Research Topics
Species | Athena AndreadisSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Publications
Tau splicing and the intricacies of dementiaAthena Andreadis
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Physiol 227:1220-5. 2012..In this review, I present our cumulative knowledge of tau splicing regulation in connection with neurodegeneration and also briefly go over the still-extensive list of questions that are connected to tau (dys)function...
Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseasesAthena Andreadis
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
Biochim Biophys Acta 1739:91-103. 2005....- An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementiaYan Wang
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Gene 485:130-8. 2011..This work provides insights into the splicing regulation of the tau gene and into possible strategies for correcting the imbalance in tauopathies caused by changes in the ratio of exon 10... - Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutationsYan Wang
Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Gene 451:23-31. 2010.... - Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylationYan Wang
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Biochem 112:3482-8. 2011..The effect of Saitohin on Abl-mediated phosphorylation appears to be allele-specific, providing evidence for a new cellular function for STH... - Misregulation of tau alternative splicing in neurodegeneration and dementiaAthena Andreadis
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 06155, USA
Prog Mol Subcell Biol 44:89-107. 2006..This review briefly presents our cumulative knowledge of tau splicing regulation in connection with the alterations in tau splicing seen in neurodegeneration... - C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1Chiranthani Sumanasekera
Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
Nucleic Acids Res 40:4025-39. 2012..Our results indicate that lipids can influence pre-mRNA processing by regulating the phosphorylation status of specific regulatory factors, which is mediated by protein phosphatase activity... - Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1Yingzi Wang
Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
J Biol Chem 280:14230-9. 2005..This work provides interesting insights into the splicing regulation of the tau gene... - Novel isoforms of tau that lack the microtubule-binding domainMin Hua Luo
Neurobiology Division, Shriver Center, Waltham, Massachusetts 02452, USA
J Neurochem 90:340-51. 2004..In both normal and Alzheimer's hippocampus, the novel isoform is found in dentate gyrus granular cells and CA1/CA3 pyramidal cells. However, it does not co-localize with canonical tau but, rather, partly co-localizes with MAP2... - The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's diseaseDaniela C Glatz
Molecular and Clinical Neurobiology, Department of Psychiatry Ludwig Maximilians University, Munich, Germany
J Neurochem 96:635-44. 2006..These findings suggest that a misregulation of alternative splicing seems to contribute to sporadic AD... - SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutationsLei Gao
Shriver Center at UMMS, Waltham, MA 02452, USA
Mol Cell Neurosci 34:48-58. 2007..These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases... - Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch pointsJunning Wang
Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
J Neurochem 100:437-45. 2007..Recent results show that tau exon 6 is specifically suppressed in the brains of people who suffer from myotonic dystrophy type 1. The understanding of how tau exon 6 splicing is regulated may give us insights into the disease... - ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type IOlivier Leroy
INSERM U815, Lille, France
J Neurosci Res 84:852-9. 2006..These results together with the analysis of Tau exon 6 and IR exon 11 splicing in brain, muscle, and cell models suggest that DM1 splicing alteration of several transcripts involves various factors... - Tau protects microtubules in the axon from severing by kataninLiang Qiang
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
J Neurosci 26:3120-9. 2006..These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules... - Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1Olivier Leroy
INSERM U422, Pl de Verdun 59045 Lille Cedex France
Biochim Biophys Acta 1762:460-7. 2006..Altogether, these results show the importance of determining all the exons and organs targeted by mis-splicing to determine the dysregulation mechanisms of mis-splicing in DM1... - Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6Lei Gao
Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
J Biol Chem 280:39268-72. 2005..The strength of the interaction appeared to be allele-specific, giving the first distinction between the two forms of Saitohin... - Transgenic mouse model of tauopathies with glial pathology and nervous system degenerationMakoto Higuchi
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 35:433-46. 2002..Thus, tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration... - Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2Karen Li
Division of Neurobiology of Developmental Disorders, Shriver Center for Mental Retardation at UMMS, Waltham, MA 02452, USA
Brain Res Mol Brain Res 116:94-105. 2003..Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 2 isoforms. Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 2... - Phosphorylation of tau by fyn: implications for Alzheimer's diseaseGloria Lee
Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 24:2304-12. 2004..We also found evidence suggesting that differentially phosphorylated tau existed within degenerating neurons. Our data add new support for a role for fyn in the neurodegenerative process... - Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factorsJunning Wang
Shriver Center at UMMS, Waltham, Massachusetts 02452, USA
J Neurochem 88:1078-90. 2004..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing... - Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongationMin Hua Luo
Neurobiology of Developmental Disorders, Shriver Center for Mental Retardation, Waltham, Massachusetts 02452, USA
J Cell Biochem 91:880-95. 2004..We found that expression of one particular combination of tau exons (the longest adult isoform plus the domain of exon 6) significantly inhibits neurite elongation... - Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicingJennifer Broderick
Neurobiology Division, Shriver Center at UMMS, Waltham, MA 02452, USA
Gene 331:107-14. 2004..Using tau exon 10 as a bait in a yeast three-hybrid screen, we discovered that it interacts with hnRNPE2. Cotransfection assays show that hnRNPE2 isoforms moderately activate the splicing of exon 10... - Transcriptional regulation of the mouse microtubule-associated protein tauLei Gao
Shriver Center for Mental Retardation, Waltham, MA 02452, USA
Biochim Biophys Acta 1681:175-81. 2005..Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript... - Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cellsHiromi Nishinaga
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Neurosci Lett 390:54-9. 2005..These findings suggest that DJ-1 regulates expressions of genes for which functions are thought to be related to cell death or neurodegeneration... - Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domainSze Wah Tse
Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02452, USA
Gene 359:63-72. 2005..In both myoblasts and neuroblastoma cells, the Solo protein is concentrated around the nucleus... - Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3Meltem Cevik Arikan
Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02454, USA
Brain Res Mol Brain Res 101:109-21. 2002..Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 3 isoforms, Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 3...
Research Grants
- Tau missplicing caused by RNA processing proteins located on chromosome 21Athena Andreadis; Fiscal Year: 2007..They may also help us find therapeutic targets and treatment options for this extremely prevalent and agonizing genetic disease. ..
- Function of saitohin, a novel protein that confers susceptibility to dementiaAthena Andreadis; Fiscal Year: 2007..These studies will clarify the function(s) of STH and its connection to normal brain function and neurodegeneration. It may also help explain the unique susceptibility of our species to the woes of senility. ..
- TAU IN FRONTOTEMPORAL DEMENTIA--REGULATION OF EXON 10Athena Andreadis; Fiscal Year: 2004....