Mark Anderson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Deletional tolerance mediated by extrathymic Aire-expressing cells
    James M Gardner
    Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
    Science 321:843-7. 2008
  2. pmc Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    Jason DeVoss
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2727-35. 2006
  3. doi request reprint Monogenic autoimmunity
    Mickie H Cheng
    Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Francisco, San Francisco, California 94143, USA
    Annu Rev Immunol 30:393-427. 2012
  4. ncbi request reprint The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
  5. pmc Update in endocrine autoimmunity
    Mark S Anderson
    University of California San Francisco Diabetes Center, San Francisco, California 94143 0540, USA
    J Clin Endocrinol Metab 93:3663-70. 2008
  6. pmc Aire and T cell development
    Mark S Anderson
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Curr Opin Immunol 23:198-206. 2011
  7. pmc Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    Maureen A Su
    Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
    J Clin Invest 118:1712-26. 2008
  8. ncbi request reprint Lessons on immune tolerance from the monogenic disease APS1
    Jason J DeVoss
    University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
    Curr Opin Genet Dev 17:193-200. 2007
  9. ncbi request reprint What's new in the Aire?
    Mickie H Cheng
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Immunol 28:321-7. 2007
  10. pmc Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1
    Jason J DeVoss
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 181:4072-9. 2008

Research Grants

  1. Aire-defieciency as a novel model of uveitis
    Mark Anderson; Fiscal Year: 2007
  2. Aire-defieciency as a novel model of uveitis
    Mark Anderson; Fiscal Year: 2009
  3. Aire-defieciency as a novel model of uveitis
    Mark S Anderson; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc Deletional tolerance mediated by extrathymic Aire-expressing cells
    James M Gardner
    Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
    Science 321:843-7. 2008
    ..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection...
  2. pmc Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    Jason DeVoss
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2727-35. 2006
    ..These results suggest that failure of thymic expression of selective single self-antigens can be sufficient to cause organ-specific autoimmune disease, even in otherwise self-tolerant individuals...
  3. doi request reprint Monogenic autoimmunity
    Mickie H Cheng
    Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Francisco, San Francisco, California 94143, USA
    Annu Rev Immunol 30:393-427. 2012
    ..The continued study of rare variants in autoimmune disease will inform future investigations and treatments directed at rare and common autoimmune diseases alike...
  4. ncbi request reprint The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  5. pmc Update in endocrine autoimmunity
    Mark S Anderson
    University of California San Francisco Diabetes Center, San Francisco, California 94143 0540, USA
    J Clin Endocrinol Metab 93:3663-70. 2008
    ..The endocrine system is a common target in pathogenic autoimmune responses, and there has been recent progress in our understanding, diagnosis, and treatment of autoimmune endocrine diseases...
  6. pmc Aire and T cell development
    Mark S Anderson
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Curr Opin Immunol 23:198-206. 2011
    ..Finally, the identity of antigen presenting cells in negative selection, including the role of medullary thymic epithelial cells in displaying tissue specific antigens to T cells, has also been clarified...
  7. pmc Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    Maureen A Su
    Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
    J Clin Invest 118:1712-26. 2008
    ..Together, these results may demonstrate a mechanism by which autoimmune predisposition to phenotypes distinct from APS 1 can be mediated in a dominant-negative fashion by Aire...
  8. ncbi request reprint Lessons on immune tolerance from the monogenic disease APS1
    Jason J DeVoss
    University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
    Curr Opin Genet Dev 17:193-200. 2007
    ..Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this disorder--autoimmune regulator (AIRE)--is providing new lessons on how immune tolerance is maintained...
  9. ncbi request reprint What's new in the Aire?
    Mickie H Cheng
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Immunol 28:321-7. 2007
    ..Recent characterization of Aire-targeted antigens continues to bear this out. Here, we review the current progress surrounding the role of Aire in central tolerance from a molecular, genetic and developmental basis...
  10. pmc Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1
    Jason J DeVoss
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 181:4072-9. 2008
    ..Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1...
  11. pmc Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    Xuyu Zhou
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1983-91. 2008
    ..These results support a central role for miRNAs in maintaining the stability of differentiated T reg cell function in vivo and homeostasis of the adaptive immune system...
  12. pmc A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy
    Cedric Louvet
    Diabetes Center and the Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:507-14. 2009
    ..Collectively, our data suggest that myelin P0 is a major autoantigen in autoimmune peripheral neuropathy...
  13. pmc AIRE in the thymus and beyond
    James M Gardner
    Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143 0540, USA
    Curr Opin Immunol 21:582-9. 2009
    ..The detection of both Aire and TSA expression by cell populations outside of the thymus raises the possibility that such expression may play a relevant role in the maintenance of self-tolerance...
  14. pmc An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse
    Jason J DeVoss
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:4236-46. 2010
    ....
  15. ncbi request reprint Expression of Aire and the early wave of apoptosis in spermatogenesis
    Claudia E Schaller
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 180:1338-43. 2008
    ..We suggest that there is a link between the scheduled and sporadic apoptotic processes and propose that scheduled apoptosis provides a counterselection mechanism that keeps the germline stable...
  16. ncbi request reprint Aire: an update
    Maureen A Su
    Diabetes Center, University of California, San Francisco, Box 0540, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Curr Opin Immunol 16:746-52. 2004
    ..Although these molecular details await further characterization, the association of Aire with the prevention of autoimmunity highlights the importance of thymic mechanisms in the maintenance of tolerance...
  17. pmc An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans
    Yafei Hou
    Division of Hematology Oncology, Department of Medicine, University of California, San Francisco, California 94143, USA
    J Clin Invest 119:2031-41. 2009
    ..Moreover, SVS2 and semenogelin are among the relevant autoantigens in mice and humans, respectively...
  18. pmc The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients
    Maureen A Su
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Clin Immunol 131:139-44. 2009
    ..These findings suggest that the autoimmune predisposition in Turner Syndrome is not due to alterations in regulatory T cells but may be associated with a change in the proportion of T cell subsets...
  19. pmc Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease
    Shimin Li
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 49:34-41. 2008
    ..The authors hypothesized that inflammation is a key inducer of pathologic keratinization and that SPRR1B represents an analytical biomarker for the study of the molecular mechanisms...
  20. pmc Monogenic autoimmune diseases: insights into self-tolerance
    Maureen A Su
    Diabetes Center and Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Pediatr Res 65:20R-25R. 2009
    ..Importantly, the knowledge and principles gained from studying these diseases have been applicable to more common autoimmune diseases and have opened the door to better diagnostic and therapeutic modalities...
  21. pmc Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance
    Anthony K Shum
    1Diabetes Center, University of California, San Francisco, CA 94143, USA
    Sci Transl Med 1:9ra20. 2009
    ....
  22. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
    ....
  23. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  24. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  25. pmc A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
    Clin Immunol 125:131-7. 2007
    ..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%...
  26. ncbi request reprint Autoimmune endocrine disease
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Immunol 14:760-4. 2002
    ..Finally, the recent cloning of the causative gene for autoimmune polyglandular syndrome type I, called AIRE, has brought central tolerance back into focus as an important mechanism in these endocrine diseases...

Research Grants8

  1. Aire-defieciency as a novel model of uveitis
    Mark Anderson; Fiscal Year: 2007
    ..These studies have important implications for understanding how autoimmunity in the eye occurs and have a direct link to the clinical realm, as patients with a defective Aire gene also develop uveitis. ..
  2. Aire-defieciency as a novel model of uveitis
    Mark Anderson; Fiscal Year: 2009
    ..These studies have important implications for understanding how autoimmunity in the eye occurs and have a direct link to the clinical realm, as patients with a defective Aire gene also develop uveitis. ..
  3. Aire-defieciency as a novel model of uveitis
    Mark S Anderson; Fiscal Year: 2010
    ....