Athena Andreadis

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Tau splicing and the intricacies of dementia
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 227:1220-5. 2012
  2. ncbi request reprint Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
    Biochim Biophys Acta 1739:91-103. 2005
  3. pmc An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Gene 485:130-8. 2011
  4. pmc Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Gene 451:23-31. 2010
  5. pmc Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylation
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 112:3482-8. 2011
  6. ncbi request reprint Misregulation of tau alternative splicing in neurodegeneration and dementia
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
    Prog Mol Subcell Biol 44:89-107. 2006
  7. pmc C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
    Chiranthani Sumanasekera
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
    Nucleic Acids Res 40:4025-39. 2012
  8. ncbi request reprint Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1
    Yingzi Wang
    Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Biol Chem 280:14230-9. 2005
  9. ncbi request reprint Novel isoforms of tau that lack the microtubule-binding domain
    Min Hua Luo
    Neurobiology Division, Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurochem 90:340-51. 2004
  10. ncbi request reprint The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease
    Daniela C Glatz
    Molecular and Clinical Neurobiology, Department of Psychiatry Ludwig Maximilians University, Munich, Germany
    J Neurochem 96:635-44. 2006

Collaborators

  • Stefan Stamm
  • Monique Beullens
  • T A Cooper
  • Hanna Ksiezak-Reding
  • Claude Alain Maurage
  • Gloria Lee
  • Virginia M Y Lee
  • Makoto Higuchi
  • Andre Delacourte
  • H Hampel
  • Lei Gao
  • Junning Wang
  • Yan Wang
  • Sze Wah Tse
  • Min Hua Luo
  • Olivier Leroy
  • Yingzi Wang
  • Chiranthani Sumanasekera
  • Robert Lafyatis
  • Meltem Cevik Arikan
  • Liang Qiang
  • Luc Buee
  • Daniela C Glatz
  • Nicolas Sergeant
  • Marie Laure Caillet-Boudin
  • Hiromi Nishinaga
  • Jennifer Broderick
  • Jennifer A Broderick
  • Karen Li
  • John Memmott
  • Mathieu Bollen
  • Manjula Sunkara
  • Joseph A Adams
  • Brandon E Aubol
  • Andrew Morris
  • Olga Kelemen
  • Christopher G Conrad
  • Bernard Sablonniere
  • Carlyn Rosenberg
  • Michel Parent
  • Minhua Luo
  • Wenqian Yu
  • Dan Rujescu
  • Hans J Möller
  • Peter W Baas
  • Frank Faltraco
  • Christine Hulette
  • Yesheng Tang
  • Kurt Jellinger
  • Karim Belarbi
  • Frank J Berendt
  • Suzanna Schraen-Maschke
  • Claire Marie Dhaenens
  • Annette M Hartmann
  • Kerstin Henkel
  • Peter Riederer
  • Hiroyoshi Ariga
  • Peter McCaffery
  • Kerry L Tucker
  • Christopher Conrad
  • Sanae M M Iguchi-Ariga
  • Mei Ling Wei
  • Kazuko Takahashi-Niki
  • Deborah Smith
  • Takahiro Taira
  • Michael L Leski
  • Qing Sheng Gao
  • Gavin Screaton

Detail Information

Publications26

  1. pmc Tau splicing and the intricacies of dementia
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 227:1220-5. 2012
    ..In this review, I present our cumulative knowledge of tau splicing regulation in connection with neurodegeneration and also briefly go over the still-extensive list of questions that are connected to tau (dys)function...
  2. ncbi request reprint Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
    Biochim Biophys Acta 1739:91-103. 2005
    ....
  3. pmc An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Gene 485:130-8. 2011
    ..This work provides insights into the splicing regulation of the tau gene and into possible strategies for correcting the imbalance in tauopathies caused by changes in the ratio of exon 10...
  4. pmc Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Gene 451:23-31. 2010
    ....
  5. pmc Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylation
    Yan Wang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 112:3482-8. 2011
    ..The effect of Saitohin on Abl-mediated phosphorylation appears to be allele-specific, providing evidence for a new cellular function for STH...
  6. ncbi request reprint Misregulation of tau alternative splicing in neurodegeneration and dementia
    Athena Andreadis
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
    Prog Mol Subcell Biol 44:89-107. 2006
    ..This review briefly presents our cumulative knowledge of tau splicing regulation in connection with the alterations in tau splicing seen in neurodegeneration...
  7. pmc C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
    Chiranthani Sumanasekera
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
    Nucleic Acids Res 40:4025-39. 2012
    ..Our results indicate that lipids can influence pre-mRNA processing by regulating the phosphorylation status of specific regulatory factors, which is mediated by protein phosphatase activity...
  8. ncbi request reprint Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1
    Yingzi Wang
    Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Biol Chem 280:14230-9. 2005
    ..This work provides interesting insights into the splicing regulation of the tau gene...
  9. ncbi request reprint Novel isoforms of tau that lack the microtubule-binding domain
    Min Hua Luo
    Neurobiology Division, Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurochem 90:340-51. 2004
    ..In both normal and Alzheimer's hippocampus, the novel isoform is found in dentate gyrus granular cells and CA1/CA3 pyramidal cells. However, it does not co-localize with canonical tau but, rather, partly co-localizes with MAP2...
  10. ncbi request reprint The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease
    Daniela C Glatz
    Molecular and Clinical Neurobiology, Department of Psychiatry Ludwig Maximilians University, Munich, Germany
    J Neurochem 96:635-44. 2006
    ..These findings suggest that a misregulation of alternative splicing seems to contribute to sporadic AD...
  11. pmc SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations
    Lei Gao
    Shriver Center at UMMS, Waltham, MA 02452, USA
    Mol Cell Neurosci 34:48-58. 2007
    ..These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases...
  12. ncbi request reprint Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points
    Junning Wang
    Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Neurochem 100:437-45. 2007
    ..Recent results show that tau exon 6 is specifically suppressed in the brains of people who suffer from myotonic dystrophy type 1. The understanding of how tau exon 6 splicing is regulated may give us insights into the disease...
  13. ncbi request reprint ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I
    Olivier Leroy
    INSERM U815, Lille, France
    J Neurosci Res 84:852-9. 2006
    ..These results together with the analysis of Tau exon 6 and IR exon 11 splicing in brain, muscle, and cell models suggest that DM1 splicing alteration of several transcripts involves various factors...
  14. ncbi request reprint Tau protects microtubules in the axon from severing by katanin
    Liang Qiang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 26:3120-9. 2006
    ..These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules...
  15. ncbi request reprint Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1
    Olivier Leroy
    INSERM U422, Pl de Verdun 59045 Lille Cedex France
    Biochim Biophys Acta 1762:460-7. 2006
    ..Altogether, these results show the importance of determining all the exons and organs targeted by mis-splicing to determine the dysregulation mechanisms of mis-splicing in DM1...
  16. ncbi request reprint Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6
    Lei Gao
    Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Biol Chem 280:39268-72. 2005
    ..The strength of the interaction appeared to be allele-specific, giving the first distinction between the two forms of Saitohin...
  17. ncbi request reprint Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 35:433-46. 2002
    ..Thus, tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration...
  18. ncbi request reprint Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2
    Karen Li
    Division of Neurobiology of Developmental Disorders, Shriver Center for Mental Retardation at UMMS, Waltham, MA 02452, USA
    Brain Res Mol Brain Res 116:94-105. 2003
    ..Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 2 isoforms. Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 2...
  19. ncbi request reprint Phosphorylation of tau by fyn: implications for Alzheimer's disease
    Gloria Lee
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 24:2304-12. 2004
    ..We also found evidence suggesting that differentially phosphorylated tau existed within degenerating neurons. Our data add new support for a role for fyn in the neurodegenerative process...
  20. ncbi request reprint Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors
    Junning Wang
    Shriver Center at UMMS, Waltham, Massachusetts 02452, USA
    J Neurochem 88:1078-90. 2004
    ..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing...
  21. ncbi request reprint Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation
    Min Hua Luo
    Neurobiology of Developmental Disorders, Shriver Center for Mental Retardation, Waltham, Massachusetts 02452, USA
    J Cell Biochem 91:880-95. 2004
    ..We found that expression of one particular combination of tau exons (the longest adult isoform plus the domain of exon 6) significantly inhibits neurite elongation...
  22. ncbi request reprint Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing
    Jennifer Broderick
    Neurobiology Division, Shriver Center at UMMS, Waltham, MA 02452, USA
    Gene 331:107-14. 2004
    ..Using tau exon 10 as a bait in a yeast three-hybrid screen, we discovered that it interacts with hnRNPE2. Cotransfection assays show that hnRNPE2 isoforms moderately activate the splicing of exon 10...
  23. ncbi request reprint Transcriptional regulation of the mouse microtubule-associated protein tau
    Lei Gao
    Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Biochim Biophys Acta 1681:175-81. 2005
    ..Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript...
  24. ncbi request reprint Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells
    Hiromi Nishinaga
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Neurosci Lett 390:54-9. 2005
    ..These findings suggest that DJ-1 regulates expressions of genes for which functions are thought to be related to cell death or neurodegeneration...
  25. ncbi request reprint Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain
    Sze Wah Tse
    Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Gene 359:63-72. 2005
    ..In both myoblasts and neuroblastoma cells, the Solo protein is concentrated around the nucleus...
  26. ncbi request reprint Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3
    Meltem Cevik Arikan
    Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02454, USA
    Brain Res Mol Brain Res 101:109-21. 2002
    ..Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 3 isoforms, Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 3...

Research Grants13

  1. Tau missplicing caused by RNA processing proteins located on chromosome 21
    Athena Andreadis; Fiscal Year: 2007
    ..They may also help us find therapeutic targets and treatment options for this extremely prevalent and agonizing genetic disease. ..
  2. Function of saitohin, a novel protein that confers susceptibility to dementia
    Athena Andreadis; Fiscal Year: 2007
    ..These studies will clarify the function(s) of STH and its connection to normal brain function and neurodegeneration. It may also help explain the unique susceptibility of our species to the woes of senility. ..
  3. TAU IN FRONTOTEMPORAL DEMENTIA--REGULATION OF EXON 10
    Athena Andreadis; Fiscal Year: 2004
    ....