MICHAEL GARY ANDERSON

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes
    Colleen M Trantow
    Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1001008. 2010
  2. pmc STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data
    Tamas Haraszti
    Biophysical Chemistry, University of Heidelberg, Im Neuenhelmer Feld 253, 69120 Heidelberg, Germany
    Chem Cent J 4:11. 2010
  3. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
  4. pmc Iris phenotypes and pigment dispersion caused by genes influencing pigmentation
    Michael G Anderson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
    Pigment Cell Melanoma Res 21:565-78. 2008
  5. pmc GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma
    Michael G Anderson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa USA
    BMC Genet 9:30. 2008
  6. pmc Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Biol 4:20. 2006
  7. ncbi request reprint Scanning transmission X-ray microscopic analysis of purified melanosomes of the mouse iris
    Michael G Anderson
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States
    Micron 37:689-98. 2006
  8. ncbi request reprint Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
  9. pmc By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma
    Jun Song Mo
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Exp Med 197:1335-44. 2003
  10. pmc Quantitative trait loci associated with murine central corneal thickness
    Geoffrey D Lively
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Physiol Genomics 42:281-6. 2010

Research Grants

  1. Genetic dissection of pigment dispersing iris disease
    Michael Anderson; Fiscal Year: 2009
  2. Genetic dissection of pigment dispersing iris disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2010
  3. Genetic dissection of pigment dispersing iris disease
    Michael Anderson; Fiscal Year: 2009
  4. Genetic dissection of pigment dispersing iris disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. pmc Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes
    Colleen M Trantow
    Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1001008. 2010
    ..These results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST...
  2. pmc STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data
    Tamas Haraszti
    Biophysical Chemistry, University of Heidelberg, Im Neuenhelmer Feld 253, 69120 Heidelberg, Germany
    Chem Cent J 4:11. 2010
    ..g. for selection of regions of interest and statistical comparisons of sample variability...
  3. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
    ..We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear...
  4. pmc Iris phenotypes and pigment dispersion caused by genes influencing pigmentation
    Michael G Anderson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
    Pigment Cell Melanoma Res 21:565-78. 2008
    ..Combined, these findings illustrate the utility of studying iris phenotypes as a means of discovering new pathways, and re-linking old ones, to processes of pigmented cells in health and disease...
  5. pmc GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma
    Michael G Anderson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa USA
    BMC Genet 9:30. 2008
    ..DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris disease and abnormalities of the immunosuppressive ocular microenvironment...
  6. pmc Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Biol 4:20. 2006
    ..We initiated a study of congenic strains to further define the genetic requirements and disease mechanisms of the D2 glaucoma...
  7. ncbi request reprint Scanning transmission X-ray microscopic analysis of purified melanosomes of the mouse iris
    Michael G Anderson
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States
    Micron 37:689-98. 2006
    ....
  8. ncbi request reprint Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  9. pmc By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma
    Jun Song Mo
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Exp Med 197:1335-44. 2003
    ..These results suggest previously unsuspected roles for bone marrow-derived cells and ocular immune privilege in the pathogenesis of PG...
  10. pmc Quantitative trait loci associated with murine central corneal thickness
    Geoffrey D Lively
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Physiol Genomics 42:281-6. 2010
    ..Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma...
  11. ncbi request reprint Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
    ..This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy...
  12. ncbi request reprint Complex genetics of glaucoma susceptibility
    Richard T Libby
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Annu Rev Genomics Hum Genet 6:15-44. 2005
    ..In this review, we focus on endogenous genetic susceptibility factors and on how experimental studies will be valuable for dissecting the multifactorial complexity of their interactions...
  13. pmc Genetic dependence of central corneal thickness among inbred strains of mice
    Geoffrey D Lively
    Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 51:160-71. 2010
    ..The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT...
  14. pmc Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome
    Colleen M Trantow
    Department of Molecular Physiology, University of Iowa, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 50:1205-14. 2009
    ..The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test whether Lyst mutant mice develop other features of XFS, and describe the molecular basis of the beige mutation...
  15. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
  16. pmc Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine
    Ana Recober
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 29:8798-804. 2009
    ..Moreover, they validate CGRP hypersensitive mice as a tool for exploring the neurobiology and novel therapies for migraine and other disorders involving photophobia...
  17. pmc Visual impairment in the absence of dystroglycan
    Jakob S Satz
    Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 29:13136-46. 2009
    ..In contrast to the role of alpha-dystroglycan extracellular interactions during early development of the CNS, beta-dystroglycan intracellular interactions are important for visual function but not the laminar development of the retina...
  18. doi request reprint Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function
    Samir M Abdelmagid
    Department of Anatomy and Cell Biology, Temple University, School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Exp Cell Res 314:2334-51. 2008
    ..Collectively, our data suggest that OA acts as a positive regulator of osteoblastogenesis...
  19. ncbi request reprint A recognition-free mechanism for reliable rejection of brood parasites
    Michael G Anderson
    Ecology and Conservation Group, Institute of Natural Resources, Massey University, Albany Campus, Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
    Trends Ecol Evol 22:283-6. 2007
    ..Discrimination without recognition has important implications for the realized trajectories of host-parasite coevolutionary arms races...

Research Grants4

  1. Genetic dissection of pigment dispersing iris disease
    Michael Anderson; Fiscal Year: 2009
    ..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..
  2. Genetic dissection of pigment dispersing iris disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2010
    ..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..
  3. Genetic dissection of pigment dispersing iris disease
    Michael Anderson; Fiscal Year: 2009
    ..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..
  4. Genetic dissection of pigment dispersing iris disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2010
    ..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..