Steven M Anderson

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase
    S M Anderson
    University of Colorado Health Sciences Center, Department of Pathology, Denver 80262, USA
    J Biol Chem 272:739-45. 1997
  2. ncbi request reprint Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells
    S M Anderson
    Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Cell Death Differ 6:454-62. 1999
  3. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
  4. pmc Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
    Michael C Rudolph
    1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
    Am J Physiol Endocrinol Metab 299:E918-27. 2010
  5. ncbi request reprint Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
    C Kenneth Kassenbrock
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 279:28017-27. 2004
  6. pmc Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell
    Michael C Rudolph
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 300:E1059-68. 2011
  7. pmc Lactation failure in Src knockout mice is due to impaired secretory activation
    Harriet Watkin
    Department of Pathology, University of Colorado Health Sciences Center, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17th Avenue, Aurora, CO 80045, USA
    BMC Dev Biol 8:6. 2008
  8. ncbi request reprint Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor
    C Kenneth Kassenbrock
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Biol Chem 277:24967-75. 2002
  9. ncbi request reprint Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
    Kathryn L Schwertfeger
    Departments of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Lipid Res 44:1100-12. 2003
  10. pmc MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src
    Weiyong Sun
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 23:2298-308. 2003

Research Grants

  1. INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULES
    Steven Anderson; Fiscal Year: 2003
  2. MAMMARY GLAND BIOLOGY GRC
    Steven Anderson; Fiscal Year: 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase
    S M Anderson
    University of Colorado Health Sciences Center, Department of Pathology, Denver 80262, USA
    J Biol Chem 272:739-45. 1997
    ..These data suggest the unexpected conclusion that the Fyn SH2 domain may bind to Cbl in a phosphotyrosine-independent manner...
  2. ncbi request reprint Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells
    S M Anderson
    Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Cell Death Differ 6:454-62. 1999
    ..These data suggest that etoposide may induce apoptosis in parotid C5 cells by activating JNKs and suppressing the activation of ERKs, thus creating an imbalance in these two signaling pathways...
  3. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
    ....
  4. pmc Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
    Michael C Rudolph
    1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
    Am J Physiol Endocrinol Metab 299:E918-27. 2010
    ....
  5. ncbi request reprint Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
    C Kenneth Kassenbrock
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 279:28017-27. 2004
    ..However, Tyr-371 point mutants of c-Cbl are still able to undergo phosphorylation-induced E3 activation, and we show that Tyr-368 can also be phosphorylated in addition to Tyr-371, and contributes to activation...
  6. pmc Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell
    Michael C Rudolph
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 300:E1059-68. 2011
    ..These data demonstrate that PRL signaling regulates MEC-specific lipogenic gene expression and that PRL signals coordinate the milk synthesis and mammary epithelial cell survival during lactation in the mouse...
  7. pmc Lactation failure in Src knockout mice is due to impaired secretory activation
    Harriet Watkin
    Department of Pathology, University of Colorado Health Sciences Center, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17th Avenue, Aurora, CO 80045, USA
    BMC Dev Biol 8:6. 2008
    ..In order to determine if Src plays a role in mammary gland development we have examined mammary gland development and function during pregnancy and lactation in mice in which expression of Src has been eliminated...
  8. ncbi request reprint Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor
    C Kenneth Kassenbrock
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Biol Chem 277:24967-75. 2002
    ..PP1 treatment blocks EGF-induced activation of the anti-apoptotic protein kinase Akt suggesting that Src may regulate activation of Akt, perhaps by a Src --> c-Cbl --> phosphatidylinositol 3'-kinase --> Akt pathway...
  9. ncbi request reprint Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
    Kathryn L Schwertfeger
    Departments of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Lipid Res 44:1100-12. 2003
    ....
  10. pmc MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src
    Weiyong Sun
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 23:2298-308. 2003
    ....
  11. doi request reprint AKT regulates BRCA1 stability in response to hormone signaling
    Andrew C Nelson
    Department of Pathology, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Cell Endocrinol 319:129-42. 2010
    ..Targets within this pathway could provide strategies for modulation of BRCA1 protein, which may prove therapeutically beneficial for breast and ovarian cancer treatment...
  12. ncbi request reprint Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
    ..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
  13. ncbi request reprint Analysis of lactation defects in transgenic mice
    Carol A Palmer
    Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 11:269-82. 2006
    ....
  14. ncbi request reprint Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
  15. pmc MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells
    Kirsten H Limesand
    Department of Pathology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
    Mol Cell Biol 26:8840-56. 2006
    ..These results indicate that MDM2 is a critical substrate of activated Akt1 in the suppression of p53-dependent apoptosis in vivo...
  16. pmc Adipose-depleted mammary epithelial cells and organoids
    Michael C Rudolph
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 14:381-6. 2009
    ..In contrast to other methods such as laser capture microdissection, the MEC enrichment method described here is performed using standard lab supplies, equipment, and techniques...
  17. ncbi request reprint Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo
    Michael J Humphries
    Department of Craniofacial Biology and School of Dentistry, University of Colorado Health Sciences Center, Aurora, Colorado 80262, USA
    J Biol Chem 281:9728-37. 2006
    ..These studies indicate an essential role for PKCdelta downstream of the p53 response and upstream of the c-Jun amino-terminal kinase activation in DNA damage-induced apoptosis in vivo and in vitro...
  18. ncbi request reprint Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils
    Marguerite R Kelher
    Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
    Cell Calcium 34:445-55. 2003
    ..Thus, fMLP concentrations that prime or activate the oxidase cause a rapid Ca2+-dependent tyrosine phosphorylation of Rel-1 involving p38 MAPK activation...
  19. pmc Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer
    Erin D Giles
    Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Cancer Res 72:6490-501. 2012
    ..Our findings have potential explanative power in understanding why obese, postmenopausal women display an increased risk of breast cancer...
  20. pmc Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
    Christian D Young
    Department of Pathology, University of Colorado Denver, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17thAvenue, Aurora, CO 80045, USA
    Breast Cancer Res 10:R70. 2008
    ..ErbB2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in 20% to 30% of human breast cancer cases and forms oncogenic signalling complexes when dimerised to ErbB3 or other EGFR family members...
  21. pmc Lactation and neonatal nutrition: defining and refining the critical questions
    Margaret C Neville
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 17:167-88. 2012
    ..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond...
  22. pmc Suppression of radiation-induced salivary gland dysfunction by IGF-1
    Kirsten H Limesand
    Department of Pathology, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    PLoS ONE 4:e4663. 2009
    ..Previous studies in a rat model have shown no correlation between induction of apoptosis in the salivary gland and either the immediate or chronic decrease in salivary function following gamma-radiation treatment...
  23. pmc Characterization of rat parotid and submandibular acinar cell apoptosis in primary culture
    Kirsten H Limesand
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    In Vitro Cell Dev Biol Anim 39:170-7. 2003
    ....
  24. pmc Sugar and fat - that's where it's at: metabolic changes in tumors
    Christian D Young
    Department of Pathology and Program in Cancer Biology, University of Colorado Denver, Anschutz Medical Campus, East 17th Avenue, Aurora, Colorado 80045, USA
    Breast Cancer Res 10:202. 2008
    ....
  25. pmc Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death
    Christian D Young
    Department of Pathology, Mailstop 8104, University of Colorado Denver, University of Colorado School of Medicine, P, O, Box 6511, Anshutz Medical Campus, Aurora, CO 80045, USA
    Breast Cancer Res 11:307. 2009
    ..These findings integrate aspects of glucose metabolism, anoikis suppression and antioxidant production in tumor cell biology and suggest that antioxidant therapy could stimulate tumor survival...
  26. pmc Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo
    Christian D Young
    Department of Pathology, University of Colorado School of Medicine, Anshutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 6:e23205. 2011
    ....
  27. ncbi request reprint Regulation of the Pro-apoptotic scaffolding protein POSH by Akt
    Traci R Lyons
    Department of Pathology, The University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Biol Chem 282:21987-97. 2007
    ..S304D mutant POSH also shows a strongly reduced ability to induce apoptosis. These findings identify a novel mechanism by which Akt promotes cell survival...
  28. ncbi request reprint Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells
    Adam C Buser
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Mol Endocrinol 21:106-25. 2007
    ..These results define a negative cross talk between PR and Stat5a/GR that may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene in the mammary gland during pregnancy...

Research Grants3

  1. INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULES
    Steven Anderson; Fiscal Year: 2003
    ..These studies will provide new information about the effect of the prolactin receptor upon mammary epithelial cells, and whether suppression of apoptosis in Important in mammary carcinogenesis. ..
  2. MAMMARY GLAND BIOLOGY GRC
    Steven Anderson; Fiscal Year: 2007
    ..The Mammary Gland Biology Gordon Conference is the premier conference in the field that stimulates cross-disciplinary interaction and supports career development of junior investigators and trainees. ..