Research Topics
| Rozalyn AndersonSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional programMichael G Edwards
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA
BMC Genomics 8:80. 2007..We have used high density oligonucleotide arrays and novel statistical methods to identify specific transcriptional classes that may uncover biological processes that play a central role in mammalian aging...- PGC-1alpha in aging and anti-aging interventionsRozalyn Anderson
Wisconsin National Primate Research Center, Madison, WI 53715, USA
Biochim Biophys Acta 1790:1059-66. 2009..We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process... - Metabolic reprogramming, caloric restriction and agingRozalyn M Anderson
Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
Trends Endocrinol Metab 21:134-41. 2010..We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process... - Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress responseRozalyn M Anderson
University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Aging Cell 7:101-11. 2008..Our data show how mitochondrial function may be adapted in response to external stimuli, and support the concept that such adaptation is critically involved in cellular survival and in lifespan extension by calorie restriction... 
Caloric restriction and aging: studies in mice and monkeysRozalyn M Anderson
Wisconsin National Primate Research Center, Madison, Wisconsin, USA
Toxicol Pathol 37:47-51. 2009..A new finding from this project is that CR reduces the rate of age-associated muscle loss (sarcopenia) in monkeys (Colman et al. 2008)...- Calorie restriction: progress during mid-2005-mid-2006Rozalyn M Anderson
University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Exp Gerontol 41:1247-9. 2006 
Metabolic reprogramming in dietary restrictionRozalyn M Anderson
Department of Medicine, University of Wisconsin, and VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Interdiscip Top Gerontol 35:18-38. 2007....- Prospects and perspectives in primate aging researchRozalyn M Anderson
Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
Antioxid Redox Signal 14:203-5. 2011.... - Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscleSusan H McKiernan
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
Exp Gerontol 46:23-9. 2011..CR did not prevent stochastic mitochondrial deletion mutations in muscle fibers but CR may have contributed to the maintenance of affected fibers... - Caloric restriction delays disease onset and mortality in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Science 325:201-4. 2009..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species... - Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
Diabetes 61:1036-42. 2012..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships... - Yeast life-span extension by calorie restriction is independent of NAD fluctuationRozalyn M Anderson
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA
Science 302:2124-6. 2003..Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR... - Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiaeRozalyn M Anderson
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 423:181-5. 2003..We conclude that yeast lifespan extension by calorie restriction is the consequence of an active cellular response to a low-intensity stress and speculate that nicotinamide might regulate critical cellular processes in higher organisms... - Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1Kevin J Bitterman
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:45099-107. 2002..We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes...
Research Grants
- Metabolic regulators in the mechanisms of caloric restrictionRozalyn Anderson; Fiscal Year: 2010....