Research Topics
Species | N C AndreasenSummaryAffiliation: University of Iowa Country: USA Publications
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Detail Information
Publications
The cerebellum plays a role in conscious episodic memory retrievalN C Andreasen
Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City 52242 1057, USA
Hum Brain Mapp 8:226-34. 1999..These activations confirm a cognitive role for the cerebellum, which may participate in an interactive cortical-cerebellar network that initiates and monitors the conscious retrieval of episodic memory...- The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomographyD D Miller
Department of Psychiatry, University of Iowa Hospital and Clinics, University of Iowa College of Medicine, Iowa City 52242 1057, USA
Biol Psychiatry 41:550-9. 1997..Functional neuroimaging techniques such as SPECT may be useful in furthering our understanding of the mechanism of antipsychotics... - Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophreniaB C Ho
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Am J Psychiatry 157:808-15. 2000..If untreated psychosis is neurotoxic, this would form a strong basis for early intervention in schizophrenia... - Prevalence of depressive symptoms early in the course of schizophreniaT H Wassink
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City 52242, USA
Am J Psychiatry 156:315-6. 1999..The rate of depressive symptoms early in the course of schizophrenia was determined... - Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysisP Nopoulos
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Cleft Palate Craniofac J 37:441-6. 2000..The aim of this study was to determine whether adult men with cleft lip and palate (CLP) have aberrant cerebral morphology... - Quantitative in vivo measurement of gyrification in the human brain: changes associated with agingV A Magnotta
Mental Health Clinical Research Center, The University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA
Cereb Cortex 9:151-60. 1999..Measurements of sulcal and gyral shape may be useful in studying the mechanisms of both neurodevelopmental and neurodegenerative changes that occur during brain maturation and aging... - Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neurolepticsP W Corson
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
Am J Psychiatry 156:1200-4. 1999.... - Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlatesP Nopoulos
Mental Health Clinic Research Centre, University of Iowa College of Medicine, Iowa City 52242, USA
J Neuropsychiatry Clin Neurosci 12:344-9. 2000..Thus, the greater the size of the anomaly, the greater the cognitive deficit. No relationship was found between severity of CSP and symptom measures... - Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patientsB Crespo-Facorro
Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1057, USA
Schizophr Res 46:35-43. 2000..These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia... - Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odorsB Crespo-Facorro
University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, Room 2911 JPP, 200 Hawkins Dr, Iowa City, IA 52242-1057, USA
JAMA 286:427-35. 2001..CONCLUSION: Abnormalities in the complex functional interactions between mesolimbic and frontal regions may underlie emotional disturbances in schizophrenia... - Heritability of BDNF alleles and their effect on brain morphology in schizophreniaT H Wassink
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa
Am J Med Genet 88:724-8. 1999..We did not find support for BDNF as a disease gene for schizophrenia. Allelic variability of the gene may, however, influence brain morphology in these same subjects. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:724-728, 1999... - Abnormal brain structure in adults with Van der Woude syndromeP Nopoulos
Department of Psychiatry, University of Iowa College of Medicine, IA 52242, USA
Clin Genet 71:511-7. 2007.... - Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flowB C Ho
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
Mol Psychiatry 10:229, 287-98. 2005..Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition... - Longitudinal study of cognitive function in first-episode and recent-onset schizophreniaS Gold
Department of Psychiatry, University of Iowa, USA
Am J Psychiatry 156:1342-8. 1999..Few studies have examined the longitudinal stability of cognitive function and the relationship between cognitive performance and clinical symptoms over time in a cohort of well-treated patients with schizophrenia... - Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidismR A Philibert
Department of Psychiatry, The University of Iowa, Iowa City 52242 1000, USA
Am J Med Genet 105:130-4. 2001.... - Functional MRI statistical software packages: a comparative analysisS Gold
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Hum Brain Mapp 6:73-84. 1998..The functionality of each package was detailed and discussed. AFNI 2.01, SPM96, Stimulate 5.0, MEDIMAX 2.01, and FIT were tested. FIASCO, Yale, and MEDx 2.0 were described but not tested. A description of each package is provided... - Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophreniaT H Wassink
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
Mol Psychiatry 5:678-82. 2000..We found no support, therefore, for TNF-RII as a disease susceptibility gene for schizophrenia. The gene may, however, modify phenotypic aspects of the disease such as brain morphology and age of onset of illness... - Correlating and predicting psychiatric symptom ratings: Spearman's r versus Kendall's tau correlationS Arndt
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City 52242, USA
J Psychiatr Res 33:97-104. 1999.... - Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and/or palateP Nopoulos
Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, IA 52242, USA
J Neuroimaging 11:418-24. 2001.... - Color enhancement of multispectral MR images: improving the visualization of subcortical structuresJ Ward
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
J Comput Assist Tomogr 25:942-9. 2001..quot; They were developed to improve the delineation of small brain structures composed of mixed tissue types, such as the basal ganglia... - Developmental brain anomalies in children with attention-deficit hyperactivity disorderP Nopoulos
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
J Child Neurol 15:102-8. 2000..These findings support and extend the idea that ADHD is of developmental origin, and further suggest that the timing of aberrant brain development could be in early gestation... - SchizophreniaS K Schultz
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City 52242, USA
Lancet 353:1425-30. 1999..Despite these advances, treatment of symptoms and psychosocial and cognitive impairments remains only partially successful for many patients... - Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controlsP C Nopoulos
Mental Health Clinical Research Center, University of Iowa College of Medicine, 52242, Iowa City, IA, USA
Schizophr Res 48:177-85. 2001..These results support the growing literature reporting structural aberration of the thalamus, as well as other midline structures in the brains of patients with schizophrenia... - Clinical features characterizing young-onset and intermediate-onset schizophreniaS K Schultz
University of Iowa, Department of Psychiatry, Mental Health Clinical Research Center, Iowa City, USA
J Neuropsychiatry Clin Neurosci 12:502-5. 2000..The dichotomy of early vs. late onset may extend to a younger population, reflecting a more continuous influence... - Schizophrenia: the fundamental questionsN C Andreasen
University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 2911 JPP, 200 Hawkins Drive, Iowa City, IA, USA
Brain Res Brain Res Rev 31:106-12. 2000..This type of unitary model may be more heuristic than early ones that were based on heterogeneous signs and symptoms... - Anatomic and functional variability: the effects of filter size in group fMRI data analysisT White
Mental Health Clinical Research Center, University of Iowa Hospital and Clinics, Iowa City, Iowa 52241, USA
Neuroimage 13:577-88. 2001..A discussion of the inherent difficulties in choosing an appropriate filter size is presented... - [Which phenotype for the psychiatric research?]N C Andreasen
Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, USA
Encephale 28:S16-20. 2002 - Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor taskK E Stephan
Computational Systems Neuroscience Group, C. and O. Vogt Brain Research Institute, Heinrich-Heine-University, , Germany
Psychol Med 31:1065-78. 2001..Altogether, our findings suggest that olanzapine has a stronger differential effect on neural activity in prefrontal cortex and thalamus than in motor structures... - [Cognition and emotion in schizophrenia: neuroimaging approach]N C Andreasen
Department of Psychiatry, University of Iowa Hospitals and Clinics, Room 2712A-JPP, 200 Hawkins Drive, Iowa City, IA 52242-1057, USA
Encephale 28:S14-5. 2002 - Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography studyB Crespo-Facorro
Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Hum Brain Mapp 12:219-31. 2001..During recognition of novel material, patients failed to activate frontal/limbic regions, recruiting a set of posterior perceptual brain regions instead... - Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficitsA S Shriver
Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Child Psychol Psychiatry 47:994-1002. 2006.... - Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophreniaD D Miller
The Mental Health Clinical Research Center--Major Psychoses, Department of Psychiatry, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Biol Psychiatry 49:704-15. 2001..These findings emphasize the importance of controlling for both medication status and the individual antipsychotic in neuroimaging studies...