R A Anderson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
    J C Loijens
    Program in Cellular and Molecular Biology and Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 271:32937-43. 1996
  2. doi request reprint A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs
    David L Mellman
    Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nature 451:1013-7. 2008
  3. pmc Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch
    Kun Ling
    Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Cell Biol 163:1339-49. 2003
  4. ncbi request reprint Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
    R A Anderson
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 274:9907-10. 1999
  5. ncbi request reprint The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI, USA
    J Cell Sci 112:2647-56. 1999
  6. ncbi request reprint Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties
    J Zhang
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Biochemistry 35:16319-27. 1996
  7. pmc Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors
    I V Boronenkov
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:3547-60. 1998
  8. pmc A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    J Cell Biol 130:711-24. 1995
  9. ncbi request reprint The phosphatidylinositol 4-phosphate 5-kinase family
    J C Loijens
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Adv Enzyme Regul 36:115-40. 1996
  10. ncbi request reprint A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Cell Sci 110:3083-90. 1997

Collaborators

  • W Li
  • J Zhang
  • M Umeda
  • Henry N Jabbour
  • P Wang
  • Matthew W Bunce
  • Kun Ling
  • Michael L Gonzales
  • Ari J Firestone
  • David L Mellman
  • Rosemary A L Bayne
  • Renee L Doughman
  • Melanie J Walton
  • Shawn F Bairstow
  • S D Gross
  • J C Loijens
  • Bolin Qin
  • Heping Cao
  • Jessica N Heck
  • David T Baird
  • Chunhua Song
  • Marina Kisseleva
  • Kurt J Sales
  • R L Doughman
  • I V Boronenkov
  • Stewart T G Burgess
  • Peter Ghazal
  • Marie Craigon
  • Sanjukta Ghosh
  • Thorsten Forster
  • Christina Kendziorski
  • Joseph F Urban
  • Khosrow Adeli
  • Rui Lin
  • Christy A Barlow
  • Igor V Boronenkov
  • Matthew P Wagoner
  • Yue Sun
  • Nicholas J Schill
  • Ian Wallace
  • Xiaojing Su
  • Chateen Carbonara
  • Michael Ward
  • Gregory D Longmore
  • Yungfeng Feng
  • Stuart A Milne
  • Alistair R W Williams
  • Michelle L Wojtasiak
  • Deane F Mosher
  • Michael D Schaller
  • A J Firestone
  • Vidhya V Iyer
  • C Simerly
  • G Schatten
  • G J Parker
  • P Baas
  • P L Fisette
  • D P Hoffman
  • G Subrahmanyam
  • P J Bertics

Detail Information

Publications27

  1. ncbi request reprint Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
    J C Loijens
    Program in Cellular and Molecular Biology and Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 271:32937-43. 1996
    ..Furthermore, the limited homology between PIP5KIs and PIP5KIIalpha, which was almost exclusively within the kinase domain core, provided a molecular basis for distinction between type I and II PIP5Ks...
  2. doi request reprint A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs
    David L Mellman
    Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nature 451:1013-7. 2008
    ..The results reveal a mechanism for the integration of nuclear phosphoinositide signals and a method for regulating gene expression...
  3. pmc Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch
    Kun Ling
    Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Cell Biol 163:1339-49. 2003
    ..This defines a novel phosphotyrosine-binding site on the talin F3 domain and a "molecular switch" for talin binding between PIPKIgamma661 and beta-integrin that may regulate dynamic FA turnover...
  4. ncbi request reprint Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
    R A Anderson
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 274:9907-10. 1999
  5. ncbi request reprint The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI, USA
    J Cell Sci 112:2647-56. 1999
    ....
  6. ncbi request reprint Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties
    J Zhang
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Biochemistry 35:16319-27. 1996
    ..These observations demonstrate that the alpha L insert within the kinase domain modulates substrate kinetics. These kinetic differences suggest that CKI alpha and CKI alpha L may perform different biological roles...
  7. pmc Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors
    I V Boronenkov
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:3547-60. 1998
    ..The putative absence of membranes at these sites suggests novel mechanisms for the generation of phosphoinositides within these structures...
  8. pmc A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    J Cell Biol 130:711-24. 1995
    ..Therefore, PIP2 may spatially regulate CKI. Since PIP2 synthesis is required for secretion, this inhibition of CKI may be important for the regulation of secretion...
  9. ncbi request reprint The phosphatidylinositol 4-phosphate 5-kinase family
    J C Loijens
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Adv Enzyme Regul 36:115-40. 1996
    ..The concept of localized complexes containing particular PIP5K isoforms that control the composition of different polyphosphoinositide pools will likely be important as the family of PIP5K isoforms grows...
  10. ncbi request reprint A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte
    S D Gross
    Department of Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Cell Sci 110:3083-90. 1997
    ..These results suggest that the kinase regulates the progression from interphase to mitosis during the first cell cycle...
  11. ncbi request reprint Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place
    R L Doughman
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Membr Biol 194:77-89. 2003
    ..This review examines both structural and regulatory features that modulate activity, localization, and substrate usage of PIPKs...
  12. pmc Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16
    W Li
    Molecular and Cellular Pharmacology Program, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Oncogene 33:928-32. 2014
    ..These data provide a mechanistic basis for increasing the sensitivity and efficiency of chemotherapy in the treatment of cancers that have low levels of wild-type p53. ..
  13. pmc Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro
    G Subrahmanyam
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706
    Proc Natl Acad Sci U S A 88:5222-6. 1991
    ..1 occurs in vivo and may be functionally significant. The tyrosine phosphorylation site is in the center of a sequence motif that is expressed by a differentiation-specific splicing mechanism...
  14. ncbi request reprint Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling
    Renee L Doughman
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 278:23036-45. 2003
    ..Combined, these data support a model where the localized production of PIP2 by PIPKIalpha is necessary for actin remodeling, whereas formation of membrane ruffles required Rac signaling...
  15. doi request reprint Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling
    Bolin Qin
    Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G1120-9. 2008
    ....
  16. pmc Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli
    Heping Cao
    Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture ARS, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Biotechnol Prog 24:326-33. 2008
    ..These results demonstrate that ZFP36L1 antiserum is useful in the detection of this protein and that TTP and ZFP36L1 are differentially expressed and regulated at the mRNA and protein levels in mouse adipocytes and macrophages...
  17. doi request reprint Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate
    Matthew W Bunce
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    J Biol Chem 283:8678-86. 2008
    ....
  18. ncbi request reprint Molecular profiling of the human testis reveals stringent pathway-specific regulation of RNA expression following gonadotropin suppression and progestogen treatment
    Rosemary A L Bayne
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Androl 29:389-403. 2008
    ....
  19. ncbi request reprint A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family
    Jessica N Heck
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin Madison, University of Wisconsin Medical School, Madison, WI 53706, USA
    Crit Rev Biochem Mol Biol 42:15-39. 2007
    ....
  20. ncbi request reprint Stress-ING out: phosphoinositides mediate the cellular stress response
    Matthew W Bunce
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Sci STKE 2006:pe46. 2006
    ..These findings highlight a previously uncharacterized function for phosphoinositides and implicate their metabolism in signaling pathways critical for cell survival...
  21. ncbi request reprint Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis
    Shawn F Bairstow
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 281:20632-42. 2006
    ..Collectively, this evidence implies an important role for PIPKIgamma661 in the AP2-mediated endocytosis of transferrin...
  22. ncbi request reprint Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis
    Melanie J Walton
    Centre for Reproductive Biology, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 91:2526-33. 2006
    ..The testicular response to gonadotropin withdrawal is important for the development of effective contraceptive methods...
  23. ncbi request reprint Nuclear phosphoinositide kinases and inositol phospholipids
    Michael L Gonzales
    Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Cell Biochem 97:252-60. 2006
    ..Here, we will introduce the components of nuclear inositol phospholipid signal transduction and discuss how their spatial arrangement may dictate which nuclear functions they are modulating...
  24. ncbi request reprint A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:4657-64. 2005
    ..Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA...
  25. pmc The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha
    Marina Kisseleva
    Department of Medicine and Cell Biology, Washington University, 660 S Euclid Avenue, St Louis, MO 63110 1010, USA
    Mol Cell Biol 25:3956-66. 2005
    ..Thus, in addition to its effects upon Rac activity Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity...
  26. ncbi request reprint Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
    Kun Ling
    Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Madison, 1300 University Avenue, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Nature 420:89-93. 2002
    ..This defines a mechanism for spatial generation of PtdIns(4,5)P(2) at focal adhesions...
  27. ncbi request reprint Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 89:986-93. 2004
    ..These data suggest that PGF(2 alpha)-FP receptor promote endometrial tumorigenesis via a phospholipase C-mediated phosphorylation of the EGFR and MAPK signaling pathways...