Research Topics
| Mark AndersonSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Deletional tolerance mediated by extrathymic Aire-expressing cellsJames M Gardner
Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
Science 321:843-7. 2008..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection...- Monogenic autoimmunityMickie H Cheng
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Francisco, San Francisco, California 94143, USA
Annu Rev Immunol 30:393-427. 2012..The continued study of rare variants in autoimmune disease will inform future investigations and treatments directed at rare and common autoimmune diseases alike... - Aire and T cell developmentMark S Anderson
Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Curr Opin Immunol 23:198-206. 2011..Finally, the identity of antigen presenting cells in negative selection, including the role of medullary thymic epithelial cells in displaying tissue specific antigens to T cells, has also been clarified... - Update in endocrine autoimmunityMark S Anderson
University of California San Francisco Diabetes Center, San Francisco, California 94143 0540, USA
J Clin Endocrinol Metab 93:3663-70. 2008..The endocrine system is a common target in pathogenic autoimmune responses, and there has been recent progress in our understanding, diagnosis, and treatment of autoimmune endocrine diseases... - The NOD mouse: a model of immune dysregulationMark S Anderson
Diabetes Center, University of California, San Francisco, California 94143, USA
Annu Rev Immunol 23:447-85. 2005..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D... - Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in AireMaureen A Su
Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
J Clin Invest 118:1712-26. 2008..Together, these results may demonstrate a mechanism by which autoimmune predisposition to phenotypes distinct from APS 1 can be mediated in a dominant-negative fashion by Aire... - Lessons on immune tolerance from the monogenic disease APS1Jason J DeVoss
University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
Curr Opin Genet Dev 17:193-200. 2007..Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this disorder--autoimmune regulator (AIRE)--is providing new lessons on how immune tolerance is maintained... - What's new in the Aire?Mickie H Cheng
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
Trends Immunol 28:321-7. 2007..Recent characterization of Aire-targeted antigens continues to bear this out. Here, we review the current progress surrounding the role of Aire in central tolerance from a molecular, genetic and developmental basis... - Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1Jason J DeVoss
Diabetes Center, University of California, San Francisco, CA 94143, USA
J Immunol 181:4072-9. 2008..Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1... - Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityXuyu Zhou
Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:1983-91. 2008..These results support a central role for miRNAs in maintaining the stability of differentiated T reg cell function in vivo and homeostasis of the adaptive immune system... - Spontaneous autoimmunity prevented by thymic expression of a single self-antigenJason DeVoss
Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 203:2727-35. 2006..These results suggest that failure of thymic expression of selective single self-antigens can be sufficient to cause organ-specific autoimmune disease, even in otherwise self-tolerant individuals... - A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathyCedric Louvet
Diabetes Center and the Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 206:507-14. 2009..Collectively, our data suggest that myelin P0 is a major autoantigen in autoimmune peripheral neuropathy... - AIRE in the thymus and beyondJames M Gardner
Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143 0540, USA
Curr Opin Immunol 21:582-9. 2009..The detection of both Aire and TSA expression by cell populations outside of the thymus raises the possibility that such expression may play a relevant role in the maintenance of self-tolerance... - An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouseJason J DeVoss
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
J Immunol 184:4236-46. 2010.... - Expression of Aire and the early wave of apoptosis in spermatogenesisClaudia E Schaller
Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
J Immunol 180:1338-43. 2008..We suggest that there is a link between the scheduled and sporadic apoptotic processes and propose that scheduled apoptosis provides a counterselection mechanism that keeps the germline stable... - Aire: an updateMaureen A Su
Diabetes Center, University of California, San Francisco, Box 0540, 513 Parnassus Avenue, San Francisco, California 94143, USA
Curr Opin Immunol 16:746-52. 2004..Although these molecular details await further characterization, the association of Aire with the prevention of autoimmunity highlights the importance of thymic mechanisms in the maintenance of tolerance... - An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humansYafei Hou
Division of Hematology Oncology, Department of Medicine, University of California, San Francisco, California 94143, USA
J Clin Invest 119:2031-41. 2009..Moreover, SVS2 and semenogelin are among the relevant autoantigens in mice and humans, respectively... - The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patientsMaureen A Su
Department of Pediatrics, University of California, San Francisco, CA 94143, USA
Clin Immunol 131:139-44. 2009..These findings suggest that the autoimmune predisposition in Turner Syndrome is not due to alterations in regulatory T cells but may be associated with a change in the proportion of T cell subsets... - Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye diseaseShimin Li
Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
Invest Ophthalmol Vis Sci 49:34-41. 2008..The authors hypothesized that inflammation is a key inducer of pathologic keratinization and that SPRR1B represents an analytical biomarker for the study of the molecular mechanisms... - Monogenic autoimmune diseases: insights into self-toleranceMaureen A Su
Diabetes Center and Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
Pediatr Res 65:20R-25R. 2009..Importantly, the knowledge and principles gained from studying these diseases have been applicable to more common autoimmune diseases and have opened the door to better diagnostic and therapeutic modalities... - Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central toleranceAnthony K Shum
1Diabetes Center, University of California, San Francisco, CA 94143, USA
Sci Transl Med 1:9ra20. 2009.... - Modifier loci condition autoimmunity provoked by Aire deficiencyWenyu Jiang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:805-15. 2005.... - The cellular mechanism of Aire control of T cell toleranceMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 23:227-39. 2005..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops... - Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity... - A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
Clin Immunol 125:131-7. 2007..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%... - Autoimmune endocrine diseaseMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Opin Immunol 14:760-4. 2002..Finally, the recent cloning of the causative gene for autoimmune polyglandular syndrome type I, called AIRE, has brought central tolerance back into focus as an important mechanism in these endocrine diseases...
Research Grants
- Aire-defieciency as a novel model of uveitisMark Anderson; Fiscal Year: 2007..These studies have important implications for understanding how autoimmunity in the eye occurs and have a direct link to the clinical realm, as patients with a defective Aire gene also develop uveitis. ..
- Aire-defieciency as a novel model of uveitisMark Anderson; Fiscal Year: 2009..These studies have important implications for understanding how autoimmunity in the eye occurs and have a direct link to the clinical realm, as patients with a defective Aire gene also develop uveitis. ..
- Aire-defieciency as a novel model of uveitisMark S Anderson; Fiscal Year: 2010....