Nancy Andreasen

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The relationship between creativity and mood disorders
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa Health Care, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1057, USA
    Dialogues Clin Neurosci 10:251-5. 2008
  2. doi request reprint Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University ofIowa Carver College of Medicine, Iowa City, USA
    Am J Psychiatry 170:609-15. 2013
  3. ncbi request reprint Schizophrenia: the fundamental questions
    N C Andreasen
    University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 2911 JPP, 200 Hawkins Drive, Iowa City, IA, USA
    Brain Res Brain Res Rev 31:106-12. 2000
  4. pmc The role of the cerebellum in schizophrenia
    Nancy C Andreasen
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Biol Psychiatry 64:81-8. 2008
  5. doi request reprint Posttraumatic stress disorder: a history and a critique
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, Iowa City, Iowa 52242, USA
    Ann N Y Acad Sci 1208:67-71. 2010
  6. ncbi request reprint The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography
    D D Miller
    Department of Psychiatry, University of Iowa Hospital and Clinics, University of Iowa College of Medicine, Iowa City 52242 1057, USA
    Biol Psychiatry 41:550-9. 1997
  7. pmc Mirror neuron function, psychosis, and empathy in schizophrenia
    Laurie M McCormick
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Psychiatry Res 201:233-9. 2012
  8. ncbi request reprint Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
    Mol Psychiatry 5:678-82. 2000
  9. ncbi request reprint Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
    B Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
    Schizophr Res 46:35-43. 2000
  10. ncbi request reprint Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits
    A S Shriver
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Child Psychol Psychiatry 47:994-1002. 2006

Research Grants

  1. Brain Imaging in Major Psychoses: Examining Structural & Functional Connectivity
    Nancy C Andreasen; Fiscal Year: 2010
  2. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 2003
  3. PHENOMENOLOGY AND CLASSIFICATION OF SCHIZOPHRENIA
    Nancy Andreasen; Fiscal Year: 2003
  4. Testing Specificity of the Cognitive Dysmetria Model
    Nancy Andreasen; Fiscal Year: 2007
  5. Brain Imaging in Major Psychoses: Functional Imaging
    Nancy Andreasen; Fiscal Year: 2009
  6. Testing Specificity of the Cognitive Dysmetria Model
    Nancy Andreasen; Fiscal Year: 2009
  7. Research Training: Major Psychoses/Clinical Neurobiology
    Nancy Andreasen; Fiscal Year: 2007
  8. PHENOMENOLOGY AND CLASSIFICATION OF SCHIZOPHRENIA
    Nancy Andreasen; Fiscal Year: 2007
  9. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 1993
  10. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 1991

Detail Information

Publications102 found, 100 shown here

  1. pmc The relationship between creativity and mood disorders
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa Health Care, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1057, USA
    Dialogues Clin Neurosci 10:251-5. 2008
    ..In the case of bipolar disorder, however, it is likely that reducing severe manic episodes may actually enhance creativity in many individuals...
  2. doi request reprint Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University ofIowa Carver College of Medicine, Iowa City, USA
    Am J Psychiatry 170:609-15. 2013
    ..Recurrent relapses are believed to play a role in this loss, but the relationship between relapse and structural MRI measures has not been rigorously assessed. The authors analyzed longitudinal data to examine this question...
  3. ncbi request reprint Schizophrenia: the fundamental questions
    N C Andreasen
    University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 2911 JPP, 200 Hawkins Drive, Iowa City, IA, USA
    Brain Res Brain Res Rev 31:106-12. 2000
    ..This type of unitary model may be more heuristic than early ones that were based on heterogeneous signs and symptoms...
  4. pmc The role of the cerebellum in schizophrenia
    Nancy C Andreasen
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Biol Psychiatry 64:81-8. 2008
    ..Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research...
  5. doi request reprint Posttraumatic stress disorder: a history and a critique
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, Iowa City, Iowa 52242, USA
    Ann N Y Acad Sci 1208:67-71. 2010
    ..Its definition continues to raise important questions about the relationship between a stressor, the individual experiencing it, and the characteristic symptoms...
  6. ncbi request reprint The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography
    D D Miller
    Department of Psychiatry, University of Iowa Hospital and Clinics, University of Iowa College of Medicine, Iowa City 52242 1057, USA
    Biol Psychiatry 41:550-9. 1997
    ..Functional neuroimaging techniques such as SPECT may be useful in furthering our understanding of the mechanism of antipsychotics...
  7. pmc Mirror neuron function, psychosis, and empathy in schizophrenia
    Laurie M McCormick
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Psychiatry Res 201:233-9. 2012
    ..The present study suggests that abnormal mirror neuron activity may exist among patients with schizophrenia during the active (psychotic) phase of the illness, and correlates with severity of psychosis...
  8. ncbi request reprint Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
    Mol Psychiatry 5:678-82. 2000
    ..We found no support, therefore, for TNF-RII as a disease susceptibility gene for schizophrenia. The gene may, however, modify phenotypic aspects of the disease such as brain morphology and age of onset of illness...
  9. ncbi request reprint Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
    B Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
    Schizophr Res 46:35-43. 2000
    ..These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia...
  10. ncbi request reprint Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits
    A S Shriver
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Child Psychol Psychiatry 47:994-1002. 2006
    ..The hypothesis for the current study was that the STP in subjects with NSCLP would be structurally abnormal and that the abnormality would be related to cognitive deficit, but not to developmental hearing deficit...
  11. ncbi request reprint Abnormal brain structure in adults with Van der Woude syndrome
    P Nopoulos
    Department of Psychiatry, University of Iowa College of Medicine, IA 52242, USA
    Clin Genet 71:511-7. 2007
    ....
  12. ncbi request reprint Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography study
    B Crespo-Facorro
    Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Brain Mapp 12:219-31. 2001
    ..During recognition of novel material, patients failed to activate frontal/limbic regions, recruiting a set of posterior perceptual brain regions instead...
  13. ncbi request reprint Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism
    R A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City 52242 1000, USA
    Am J Med Genet 105:130-4. 2001
    ....
  14. ncbi request reprint Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors
    B Crespo-Facorro
    University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, Room 2911 JPP, 200 Hawkins Dr, Iowa City, IA 52242-1057, USA
    JAMA 286:427-35. 2001
    ..CONCLUSION: Abnormalities in the complex functional interactions between mesolimbic and frontal regions may underlie emotional disturbances in schizophrenia...
  15. ncbi request reprint Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and/or palate
    P Nopoulos
    Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, IA 52242, USA
    J Neuroimaging 11:418-24. 2001
    ....
  16. ncbi request reprint Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow
    B C Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
    Mol Psychiatry 10:229, 287-98. 2005
    ..Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition...
  17. ncbi request reprint Clinical features characterizing young-onset and intermediate-onset schizophrenia
    S K Schultz
    University of Iowa, Department of Psychiatry, Mental Health Clinical Research Center, Iowa City, USA
    J Neuropsychiatry Clin Neurosci 12:502-5. 2000
    ..The dichotomy of early vs. late onset may extend to a younger population, reflecting a more continuous influence...
  18. ncbi request reprint Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysis
    P Nopoulos
    Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Cleft Palate Craniofac J 37:441-6. 2000
    ..The aim of this study was to determine whether adult men with cleft lip and palate (CLP) have aberrant cerebral morphology...
  19. ncbi request reprint Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates
    P Nopoulos
    Mental Health Clinic Research Centre, University of Iowa College of Medicine, Iowa City 52242, USA
    J Neuropsychiatry Clin Neurosci 12:344-9. 2000
    ..Thus, the greater the size of the anomaly, the greater the cognitive deficit. No relationship was found between severity of CSP and symptom measures...
  20. ncbi request reprint Prevalence of depressive symptoms early in the course of schizophrenia
    T H Wassink
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Psychiatry 156:315-6. 1999
    ..The rate of depressive symptoms early in the course of schizophrenia was determined...
  21. ncbi request reprint Correlating and predicting psychiatric symptom ratings: Spearman's r versus Kendall's tau correlation
    S Arndt
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City 52242, USA
    J Psychiatr Res 33:97-104. 1999
    ....
  22. ncbi request reprint Schizophrenia
    S K Schultz
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City 52242, USA
    Lancet 353:1425-30. 1999
    ..Despite these advances, treatment of symptoms and psychosocial and cognitive impairments remains only partially successful for many patients...
  23. ncbi request reprint Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics
    P W Corson
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Psychiatry 156:1200-4. 1999
    ....
  24. ncbi request reprint Functional MRI statistical software packages: a comparative analysis
    S Gold
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Hum Brain Mapp 6:73-84. 1998
    ..The functionality of each package was detailed and discussed. AFNI 2.01, SPM96, Stimulate 5.0, MEDIMAX 2.01, and FIT were tested. FIASCO, Yale, and MEDx 2.0 were described but not tested. A description of each package is provided...
  25. ncbi request reprint Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia
    S Gold
    Department of Psychiatry, University of Iowa, USA
    Am J Psychiatry 156:1342-8. 1999
    ..Few studies have examined the longitudinal stability of cognitive function and the relationship between cognitive performance and clinical symptoms over time in a cohort of well-treated patients with schizophrenia...
  26. ncbi request reprint Heritability of BDNF alleles and their effect on brain morphology in schizophrenia
    T H Wassink
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa
    Am J Med Genet 88:724-8. 1999
    ..We did not find support for BDNF as a disease gene for schizophrenia. Allelic variability of the gene may, however, influence brain morphology in these same subjects. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:724-728, 1999...
  27. ncbi request reprint The cerebellum plays a role in conscious episodic memory retrieval
    N C Andreasen
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City 52242 1057, USA
    Hum Brain Mapp 8:226-34. 1999
    ..These activations confirm a cognitive role for the cerebellum, which may participate in an interactive cortical-cerebellar network that initiates and monitors the conscious retrieval of episodic memory...
  28. ncbi request reprint Smaller brain size associated with unawareness of illness in patients with schizophrenia
    L A Flashman
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Psychiatry 157:1167-9. 2000
    ..Although several neuropsychological studies have supported the notion of frontal and parietal lobe involvement in unawareness of illness in schizophrenia, neuroanatomic differences have not been examined...
  29. ncbi request reprint Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia
    B C Ho
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Psychiatry 157:808-15. 2000
    ..If untreated psychosis is neurotoxic, this would form a strong basis for early intervention in schizophrenia...
  30. ncbi request reprint Developmental brain anomalies in children with attention-deficit hyperactivity disorder
    P Nopoulos
    Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Child Neurol 15:102-8. 2000
    ..These findings support and extend the idea that ADHD is of developmental origin, and further suggest that the timing of aberrant brain development could be in early gestation...
  31. ncbi request reprint Quantitative in vivo measurement of gyrification in the human brain: changes associated with aging
    V A Magnotta
    Mental Health Clinical Research Center, The University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA
    Cereb Cortex 9:151-60. 1999
    ..Measurements of sulcal and gyral shape may be useful in studying the mechanisms of both neurodevelopmental and neurodegenerative changes that occur during brain maturation and aging...
  32. ncbi request reprint Genome scan of schizophrenia
    D F Levinson
    Department of Psychiatry, Allegheny University of the Health Sciences, Philadelphia, USA
    Am J Psychiatry 155:741-50. 1998
    ..The goal of this study was to identify chromosomal regions likely to contain schizophrenia susceptibility genes...
  33. ncbi request reprint Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia
    D D Miller
    The Mental Health Clinical Research Center--Major Psychoses, Department of Psychiatry, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Biol Psychiatry 49:704-15. 2001
    ..These findings emphasize the importance of controlling for both medication status and the individual antipsychotic in neuroimaging studies...
  34. ncbi request reprint Effects of retroactive and proactive interference on word list recall in schizophrenia
    I J Torres
    Department of Psychiatry, University of Chicago Medical School, IL 60637 1470, USA
    J Int Neuropsychol Soc 7:481-90. 2001
    ..Furthermore, this difference appeared to be related to the frontally-mediated central executive functions that were preferentially associated with RI but not PI susceptibility...
  35. ncbi request reprint Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophrenia
    Laurie McCormick
    The University of Iowa, Carver College of Medicine, Department of Psychiatry, W278 GH, University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Res 80:73-84. 2005
    ..The increase in anterior cingulate volume with typicals is correlated to improved psychotic symptoms over time...
  36. ncbi request reprint Cognitive dysfunction in adults with Van der Woude syndrome
    Peg Nopoulos
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Genet Med 9:213-8. 2007
    ..Given the similarities between Van der Woude syndrome and isolated cleft of the lip and/or palate, the current study was designed to evaluate the pattern of cognitive function in adults with Van der Woude syndrome...
  37. pmc Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa
    Laurie M McCormick
    Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Int J Eat Disord 41:602-10. 2008
    ..This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance...
  38. ncbi request reprint Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls
    P C Nopoulos
    Mental Health Clinical Research Center, University of Iowa College of Medicine, 52242, Iowa City, IA, USA
    Schizophr Res 48:177-85. 2001
    ..These results support the growing literature reporting structural aberration of the thalamus, as well as other midline structures in the brains of patients with schizophrenia...
  39. ncbi request reprint [Cognition and emotion in schizophrenia: neuroimaging approach]
    N C Andreasen
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Room 2712A JPP, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
    Encephale 28:S14-5. 2002
  40. ncbi request reprint Color enhancement of multispectral MR images: improving the visualization of subcortical structures
    J Ward
    Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    J Comput Assist Tomogr 25:942-9. 2001
    ..quot; They were developed to improve the delineation of small brain structures composed of mixed tissue types, such as the basal ganglia...
  41. ncbi request reprint [Which phenotype for the psychiatric research?]
    N C Andreasen
    Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Encephale 28:S16-20. 2002
  42. ncbi request reprint Factors associated with suicide attempts among patients with schizophrenia
    S Gupta
    Department of Psychiatry, State University of New York Health Sciences Center, Syracuse, USA
    Psychiatr Serv 49:1353-5. 1998
    ..Compared with patients who had not attempted suicide, patients who had made an attempt had a greater number of lifetime depressive episodes, an earlier age of onset of their illness, and an earlier age at first hospitalization...
  43. pmc Using a brief intervention to improve decisional capacity in schizophrenia research
    David J Moser
    Department of Psychiatry MEB 1 328, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Schizophr Bull 32:116-20. 2006
    ..The use of such interventions will enable a larger number of people with schizophrenia to make informed decisions regarding research participation...
  44. ncbi request reprint Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects
    Tonya White
    Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
    Biol Psychiatry 60:463-71. 2006
    ..The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia...
  45. ncbi request reprint Brain structure in preclinical Huntington's disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 59:57-63. 2006
    ..This study was designed to assess the morphology of the brain in participants who had previously undergone elective DNA analyses for the HD mutation who did not currently have a clinical diagnosis of HD (preclinical HD subjects)...
  46. ncbi request reprint Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications
    William Coryell
    Department of Psychiatry, 2 205 MEB, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Psychiatry 162:1706-12. 2005
    ..There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time...
  47. ncbi request reprint Perception of socially relevant stimuli in schizophrenia
    Nirav O Bigelow
    University of Iowa, Department of Psychiatry, United States
    Schizophr Res 83:257-67. 2006
    ..The findings point towards circumscribed domains of impaired social cognition in schizophrenia and suggest specific further hypotheses about the neural dysfunction that may underlie them...
  48. ncbi request reprint Standardized remission criteria in schizophrenia
    Nancy C Andreasen
    Acta Psychiatr Scand 113:81. 2006
  49. ncbi request reprint Hippocampus volume and treatment delays in first-episode schizophrenia
    Beng Choon Ho
    Center for Bipolar Disorders Research, Department of Psychiatry, 2880 JPP, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1527-9. 2005
    ..Previous MRI studies have reported no significant correlations between duration of untreated initial psychosis and brain volumes but have not examined specific brain regions that may be most susceptible to neuronal damage...
  50. ncbi request reprint Informed consent in medication-free schizophrenia research
    David J Moser
    Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1209-11. 2005
    ..The authors' goal was to determine whether people with schizophrenia experience changes in decisional capacity when their antipsychotic regimens are discontinued for research purposes...
  51. ncbi request reprint Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identification
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Ann Clin Psychiatry 17:11-8. 2005
    ..Early detection and prompt treatment may improve outcome in schizophrenia. In this study, we examine the value of using pre-morbid cognitive impairment in early detection...
  52. ncbi request reprint Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposure
    Alison Kopelman
    University of Iowa Health Care, Department of Psychiatry, 1 180 MEB, 500 Newton Rd, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 162:1872-8. 2005
    ..Many of the studies have not accounted for confounding factors such as gender, handedness, or clinical variables such as neuroleptic exposure...
  53. ncbi request reprint Evaluation of the GTRACT diffusion tensor tractography algorithm: a validation and reliability study
    Peng Cheng
    Department of Radiology, Georgetown University, Washington, DC 20007, USA
    Neuroimage 31:1075-85. 2006
    ..The results demonstrate that the GTRACT algorithm is less sensitive to image noise and more capable of handling areas of complex fiber crossing, compared to conventional streamline methods...
  54. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006
    ..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied...
  55. ncbi request reprint Anterior cingulate cortex: an MRI-based parcellation method
    Laurie M McCormick
    Department of Psychiatry, University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, W268 GH, Iowa City, IA 52242, USA
    Neuroimage 32:1167-75. 2006
    ..Our main purpose was to develop an MRI-based parcellation method of the ACC that permits us to explore plausible abnormalities in 4 functionally relevant subregions: dorsal, rostral, subcallosal and subgenual...
  56. doi request reprint Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study
    Vincent A Magnotta
    Department of Radiology, The University of Iowa, Iowa, Iowa City, IA 52242, USA
    Psychiatry Res 163:193-200. 2008
    ..The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus...
  57. pmc Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients
    Nancy C Andreasen
    Department of Psychiatry, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Room W278GH, Iowa City, IA 52242 1057, USA
    Schizophr Bull 34:708-19. 2008
    ..This capacity, critical for social competence, is impaired in schizophrenia. We undertook a study of TOM in a group of patients with schizophrenia and healthy controls...
  58. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  59. pmc The neural correlates of implicit sequence learning in schizophrenia
    Cherie L Marvel
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, USA
    Neuropsychology 21:761-77. 2007
    ..This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern...
  60. pmc Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures
    Stephanie Powell
    Department of Radiology, The University of Iowa, Iowa City, Iowa 52242 1057, USA
    Neuroimage 39:238-47. 2008
    ..Results show that the machine learning methods outperform the template and probability-based methods. Utilization of these automated segmentation methods may be as reliable as manual raters and require no rater intervention...
  61. ncbi request reprint Morphology of the cerebral cortex in preclinical Huntington's disease
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA
    Am J Psychiatry 164:1428-34. 2007
    ..Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease...
  62. ncbi request reprint Morphology of the ventral frontal cortex: relationship to femininity and social cognition
    Jessica L Wood
    Mental Health Clinical Research Center, Iowa City, IA, USA
    Cereb Cortex 18:534-40. 2008
    ..In addition, higher degrees of femininity correlated with better performance on the IPT. Taken together, these data suggest a complex relationship between femininity, social cognition, and the structure of the SG...
  63. ncbi request reprint Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
    Neuroimage 35:1613-23. 2007
    ..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes...
  64. ncbi request reprint Correlation between extraversion and regional cerebral blood flow in response to olfactory stimuli
    Jatin G Vaidya
    W278 GH, Department of Psychiatry, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 164:339-41. 2007
    ....
  65. pmc DSM and the death of phenomenology in america: an example of unintended consequences
    Nancy C Andreasen
    The University of Iowa Roy J and Lucille A Carver College of Medicine Mental Health Clinical Research Center, Room W 278 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Bull 33:108-12. 2007
    ..By 2005, the decline has become so severe that it could be referred to as "the death of phenomenology in the United States."..
  66. ncbi request reprint Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia
    Rodrigo D Paz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA
    Am J Psychiatry 163:1829-31. 2006
    ..The purpose of this study was to evaluate the functional state of glutamatergic neurons in the cerebellar cortex of patients with schizophrenia...
  67. ncbi request reprint Prism adaptation in schizophrenia
    Nirav O Bigelow
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Brain Cogn 61:235-42. 2006
    ..Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL...
  68. ncbi request reprint Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up
    Peter Milev
    Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
    Am J Psychiatry 162:495-506. 2005
    ..An additional area of interest was whether the severity of negative symptoms would predict outcome independently from neurocognitive variables or whether there would be an overlap in their predictive power...
  69. ncbi request reprint Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptoms
    Jae Jin Kim
    BK21 Human Life Sciences, Seoul National University, Seoul, South Korea
    Schizophr Res 60:173-81. 2003
    ..Furthermore, relationships between the morphology of these regions and symptoms of the illness were explored...
  70. ncbi request reprint Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Psychiatry 160:142-8. 2003
    ..This study investigated the relationships between duration of untreated initial psychosis and neurocognitive functioning and high-resolution imaging brain measurements...
  71. ncbi request reprint Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization
    Victor W Swayze
    Department of Psychiatry, The University of Iowa Hospitals and Clinics, College of Medicine, Iowa City, Iowa 52246 2208, USA
    Int J Eat Disord 33:33-44. 2003
    ....
  72. ncbi request reprint The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naïve and medicated states
    Patricia Westmoreland Corson
    Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 52:855-62. 2002
    ..Subsequent exposure to neuroleptic medication appears to induce volumetric change. Possible reasons for this include differences in blood flow and metabolism between the neuroleptic-naïve and medicated states...
  73. ncbi request reprint Manual and automated measurement of the whole thalamus and mediodorsal nucleus using magnetic resonance imaging
    Ruth Spinks
    Mental Health Clinical Research Center, University of Iowa, Iowa City 52242, USA
    Neuroimage 17:631-42. 2002
    ..The ANN provides an efficient automated method, making studies using larger sample sizes more feasible...
  74. ncbi request reprint Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Compr Psychiatry 43:393-6. 2002
    ..The implications of these findings in research and clinical settings are discussed...
  75. ncbi request reprint Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia
    Nicolas Franck
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Neuropsychiatry Clin Neurosci 14:277-82. 2002
    ..The results of this study demonstrate a cerebral pattern of activation related to Schneiderian symptoms and reinforce the hypothesis of an involvement of cortical areas that mediate space and body representation in such phenomena...
  76. ncbi request reprint Possible association of a cholecystokinin promoter variant to schizophrenia
    Zhewu Wang
    Mental Health Care Line, Cincinnati VA Medical Center, Cincinnati, Ohio 45220, USA
    Am J Med Genet 114:479-82. 2002
    ..While our family-based tests seem to support the CCK involvement in schizophrenia, no definite conclusion can be drawn based on such a small sample size. This preliminary finding is subjected to future investigations...
  77. ncbi request reprint Capacity to provide informed consent for participation in schizophrenia and HIV research
    David J Moser
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1201-7. 2002
    ....
  78. ncbi request reprint Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
    Rebecca Fuller
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1183-9. 2002
    ..The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results...
  79. ncbi request reprint Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 52:1-8. 2002
    ..This impairment has also been observed to emerge after lesions in the ventral aspect of the frontal cortex (i.e., straight gyrus and orbitofrontal cortex)...
  80. ncbi request reprint Structural MR image processing using the BRAINS2 toolbox
    Vincent A Magnotta
    Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, Room 2911 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Comput Med Imaging Graph 26:251-64. 2002
    ..These features are described in detail, as well as the reliability of these procedures...
  81. ncbi request reprint Effects of smoking marijuana on brain perfusion and cognition
    DANIEL S O'LEARY
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
    Neuropsychopharmacology 26:802-16. 2002
    ..There was no significant rCBF change in the nucleus accumbens or other reward-related brain regions, nor in basal ganglia or hippocampus, which have a high density of cannabinoid receptors...
  82. ncbi request reprint Effects of frequent marijuana use on memory-related regional cerebral blood flow
    Robert I Block
    Department of Anesthesia, University of Iowa, Room 5140, Westlawn Building, Iowa City, IA 52242, USA
    Pharmacol Biochem Behav 72:237-50. 2002
    ..These findings indicate altered memory-related brain function in marijuana users...
  83. ncbi request reprint Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex
    Susan K Schultz
    Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
    J Neuropsychiatry Clin Neurosci 14:19-24. 2002
    ..In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia...
  84. ncbi request reprint NOTCH4 and the frontal lobe in schizophrenia
    Thomas H Wassink
    Department of Psychiatry, Psychiatry Research MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 118:1-7. 2003
    ..These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development...
  85. ncbi request reprint Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Iowa City, Iowa, USA
    Arch Gen Psychiatry 60:585-94. 2003
    ..However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved...
  86. ncbi request reprint Subcortical, cerebellar, and magnetic resonance based consistent brain image registration
    Vincent A Magnotta
    Iowa Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
    Neuroimage 19:233-45. 2003
    ..Furthermore, statistically significant improvements for all structures were achieved using the LI-SI algorithm compared to the intensity-only algorithm...
  87. ncbi request reprint Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  88. ncbi request reprint Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
    Marcus Pressler
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Biol Psychiatry 57:394-8. 2005
    ..Previously, we found that neuroleptic-naive subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms...
  89. ncbi request reprint Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
    Peg Nopoulos
    Psychiatry Research, University of Iowa College of Medicine, 1 180 MEB, 500 Newton Road, Iowa City 52242, USA
    Neuropsychologia 40:2178-84. 2002
    ..As the development of the face is highly interdependent with the development of the brain, it is theorized that the etiology of these cognitive deficits is a primary problem with abnormal brain development...
  90. ncbi request reprint Temporal pole morphology and psychopathology in males with schizophrenia
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Psychiatry Res 132:107-15. 2004
    ..Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms...
  91. ncbi request reprint Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuropsychiatry Clin Neurosci 16:284-94. 2004
    ....
  92. ncbi request reprint Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, Lucille A Carver College of Medicine, Iowa City, Iowa 52252, USA
    Biol Psychiatry 55:1146-53. 2004
    ..The goal of this study was to investigate cerebellar dysfunction in schizophrenia by examining the clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs in schizophrenia patients...
  93. ncbi request reprint Symptoms and interference from memory in schizophrenia: evaluation of Frith's model of willed action
    Ivan J Torres
    Department of Psychology, Simon Fraser University and Riverview Hospital, 8888 University Drive Burnaby, BC, Canada V5A 1S6
    Schizophr Res 69:35-43. 2004
    ..These findings provide some support for Frith's hypothesis that impaired regulation of action systems may underlie some of the specific symptoms and cognitive impairments of this illness...
  94. ncbi request reprint Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophrenia
    Ruth Spinks
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, USA
    Am J Med Genet B Neuropsychiatr Genet 127:20-7. 2004
    ....
  95. ncbi request reprint Validity of symptom assessment in psychotic disorders: information variance across different sources of history
    Beng Choon Ho
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Schizophr Res 68:299-307. 2004
    ..This study was designed to determine the degree to which history provided by such subjects is consistent with that obtained from other sources...
  96. ncbi request reprint Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent
    Dwayne R Heitmiller
    Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Schizophr Res 66:137-42. 2004
    ..Few studies have evaluated caudate volume in subjects with schizophrenia who were neuroleptic naive at intake and treated exclusively with atypical neuroleptics...
  97. ncbi request reprint Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging
    Gaku Okugawa
    Dept of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Eur Arch Psychiatry Clin Neurosci 253:301-6. 2003
    ..971 and 0.999. The segmentation and measurement are useful for volumetric studies in the human brain using BRAINS...
  98. ncbi request reprint Visualizing how one brain understands another: a PET study of theory of mind
    Chadi Calarge
    Department of Psychiatry, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 160:1954-64. 2003
    ..The authors conducted a positron emission tomography (PET) study to examine the neural substrates of TOM, using a task that mimics real-life social interaction...
  99. ncbi request reprint Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography
    Sergio Paradiso
    Mental Health Clinical Research Center, Dapartment of Psychiatry, Univeristy of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 160:1775-83. 2003
    ..The authors measured regional cerebral blood flow (rCBF) during performance of a task that required unmedicated patients to recognize the emotional valence of visual images and to determine whether they were pleasant or unpleasant...
  100. ncbi request reprint Gyrification abnormalities in childhood- and adolescent-onset schizophrenia
    Tonya White
    Univeristy of Iowa, Iowa City, USA
    Biol Psychiatry 54:418-26. 2003
    ..We used magnetic resonance scanning technology to compare brain surface morphology and measures of gyrification in children and adolescents with a schizophrenia spectrum disorder and in age-equivalent healthy controls...
  101. ncbi request reprint Marijuana alters the human cerebellar clock
    DANIEL S O'LEARY
    Department of Psychiatry, University of Iowa Hospital and Clinic, Iowa City, IA 52242, USA
    Neuroreport 14:1145-51. 2003
    ..Smoking marijuana appears to accelerate a cerebellar clock altering self-paced behaviors...

Research Grants47

  1. Brain Imaging in Major Psychoses: Examining Structural & Functional Connectivity
    Nancy C Andreasen; Fiscal Year: 2010
    ..We will use novel statistical techniques for "data fusion" to integrate the information from DTI measures of structural connectivity with fMR measures of functional connectivity. Thus the proposed work with is highly innovative. ..
  2. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 2003
    ..abstract_text> ..
  3. PHENOMENOLOGY AND CLASSIFICATION OF SCHIZOPHRENIA
    Nancy Andreasen; Fiscal Year: 2003
    ..The predictive validity of these two models will be compared using four validators derived from the evaluation of long-term course: clinical outcome psychosocial outcome, cognition, and brain morphology. ..
  4. Testing Specificity of the Cognitive Dysmetria Model
    Nancy Andreasen; Fiscal Year: 2007
    ..These are tasks that patients with schizophrenia are able to do at a normal or superior level. This group of tasks will give us an additional test of the specificity of the CCTCC/cognitive dysmetria construct. ..
  5. Brain Imaging in Major Psychoses: Functional Imaging
    Nancy Andreasen; Fiscal Year: 2009
    ..abstract_text> ..
  6. Testing Specificity of the Cognitive Dysmetria Model
    Nancy Andreasen; Fiscal Year: 2009
    ..These are tasks that patients with schizophrenia are able to do at a normal or superior level. This group of tasks will give us an additional test of the specificity of the CCTCC/cognitive dysmetria construct. ..
  7. Research Training: Major Psychoses/Clinical Neurobiology
    Nancy Andreasen; Fiscal Year: 2007
    ....
  8. PHENOMENOLOGY AND CLASSIFICATION OF SCHIZOPHRENIA
    Nancy Andreasen; Fiscal Year: 2007
    ..abstract_text> ..
  9. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 1993
    ..The PET studies will emphasize three cognitive systems of interest to schizophrenia: language, attention, and memory...
  10. BRAIN IMAGING IN THE MAJOR PSYCHOSES
    Nancy Andreasen; Fiscal Year: 1991
    ..PET studies of cognitive activation (frontal and language systems) will also be conducted with both normals and schizophrenics, probably using oxygen-15 labelled water to measure changes-- in cerebral perfusion...
  11. LANGUAGE PERCEPTION AND PRODUCTION IN PSYCHOSIS
    Nancy Andreasen; Fiscal Year: 1980
    ..e., mania, schizoaffective disorder, paranoid schizophrenia, and hebephrenic schizophrenia). Evaluations will be completed longitudinally, with assessment at admission, at discharge, and at two months after discharge...