogr 9:42-53. 2011
  2. pmc Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes
    N C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Psychiatry 17:1093-102. 2012
  3. pmc Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients
    Nancy C Andreasen
    Department of Psychiatry, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Room W278GH, Iowa City, IA 52242 1057, USA
    Schizophr Bull 34:708-19. 2008
  4. pmc DSM and the death of phenomenology in america: an example of unintended consequences
    Nancy C Andreasen
    The University of Iowa Roy J and Lucille A Carver College of Medicine Mental Health Clinical Research Center, Room W 278 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Bull 33:108-12. 2007
  5. pmc The lifetime trajectory of schizophrenia and the concept of neurodevelopment
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
    Dialogues Clin Neurosci 12:409-15. 2010
  6. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
  7. pmc Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
  8. ncbi request reprint Marijuana alters the human cerebellar clock
    DANIEL S O'LEARY
    Department of Psychiatry, University of Iowa Hospital and Clinic, Iowa City, IA 52242, USA
    Neuroreport 14:1145-51. 2003
  9. ncbi request reprint Informed consent in medication-free schizophrenia research
    David J Moser
    Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1209-11. 2005
  10. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006

Detail Information

Publications85

  1. pmc A journey into chaos: creativity and the unconscious
    Nancy C Andreasen
    Andrew H Woods Chair of Psychiatry, W278GH, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Mens Sana Monogr 9:42-53. 2011
    ..This raises interesting questions about the relationship between the nature of the unconscious, the unconscious and the predisposition to both creativity and mental illness...
  2. pmc Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes
    N C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Psychiatry 17:1093-102. 2012
    ..This ability to replicate previous work suggests that our method has potential for detecting a meaningful epistatic relationship among the genes that influence brain abnormalities in schizophrenia...
  3. pmc Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients
    Nancy C Andreasen
    Department of Psychiatry, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Room W278GH, Iowa City, IA 52242 1057, USA
    Schizophr Bull 34:708-19. 2008
    ..This capacity, critical for social competence, is impaired in schizophrenia. We undertook a study of TOM in a group of patients with schizophrenia and healthy controls...
  4. pmc DSM and the death of phenomenology in america: an example of unintended consequences
    Nancy C Andreasen
    The University of Iowa Roy J and Lucille A Carver College of Medicine Mental Health Clinical Research Center, Room W 278 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Bull 33:108-12. 2007
    ..By 2005, the decline has become so severe that it could be referred to as "the death of phenomenology in the United States."..
  5. pmc The lifetime trajectory of schizophrenia and the concept of neurodevelopment
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
    Dialogues Clin Neurosci 12:409-15. 2010
    ....
  6. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  7. pmc Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
    ..Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia...
  8. ncbi request reprint Marijuana alters the human cerebellar clock
    DANIEL S O'LEARY
    Department of Psychiatry, University of Iowa Hospital and Clinic, Iowa City, IA 52242, USA
    Neuroreport 14:1145-51. 2003
    ..Smoking marijuana appears to accelerate a cerebellar clock altering self-paced behaviors...
  9. ncbi request reprint Informed consent in medication-free schizophrenia research
    David J Moser
    Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1209-11. 2005
    ..The authors' goal was to determine whether people with schizophrenia experience changes in decisional capacity when their antipsychotic regimens are discontinued for research purposes...
  10. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006
    ..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied...
  11. ncbi request reprint Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Psychiatry 160:142-8. 2003
    ..This study investigated the relationships between duration of untreated initial psychosis and neurocognitive functioning and high-resolution imaging brain measurements...
  12. pmc The role of the cerebellum in schizophrenia
    Nancy C Andreasen
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Biol Psychiatry 64:81-8. 2008
    ..Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research...
  13. pmc Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, USA
    Schizophr Res 106:192-9. 2008
    ..rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia...
  14. pmc Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 70:672-9. 2011
    ..Structural magnetic resonance studies indicate that brain abnormalities are present at onset, but longitudinal studies to assess neuroprogression have been limited by small samples and short or infrequent follow-up intervals...
  15. pmc Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia
    Beng Choon Ho
    Departments of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 68:128-37. 2011
    ..Because antipsychotics are prescribed for long periods for schizophrenia patients and have increasingly widespread use in other psychiatric disorders, it is imperative to determine their long-term effects on the human brain...
  16. pmc The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia
    Randy L Gollub
    Department of Psychiatry, Massachusetts General Hospital, Building 120, Suite 101D, Charlestown, MA 02129 2000, USA
    Neuroinformatics 11:367-88. 2013
    ..This manuscript describes the inclusion/exclusion criteria, imaging parameters and other information that will assist those wishing to use this data repository. ..
  17. ncbi request reprint Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identification
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Ann Clin Psychiatry 17:11-8. 2005
    ..Early detection and prompt treatment may improve outcome in schizophrenia. In this study, we examine the value of using pre-morbid cognitive impairment in early detection...
  18. ncbi request reprint Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography
    Sergio Paradiso
    Mental Health Clinical Research Center, Dapartment of Psychiatry, Univeristy of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 160:1775-83. 2003
    ..The authors measured regional cerebral blood flow (rCBF) during performance of a task that required unmedicated patients to recognize the emotional valence of visual images and to determine whether they were pleasant or unpleasant...
  19. ncbi request reprint Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
    Marcus Pressler
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Biol Psychiatry 57:394-8. 2005
    ..Previously, we found that neuroleptic-naive subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms...
  20. ncbi request reprint Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Iowa City, Iowa, USA
    Arch Gen Psychiatry 60:585-94. 2003
    ..However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved...
  21. ncbi request reprint Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up
    Peter Milev
    Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
    Am J Psychiatry 162:495-506. 2005
    ..An additional area of interest was whether the severity of negative symptoms would predict outcome independently from neurocognitive variables or whether there would be an overlap in their predictive power...
  22. ncbi request reprint Prism adaptation in schizophrenia
    Nirav O Bigelow
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Brain Cogn 61:235-42. 2006
    ..Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL...
  23. pmc G72 influences longitudinal change in frontal lobe volume in schizophrenia
    Sarah M Hartz
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 153:640-7. 2010
    ..This same haplotype was also associated with more severe psychotic symptoms at the time of the second scan. These data thus suggest that variation in G72 modulates the progressive brain changes that characterize schizophrenia...
  24. ncbi request reprint Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuropsychiatry Clin Neurosci 16:284-94. 2004
    ....
  25. ncbi request reprint Hippocampus volume and treatment delays in first-episode schizophrenia
    Beng Choon Ho
    Center for Bipolar Disorders Research, Department of Psychiatry, 2880 JPP, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1527-9. 2005
    ..Previous MRI studies have reported no significant correlations between duration of untreated initial psychosis and brain volumes but have not examined specific brain regions that may be most susceptible to neuronal damage...
  26. pmc Cigarette smoking and white matter microstructure in schizophrenia
    Kathryn R Cullen
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA
    Psychiatry Res 201:152-8. 2012
    ..Further, low FA in specific brain areas may be a neural marker for complex pathophysiology and risk for diverse problems such as schizophrenia, low IQ, and nicotine addiction...
  27. ncbi request reprint Correlation between extraversion and regional cerebral blood flow in response to olfactory stimuli
    Jatin G Vaidya
    W278 GH, Department of Psychiatry, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 164:339-41. 2007
    ....
  28. ncbi request reprint Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposure
    Alison Kopelman
    University of Iowa Health Care, Department of Psychiatry, 1 180 MEB, 500 Newton Rd, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 162:1872-8. 2005
    ..Many of the studies have not accounted for confounding factors such as gender, handedness, or clinical variables such as neuroleptic exposure...
  29. ncbi request reprint Temporal pole morphology and psychopathology in males with schizophrenia
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Psychiatry Res 132:107-15. 2004
    ..Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms...
  30. pmc Sex differences in parietal lobe morphology: relationship to mental rotation performance
    Tim Koscik
    University of Iowa Neuroscience Graduate Program Drive, Department of Neurology, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Brain Cogn 69:451-9. 2009
    ..These findings support the possibility that the sexual dimorphism in the structure of the parietal lobe is a neurobiological substrate for the sex difference in performance on the mental rotations test...
  31. ncbi request reprint Effects of smoking marijuana on brain perfusion and cognition
    DANIEL S O'LEARY
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
    Neuropsychopharmacology 26:802-16. 2002
    ..There was no significant rCBF change in the nucleus accumbens or other reward-related brain regions, nor in basal ganglia or hippocampus, which have a high density of cannabinoid receptors...
  32. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
    ..Our findings suggest that heavy cannabis use in the context of specific CNR1 genotypes may contribute to greater WM volume deficits and cognitive impairment, which could in turn increase schizophrenia risk...
  33. ncbi request reprint Gyrification abnormalities in childhood- and adolescent-onset schizophrenia
    Tonya White
    Univeristy of Iowa, Iowa City, USA
    Biol Psychiatry 54:418-26. 2003
    ..We used magnetic resonance scanning technology to compare brain surface morphology and measures of gyrification in children and adolescents with a schizophrenia spectrum disorder and in age-equivalent healthy controls...
  34. ncbi request reprint Morphology of the cerebral cortex in preclinical Huntington's disease
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA
    Am J Psychiatry 164:1428-34. 2007
    ..Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease...
  35. pmc The neural correlates of implicit sequence learning in schizophrenia
    Cherie L Marvel
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, USA
    Neuropsychology 21:761-77. 2007
    ..This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern...
  36. ncbi request reprint Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia
    Nicolas Franck
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Neuropsychiatry Clin Neurosci 14:277-82. 2002
    ..The results of this study demonstrate a cerebral pattern of activation related to Schneiderian symptoms and reinforce the hypothesis of an involvement of cortical areas that mediate space and body representation in such phenomena...
  37. pmc Fully automated analysis using BRAINS: AutoWorkup
    Ronald Pierson
    The University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA
    Neuroimage 54:328-36. 2011
    ..Application of AutoWorkup for the analysis of data from the 32-site, multivendor PREDICT-HD study yield estimates of reliability to be greater than or equal to 0.90 for all tissues and regions...
  38. pmc Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures
    Stephanie Powell
    Department of Radiology, The University of Iowa, Iowa City, Iowa 52242 1057, USA
    Neuroimage 39:238-47. 2008
    ..Results show that the machine learning methods outperform the template and probability-based methods. Utilization of these automated segmentation methods may be as reliable as manual raters and require no rater intervention...
  39. ncbi request reprint Validity of symptom assessment in psychotic disorders: information variance across different sources of history
    Beng Choon Ho
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Schizophr Res 68:299-307. 2004
    ..This study was designed to determine the degree to which history provided by such subjects is consistent with that obtained from other sources...
  40. ncbi request reprint Visualizing how one brain understands another: a PET study of theory of mind
    Chadi Calarge
    Department of Psychiatry, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 160:1954-64. 2003
    ..The authors conducted a positron emission tomography (PET) study to examine the neural substrates of TOM, using a task that mimics real-life social interaction...
  41. pmc Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs
    Nancy C Andreasen
    Mental Health Clinical Research Center, Department of Psychiatry, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 67:255-62. 2010
    ..An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study...
  42. ncbi request reprint Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, Lucille A Carver College of Medicine, Iowa City, Iowa 52252, USA
    Biol Psychiatry 55:1146-53. 2004
    ..The goal of this study was to investigate cerebellar dysfunction in schizophrenia by examining the clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs in schizophrenia patients...
  43. ncbi request reprint Morphology of the ventral frontal cortex: relationship to femininity and social cognition
    Jessica L Wood
    Mental Health Clinical Research Center, Iowa City, IA, USA
    Cereb Cortex 18:534-40. 2008
    ..In addition, higher degrees of femininity correlated with better performance on the IPT. Taken together, these data suggest a complex relationship between femininity, social cognition, and the structure of the SG...
  44. pmc Using a brief intervention to improve decisional capacity in schizophrenia research
    David J Moser
    Department of Psychiatry MEB 1 328, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Schizophr Bull 32:116-20. 2006
    ..The use of such interventions will enable a larger number of people with schizophrenia to make informed decisions regarding research participation...
  45. pmc Eyeblink conditioning in healthy adults: a positron emission tomography study
    Krystal L Parker
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
    Cerebellum 11:946-56. 2012
    ..Specifically, large peaks were noted in cerebellar lobules IV/V, the frontal lobes, and cingulate gyri...
  46. ncbi request reprint Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications
    William Coryell
    Department of Psychiatry, 2 205 MEB, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Psychiatry 162:1706-12. 2005
    ..There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time...
  47. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
    ..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype...
  48. pmc Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study
    Vincent A Magnotta
    Department of Radiology, The University of Iowa, Iowa, Iowa City, IA 52242, USA
    Psychiatry Res 163:193-200. 2008
    ..The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus...
  49. ncbi request reprint Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Compr Psychiatry 43:393-6. 2002
    ..The implications of these findings in research and clinical settings are discussed...
  50. ncbi request reprint Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
    Rebecca Fuller
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1183-9. 2002
    ..The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results...
  51. ncbi request reprint Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia
    Ruth Spinks
    Schizophrenia Research Center, University of Iowa, Iowa City, IA 52242, United States
    Schizophr Res 73:229-33. 2005
    ..The volume for the GP, GPe, and internal segment (GPi) did not differ between groups...
  52. ncbi request reprint Subcortical, cerebellar, and magnetic resonance based consistent brain image registration
    Vincent A Magnotta
    Iowa Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
    Neuroimage 19:233-45. 2003
    ..Furthermore, statistically significant improvements for all structures were achieved using the LI-SI algorithm compared to the intensity-only algorithm...
  53. ncbi request reprint Effects of frequent marijuana use on memory-related regional cerebral blood flow
    Robert I Block
    Department of Anesthesia, University of Iowa, Room 5140, Westlawn Building, Iowa City, IA 52242, USA
    Pharmacol Biochem Behav 72:237-50. 2002
    ..These findings indicate altered memory-related brain function in marijuana users...
  54. pmc Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University ofIowa Carver College of Medicine, Iowa City, USA
    Am J Psychiatry 170:609-15. 2013
    ..Recurrent relapses are believed to play a role in this loss, but the relationship between relapse and structural MRI measures has not been rigorously assessed. The authors analyzed longitudinal data to examine this question...
  55. ncbi request reprint Capacity to provide informed consent for participation in schizophrenia and HIV research
    David J Moser
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1201-7. 2002
    ....
  56. ncbi request reprint NOTCH4 and the frontal lobe in schizophrenia
    Thomas H Wassink
    Department of Psychiatry, Psychiatry Research MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 118:1-7. 2003
    ..These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development...
  57. ncbi request reprint Initial magnetic resonance imaging volumetric brain measurements and outcome in schizophrenia: a prospective longitudinal study with 5-year follow-up
    Peter Milev
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 54:608-15. 2003
    ..Far fewer studies have examined the relationships between brain morphology assessed at illness onset and subsequent outcome, and their results have been contradictory...
  58. ncbi request reprint Anterior cingulate cortex: an MRI-based parcellation method
    Laurie M McCormick
    Department of Psychiatry, University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, W268 GH, Iowa City, IA 52242, USA
    Neuroimage 32:1167-75. 2006
    ..Our main purpose was to develop an MRI-based parcellation method of the ACC that permits us to explore plausible abnormalities in 4 functionally relevant subregions: dorsal, rostral, subcallosal and subgenual...
  59. ncbi request reprint The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naïve and medicated states
    Patricia Westmoreland Corson
    Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 52:855-62. 2002
    ..Subsequent exposure to neuroleptic medication appears to induce volumetric change. Possible reasons for this include differences in blood flow and metabolism between the neuroleptic-naïve and medicated states...
  60. ncbi request reprint Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophrenia
    Ruth Spinks
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, USA
    Am J Med Genet B Neuropsychiatr Genet 127:20-7. 2004
    ....
  61. pmc Sex differences in parietal lobe structure and development
    Joel Salinas
    University of Iowa Doris Duke Clinical Research Fellowship Program, Iowa City, Iowa 52242, USA
    Gend Med 9:44-55. 2012
    ..These findings support the notion of structural sex differences in the parietal lobe, not only in the context of cross-sectional assessment but also in terms of differences in developmental trajectories...
  62. pmc Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial clefting
    Seth M Weinberg
    Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, USA
    J Anat 214:926-36. 2009
    ....
  63. ncbi request reprint Manual and semiautomated measurement of cerebellar subregions on MR images
    Ronald Pierson
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242 1057, USA
    Neuroimage 17:61-76. 2002
    ..97 to 0.99. The semiautomated method was built on the groundwork of the manual method to produce more reliable results in a fraction of the time, making valid measurements possible on a large number of subjects...
  64. ncbi request reprint Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 52:1-8. 2002
    ..This impairment has also been observed to emerge after lesions in the ventral aspect of the frontal cortex (i.e., straight gyrus and orbitofrontal cortex)...
  65. ncbi request reprint Brain structure in preclinical Huntington's disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 59:57-63. 2006
    ..This study was designed to assess the morphology of the brain in participants who had previously undergone elective DNA analyses for the HD mutation who did not currently have a clinical diagnosis of HD (preclinical HD subjects)...
  66. ncbi request reprint Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  67. ncbi request reprint Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
    Peg Nopoulos
    Psychiatry Research, University of Iowa College of Medicine, 1 180 MEB, 500 Newton Road, Iowa City 52242, USA
    Neuropsychologia 40:2178-84. 2002
    ..As the development of the face is highly interdependent with the development of the brain, it is theorized that the etiology of these cognitive deficits is a primary problem with abnormal brain development...
  68. pmc The relationship between creativity and mood disorders
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa Health Care, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1057, USA
    Dialogues Clin Neurosci 10:251-5. 2008
    ..In the case of bipolar disorder, however, it is likely that reducing severe manic episodes may actually enhance creativity in many individuals...
  69. ncbi request reprint Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex
    Susan K Schultz
    Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
    J Neuropsychiatry Clin Neurosci 14:19-24. 2002
    ..In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia...
  70. ncbi request reprint Structural MR image processing using the BRAINS2 toolbox
    Vincent A Magnotta
    Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, Room 2911 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Comput Med Imaging Graph 26:251-64. 2002
    ..These features are described in detail, as well as the reliability of these procedures...
  71. ncbi request reprint Structural brain abnormalities in adult males with clefts of the lip and/or palate
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Hospital, Iowa City, Iowa 52242, USA
    Genet Med 4:1-9. 2002
    ..To evaluate brain morphology of adult males with nonsyndromic clefts of the lip and/or palate (NSCLP) in comparison to a matched healthy control group...
  72. doi request reprint Posttraumatic stress disorder: a history and a critique
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, Iowa City, Iowa 52242, USA
    Ann N Y Acad Sci 1208:67-71. 2010
    ..Its definition continues to raise important questions about the relationship between a stressor, the individual experiencing it, and the characteristic symptoms...
  73. ncbi request reprint Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization
    Victor W Swayze
    Department of Psychiatry, The University of Iowa Hospitals and Clinics, College of Medicine, Iowa City, Iowa 52246 2208, USA
    Int J Eat Disord 33:33-44. 2003
    ....
  74. ncbi request reprint Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects
    Tonya White
    Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
    Biol Psychiatry 60:463-71. 2006
    ..The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia...
  75. ncbi request reprint Perception of socially relevant stimuli in schizophrenia
    Nirav O Bigelow
    University of Iowa, Department of Psychiatry, United States
    Schizophr Res 83:257-67. 2006
    ..The findings point towards circumscribed domains of impaired social cognition in schizophrenia and suggest specific further hypotheses about the neural dysfunction that may underlie them...
  76. ncbi request reprint Evaluation of the GTRACT diffusion tensor tractography algorithm: a validation and reliability study
    Peng Cheng
    Department of Radiology, Georgetown University, Washington, DC 20007, USA
    Neuroimage 31:1075-85. 2006
    ..The results demonstrate that the GTRACT algorithm is less sensitive to image noise and more capable of handling areas of complex fiber crossing, compared to conventional streamline methods...
  77. ncbi request reprint Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia
    Rodrigo D Paz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA
    Am J Psychiatry 163:1829-31. 2006
    ..The purpose of this study was to evaluate the functional state of glutamatergic neurons in the cerebellar cortex of patients with schizophrenia...
  78. ncbi request reprint Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
    Neuroimage 35:1613-23. 2007
    ..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes...
  79. ncbi request reprint Symptoms and interference from memory in schizophrenia: evaluation of Frith's model of willed action
    Ivan J Torres
    Department of Psychology, Simon Fraser University and Riverview Hospital, 8888 University Drive Burnaby, BC, Canada V5A 1S6
    Schizophr Res 69:35-43. 2004
    ..These findings provide some support for Frith's hypothesis that impaired regulation of action systems may underlie some of the specific symptoms and cognitive impairments of this illness...
  80. ncbi request reprint Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent
    Dwayne R Heitmiller
    Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Schizophr Res 66:137-42. 2004
    ..Few studies have evaluated caudate volume in subjects with schizophrenia who were neuroleptic naive at intake and treated exclusively with atypical neuroleptics...
  81. ncbi request reprint Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging
    Gaku Okugawa
    Dept of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Eur Arch Psychiatry Clin Neurosci 253:301-6. 2003
    ..971 and 0.999. The segmentation and measurement are useful for volumetric studies in the human brain using BRAINS...
  82. ncbi request reprint Possible association of a cholecystokinin promoter variant to schizophrenia
    Zhewu Wang
    Mental Health Care Line, Cincinnati VA Medical Center, Cincinnati, Ohio 45220, USA
    Am J Med Genet 114:479-82. 2002
    ..While our family-based tests seem to support the CCK involvement in schizophrenia, no definite conclusion can be drawn based on such a small sample size. This preliminary finding is subjected to future investigations...
  83. ncbi request reprint Manual and automated measurement of the whole thalamus and mediodorsal nucleus using magnetic resonance imaging
    Ruth Spinks
    Mental Health Clinical Research Center, University of Iowa, Iowa City 52242, USA
    Neuroimage 17:631-42. 2002
    ..The ANN provides an efficient automated method, making studies using larger sample sizes more feasible...
  84. ncbi request reprint Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptoms
    Jae Jin Kim
    BK21 Human Life Sciences, Seoul National University, Seoul, South Korea
    Schizophr Res 60:173-81. 2003
    ..Furthermore, relationships between the morphology of these regions and symptoms of the illness were explored...
  85. ncbi request reprint Standardized remission criteria in schizophrenia
    Nancy C Andreasen
    Acta Psychiatr Scand 113:81. 2006