Rozalyn Anderson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
    Michael G Edwards
    Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA
    BMC Genomics 8:80. 2007
  2. pmc PGC-1alpha in aging and anti-aging interventions
    Rozalyn Anderson
    Wisconsin National Primate Research Center, Madison, WI 53715, USA
    Biochim Biophys Acta 1790:1059-66. 2009
  3. pmc Metabolic reprogramming, caloric restriction and aging
    Rozalyn M Anderson
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
    Trends Endocrinol Metab 21:134-41. 2010
  4. pmc Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
    Rozalyn M Anderson
    University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Aging Cell 7:101-11. 2008
  5. pmc Caloric restriction and aging: studies in mice and monkeys
    Rozalyn M Anderson
    Wisconsin National Primate Research Center, Madison, Wisconsin, USA
    Toxicol Pathol 37:47-51. 2009
  6. pmc Calorie restriction: progress during mid-2005-mid-2006
    Rozalyn M Anderson
    University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Exp Gerontol 41:1247-9. 2006
  7. ncbi request reprint Metabolic reprogramming in dietary restriction
    Rozalyn M Anderson
    Department of Medicine, University of Wisconsin, and VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Interdiscip Top Gerontol 35:18-38. 2007
  8. pmc Prospects and perspectives in primate aging research
    Rozalyn M Anderson
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Antioxid Redox Signal 14:203-5. 2011
  9. pmc Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle
    Susan H McKiernan
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
    Exp Gerontol 46:23-9. 2011
  10. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
    Michael G Edwards
    Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA
    BMC Genomics 8:80. 2007
    ..We have used high density oligonucleotide arrays and novel statistical methods to identify specific transcriptional classes that may uncover biological processes that play a central role in mammalian aging...
  2. pmc PGC-1alpha in aging and anti-aging interventions
    Rozalyn Anderson
    Wisconsin National Primate Research Center, Madison, WI 53715, USA
    Biochim Biophys Acta 1790:1059-66. 2009
    ..We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process...
  3. pmc Metabolic reprogramming, caloric restriction and aging
    Rozalyn M Anderson
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
    Trends Endocrinol Metab 21:134-41. 2010
    ..We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process...
  4. pmc Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
    Rozalyn M Anderson
    University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Aging Cell 7:101-11. 2008
    ..Our data show how mitochondrial function may be adapted in response to external stimuli, and support the concept that such adaptation is critically involved in cellular survival and in lifespan extension by calorie restriction...
  5. pmc Caloric restriction and aging: studies in mice and monkeys
    Rozalyn M Anderson
    Wisconsin National Primate Research Center, Madison, Wisconsin, USA
    Toxicol Pathol 37:47-51. 2009
    ..A new finding from this project is that CR reduces the rate of age-associated muscle loss (sarcopenia) in monkeys (Colman et al. 2008)...
  6. pmc Calorie restriction: progress during mid-2005-mid-2006
    Rozalyn M Anderson
    University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Exp Gerontol 41:1247-9. 2006
  7. ncbi request reprint Metabolic reprogramming in dietary restriction
    Rozalyn M Anderson
    Department of Medicine, University of Wisconsin, and VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Interdiscip Top Gerontol 35:18-38. 2007
    ....
  8. pmc Prospects and perspectives in primate aging research
    Rozalyn M Anderson
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Antioxid Redox Signal 14:203-5. 2011
    ....
  9. pmc Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle
    Susan H McKiernan
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
    Exp Gerontol 46:23-9. 2011
    ..CR did not prevent stochastic mitochondrial deletion mutations in muscle fibers but CR may have contributed to the maintenance of affected fibers...
  10. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009
    ..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species...
  11. pmc Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys
    Auriel A Willette
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
    Diabetes 61:1036-42. 2012
    ..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships...
  12. ncbi request reprint Yeast life-span extension by calorie restriction is independent of NAD fluctuation
    Rozalyn M Anderson
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA
    Science 302:2124-6. 2003
    ..Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR...
  13. ncbi request reprint Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    Rozalyn M Anderson
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 423:181-5. 2003
    ..We conclude that yeast lifespan extension by calorie restriction is the consequence of an active cellular response to a low-intensity stress and speculate that nicotinamide might regulate critical cellular processes in higher organisms...
  14. ncbi request reprint Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    Kevin J Bitterman
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:45099-107. 2002
    ..We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes...

Research Grants1