Genomes and Genes
MICHAEL GARY ANDERSON
Affiliation: University of Iowa
- Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypesColleen M Trantow
Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, United States of America
PLoS Genet 6:e1001008. 2010..These results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST...
- STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES dataTamas Haraszti
Biophysical Chemistry, University of Heidelberg, Im Neuenhelmer Feld 253, 69120 Heidelberg, Germany
Chem Cent J 4:11. 2010..g. for selection of regions of interest and statistical comparisons of sample variability...
- Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1Gareth R Howell
The Jackson Laboratory, Bar Harbor, Maine, USA
BMC Genet 8:45. 2007..We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear...
- Iris phenotypes and pigment dispersion caused by genes influencing pigmentationMichael G Anderson
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
Pigment Cell Melanoma Res 21:565-78. 2008..Combined, these findings illustrate the utility of studying iris phenotypes as a means of discovering new pathways, and re-linking old ones, to processes of pigmented cells in health and disease...
- GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucomaMichael G Anderson
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa USA
BMC Genet 9:30. 2008..DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris disease and abnormalities of the immunosuppressive ocular microenvironment...
- Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucomaMichael G Anderson
The Jackson Laboratory, Bar Harbor, ME, USA
BMC Biol 4:20. 2006..We initiated a study of congenic strains to further define the genetic requirements and disease mechanisms of the D2 glaucoma...
- Scanning transmission X-ray microscopic analysis of purified melanosomes of the mouse irisMichael G Anderson
Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States
Micron 37:689-98. 2006....
- Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J miceMichael G Anderson
The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
Nat Genet 30:81-5. 2002..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
- By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucomaJun Song Mo
The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
J Exp Med 197:1335-44. 2003..These results suggest previously unsuspected roles for bone marrow-derived cells and ocular immune privilege in the pathogenesis of PG...
- Quantitative trait loci associated with murine central corneal thicknessGeoffrey D Lively
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
Physiol Genomics 42:281-6. 2010..Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma...
- Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegenerationRichard T Libby
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Vis Neurosci 22:637-48. 2005..This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy...
- Complex genetics of glaucoma susceptibilityRichard T Libby
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Annu Rev Genomics Hum Genet 6:15-44. 2005..In this review, we focus on endogenous genetic susceptibility factors and on how experimental studies will be valuable for dissecting the multifactorial complexity of their interactions...
- Genetic dependence of central corneal thickness among inbred strains of miceGeoffrey D Lively
Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, USA
Invest Ophthalmol Vis Sci 51:160-71. 2010..The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT...
- Lyst mutation in mice recapitulates iris defects of human exfoliation syndromeColleen M Trantow
Department of Molecular Physiology, University of Iowa, Iowa City, Iowa 52242, USA
Invest Ophthalmol Vis Sci 50:1205-14. 2009..The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test whether Lyst mutant mice develop other features of XFS, and describe the molecular basis of the beige mutation...
- High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucomaMichael G Anderson
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Proc Natl Acad Sci U S A 102:4566-71. 2005..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
- Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraineAna Recober
Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
J Neurosci 29:8798-804. 2009..Moreover, they validate CGRP hypersensitive mice as a tool for exploring the neurobiology and novel therapies for migraine and other disorders involving photophobia...
- Visual impairment in the absence of dystroglycanJakob S Satz
Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
J Neurosci 29:13136-46. 2009..In contrast to the role of alpha-dystroglycan extracellular interactions during early development of the CNS, beta-dystroglycan intracellular interactions are important for visual function but not the laminar development of the retina...
- Osteoactivin, an anabolic factor that regulates osteoblast differentiation and functionSamir M Abdelmagid
Department of Anatomy and Cell Biology, Temple University, School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
Exp Cell Res 314:2334-51. 2008..Collectively, our data suggest that OA acts as a positive regulator of osteoblastogenesis...
- A recognition-free mechanism for reliable rejection of brood parasitesMichael G Anderson
Ecology and Conservation Group, Institute of Natural Resources, Massey University, Albany Campus, Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
Trends Ecol Evol 22:283-6. 2007..Discrimination without recognition has important implications for the realized trajectories of host-parasite coevolutionary arms races...